CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000014647 ------------------------------------------------------------ ENST00000230643 ------------------------------------------------------------ ENST00000237596 -----------------MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAP ENSMUST00000046660 -----------------MVNSRRVQPQPPGDAGRSPAPRASGPGRLVAG----GAGLTVP SINFRUP00000143629 ------------------------------------------------------------ ci0100145568 ------------------------------------------------------------ ENSMUST00000042026 ------------------------------------------------------------ ENST00000266049 ------------------------------------------------------------ SINFRUP00000137781 ------------------------------------------------------------ CG6504-RA MAQQGQSGRSPSGPPGPPPPRPPKTPPGASPRGTPTADSTPGDVTPARGPPPPPATKRVS ENSMUST00000014647 ------------------------------------------------------------ ENST00000230643 ------------------------------------------------------------ ENST00000237596 GGLCEQRGLEIEMQRIRQAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEV ENSMUST00000046660 GGLGEQRGLEIEMERIRQAAARDPPAGASASPSPPLSSCSRQAWSRDNPGFEAEEDDDDE SINFRUP00000143629 ------------------------------------------------------------ ci0100145568 ------------------------------------------------------------ ENSMUST00000042026 -MNSMESPKNQELQTLGNRAWDNPAYSDPPSPNRTLRICT-------------------- ENST00000266049 -MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCT-------------------- SINFRUP00000137781 ------------------------------------------------------------ CG6504-RA IGVGSTRSAPPPATDPTGPPPTAGKPVRDTGPSTSPRPSLRDPGQSTSDKPSTSDKPSTS ENSMUST00000014647 ------------------------------------------------------------ ENST00000230643 ------------------------------------------------------------ ENST00000237596 EGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPP ENSMUST00000046660 D----------------------------RVSLCSPGCPGIHSVDQAGLELRIPPASASQ SINFRUP00000143629 ------------------------------------------------------------ ci0100145568 ------------------------------------------------------------ ENSMUST00000042026 --------------------------------------------------------VSSV ENST00000266049 --------------------------------------------------------ISST SINFRUP00000137781 ------------------------------------------------------------ CG6504-RA DKPSTSARTTVREPGPSSSPSRPVSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPE ENSMUST00000014647 -----------------------------MSEATWWYRGGTSKHDLHYRREAEVNTTLEE ENST00000230643 -----------------------------MAEASRWHRGGASKHKLHYRKEVEITTTLQE ENST00000237596 CPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRE ENSMUST00000046660 VLGLKACATAPGSLVKFLGEMTYVLFFR----YVQGLWGTRLMEESNANREKYLKSVLRE SINFRUP00000143629 ------------------------------------LWGTELMEDRDSSRERYLRNILRE ci0100145568 --------------------------------MILGLWGTRQTEDTQTDRELYIRTTIRE ENSMUST00000042026 ALPETQPKKPEVRCQEKTQRTLVSSCCLHICRSIRGLWGTTLTENTAENRELYVKTTLRE ENST00000266049 GPLQPQPKKPEDEPQETAYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRE SINFRUP00000137781 -----------------------------------GLWGTTLTEDTSGNRELFVRTTLRE CG6504-RA KEGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVE . . : : : * ENSMUST00000014647 LLLYFIFLINLCILTFGMVN----------PHMYYLNKVMSSLFVDTSLPDDERSSFRSI ENST00000230643 LLLYFIFLINLCILTFGMVN----------PHMYYLNKVMSSLFLDTSVPGEERTNFKSI ENST00000237596 LVTYLLFLIVLCILTYGMMS----------SNVYYYTRMMSQLFLDTPVSKTEKTNFKTL ENSMUST00000046660 LVTYLFFLVVLCILTYGMMS----------SNVYYYTRTLSQLFIDTPVSKTEKTNFKTL SINFRUP00000143629 MITYIAFLVTICILTYGMVS----------ANMYYYTKVMSQLFLDTPLSPGDPATFRSL ci0100145568 LVIYVFFIATLCILTFGMTS----------STHYYYTKVMQELFVDAQFPDT-KNTFKGM ENSMUST00000042026 LVVYIVFLVDICLLTYGMTS----------SSAYYYTKVMSELFLHTPSDSG--VSFQTI ENST00000266049 LLVYIVFLVDICLLTYGMTS----------SSAYYYTKVMSELFLHTPSDTG--VSFQAI SINFRUP00000137781 LVVYLVFLVDICLLTYGMTS----------SSTYYYTKAMTDLFVNAAGESG--VKFQSI CG6504-RA FSVFIIFLILTSLVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSM : :. *: .::: .: * . : *. . .: : ENSMUST00000014647 RSITEFWKFMEG--------------------PLIDGLYWDSWYGNKQLYSVK------- ENST00000230643 RSITDFWKFMEG--------------------PLLEGLYWDSWYNNQQLYNLK------- ENST00000237596 SSMEDFWKFTEG--------------------SLLDGLYWKMQPSNQTEAD--------- ENSMUST00000046660 SSMEDFWKFTEG--------------------SFLDGLYWKAQTSNHTQAD--------- SINFRUP00000143629 ATMEEFWKFTEG--------------------PFLNGMYWEVWYNNKSLPE--------- ci0100145568 TTMQDFWRFSEG--------------------PLMDGLYWETWYNQKNVSEE-------- ENSMUST00000042026 SSMSDFWDFAQG--------------------PLLDSLYWTKWYNNQSLGRG-------- ENST00000266049 SSMADFWDFAQG--------------------PLLDSLYWTKWYNNQSLGHG-------- SINFRUP00000137781 SSMTDFWTYAQG--------------------PLLDGLYWTKWYNNQSMNTG-------- CG6504-RA PPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKR . . :* . :: : . : ENSMUST00000014647 ------------------------------------NSSRIYYENVLLGIPRVRQLRVRN ENST00000230643 ------------------------------------NSSRIYYENILLGVPRVRQLKVRN ENST00000237596 ------------------------------------NRSFIFYENLLLGVPRIRQLRVRN ENSMUST00000046660 ------------------------------------NRSFIFYENLLLGVPRLRQLRVRN SINFRUP00000143629 ------------------------------------NQSLIYYENLLLGVPRLRQVKVRN ci0100145568 ------------------------------------DLGYIYYENKLLGVPRIRQLKVRN ENSMUST00000042026 ------------------------------------SHSFIYYENLLLGAPRLRQLRVRN ENST00000266049 ------------------------------------SHSFIYYENMLLGVPRLRQLKVRN SINFRUP00000137781 ------------------------------------DQSFIYYENMLLGVPRMRQIKILN CG6504-RA QSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRK . : *** *** **:**::: : ENSMUST00000014647 NTCKVYPAFQSLVSDCYSKYTVENEDFSDFGLKRNPEWTHTPSS-RTAPWHWGFVG-VYR ENST00000230643 NTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSN-TNSPWHWGFLG-VYR ENST00000237596 GSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIA-TYS ENSMUST00000046660 GSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWMYTSEKELNGSSHWGIIA-SYS SINFRUP00000143629 ESCSIHQDLKGEVLECYNLYTPSNEDTASFGPKNGTAWVYASETEVNGSSYWGQVS-KYG ci0100145568 GSCEVHPDFQEEITACYDSYAKAKEDTSPFGSENGTAWVYHTEDELDGSSHWGLLDYTYS ENSMUST00000042026 DSCVVHEDFREDILNCYDVYSPDKEDQLPFGPQNGTAWTYHSQNELGGSSHWGRLT-SYS ENST00000266049 DSCVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLT-SYS SINFRUP00000137781 NSCNVHSDFRDEIAGCFDVYNEKKEDYFNFGLINGTAWSYHTEKQIKGSSHWGLLT-TYS CG6504-RA ESCYVNDAFIRYFNTCYAAYSSGAEDRKPMHKGS----PFRTMHDLDSTPIWTVLA-FYR :* : : . *: * *: : . . . * : * ENSMUST00000014647 DGGYIVTLSKSKSETKAKFVDLRLNNWISRGTRAVFIDFSLYNANVNLFCIIRLLAEFPA ENST00000230643 NGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPA ENST00000237596 GAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPA ENSMUST00000046660 GAGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLAEFPA SINFRUP00000143629 GGGYYQDLSRTKEESMTKLQLLREHLWLDRGTRAVFLDFSVYNGNINLFCIVRLLVEFPA ci0100145568 GGGYYQDLLDTKTKSLAIIKNLKENLWLDRGTRVVLVDFTVYNANINLFCVVRLVVEFPA ENSMUST00000042026 GGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPA ENST00000266049 GGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPA SINFRUP00000137781 GAGYYQDLRRTKEESAAILKDLLDNLWLDRGTRVTFIDFSTYNANINMFCIIRLVVEFPA CG6504-RA TGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPP .** * : . . * *: **:* :::*. :* * ::* ::*:.*:*. ENSMUST00000014647 TGGLLTSWQFYSVKLLRYVSYYDYFIASCEVIFCIFLFVFIIQELRKVNEF-KSAYFRSV ENST00000230643 TGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEF-KSAYFKSI ENST00000237596 TGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIH-KLHYFRSF ENSMUST00000046660 TGGVVPSWQFQPVKLIRYVTAFDFFLAACEIIFCFFIIYYVVEEILEIRIH-RLSYFRSF SINFRUP00000143629 TGGVLTSWQFQTVRLIRYMSSWDYFVGLCEVAFSLFILYYIVEEVLEIRIH-RLHYFRSL ci0100145568 TGGAVPSYQFRTVKLLRYVTTYDYFLMGCEVLYMLFILYYIVEEVLEIRKN-KCSYFKSV ENSMUST00000042026 TGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLH-RLRYLSSV ENST00000266049 TGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIH-RLRYLSSI SINFRUP00000137781 TGGAIPSYQIRTVKLIRYISVWDYFILGCETLFCLFILYYVVEEILELRIH-KFSYFKSI CG6504-RA TGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSM *** :.. :: .::: :.. . :: : .::: : *: ::. *: *. ENSMUST00000014647 WNWLEMLLLLLCFLAVSFYAYCNMQSFLLLGQLLKNTDSYPDFYFLAYWHIYYNNVIAIT ENST00000230643 WNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAIT ENST00000237596 WNCLDVVIVVLSVVAIGINIYRTSNVEVLLQ-FLEDQNTFPNFEHLAYWQIQFNNIAAVT ENSMUST00000046660 WNCLDVVIVVLSVVAMVINIYRMSNAEGLLQ-FLEDQNSFPNFEHVAYWQIQFNNISAVM SINFRUP00000143629 WNCLDVLIIVLSVIAIIMNITRTAMVGKLLKGLLENHTAHPSFGSLAHLQVQFNNVAAII ci0100145568 WNCLDVLVILLSIVAFSFNIYRTITVDSLLGKLLDQPLTYPDFEFLGFWQMQYNNMVAIV ENSMUST00000042026 WNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVN ENST00000266049 WNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVN SINFRUP00000137781 WNILDIIVILLAIVAIIFNIFRTVKVDNLLTKLLEQPDVYADFEFLAFWQTQYNNMNAVN CG6504-RA LNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSD-VTYQSLDVLCFWNIIYVDMMAIL * *: ::: . :*. * .. . .: : : : :: *: ENSMUST00000014647 IFFAWIKIFKFISFNETMSQLSSTLSRCMKDIVGFAIMFFIIFSAYAQLGFLVFGSQVDD ENST00000230643 IFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDD ENST00000237596 VFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDD ENSMUST00000046660 VFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFSIIFLAYAQLAYLVFGTQVDD SINFRUP00000143629 VFFSWVKLFKFINLNKTMSQLTTTMSRCAKDLVGFAIMFFIIFLAYAQLAYLVFGTQVDD ci0100145568 VFFAWIKIFKYISFNRTMTQLQSTLSRCSKDIAGFAVMFFIIFLAYAQLGYLVFGTQVKD ENSMUST00000042026 LFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVEN ENST00000266049 LFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVEN SINFRUP00000137781 LFFAWIKVFKYISINKTMTQLSSTLGRCAKDILGFAIMFFIVFFAYAQLGYLLFGTEVES CG6504-RA AFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPD *: *:*:**:*.:*.*: *: :*: ** **: **::** *:* *****. *:**:: . ENSMUST00000014647 FSTFQNSIFAQFRIVLGDFNFAGIQQANWILGPIYFITFIFFVFFVLLNMFLAIINDTYS ENST00000230643 FSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYS ENST00000237596 FSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYS ENSMUST00000046660 FSTFQECIFTQFRIILGDINFAEIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYS SINFRUP00000143629 FSTFQASIFTQFRIILGDFEFSEIEEANPVLGPIYFTTFVFFIFFILMNMFLAIINDTYS ci0100145568 FSTFQESIFTQFRIILGDFDFHALEAANRVLGPIFFLTYVFFVFFVLLNMFLAIINDTYS ENSMUST00000042026 FSTFVKCIFTQFRIILGDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYS ENST00000266049 FSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYS SINFRUP00000137781 FSTFAKCIFTQFRIILGDFDYDAIDRANRVLGPIYFVTYVFFVFFVLLNMFLAIINDTYT CG6504-RA FRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYN * .* .*:: :*::***::: :: ** :*** :* *:::::**:*:******* ::*. ENSMUST00000014647 EVKADYSIGRRPDFELGKIIQKSCFNVLEKLRLKKAQAKEEKKMQTT------------D ENST00000230643 EVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSG-----------D ENST00000237596 EVKSDLAQ-QKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQG----GGKLNFDE ENSMUST00000046660 EVKSDLAQ-QKAEMELSDLIRKGCQKALVKLKLKRNTVDAISESLRQG----GGKLNFDE SINFRUP00000143629 EVKADMSQ-QRSEMEMTDFIKKGCNKALMKLRLKKTAVDDITDSLRQA----GGKLNLDE ci0100145568 EVKAEISM-QKSEFEISDYIKRGYNKVLEKLSLKKDRIRDIQDAIQTADLNQDRHLDWEE ENSMUST00000042026 EVKEELAG-QKDQLQLSDFLKQSYNKTLLRLRLRKERVSDVQKVLKGG----EPEIQFED ENST00000266049 EVKEELAG-QKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGG----EQEIQFED SINFRUP00000137781 EVKEELSS-QKDELQITDIIKQSYMKTIIKLKLKKEKISDVQKVLRSE----SGDIEFKD CG6504-RA TVKGEITQ---GRSHLGSYIYRKLSGMLYWITHCGRKRRHHPQASETE---------DKD ** : : .: . : : : : . : : ENSMUST00000014647 LAQRARRDGFDESEIQ-----------------EAEQMKRWKERLEKKYYSTEIQDDYQP ENST00000230643 LAEQARREGFDENEIQ-----------------NAEQMKKWKERLEKKYYSMEIQDDYQP ENST00000237596 LRQDLKGKGHTDAEIE---AIFTKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLP ENSMUST00000046660 LRQDLKGKGHTDAEIE---AIFTKYDQDGDQELTEREHQQMRDDLEKEREDLDLEHSSLP SINFRUP00000143629 LRQDLKGKGHTDAEIQ---AIFAKYDQEGDQELTEHEHQQMRDDLEKEREDLELERNSLT ci0100145568 WRLDLKMRGIPDAEIE---AVFAKYDQDGDMILNENEQKKLKADLERQKVELSNELDEME ENSMUST00000042026 FTSTLRELGHEEHEIT---AAFTRFDQDGDHILDEEEQEQMRQGLEEERVTLNAEIENLG ENST00000266049 FTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEKLG SINFRUP00000137781 FRQTLKEMGHAEREIS---EAFSQFDRDGNQILDEEEQKRMKSELEEKR----------- CG6504-RA AEHDVGAAHDETHEIR--------------KNMTPAEQQYFKDIPQGEN----------- ** : : : : : : : ENSMUST00000014647 ------------------------------------------------VTQQEFRELFLY ENST00000230643 ------------------------------------------------VTQEEFRELFLY ENST00000237596 RPMSSRSFPRSLDDSE------------EDDDEDSGHSSRRRGSISSGVSYEEFQVLVRR ENSMUST00000046660 RPMSSRSFPRSLDDSE------------EEDDEDSGHSSRRRGSISSGVSYEEFQVLVRR SINFRUP00000143629 RPISGRSFPRTQEDSE------------EDDDEDSGHSSRRRGSSSGGVSYEEFQVLVRR ci0100145568 RDKSGATTPGARPASARSKGAVSHVSCNDSANESDDDDEDRPISSKNFVSRDDFQILARR ENSMUST00000042026 RSVGHSPPGELGAEAA---------------------------RGQSWVSGEEFDMLTRR ENST00000266049 RSIVSSPQGKSGPEAA---------------------------RAGGWVSGEEFYMLTRR SINFRUP00000137781 ------------------------------------------------------------ CG6504-RA ---------------------------------------------------QDMVRLNNR : : : ENSMUST00000014647 AVELEKELHYVSLKLNQLMRKLH------------------------------------- ENST00000230643 AVELEKELHYINLKLNQVVRKVSAL----------------------------------- ENST00000237596 VDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGR-DSEIHREQ ENSMUST00000046660 VDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDARLGR-DSEIHREQ SINFRUP00000143629 VDRMEHSIGSIVSKIDAVIVKLEAMERAKVKRRDVLGRLLDGVMEDERLGR-DTDAHREQ ci0100145568 VDRMEHSIGSIVSKIDAVIVKLEAMERAKLKRRETMGKLLDNITEDERNGRSDDELRREQ ENSMUST00000042026 VLQLQCVLEGVVSQIDAVGSKLKMLERKGELAPSPGM----------------------- ENST00000266049 VLQLETVLEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQ SINFRUP00000137781 ------------------------------------------------------------ CG6504-RA VGLLEEILEKLINNMDDILKRVEKDYHNKKK----------------------------- : : : : : : ENSMUST00000014647 ------------------------------------------------------------ ENST00000230643 ------------------------------------------------------------ ENST00000237596 MERLVREELERWESDDAASQISH-GLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGS ENSMUST00000046660 MERLVREELERWESDDAASQTGH-GVSTQVGLGGQPHPRNPRPPSSQSAEGLEGGGGNGS SINFRUP00000143629 MERLVREELERWECDDMGSQVSHPQPATPVG----PRPR---PSSSMSTDGLDTVT-NGS ci0100145568 MERLVREELERWDSDASIASTGRRGNRPQSG--------RSTASSSASSNRVRVPGSHGN ENSMUST00000042026 ------------------------------------------------------------ ENST00000266049 GGQESEVPYKREEEALEERRLSRGEIPTLQRS---------------------------- SINFRUP00000137781 ------------------------------------------------------------ CG6504-RA ------------------------------------------------------------ : ENSMUST00000014647 ----- ENST00000230643 ----- ENST00000237596 SNVHV ENSMUST00000046660 ANVHA SINFRUP00000143629 SHV-- ci0100145568 TSSA- ENSMUST00000042026 ----- ENST00000266049 ----- SINFRUP00000137781 ----- CG6504-RA -----