CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000033340 ------------------------------------------------------------ ENST00000315193 ------------------------------------------------------------ ci0100143608 ------------------------------------------------------------ ENST00000308912 ------------------------------------------------------------ ENSMUST00000061234 ------------------------------------------------------------ SINFRUP00000128103 ------------------------------------------------------------ ENSMUST00000049071 ------------------------------------------------------------ ENST00000246032 AYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARAATSRAARSRRQPGPGA SINFRUP00000138607 ------------------------------------------------------------ SINFRUP00000160857 ------------------------------------------------------------ CG10895-RA ---------------MARDTQGTQGTQSQASNIWTQVESQPMEKIVWGRLYGKNIKIKSL ENSMUST00000033340 ------------------MADPSLNDNPTACPHCASSQAGLLCVCPAGKSPVLVVEMSQT ENST00000315193 ---------------------------AAVCPRAAP------VHCPA------------- ci0100143608 ------------------------------------------------------------ ENST00000308912 ------------------------------------------------------------ ENSMUST00000061234 ------------------------------------------------------------ SINFRUP00000128103 ------------------------------------------------------------ ENSMUST00000049071 ---------------------------------------------------------MET ENST00000246032 DHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMET SINFRUP00000138607 ------------------------------------------------------------ SINFRUP00000160857 ------------------------------------------------------------ CG10895-RA GTSSKYRIIYTHSSFSVDLNNDEFTAGRGEANDLILTLNDLPEKILTRISKVHFIIKRAN ENSMUST00000033340 SSIGSTEFFASQERKKERNTSRESSLKDLSIRTSNVERKPQAQWSRSNVTVGKIPHIRMD ENST00000315193 VALRAEKFLPVQ------NSGLSDSLR------------------RVCAPVGDPPVRRP- ci0100143608 ---------------------MATSAR-----------------PRVASAEHKIPHRRIE ENST00000308912 ------------------------------------------------------------ ENSMUST00000061234 ------------------------------------------------------------ SINFRUP00000128103 ------------------------------------------------------------ ENSMUST00000049071 GKENGARRGTKSPERKRRSPVQRVLCEKLRP--AAQAMDPAGAEVPGEAFLARRRPDGGG ENST00000246032 GKD-GARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGG SINFRUP00000138607 ------------------------------------------------------------ SINFRUP00000160857 ------------------------------------------------------------ CG10895-RA CELTNPVYIQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIG ENSMUST00000033340 DGAGIEEFYTFGRILGQGSFGMVFEAIDKETGAKWAIKKVNK-------EKAGSSAMKLL ENST00000315193 ------EIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNK-------EKAGSSAVKLL ci0100143608 DETIIEEMYSFGDKLGQGSFGIVIEACNLQTKQKWAIKKVNK-------EKAGSSAITLL ENST00000308912 -MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRC-------HAPENVELALR ENSMUST00000061234 -MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRC-------HAPENVELALR SINFRUP00000128103 -MVSSQPKYDLIQEVGRGSYGVVYEAAVKRTGARVAVKKIRC-------HSPENVELALR ENSMUST00000049071 GDVPARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRC-------DAPENVELALA ENST00000246032 G--SARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRC-------DAPENVELALA SINFRUP00000138607 ------PRYSLLREVGRGTYGVVYEALARRSGSGVAVKKLRC-------DAPENVELALQ SINFRUP00000160857 --------YTLEKEVGRGSYGVVFEGYIAKTGQKVAIKRLPC-------SKPECIELYLQ CG10895-RA LPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRV * . :* *::*:* .: *:* : . ENSMUST00000033340 EREVSILKTVNHQHIIHLEQVFES------------------------------------ ENST00000315193 EREVNILKSVKHEHIIHLEQVFET------------------------------------ ci0100143608 AREVTILKRVKHENIIHLEEVFET------------------------------------ ENST00000308912 EFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGS-NSSLYLQLVETSLKGEIAFDPRS ENSMUST00000061234 EFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGS-NSSLYLQLVETSLKGEIAFDPRS SINFRUP00000128103 EFWALSSIQSQHPNVIHLEECILQRDQLAQKMSHGS-SSPLYLQLVETSLKGEIAFDPCC ENSMUST00000049071 EFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAE ENST00000246032 EFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAE SINFRUP00000138607 EFWALTSLEKRHQNVVHLEECVLQKNGMAQRMSHGNKRSRQYLRLVETSLKGERVLSPQE SINFRUP00000160857 EIWAMRATAKNHVNVIALHSCLLQTGPRTLKPLTAG---KLPGQLVESVLKGTPLY---- CG10895-RA LNEAKIMKNLSHPCVVRMHDIVDK------------------------------------ . * :: :.. . :: : ENSMUST00000033340 -PQKMYLVMELCEDGELKAVMDQRGHFSENETRLIIQSLASAIAYLHNKDIVHRDLKLEN ENST00000315193 -PKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLEN ci0100143608 -AQKMYLVMELCEFGELRGLLFKTGPFTEISARYIIKSLADAIVYLHKNGIVHRDLKLEN ENST00000308912 -AYYLWFVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQ-LSSALAFLHKNQIIHRDLKPDN ENSMUST00000061234 -AYYLWFVMDFCDGGDMNEYLLSRKPNRKTNTSFMLQ-LSSALAFLHKNQIIHRDLKPDN SINFRUP00000128103 -AYYLWFVMDFCDGGDMNAYLLSRKPSRKTNTSFMLQ-LGSALAFLHRNQIIHRDLKPDN ENSMUST00000049071 EPCYLWFVMEYCEGGDLNQYVLSRRPDPATNKSFMLQ-LTSAIAFLHKNHIVHRDLKPDN ENST00000246032 EPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQ-LTSAIAFLHKNHIVHRDLKPDN SINFRUP00000138607 EPCYLWFVMEFCEGGDLNQFILSRQPNSQTNNSFMLQ-LTSALAFLHENNIVHRDLKPDN SINFRUP00000160857 -CVALWLVMEYCDGGDLNHFLLSRLPDNQNNHAVVRQ-LCSAVAFLHNLGITHRDLKPDN CG10895-RA -PDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDN :::*:: *:: : : *: :** * ***** :* ENSMUST00000033340 IMVKSSFIDDNNEMNLNIKVTDFGLSVQKHG---------------SRSEGMMQTTCGTP ENST00000315193 IMVKSSLIDDNNEINLNIKVTDFGLAVKKQ----------------SRSEAMLQATCGTP ci0100143608 ILIASCSDTNGENPLYDIKLTDFGLSVVKGG---------------VGSDAMLQASCGTP ENST00000308912 ILISQTRLDTSD-LEPTLKVADFGLSKVCS------ASGQNPEEPVSVNKCFLSTACGTD ENSMUST00000061234 ILISQSRMDTSD-LEPTLKVADFGLSKVCS------ASGQNPEEPVSVNKCFLSTACGTD SINFRUP00000128103 ILISQARSPAGS-TEPTLKVADFGLSKVCS------TSGLNPEEPASVNKCFLSTACGTD ENSMUST00000049071 ILITE-RSGT-----PILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSD ENST00000246032 ILITE-RSGT-----PILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSD SINFRUP00000138607 ILISE-RSGT-----PVLKVADFGLSKVCAGLSDGGMGSNSEGKNRNINKFWLSSACGSD SINFRUP00000160857 VLVCVTSKGP------VVKVADFGLSKMSP--------GVSEGE---LTRQHFSSTCGSD CG10895-RA VLLETNDEET------LLKVSDFGLSKFVQ------------------KDSVMRTLCGTP ::: :*::****: . : : **: ENSMUST00000033340 IYMAPEVINAH---DYSQQCDIWSIGVIMFILLCGEPPFLANS-EEKLYELIKKGELRFE ENST00000315193 IYMAPEVISAH---DYSQQCDIWSIGVVMYMLLRGEPPFLASS-EEKLFELIRKGELHFE ci0100143608 VYMAPEVIQNH---DYSQQCDNWSIGVILYALLARDFPFVAEK-EDRLFELIKLGKVDFS ENST00000308912 FYMAPEVWEG----HYTAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTE--I ENSMUST00000061234 FYMAPEVWEG----HYTAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTE--I SINFRUP00000128103 FYMAPEVWEG----HYTAKADIFALGVIIWAMVERITFVDVETQKELLGSYVQQGSE--I ENSMUST00000049071 FYMAPEVWEG----HYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTE--I ENST00000246032 FYMAPEVWEG----HYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTE--I SINFRUP00000138607 FFMAPEVWVG----HYTAKADIFALGIVIWAMLERITFIDAESKRELLGTYVRQGAE--I SINFRUP00000160857 FYMAPEVWGGL---TYTAQADIFSLGAMFWAVLERITFVEEGTTQEQLGAYVWKGRSGRL CG10895-RA LYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEY-GTPAAQQIKKGRFAYG .::**** *: : * :::* ::: : . : * ENSMUST00000033340 NPVWESVSDSAKNTLKQLMKVDPAHRIT------AKELLDNQWLT--------------- ENST00000315193 NAVWNSISDCAKSVLKQLMKVDPAHRIT------AKELLDNQWLTGNKLSSVRPTNVLEM ci0100143608 KPVWTPISKSAKNLVCKLLNVDPAHRLT------ASEVASHPWTLGSNDSSSNPTNVLDM ENST00000308912 VPVGEALLENPKMELLIPVKKK-SMNGR------MKQLIKEMLAANPQDRPDAFELELRL ENSMUST00000061234 VPVGEALLENPKMELLIPVKKK-SMNGR------MKQLIKEMLAANPQDRPDAFELELRL SINFRUP00000128103 VPLGEALLENPKMELLIPARKK-SMNSH------MKQLIRDMLSANPQERPDAFELELRL ENSMUST00000049071 VPVGEALLENPKMELHIPQKRRTSMSEG------VKQLLKDMLAANPQDRPDAFELETRM ENST00000246032 VPVGEALLENPKMELHIPQKRRTSMSEG------IKQLLKDMLAANPQDRPDAFELETRM SINFRUP00000138607 VPVGEALLENPKMVLHIPQKHRSCMSNA------VGKLLQDMLAVNLQDRPSAFELQARM SINFRUP00000160857 VPLGEALWENAELQLSIPIKFRRAPPLPPPPGPATCTLLLDMLAADPDARPTATQLEARV CG10895-RA HPSWKSVSQRAKLLINQMLIVDPERRPS------IDDVLQSSWLRDAPMLQKAKRLMKLD . .: . .: : : ENSMUST00000033340 ------------------------------------------------------------ ENST00000315193 MKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFP ci0100143608 MKDY-----------AKEMAGNDVEDQVWHYLYFH------------------------- ENST00000308912 VQIAFKDSSWET------------------------------------------------ ENSMUST00000061234 VQIAFKDSSWET------------------------------------------------ SINFRUP00000128103 VRIACRELDWDT------------------------------------------------ ENSMUST00000049071 DQVTCAA----------------------------------------------------- ENST00000246032 DQVTCAA----------------------------------------------------- SINFRUP00000138607 EQVTCAA----------------------------------------------------- SINFRUP00000160857 ------------------------------------------------------------ CG10895-RA GMEIEEENFLEPPTKRSRR----------------------------------------- ENSMUST00000033340 --------------------------------------------------------- ENST00000315193 ATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL ci0100143608 --------------------------------------------------------- ENST00000308912 --------------------------------------------------------- ENSMUST00000061234 --------------------------------------------------------- SINFRUP00000128103 --------------------------------------------------------- ENSMUST00000049071 --------------------------------------------------------- ENST00000246032 --------------------------------------------------------- SINFRUP00000138607 --------------------------------------------------------- SINFRUP00000160857 --------------------------------------------------------- CG10895-RA ---------------------------------------------------------