CLUSTAL W (1.82) multiple sequence alignment ENST00000271757 -----------------MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKC ENSMUST00000016670 -----------------MGGAARDRGRKDAALPGAGLPPQQRRLGDGVYDTFMMIDETKG SINFRUP00000164738 ------------------------------------------------------------ SINFRUP00000137047 ------------------------------------------------------------ ENST00000319833 MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA ci0100143899 ------------------------------------------------------------ ENST00000010132 ------------------------------------------------------------ ENSMUST00000032495 -----MQLLRLPALTRTETSMDTNKARKRSLTTFPILKARKKQSFTSVKVESKPLGHLQK ci0100142555 ------------------------------------------------------------ CG4551-RA ------------MLDRCEMPIQLDNEKLRR----------------DVRLSGSRLDLPQL ENST00000271757 PPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSD ENSMUST00000016670 PPYSDTFSNPSEAPVSRRLNITTEPLTRGHTQHFVNGSEMKVEQLFQEFGNRRSNTLQSD SINFRUP00000164738 ------------------------------------------------------------ SINFRUP00000137047 -------GGAKVAMTDPVQLLSHS--QVHITQLFEENTNKRPVLASQLNGQARSGLS-LP ENST00000319833 AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP ci0100143899 ------------------------------------------------------------ ENST00000010132 --------------------------------------HISKKVLLKSSLLYQENQAHNQ ENSMUST00000032495 PSSKNKKLRVNRCPQKIPSNTAFPFVDTKGKRNTVNFPQIGNKVPSKGPMQYQENQIHNQ ci0100142555 ------------------------------------------------------------ CG4551-RA CNGSRRLDGHNNHVAANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSSNGGN ENST00000271757 GISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEII ENSMUST00000016670 GISNSEKSSP-ASQGKSSESLSAVKCNLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIV SINFRUP00000164738 ------------------------------------PLTPDQALRLYRSQLTPLEQAEIQ SINFRUP00000137047 DHHATAAAATESPHHSRQGSATSNKLMD--SKPKPGFLSPEQAMKQFMSKLSTFEHHEVF ENST00000319833 ----VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIF ci0100143899 -------------------------------------ISPDEAMKQFMQKLTSYEHHEVF ENST00000010132 MPASELKASEIPFHPSIKT--QDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEIL ENSMUST00000032495 VLSSELKTSEIPFNINTKA--QDTKPHPELQKKHKVPLTVAEALKFFKNQLSPYEQSEIL ci0100142555 -------------------------------------LSHTEAVKVFGSRLTTFEQSEIV CG4551-RA ERGSSTKSNSS-SGSGSSG--NSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELK :: : :: : *: * *: ENST00000271757 NYPEIYFVGPNAKKRHGVIGGPNNGG---YDDADGAYIHVPRDHLAYRYEVLKIIGKGSF ENSMUST00000016670 SYPEIYFVGPNAKKRQGVIGGPNNGG---YDDADGAYIHVPRDHLAYRYEVLKIIGKGSF SINFRUP00000164738 SYPDVYFVGPNAKKRPAVAGGTNNSG---YDDEQGGYIHVAHDHLAYRYEFLKIIGKGSF SINFRUP00000137047 NYPEVYFVGPNAKKRLGIMGGANNGG---YDDDQGSYIHVPHDHISYRYEVLKVIGKGSF ENST00000319833 SYPEIYFLGLNAKKRQGMTGGPNNGG---YDDDQGSYVQVPHDHVAYRYEVLKVIGKGSF ci0100143899 SYPRIYFTGTSAKKRPGVVGASNNCG---YDDDQCSYIAVPHDHIAYRYEILKVIGKGSF ENST00000010132 GYAELWFLGLEAKKLDTAPEKFSKTS---FDDEHGFYLKVLHDHIAYRYEVLETIGKGSF ENSMUST00000032495 GYSELWFLGLEAKKLNVVPEKFSKTS---FDDEHGSYMKVLHDHIAYRYEVLEMIGKGSF ci0100142555 DYNDIWFLGLDGKKVQGVHGASQNCG---YDDENGSYIKVLHDHMIYRYEVLEVIGKGSF CG4551-RA VYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSF * ::: * ..* : :** . * : :**: :***.*: ****** ENST00000271757 GQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF ENSMUST00000016670 GQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF SINFRUP00000164738 GQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLRKQDRNGTMNVVHMLENFTF SINFRUP00000137047 GQVVKAYDHKCQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSGMNVIHMLENFTF ENST00000319833 GQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTF ci0100143899 GQVMKAFDHKLHQHVALKIVRNEKRFHRQAAEEIRILEHLRKQDKDNAMNIIHMMESFTF ENST00000010132 GQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYF ENSMUST00000032495 GQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYF ci0100142555 GQVVKALDHKTNTLVAIKIIRNKKRFHHQALVEVRILDALRRNDKDGGHNVIHMMESFYF CG4551-RA GQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYF *** : *** . :*:*::**:*** .** *:.**: *:.:* . *::** : * ENST00000271757 RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPEN ENSMUST00000016670 RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPEN SINFRUP00000164738 RNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPEN SINFRUP00000137047 RNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAYSILQCLDSLHKNRIIHCDLKPEN ENST00000319833 RNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPEN ci0100143899 RNHICMTFELLSINLYELIKKNKFQGFSLQLVRKFAHSILQCLEALSRNRIIHCDLKPEN ENST00000010132 RNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPEN ENSMUST00000032495 RNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPEN ci0100142555 RNHLCITFELLGMNLYELIKKNNFQGFSLPLIRRIAHALLKCLCLIYKERIIHCDMKPEN CG4551-RA RKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPEN *:*.*::***:.::****:*.*.::**.: ::*:: ::::.* : ..*****:**** ENST00000271757 ILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILA ENSMUST00000016670 ILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILA SINFRUP00000164738 ILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILA SINFRUP00000137047 ILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILA ENST00000319833 ILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILA ci0100143899 ILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSFGCILA ENST00000010132 IVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITA ENSMUST00000032495 IVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMA ci0100142555 ILIRQKGQSSIKVIDFGSSCYEHRRVYTYIQSRFYRSPEVILGHQYSMAIDMWSFGCILA CG4551-RA ILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILA *:: ::* *********: :::**********:**:*** *. .**:**:*** * ENST00000271757 ELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN------SKGIPRYCSV ENSMUST00000016670 ELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFIN------SKGLPRYCSV SINFRUP00000164738 ELLTGYPLFPGEDEGDQLACVMELLGMPPQKVLEQAKRAKNFIN------SKGHPRYCGA SINFRUP00000137047 ELLTGYPLLPGEDEGDQLACTMELLGMPGQKLLDA-KRSKNFVS------SKGYPRYCTV ENST00000319833 ELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVS------SKGYPRYCTV ci0100143899 ELLTGYPLLPGEDEADQLACSIELLGMPPRRLLDQSKRAKNFIS------SKGHPRYCQV ENST00000010132 ELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFD------SKGFPKNITN ENSMUST00000032495 ELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFECCFSEDSKGLPKNINN ci0100142555 ELYTGYPLFPGENEVEQLACIMEVLGLPPSDYIETAQRKRLFFD------SKGQPRCITN CG4551-RA ELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFD------SRDAPRCITN ** ** **:***:* :**** :*:**:* . * : *.. *:. *: ENST00000271757 TTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPA ENSMUST00000016670 STQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPA SINFRUP00000164738 NTLPTGATVLTGSRSRRGKMRGPPGSKEWSVALKGCEDPTFTDFIKKCLDWDPSTRLTPS SINFRUP00000137047 TTLPDGTTVLNGGRSRRGKARGPPGSKDWSAALKGCDEPLFLDFLKQCLEWDPGLRMTPS ENST00000319833 TTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPG ci0100143899 TTLSDGSTVLGPGRSRRGKLRGPPGQREWVTALKGCDDPLFTDFLRRCLDWDPAARMTPS ENST00000010132 N---------------RGKKR-YPDSKDLTMVLK-TYDTSFLDFLRRCLVWEPSLRMTPD ENSMUST00000032495 N---------------RGGKR-YPDSKDLTMVVK-TYDSSFLDFLRRCLVWEPSLRMTPE ci0100142555 S---------------KGRKR-RPNSKDISTAVR-TSDPVFLHFLRRCLEWEPSKRMTPD CG4551-RA T---------------KGRKR-SPGSKSLAHILH-CQDRYFIDFLQRCLEWDPAERMTPD . :: :* * * .:. :: : * .*:::** *:*. *:** ENST00000271757 QALRHPWISKSVPRPLTTIDKVSG------------------------------------ ENSMUST00000016670 QALRHPWISKSTPKPLT-MDKVPG------------------------------------ SINFRUP00000164738 QALRHPWLYRRLPKPLPGNDKSPGVV---------------------------------- SINFRUP00000137047 QALRHPWLKKRLPKPPGGTTTTEKTS---------------------------------- ENST00000319833 QALRHPWLRRRLPKPPTGEKTSVKR----------------------------------- ci0100143899 QALRHSWLRRRLPKPPGGATAHRGD----------------------------------- ENST00000010132 QALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETR-------------KDKVQ------- ENSMUST00000032495 QALKHAWIHEPRKFKPRPKPQILRKPGASISSEIS-------------TEKAE------- ci0100142555 EAMHHEWIVEGRFQKTRGQSRHVGKKSIVPGSNTKPVSATNNSNNTTDTEKASNLQPEKT CG4551-RA EAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQ------KSSCYSFSEISPGTNGPVV :* :* :: ENST00000271757 ----KRVVN-PASAFQGLGSKLPPVVG--------------------------------- ENSMUST00000016670 ----KRVVN-PTNAFQGLGSKLPPVVG--------------------------------- SINFRUP00000164738 ----KRLPEHHSTSFPSILAKGGPVLGT-------------------------------- SINFRUP00000137047 ----RRIGTTATDGAITSISKIATASSAT------------------------------- ENST00000319833 --------ITESTGAITSISKLPPPS---------------------------------- ci0100143899 ---------NSTIKNHSSFNRQPSGN---------------------------------- ENST00000010132 GCHHS-SRKDEITKETTEKTKDSPTK---------------------------------- ENSMUST00000032495 EQQASKGKKDEATKETTDKLKDEAEK---------------------------------- ci0100142555 VQPSSGTRKGKSGKNTTAKIKEETTEGGN------------------------------- CG4551-RA ASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSK : . ENST00000271757 ------------------------------------------------------------ ENSMUST00000016670 ------------------------------------------------------------ SINFRUP00000164738 ------------------------------------------------------------ SINFRUP00000137047 -------------------------------------------------M---------- ENST00000319833 ------------------------------------------------------------ ci0100143899 ------------------------------------------------------------ ENST00000010132 ----------------HVQHSGDQQDCLQHGAD-----------------------TVQL ENSMUST00000032495 ----------------HLENSGKQQSSVEHTAD-----------------------TIQL ci0100142555 -----------DGTGQSTDHSGENNRSTETFSDEDASRERLQP--------IGASNTSML CG4551-RA ITSSVSDLESVQQYSLHRIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTL ENST00000271757 -----IANKLKANLMSET--NGSIPLCSVLPKLIS------------------------- ENSMUST00000016670 -----IASKLKANLMSET--SGSIPLCSVLPKLIS------------------------- SINFRUP00000164738 -----TADKLRSNMMGDS--GEAIPLRTVLPKLVS------------------------- SINFRUP00000137047 --SSSSSSKTRTNLAAITDTNGNIQPRTVLPKLVS------------------------- ENST00000319833 ----SSASKLRTNLAQMTDANGNIQQRTVLPKLVS------------------------- ci0100143899 -----KAKDMSVTVAATT--------RTVLPKIVG------------------------- ENST00000010132 PQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTN--------VLPPIV----------- ENSMUST00000032495 PHLTEASGKSETVAGSEMSAEQQSTS---SPKSTN--------ILPPIV----------- ci0100142555 ADDVENGDIEAEKTAAKESTKNPQKQTSAKENQENKLIVPEATKLPPIA----------- CG4551-RA AHNHHNVTHHNASTATIATTTHHHHHHGGQQQQQSSSGASTMAMSHSQSTGDVSDRAIFG : . ENST00000271757 -- ENSMUST00000016670 -- SINFRUP00000164738 -- SINFRUP00000137047 -- ENST00000319833 -- ci0100143899 -- ENST00000010132 -- ENSMUST00000032495 -- ci0100142555 -- CG4551-RA RA