CLUSTAL W (1.82) multiple sequence alignment ENST00000251472 ------------------------------------------------------------ ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 ------------------------------------------------------------ ENSMUST00000003908 ------------------------------------------------------------ ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA MSRQEGAASRPADGATGPVASSSSSTSSNHSVSAVLGSKISTSTPQKNDEHQEQEFINQS ci0100147176 ------------------------------------------------------------ ENST00000251472 ------------------------------------------------------------ ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 -----------------------------MKRSRCRDRPQPPPPDRREDGVQRAAELSQS ENSMUST00000003908 ------------------------------------------------------------ ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA VASEIEAMSISDSASAESSSGATATATATMSGSPVPKRHLSTANLSRIRPQSSYSARVLI ci0100147176 ------------------------------------------------------------ ENST00000251472 ------------------------------------------------------------ ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 LPPRRRAPPGRQRLEERTGPAGPEGKEQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQL ENSMUST00000003908 -----------------------------MVTGLSPLLFRKLSNPDIFAPTGKVKLQRQL ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA FDDSDQEAAAAAAALAAASSSCNSSVKSCSGLELLPTSPAKLSIGNDSTNGSSMMRNLNL ci0100147176 ------------------------------------------------------------ ENST00000251472 -----------------------------------LLPHLPPCRRRRVMSDSLWTALSNF ENSMUST00000053038 --------------------------------------------------------QKDL SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 SQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPS ENSMUST00000003908 SQDDCKLRRGSLASSLSGKQLLPLSSSVHSSVGQVTWQSTGEASNLVRMRNQSLGQSAPS ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA TKSSSGGLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPC ci0100147176 ------------------------------------------------------------ ENST00000251472 SMPSFPGGSMFRRTKSCR------------------------------------------ ENSMUST00000053038 PLP--------RKSSSCR------------------------------------------ SINFRUP00000139259 ---------------SCR------------------------------------------ ENST00000262742 LTAGLKELSLPRRGSFCR------------------------------------------ ENSMUST00000003908 LTAGLKELSLPRRGSFCR------------------------------------------ ENST00000262811 ----------------CR------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA LTGNYFRHELTAPLPVQPPGFGASPLGGHNISRSGSCAGIGLAKHHHHHHLHGVVMRGSA ci0100147176 ------------------------------------------------------------ ENST00000251472 --------------TSNRKSLILTS-TSPTLP--RPHSPLPG-HLGSSPLDSPRNFSPNT ENSMUST00000053038 --------------TSNRKSLILTS-TSPTLP--RPHSPLPG-HLGSSPLDSPRNFSPNT SINFRUP00000139259 --------------TSNRKSLILTS-TSPTLP--RPHSPLPG-HIGSSPLDSPRNFSPSG ENST00000262742 --------------TSNRKSLIVTSSTSPTLP--RPHSPLHG-HTGNSPLDSPRNFSPNA ENSMUST00000003908 --------------TSNRKSLIVTSSTSPTLP--RPHSPLHG-HTGNSPLDSPRNFSPNA ENST00000262811 --------------SGNRKSLVVGT-PSPTLS--RPLSPLSVPTAGSSPLDSPRNFSAAS SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA GGGAGSGGGSSSGVAHHRLSLVTNSAAVAAAGGSRTHSPYSASPVDSPRLNSPMPFAFAP ci0100147176 ------------------------------------------------------------ :: : : ENST00000251472 PAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPY--------- ENSMUST00000053038 PAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPY--------- SINFRUP00000139259 PAHFSFTSSRRADGRRWSLASLPSSGYGTNTPSSTVSSGVGGRFVPFLILF--------- ENST00000262742 PAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPF--------- ENSMUST00000003908 PAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPF--------- ENST00000262811 ALNFPFA--RRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPF--------- SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA IKRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEA ci0100147176 ------------------------------------------------------------ : : : : : ENST00000251472 -------------------------------------QPTVDELHFLS------------ ENSMUST00000053038 -------------------------------------QPTVDELHFLS------------ SINFRUP00000139259 -------------------------------------IFTLRPLLPIV------------ ENST00000262742 -------------------------------------QPTADELHFLT------------ ENSMUST00000003908 -------------------------------------QPTADELHFLT------------ ENST00000262811 -------------------------------------QPTPDELHFLS------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA DAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAE ci0100147176 ------------------------------------------------------------ : ENST00000251472 ------------------KHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIV ENSMUST00000053038 ------------------KHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIV SINFRUP00000139259 ------------------GSI-------------------PTSTRLHAG----------- ENST00000262742 ------------------KHFSTESVPDEE--GRQSPAMRPRSRSLSPGRSPVSFDSEII ENSMUST00000003908 ------------------KHFSTENVPDEE--GRRSPAMRPRSRSLSPGRSPVSFDSEII ENST00000262811 ------------------KHFRSSENVLDEE-GGRSPRLRPRSRSLSPGRATGTFDNEIV SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA LSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPIVDNEIA ci0100147176 ------------------------------------------------------------ : ENST00000251472 MMNHVYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADG--VLSFIHHQIIELARDCLTK ENSMUST00000053038 MMNHVYKERFPKATAQMEEKLRDFARAYEPDSVLPLADG--VLSFIHHQIIELARDCLTK SINFRUP00000139259 LLTLVCLT---QATAQMEERLAEFIQNYTPENVLPVADG--VLSFIHHQIAELSRDCLTK ENST00000262742 MMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADG--ALSFIHHQVIEMARDCLDK ENSMUST00000003908 MMNHVYKERFPKATAQMEERLADFISSNTPDSVLPLADG--ALSFIHHQVIEMARDCLDK ENST00000262811 MMNHVYRERFPKATAQMEGRLQEFLTAYAPGARLALADG--VLGFIHHQIVELARDCLAK SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA VMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHK ci0100147176 ------------------------------------------------------------ :: : : : : . : :: : : : ENST00000251472 SRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEF ENSMUST00000053038 SRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEF SINFRUP00000139259 SREGLITSVYFCELQENLEKLLHDAYERSESSELTFVIELVKKLFIIISRPARLLECLEF ENST00000262742 SRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEF ENSMUST00000003908 SRSGLITSHYFYELQENLEKLLQDAHERSESSDVAFVIQLVKKLMIIIARPARLLECLEF ENST00000262811 SGENLVTSRYFLEMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEF SINFRUP00000157781 ------------------------AYERSESEEVAIIVDLVRKILIIISRPARLLECLEF SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA SEAKLITSQYFYELSENLERLLVETKEKS-PEAAAELNGVIKKLLLIISRPARLLECLEF ci0100147176 ----------------------------------------------------------EF :: : : : :: : :: ::::: :: : : ENST00000251472 NPEEFYHLLEAAEGHAKEGH-LVKTDIPRYIIRQLGLTRDPFPDVVHLE----------- ENSMUST00000053038 NPEEFYHLLEAAEGHAKEGH-LVKTDIPRYIIRQLGLTRDPFPDVVRLE----------- SINFRUP00000139259 NPEEFYHLLEAAEDHAKEGQ-LMKADIPRYIINQLGLTRDPLEEIVSLD----------- ENST00000262742 DPEEFYHLLEAAEGHAKEGQ-GIKCDIPRYIVSQLGLTRDPLEEMAQLS----------- ENSMUST00000003908 DPEEFYHLLEAAEGHAKEGH-GIKCDIPRYIVSQLGLTRDPLEEMAQLS----------- ENST00000262811 DPEEFYHLLEAAEGHAREGQ-GIKTDLPQYIIGQLGLAKDPLEEMVPLS----------- SINFRUP00000157781 DPEEFYHLLEAAEGVAKVGQ-GIKTDIPRYIISQLGLTRDPLEGKALFA----------- SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA DPQEFYELLEAAEGHAKAMP-VIKADIPQYIIHKLGLNRDPIAELQQELRETQQMCSEQV ci0100147176 SPEEFYQLLESAEYVAKESRGCIGTEIPQYIVQQLGLTSVRFFRSSSSD----------- : :: : : :: : : : ENST00000251472 ------------------------------------------------------------ ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 ------------------------------------------------------------ ENSMUST00000003908 ------------------------------------------------------------ ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ------------------------------------------------------------ CG6498-RA TVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATCDTAP ci0100147176 ------------------------------------------------------------ ENST00000251472 -----------------------EQDSGGSNTPEQDDLSEGRS--SKAKKPPGENDFDTI ENSMUST00000053038 -----------------------EQDSGGSNTPEQDDTSEGRSSTSKAKKPPGESDFDTI SINFRUP00000139259 -----------------------SYDSEGPHTPETDDSAEGKG---RAIKPPSEEDFQSI ENST00000262742 -----------------------SCDS--PDTPETDDSIEGHGASLPSKKTPSEEDFETI ENSMUST00000003908 -----------------------SYDS--PDTPETDDSVEGRGVSQPSQKTPSEEDFETI ENST00000262811 -----------------------HLEEEQPPAPE---SPESRALVGQSRRKPCESDFETI SINFRUP00000157781 -----------------------SLASLSRGAESEKIAFKSPQMLTPTRRKPLESDFETI SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 ----------------------------------------SLSTALKSRRKPCELDFEMT CG6498-RA SFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIV ci0100147176 -------------------------------------SEENEENSCPQPQQVTEDDFIVK : ENST00000251472 KLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGM ENSMUST00000053038 KLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGM SINFRUP00000139259 KLISNGAYGAVYLVRHRETRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSM ENST00000262742 KLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSM ENSMUST00000003908 KLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSM ENST00000262811 KLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSM SINFRUP00000157781 KLISNGAYGAVYLVRHKETRQRFAMKKINRQNLVLRNQIQQAFVERDILTFAE-PFVVSM SINFRUP00000128421 -------YRAVFLVRHKETRQRFAMKKINRQNLILRNQIQQVFVERDILTFAENPFVVSM SINFRUP00000139083 KLISNGAYGAVYLVRHKETKQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVV-M CG6498-RA KLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSM ci0100147176 KLISNGAYGSVFLVRHKETSQRFALKKINKHNLALRNEVQQVFAERDILTFVENPFVVTM :: * :*:**:*: * ****:****::** ***:::*.*.*****:*.: **** * ENST00000251472 FCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRD ENSMUST00000053038 FCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRD SINFRUP00000139259 FCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVELTRMYFAETVLALEYLHNYGIVHRD ENST00000262742 FCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRD ENSMUST00000003908 FCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRD ENST00000262811 FCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRD SINFRUP00000157781 FCSFETRRHLCMVMEYVEGGDCANLLKNMGPLPVEMSRMYFAETVLALEYLHNYGIVHRD SINFRUP00000128421 FCSFETRRHLCMVMEYVEGGDCAHLLKNIGPLPVDMARMYFAETVLALEYLHNYGIVHRD SINFRUP00000139083 YCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRD CG6498-RA YCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRD ci0100147176 YCSFQTKHHLCMVMEYVEGGDVASLIKNISVLPDEVAQMYFAETVLALEYLHNYGVVHRD :***:*::***:********* . *:**:. ** :: ::********:****.**:**** ENST00000251472 LKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPE ENSMUST00000053038 LKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPE SINFRUP00000139259 LKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPE ENST00000262742 LKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPE ENSMUST00000003908 LKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPE ENST00000262811 LKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPE SINFRUP00000157781 LKPDNLLITSMGHIKLTDFGLSKIGLMNMTTNLYEGHMEKDTREFLDKQVCGTPEYIAPE SINFRUP00000128421 LKPDNLLITSMGHIKLTDFGLSKIGLMNMTTNLYEGHIEKDTREFIDKQVCGTPEYIAPE SINFRUP00000139083 LKPDNLLVTSMGHIKLTDFGLSKVGLMNMTTNLYEGHIEKDAREFSDKQVCGTPEYIAPE CG6498-RA LKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPE ci0100147176 LKPDNLLITSMGHIKLTDFGLSKVGLMSRTTNLYESHLDTQQ-QFNDRQVHGTPEYIAPE *******:*::************:***. :*****.:::.: :* *:** ********* ENST00000251472 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDE-ALPTE ENSMUST00000053038 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDE-ALPTD SINFRUP00000139259 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVITDDIVWPEGDE-ALPAD ENST00000262742 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDE-ALPPD ENSMUST00000003908 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDD-ALPPD ENST00000262811 VIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDE-ALPAD SINFRUP00000157781 VILRQGYGKPVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVVSDEIIWPEGDD-ALPTD SINFRUP00000128421 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEQLFGQVVNDDLIWPDGED-ALPAD SINFRUP00000139083 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEGED-APPPD CG6498-RA VILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAE ci0100147176 VILHLGYGTPVDWWSAGICLYEFLVGCVPFFGQTPDELFMQAINDDIVWPEGED-ALSED **:: ***.*****: *: *****:*******:*.::** :.:.*:: **:.:: . : ENST00000251472 AQLLISSLLQTNPLVRLGAGG-AFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYF ENSMUST00000053038 AQLLISSLLQTNPLVRLGAGG-AFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYF SINFRUP00000139259 AQALISALLQTNPLVRLGTGG-AFEVKQHSFFTELDWNTLLRQKAEFIPHLESEEDTSYF ENST00000262742 AQDLTSKLLHQNPLERLGTGS-AYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYF ENSMUST00000003908 AQDLTSKLLHQNPLERLGTSS-AYEVKQHPFFMGLDWTGLLRQKAEFIPQLESEDDTSYF ENST00000262811 AQDLITRLLRQSPLDRLGTGG-THEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYF SINFRUP00000157781 AQDLITSLLKQNPLERLGTG--TVHFMQTPQSQTLSFFPNHKTLKVFIIDKEDRGD---- SINFRUP00000128421 AQDLITRLLRQNPLERLGTGG-TAEVKMHTFFLGLDWNGLLRQKAEFIPQLETEDDTSYF SINFRUP00000139083 AQELITLLLRQNPLERLGTGG-AAEVKQHQFFHNLDWNSLLRQKAEFIPQLESEDDTSYF CG6498-RA AKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYF ci0100147176 AISLISCLLDRDPLNRLGSRG-AFEVKSHPYFDSMDWNNLLRQKAQFVPQIDDEEDTSYF * : : ** .* ***: : .. :.: : *: . . * : ENST00000251472 DTRSDRYHHVNSYDE---DDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAA ENSMUST00000053038 DTRSDRYHHVNSYDE---DDTTEEEPVEIRQFSSCSPRFSKVR----------------- SINFRUP00000139259 DTRSDRYHHINTYDE---DDTNDDEPVEIRQFSSCSPRFSKVYSSMEHLSQLEHKATTSV ENST00000262742 DTRSERYHHMDSEDE---EEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPP ENSMUST00000003908 DTRSERYHHVDSEDE---EEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEERRTPPP ENST00000262811 DTRSERYRHLGSEDD---ETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQP----TPT SINFRUP00000157781 ---------MGGHSH---SPAPADGSIEQKQTARMARKE-----QSEFMTVTN----GRS SINFRUP00000128421 DTRSERYCHLGSDDDD--ETNDDESSLELRQFSSVAHRFSKVYSSTEHLSTSTPSNQSLS SINFRUP00000139083 DTRSEKYHHLETEEE---DTNDEDFNVELRQFSSCSHRFSKVYSSLDLSRGHLEEKGETE CG6498-RA DTRMDRYNHDLGGED----TDDTDDTPVFGSFNSYTPQYRKQHYSWSRHATPTSTDGAKP ci0100147176 DTRRDRYTHDSDIPDTSECDDATNDQFDVANFSSSTKRFSESLSDSTAPPTITKSPLNST . : . : : ENST00000251472 AGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIK--RFSASEASFL------ ENSMUST00000053038 ----------------------------------RAG----------------------- SINFRUP00000139259 CRR-----EHKGPREDKVTKRESLGSFSMRDKSWRTGSPEMK--RLSCSESLYM------ ENST00000262742 TKR--------SLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHT------ ENSMUST00000003908 TKR--------SLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHT------ ENST00000262811 FAERSFSEDREEGWER----SEVDYGRRLSADIRLRSWTSS--GSSCQSSSSQP------ SINFRUP00000157781 LCFFLIS-------------------------ILHLSWTVCSLRPRALSSSSQS------ SINFRUP00000128421 SSERSHSEEKEERWEGRGILSPGDGYRHLSSGDRRADGQKGSLRPRASSSSSQS------ SINFRUP00000139083 GKK-------------------SESPLTLDSLSWTPDFAELP----SLSQSTDT------ CG6498-RA TGPPPLSSLPSRAQETPAATVGATSTGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNKF ci0100147176 LDRSSSKSPEMGCLRNIKKSRSMSADSPLLQTSDSINPSPDAGSAFKPSTTVTPPVTSHQ . ENST00000251472 -------------EGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPR------- ENSMUST00000053038 ------------------------------LEPGREGAP--------------------- SINFRUP00000139259 -------------EGDASPPLGARRRFSALMDTHRFASPADGEPDFLSRQVPI------- ENST00000262742 -------------ESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWV--- ENSMUST00000003908 -------------ESDSSPPMTVRHRCSGLPDGPHCP---EETSSTPRKQQQEGIWV--- ENST00000262811 -------------ERGPSPSLLN-TISLDTMPKFAFSSEDEGVGPGPAGPKRP------- SINFRUP00000157781 -------------ERSANPLVMTSTHSLETMPRVALSTDDEGTFR-HCLDIDS------- SINFRUP00000128421 -------------ERSASPLVMNSTQSLDIMPRFAVAAEEEGVTG-NGAVCAL------- SINFRUP00000139083 -------------DGVNPGPRPN------LLPKLAISAESEGDETSGLGDPSK------- CG6498-RA LNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGAT--- ci0100147176 LHPHHAIRN--RASSSSEDRVLPHSPLLSVIPQKQVTPATHPHYPHHRPRYRRMSSCSSV ENST00000251472 --------PSSDPAGSLDARAPKEETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGP ENSMUST00000053038 -------------------------------CNCG--RKVVWPQGGVMKNP--------- SINFRUP00000139259 --------KVRGTSLDGTSIPSPNLLEQKNSLRDINGAATGRDVVTPLYDP------LGS ENST00000262742 -----LTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATA ENSMUST00000003908 -----LIPPSGEGSSRPVPERPLERQLKLDEEPPGQSSRCCPALETRGRGTPQLAEEATA ENST00000262811 -----VFILGEPDPPPAATPVMPKPSSLSADTAALSHARLRSNSIGARHSTPRPLDAGRG SINFRUP00000157781 -----IIQLCSNLSIPAAEVVVSN----------LRRIRIRSNSTGAKHSSPK--EPTGP SINFRUP00000128421 -----YFAACTKLPVHPLFPLTVDG-----MVSNLQRIRLRSNSTGTRPSFRR----GAS SINFRUP00000139083 ------TSLSIAELPQDEHDATTPGSTHSGATLSGSFSEHLDQLTPRGEGMESPDATSQA CG6498-RA -----QRMQQRHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRSTPESSQTD ci0100147176 GSLNYMATARSGTATPIPIDKMLDPSLVTPVTKQRNQFSPTSSVSSEANSPDLNSHPSHT ENST00000251472 RATNDLVLRRARH---------------------------------------------QQ ENSMUST00000053038 -------LWGFRI---------------------------------------------EE SINFRUP00000139259 RATNDLVLRRARH---------------------------------------------QH ENST00000262742 KAISDLAVRRARH---------------------------------------------RL ENSMUST00000003908 KAISDLAVRRARH---------------------------------------------RL ENST00000262811 RRLGGPRDPAPEK---------------------------------------------SR SINFRUP00000157781 RRFGN-QLETPDK---------------------------------------------QR SINFRUP00000128421 RRIAH-QLETPEK---------------------------------------------PR SINFRUP00000139083 SADQDGQTNPVQN---------------------------------------------KR CG6498-RA SDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQPKS ci0100147176 PSKTPFQEPSLEEVMHRRFHHYPAN--------------------------------SPR ENST00000251472 MSGDVAVEKRPSRTGGKVIKSASATALSVMIPA--VDPHGS-SPLASPMSPR----SLSS ENSMUST00000053038 QS----------------VRFALISNHHGFVPV--VDPHGG-SPLASPMSPR----SLSS SINFRUP00000139259 LSGD--GEKHNSRAGTKVIKSASATALSVIIPS--VEQHGGFSPLASPMSPH----SFSS ENST00000262742 LSGD-STEKRTARPVNKVIKSASATALSLLIP----SEHHTCSPLASPMSPH----SQSS ENSMUST00000003908 LSGD-SIEKRTTRPVNKVIKSASATALSLLIP----SEHHACSPLASPMSPH----SQSS ENST00000262811 ASSS---GGSGGGSGGRVPKSASVSALSLIIT----ADDGSGGPLMSPLSPR----SLSS SINFRUP00000157781 LS-----------CGGKVPKSASISSLSLIIT----PDESPSGLQPSPISPR----SLSS SINFRUP00000128421 SP------------TGKVPKSASVSGLSLIIT----PDDS-AGPPLSPKSSL----SLSS SINFRUP00000139083 PAER-------TGAVPKVPKSVSTGALSLMIP----GDIFGVSPLASPLSPY----SLSS CG6498-RA MDGSTSGSSVKHHRSRSIVKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGG----NGSS ci0100147176 SRNHSGEIKRSRSIKRSIIKSSSASSLQLMIPN--IDDSLPPSPLASPRSVHPPHPSILS : : : . ** . . * ENST00000251472 NPSSRDSSPSRDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVE ENSMUST00000053038 NPSSRDSSPSRDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDSDVYSVHHIVWHVE SINFRUP00000139259 NPSSRDSSPSRDFCPAVNVPRSPITIHRSGKKYGFTLRAIRVYIGDSDIYSVHHIVWHVE ENST00000262742 NPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVE ENSMUST00000003908 NPSSRDSSPSRDFLPALGSLRPPIIIHRAGKKYGFTLRAIRVYMGDTDVYTVHHMVWHVE ENST00000262811 NPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVE SINFRUP00000157781 NPSSRDSSPNRDLSLFSGSLKPPIVIQISGKKFGFTLQAIRVYMGDSDVYTVHHMVASVE SINFRUP00000128421 NPSSRDSSPSRDLSISVSCLRPPVVIHSSGKRFGFALRAIRVYMGNTDIYTVHHMVWCVE SINFRUP00000139083 DPSSRDSSPSRDSSLFSASPRQPIIIHSSGKKFGFTLRAIRVYACDGDVYTVYHMVWNVD CG6498-RA TASSRDTSPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVD ci0100147176 NPSSRDSSPGRSFSPVPGSPRPPIVIPRTTRGFGFKIQAIPVFRNNGNTFDVHHIVTQVD .****:** *. : *: * : :** :::* *: : : : ::*:* *: ENST00000251472 EGGPAQEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPA ENSMUST00000053038 EGGPAQEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPA SINFRUP00000139259 DGGPAQEAGLCAGDLITHVNGEPVHGLVHTEVVELILKSGNKVTVTTTPFENTSIKVGPA ENST00000262742 DGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPA ENSMUST00000003908 DGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELVLKSGNKVSISTTPLENTSIKVGPA ENST00000262811 DGSPAQEAGLRAGDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPA SINFRUP00000157781 D-SPAHEAGLHTGDLITHINGESVQGLVHPEMMELLLKSGSRVVLQTIALENTSIKVGPA SINFRUP00000128421 DGSPAHEAGLKAGDLITHINGESVQGLVHTEVVELLLKSGNRVTLQTTALENTSIKVGPA SINFRUP00000139083 DGGPAHKAGLKAGDLITHVNGEAVHGLVHTEVVELLIKSGNKVAISTTPFENTSIKTGPA CG6498-RA EGSPAFEAGLRPADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGR ci0100147176 EKGSAYTAGLRVGDLITHVNNELVQGMVHTSVLQLMYRS-NKISIQAVPLESTSIKIG-R : ..* *** .*****:*.* * *:.* .:::*: . .:: : : .:* ***: * ENST00000251472 RRSSYKAKMARR---NKRPSAKEGQESKKRSSLFRKIT-KQS--NLLHT-SRSLSS-LNR ENSMUST00000053038 RRSSYKAKMARR---NKRPSAKDGQES------FRKIT-KHS--NLLHT-SRSLSS-LNR SINFRUP00000139259 RKASYKCKMARR---NKRTMGKDSQDSKKRNSLFRKIT-KQS--NLLHT-SRSLSS-LNR ENST00000262742 RKGSYKAKMARR---SKRSRGKDGQESRKRSSLFRKIT-KQA--SLLHT-SRSLSS-LNR ENSMUST00000003908 RKGSYKAKMARR---SKRSKGKDGQESRKRSSLFRKIT-KQA--SLLHT-SRSLSS-LNR ENST00000262811 RKNVAKGRMARR---SKRSRRRETQD--RRKSLFKKIS-KQT--SVLHT-SRSFSSGLHH SINFRUP00000157781 RKIKNKGKMARR---SKKSKRRDNYD--RRRGILKKLS-KGS--TVMHT-SRSFSSGLQH SINFRUP00000128421 RKVSCKAKMARR---SKKSKRKDGQDS-RRRSILKKLS-KQTPPPPMQS-SRSFSSGFHQ SINFRUP00000139083 RRNSYRSKMVRC---AKKPKKEKTPE--RRRSLFRRFA-MQPS-PLLHT-SRSFSS-LNH CG6498-RA KRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRRISSKRANAEMQQY-SAGTSSPTTP ci0100147176 RPSKNRSKPIRR---RKRQFIPHRTGSITSKRYTGTSAGGGSSPAMVSSPLHCYKNKRRG : : : : :: : . .. ENST00000251472 SLSSSDSLPGSPTHG--LPARSPTHSYRSTPDSAY--LGASSQSSSPASSTPNSPASSAS ENSMUST00000053038 SLSSSDSLPGSPTHG--LPARSPTHSYRSTPDSAY--LGASSQSSSPASSTPNSPASSAS SINFRUP00000139259 SLSSSESLPGSPTHS--LSARSPTQGHRSTPEHSY--LGASSQSSSPASSTPNSPAP--S ENST00000262742 SLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAG--S ENSMUST00000003908 SLSSGESGPGSPTHSHSLSPRSPPQGYRVAPDAVHSVGGNSSQSSSPSSSVPSSPAG--S ENST00000262811 SLSSSESLPGSPTHS--LSPS-PTTPCRSPAPDVPADTTASPPSASPSSSSPASPAA--A SINFRUP00000157781 SVSSTESLPGSPTHS--LSPG-PSTPCRSPAPDHQTLDNNSPQNTSPCSSSSSSP----A SINFRUP00000128421 --SSSDSLSGSPTQS--LSPG-PSTPCRSPAPDHSGDS-----SSSPCSSSPNSP----V SINFRUP00000139083 SLSSGESLPGSPTHS--LSPHSPTAALRPTPDFTQS-GGNSSQSSSPSSSAPNSPAG--S CG6498-RA SARNLSPLDSSYHSSCCQSAANSSSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSAL ci0100147176 SIIRNGRQTDTRVHSPLLTPNRSKSKMMTSASSGEIQEASHPQSPPLGRLEQDLSSASSK .: . .. . .. . ENST00000251472 HHIRPSTLHGLSPKLH--RQYRSARC-KSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSS ENSMUST00000053038 HHIRPSTLHGLSPKLH--RQYRSARC-KSAGNIPLSPLAHTPSPTQASPPPLPGH----- SINFRUP00000139259 QHMRPSSLHGLSPKLH--RQYRSARC-KSAGNIPLSPLAHTPSPTQSSPPPMPGHTVGSS ENST00000262742 GHTRPSSLHGLAPKLQ--RQYRSPRR-KSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSG ENSMUST00000003908 GHTRPSSLHGLAPKLQ--RQYRSPRR-KSAGSIPLSPLAHTPSPPATAASPQRSPSPLSG ENST00000262811 GHTRPSSLHGLAAKLGPPR-PKTGRR-KSTSSIPPSPLACPPISAPPPRSPSP------- SINFRUP00000157781 AHIRPSSLHGLSSKLNTQRFAKVNRR-KSTSNIPPSPLACNSSSSS-------------- SINFRUP00000128421 PQARPSSLHVLG------RYTKAGRC-KSTSSIPPSPLACIP------------------ SINFRUP00000139083 GHIRPSTLHGLGPKLP-GQRLRQGRR-KSASSIPLSPLARTPSPTPQPTSPQRSPSPLLS CG6498-RA SVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVSPTGVVPQLYQRPSTLHGLKHKLHA ci0100147176 STSPNSTLSDSATPTPLLMADTSTPGPSKSASFTMTPNPRPTSRPMSLEKLTRS------ *: .. .... :* . ENST00000251472 -----------HTTQSFPAKLHSSPPVVR--PRPKSAEPPRSPLLKRVQSAE---KLGAS ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 -----------NTTQSFPAKLHSSPPVVR--PRPKSAEPPRSPLLKRVQSAE---KLGSP ENST00000262742 -----------HVAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAE---KLAAA ENSMUST00000003908 -----------HGSQSFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAE---KLAAA ENST00000262811 -------------------------------LPGHPPAPARSPRLRRGQSAD---KLGTG SINFRUP00000157781 ---------------------------------AQPLSPQRSPSPLSG------------ SINFRUP00000128421 --------------------------------PPQPLSPSYLPTHP-------------- SINFRUP00000139083 GHSVSI----SKTTQAFPAKIHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEE---KLSPS CG6498-RA ATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPLSPLARTPSPSP---LPSSP ci0100147176 ---------------------------IRSSRRKSTGHIPLSPLARVPNSPSPLLLIDPS : ENST00000251472 LSADKK----GALRKHSLEVGHPDFRKD-FHGELALHSLAESDGETPPVEGLGAPRQVAV ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 LTQSSATGGLGGPLRHSLEVQHSEYRKDAFLCELGLQSLLETEGEILPPN---------- ENST00000262742 LAASEKK--LATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKG---- ENSMUST00000003908 LAAAEKK--LAPSRKHSLDLPHGELKKELTPREASPLEVVGTRSVLSGKGPLPGKG---- ENST00000262811 ERLDGEAGRRTRGPEAELVVMRRLHLSERRDSFKKQEAVQEVS----------------- SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 YTGEKK---HLCSRKHSLEVTQEEVQDEEPATGDQDHTVLQSVDETVCEPPAVTRIRPVE CG6498-RA TRSPSPLAFPLVGHQPGASNTTQSYSPGSTLPTLQTAVNANTKKAGFARTKSAEPSSPLL ci0100147176 FTQSSDATPASSSKDQGPELLASRSTDSSSSSKVFSMFKSGSRQKLKATK---------- ENST00000251472 RRLGRQESPLSLGADP---------------LLPEGASRPPVSSKEKESPGGAEACTPPR ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------PPPLPSASST---------------NPESGVLKPVRRLGRQESPLS-------- ENST00000262742 -----VLQPAPSRALG---------------TLRQDRAERRESLQKQEAIREVDSSEDDT ENSMUST00000003908 -----VLQPAPSRALG---------------TLRQDRAERRESLQKQEAIREVDSSEDDT ENST00000262811 ---FDEPQEEATGLPT---------------SVPQIAVEGEEAVPVALGPTGRD------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 QGCLKRPVGRKMGRQESVEDLDKEKLKCKMVAKRQEWSERRDSLQKQDALREPDSYSSCG CG6498-RA RRALSPDRLHPRSAET---------------KISPLCCSPPIKQPTHQRVVTTTWRSTPG ci0100147176 -------PQRSKSFKG---------------ALKQDRGVQHSDPSSTDVPTNLRD----- ENST00000251472 ATTPGGRTLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAG-TP ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 EEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTG-IT ENSMUST00000003908 DEEPENSQATQEPRLSPHPEASHNLLPKGSGEGTEEDTFLHRDLKKQGPVLSGLVTG-AT ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 DCREEGFLVRGLNKSSSDSGPLETKAAGSTLKDVLYKKLSTRVSDAKTEMCMSSGEGDGG CG6498-RA GSASGAGGAVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAAGTDPSATAVVTLANCE ci0100147176 ------------------------------------------------------------ ENST00000251472 L-VPIVVEPARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTL ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 LGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQAL ENSMUST00000003908 LGSPRVDVPGLSPRKLSRPQAFEEATN-PLQVPSLSRSGPTSPTPSEGCWKAQHLHTQAL ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 LKPNICSVHPEWPSRQSRDSTKPDRLDFKAPSIEFTRKRLSFEEREDCICRCSSSIHENL CG6498-RA PLPRIAEEKDSPTSTQDSSSVSEGFMPAIEEFAEGESSSSPTQTLEKPTKVKATEQPEME ci0100147176 ------------------------------------------------------------ ENST00000251472 SGPRSKPASPKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEA ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 TALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQDLE ENSMUST00000003908 TALCPSFSELTPTG-CSAATSTSGKPGTWSWKFLIEGPDRASTNKTITRKGEPANSQDTN ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 HFGSTRSKSLQLDTAMSHDHVKPGIVSLHSSPEGLAPKIFSGRAESAVEKLQLISSAESS CG6498-RA PAGKSKKVDQGKTTTPGTPKTKPHNSGCKTSMTTTKPASPSVTISTAPRKDTSAVTGGGS ci0100147176 ------------------------------------------------------------ ENST00000251472 VPPAGLTKKGVSSPAPPGP----------------------------------------- ENSMUST00000053038 ------------------------------------------------------------ SINFRUP00000139259 ------------------------------------------------------------ ENST00000262742 QLQPSLRTCLPGSRGRHSHLVPPDWPIHLMRIPAR------------AGYGSLSVHKQ-- ENSMUST00000003908 TTVPNLLKNLSPEEEKPQPPSVPGLTHPLLEVPSQNWPWESECEQMEKEEPSLSITEVPD ENST00000262811 ------------------------------------------------------------ SINFRUP00000157781 ------------------------------------------------------------ SINFRUP00000128421 ------------------------------------------------------------ SINFRUP00000139083 LRKTSSEYKLEGRQVSSLRPLEGTLDIGLLSGPRVSKTE--------------------- CG6498-RA SGSGGSAATSAAKQRK-------------------------------------------- ci0100147176 ------------------------------------------------------------ ENST00000251472 --------------------------------------------------- ENSMUST00000053038 --------------------------------------------------- SINFRUP00000139259 --------------------------------------------------- ENST00000262742 --------------------------------------------------- ENSMUST00000003908 SSGDRRQDIPCRAHPLSPETRPSLLWKSQELGGQQDHQDLALTSDELLKQT ENST00000262811 --------------------------------------------------- SINFRUP00000157781 --------------------------------------------------- SINFRUP00000128421 --------------------------------------------------- SINFRUP00000139083 --------------------------------------------------- CG6498-RA --------------------------------------------------- ci0100147176 ---------------------------------------------------