CLUSTAL W (1.82) multiple sequence alignment ENST00000253339 -MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDA----------AK ENSMUST00000040043 ------------------------------------------------------------ SINFRUP00000134691 YMKRGGKSEGNRQMRPKTFPTSNYSGNSQQMLQEIRNSLRNLSKPSEP----------PK ENSMUST00000022531 -------------MRPKTFPATTYSGNSRQRLQEIREGLKQPSKASTQGLLVGPN-SDTS ENST00000279994 -------------MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPN-SDTS SINFRUP00000137140 -------------MRPKTFPAAPYVGNTRQRLQEIKEGLKQPAKLVSQALHGGSSRAEGS CG12072-RA ----MHPAGEKRGGRPNDKYTAEALESIKQDLTRFEVQNNHRNNQNYTPLR-----YTAT : : : ENST00000253339 AEHN-MSKMSTEDPRQV-RNPPKFGTHHKALQEIRNSLLPFANETNSSRST------SEV ENSMUST00000040043 ------------------------------------------------------------ SINFRUP00000134691 VDIGGAAKMPPEDPRLQGRCSNPKNPYHKALQEIRKSLLPFANEPVTSGP--------ET ENSMUST00000022531 LDAKVLGSKDASRQQQ-MRATPKFGPYQKALREIRYSLLPFANESGTS-------AAAEV ENST00000279994 LDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTS-------AAAEV SINFRUP00000137140 RGADCKSGKDAASRQQQLRPPQKFNNYQNALREIRRSLMPFANESGPSSGSGHPAGAGEV CG12072-RA NGRNDALTPDYHHAKQPMEPPPSASPAPDVVIPPPPAIVGQPGAGSISVSG-----VGVG : :: ENST00000253339 NPQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINA ENSMUST00000040043 ------------------------------------------------------------ SINFRUP00000134691 RKHTSQEPPFIGFDE-----------NNIRSIGPDYMGKVSYQDSMREQMVVPNPNTTGL ENSMUST00000022531 NRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTS-- ENST00000279994 NRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTS-- SINFRUP00000137140 NRQMLQELVNAGCDQEMAVRALKQTGSRNIEAALEYISKMGYLDPRNELIVRVIKQTS-- CG12072-RA VVGVANGRVPKMMTALMPNKLIRKPSIERDTASSHYLRCSPALDSGAGSSRSDSPHSH-- : ENST00000253339 SMK-PGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGI ENSMUST00000040043 -------VQHSINRKQSWKGSKESLVPQRHGPSLGENVVYRSESPNSQADVGRPLSGSGI SINFRUP00000134691 KAPGASHIQQAVLRRPSWKGSKESLAP-RHGPLMADAIMYHSDSP------GPPP----- ENSMUST00000022531 --PGKGLAPTPVTRRPSFEGTGEA--LPSYHQLGGA----NYEG-------PAALE---- ENST00000279994 --PGKGLMPTPVTRRPSFEGTGDS--FASYHQLSGT----PYEGPSFGADGPTALE---- SINFRUP00000137140 --PGKAGIPNSMDHRPSLEASGEAGAMPPYHQMGAP----MYEGP----AGYTPDG---- CG12072-RA ----HTHQPSSRTVGNPGGNGGFSPSPSGFSEVAPPAPPPRNPTACSAATPPPPVPPTSQ . . : . . ENST00000253339 SAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGN ENSMUST00000040043 AAFAQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPSSQTKRYSGN SINFRUP00000134691 -AFPQGHAGANQRVNPPLPPQVRSVTP--------PPNRSGMPPAPSWD---NPKRYSGN ENSMUST00000022531 -EMPRQYLD-------FLFPGAGAGTHG-AQAHQHPPKGYSTAVEPS-AHFP--GTHYGR ENST00000279994 -EMPRPYVD-------YLFPGVGP--HGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGR SINFRUP00000137140 -EISRPYMSSAPVMNYMMPPTSSMEQHGPMMSYNVPGQPLQLQPQPPGGPVP--GPHYDY CG12072-RA AYVKRRSPALNNRPPAIAPPTQRGNSPVITQNGLKNPQQQLTQQLKSLNLYPGGGSGAVV . : * . ENST00000253339 MEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSS--SKF ENSMUST00000040043 MEYVISRISPVPPGAWQEGYPPPPLTTSPMNPPSQAQRAISSVPVGRQPIIMQST--SKF SINFRUP00000134691 MDYLVPRISPVPQGAWPDGYQS---------AAPQSQRGISPVSVGHQPIIMQSSGGNKF ENSMUST00000022531 GHLLS---EQPGYGVQRS---------------SSFQNKTPPDA------YSSM---AKA ENST00000279994 PHLLVPG-EPLGYGVQRS---------------PSFQSKTPPETGG----YASLP--TKG SINFRUP00000137140 SHARPHMMDPAGYGVKRT---------------ASFQNKMAPPPMAPPDNYVNMQ--GKG CG12072-RA EPPPPYLIQGGAGGAAPPPPPP---------SYTASMQSRQSPTQSQQSDYRKSP--SSG :. *. . . . . ENST00000253339 NFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPS--ALQTGGSAA ENSMUST00000040043 NFTPGRPGVQNGGGQSDFIVHQN-VPTGSVTRQPPPPYPLTPANGQSPS--ALQTGASAA SINFRUP00000134691 TFPPSWS--QSGSAQADYMAGGS--------RQPPPPYPVTQGSRHSPTDQQMQAGGPAA ENSMUST00000022531 QGGPP-ASLTFP-----AHAGLY----------TASHHKPAATPPGAHPLHVLGTRGPTF ENST00000279994 QGGPPGAGLAFPP----PAAGLY----------VPHPHHKQAG-PAAHQLHVLGSRSQVF SINFRUP00000137140 AMGQNVPGGGGAGGGGGYPANRY----------LPPHSHPRQASPTSHQVHLMSRSPGGV CG12072-RA IYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQ . : ENST00000253339 PSSYTNG-SIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSG--HEIPT ENSMUST00000040043 PPSFANG-NVPQSMMVPNRNSHNMELYNINVPGLQTAWPQSSSAPAQSSPSGG--HEIPT SINFRUP00000134691 SPSYVNGGNIPQSMMVPNRNSHNLDSYNVGLQ-LWSQSPLASNQPQSSSCNSTNQDLSPS ENSMUST00000022531 TGESS-----AQAVLAPSRNSLNADLYELGST--VPWSAAPLARRDSLQK--QGLEAS-R ENST00000279994 ASDSP-----PQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQK--PGLEAPPR SINFRUP00000137140 AAMGPDFSDIPQGLMTPSRASLNLDIYEHHWAGPPGPEGAPPGRQPQPQGPFRGEVRVPS CG12072-RA SPSSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLV . . ::.. : . . . ENST00000253339 WQPNIPVRSNSFNN-PLGNRASHSAN-------SQPSATTVTAITPAPIQQP--VKSMRV ENSMUST00000040043 WQPNIPVRSNSFNN-PLGSRASHSAN-------SQPSATTVTAITPAPIQQP--VKSMRV SINFRUP00000134691 WQHNIPVRSSSFNNHQMSSRPAHPAS-------SQPSATTVTAITQAPILQP--VKSMRV ENSMUST00000022531 PHVAFR---AGPSRTNSFNNPQP--------EPSLPAPNTVTAVTAAHILHP--VKSVRV ENST00000279994 AHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHP--VKSVRV SINFRUP00000137140 RTNSFNSRSAGPNGVRPTLTAPPTAG---KQDPSLGPPNTITAVTSPPIQQP--VKSIRV CG12072-RA GLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRV . . : : ::::** ENST00000253339 LKPELQTALAPTHPSWIPQPI-------QTVQPSPFPEG------TASNVTVMPPVAEAP ENSMUST00000040043 LKPELQTALAPTHPSWMPQPV-------QTVQPTPFSEG------TASSVPVIPPVAEAP SINFRUP00000134691 QKPELHTAVAPTHPPWIQQAQ-------PPPLPAPTYQE------PSAPVPQISVVPEVP ENSMUST00000022531 LRPEPQTAVGPSHPAWVAAPT-------APATESLETKE------GSAGPHPLDVDYGGS ENST00000279994 LRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGP SINFRUP00000137140 MRPEPKTAVGPCHPGWMAAQT-------QDAGEPLAYMA--------EEPYPIEPAQ--- CG12072-RA LQAQAQRERDQRERDQRERER------DQQKLANGNPGR------QMLPPPPYQSNNNNN :.: : . ENST00000253339 NYQGPPPPYPKHLLHQN--PSVPPYESISKPS-----------KEDQPSLPKEDESEKSY ENSMUST00000040043 SYQGPPPPYPKHLLHQN--PSVPPYESVSKPC-----------KDEQPSLPKEDDSEKSA SINFRUP00000134691 SYQGPPPPYPKHLLQQQAAPCPPTYDPLTNST-----------EEEGGGGAQDRTPETSE ENSMUST00000022531 ERRCPPPPYPKHLLLPSKSEQYS--VDLDSLC-------TSVQQSLRGG-TEQDRSDKSH ENST00000279994 DRRCPPPPYPKHLLLRSKSEQY----DLDSLC-------AGMEQSLRAGPNEPEGGDKSR SINFRUP00000137140 EPRCPPPPYPKNLLMPGPTAEPGGLEAAGAMCGAQDIGNAAVRSTHGSGSGGSGKVEESH CG12072-RA SEIKPPSCNNNNIQISNSNLATTPPIPPAKYN----------NNSSNTGANSSGGSNGST . **. ::: . . : * ENST00000253339 E-----------NVDSGDKEKKQITTSPITVRK--NKKDEERR-ES-RIQSYSPQAFKFF ENSMUST00000040043 D-----------SGDSGDKEKKQITTSPITVRK--NKKDEERR-ES-RIQSYSPQAFKFF SINFRUP00000134691 T-----------STE---RENKQITTSPVPVRR--NKKDEERRGESGRIAVYSPQAFKFF ENSMUST00000022531 ---------KGAKGDKAGRDKKQIQTSPVPVRK--NSRDEEKR-ES-RIKSYSPYAFKFF ENST00000279994 ---------KSAKGDKGGKDKKQIQTSPVPVRK--NSRDEEKR-ES-RIKSYSPYAFKFF SINFRUP00000137140 QVKEKTKMCKTDKTDKTVKDKKQIQTSPVPVRK--NGRDEEKR-ES-RIKTYSPFAFKFY CG12072-RA G----------TTASSSTSCKKIKHASPIPERKKISKEKEEER-KEFRIRQYSPQAFKFF . . :* :**:. *: . ..**.* :. ** *** ****: ENST00000253339 MEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDK ENSMUST00000040043 MEQHVENVLKSHQQRLHRKKQLENEMMRV-----------------------LNFLRLDH SINFRUP00000134691 MEQHVENILKNHQQRIRRRKQLESEMQRVGLSSEAQEQMRMMLCQKESNYIRLKRAKMEK ENSMUST00000022531 MEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDK ENST00000279994 MEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDK SINFRUP00000137140 MEQHIENVMKTYNQKLNRRLQLEQEMSKAGLSEAEQEQMRKMLNQKESNYNRLRRAKMDK CG12072-RA MEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDK ****:**::*.:.*: *: ***.** :. : : :: *. :::: ENST00000253339 SMFVKIKTLGIGAFGEVCLARKVDTK-ALYATKTLRKKDVLLRNQV-AHVKAERDILAEA ENSMUST00000040043 LFPWYFKVVGS---------------------------SILVG-------KCSMDILAEA SINFRUP00000134691 SMFKRIKTLGIGAFGEVCLARKEDTG-SLYAMKTLRKKDVLLRNQV-AHVKAERDILAEA ENSMUST00000022531 SMFVKIKTLGIGAFGEVCLACKLDTH-ALYAMKTLRKKDVLNRNQV-AHVKAERDILAEA ENST00000279994 SMFVKIKTLGIGAFGEVCLACKVDTH-ALYAMKTLRKKDVLNRNQV-AHVKAERDILAEA SINFRUP00000137140 SMFVKIKTLGIGAFGEVCLTRKVDTC-ALYAMKTLRKKDVLNRNQASAHVKAERDILAEA CG12072-RA SMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQV-AHVKAERDILAEA : :* :* : : : : : .:* :*.. ****** ENST00000253339 DNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVH ENSMUST00000040043 DNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVH SINFRUP00000134691 DNEWVVRLYYSFQDKDNLYFVMEYIPGGDMMSLLIRLGIFKEELAQFYIAELTCAVESVH ENSMUST00000022531 DNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVH ENST00000279994 DNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVH SINFRUP00000137140 DNEWVVRLYYSFQDRESLYFVMDYIPGGDMMSLLIRMGVFPEILACFYVAELTLAIESVH CG12072-RA DNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVH **:***:*******::.*****:******:*****:: :* * ** **:**:* *::*** ENST00000253339 KMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQ-SGDHPRQDSMDFSNEW ENSMUST00000040043 KMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQ-SGDHPRQDSMDFSNEW SINFRUP00000134691 KMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQ-SGDHVRQDSMDFSKDW ENSMUST00000022531 KMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQ-KGNHMRQDSMEPGDLW ENST00000279994 KMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQ-KGSHVRQDSMEPSDLW SINFRUP00000137140 KMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQ-KGSHVRQDSMEPSDFW CG12072-RA KMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEP---W ***************** *******************:***** .*.* *****: * ENST00000253339 GDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVI ENSMUST00000040043 GDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVI SINFRUP00000134691 EDPANCRCSDRLKPLERRKARQHQRCLAHSLVGTPNYIAPEVLLRTG------------- ENSMUST00000022531 DDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVI ENST00000279994 DDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVI SINFRUP00000137140 DDVSNCRCGDRLMTLEQRANRQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVI CG12072-RA EEYSEN--GPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVI : :. . : **:* ::*** ***************** *.* ENST00000253339 LFEMLVGQPPFLAQTPLETQMKV------------------------------------- ENSMUST00000040043 LFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKN SINFRUP00000134691 ------------------------------------------------------------ ENSMUST00000022531 LFEMLVGQPPFLAPTPTETQLKVINWESTLHIPTQVRLSAEARDLITKLCCAADCRLGRD ENST00000279994 LFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRN SINFRUP00000137140 LFEMLVGQPPFLAPTPTETQIKVINWESTLQVPAQVKLSPEAIDIIGRLCCSAEDRLGAN CG12072-RA LYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKS ENST00000253339 ------------------------------------------------------------ ENSMUST00000040043 GADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKL--WSDGSEEENI SINFRUP00000134691 ------------------------------------------------------------ ENSMUST00000022531 GADDLKAHPFFNTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEES---PWHEASGESA ENST00000279994 GADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEES---PWNDASEGST SINFRUP00000137140 GAGEIKAHPFFSQTDFSSNLRQQPAPYRPKIAHPMDTSNFDPVEEEGGPGAWSDS-GDST CG12072-RA -VDEVKSHDFFKGIDFA-DMRKQKAPYIPEIKHPTDTSNFDPVDPEKLR--SNDSTMSSG ENST00000253339 ------------------------------------------------------------ ENSMUST00000040043 SDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYIHSQGSEQQSDEDDQH SINFRUP00000134691 ------------------------------------------------------------ ENSMUST00000022531 KAWDTLASPSSKHPEHAFYEFTFRRFFDDNGYPFRCPKPS----EPAESADPGDADLEGA ENST00000279994 KAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQ SINFRUP00000137140 RTLDMLCSPQGKHPEHAFYEFTFRRFFDDNGCPFRYPKP--------------------- CG12072-RA DDVD-----QNDRTFHGFFEFTFRRFFDDKQPPDMTDDQAPVYV---------------- ENST00000253339 ------------- ENSMUST00000040043 TSSDGNNRDLVYV SINFRUP00000134691 ------------- ENSMUST00000022531 AEGCQPVYV---- ENST00000279994 TEGCQPVYV---- SINFRUP00000137140 ------------- CG12072-RA -------------