CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000025739 ------------------------------------------------------------ ENST00000276893 GGVCGSASEWFRSSLLKSASRARALRVVAACRARRPVGPVGALARLPLRARAAGKAARAG ENSMUST00000001258 ------------------------------------------------------------ ENST00000262952 ------------KSEQLAARRAAFAERALRVARKSARGPGHARGFIAIPSRATRAGRQAV SINFRUP00000162015 ------------------------------------------------------------ ci0100139112 ------------------------------------------------------------ SINFRUP00000155873 ------------------------------------------------------------ ci0100152860 ------------------------------------------------------------ ci0100139520 ------------------------------------------------------------ CG11624-RA ------------------------------------------------------------ ENSMUST00000025739 ---------------------MWIQVRTIDGSQTRTIEDVSRKATIEELRERVWALFDVR ENST00000276893 RGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVR ENSMUST00000001258 ---------------------MWIQVRTMDGKETHTVNSLSRLTKVQELRKKIEEVFHVE ENST00000262952 RGDRRADT-------------MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVE SINFRUP00000162015 ---------------------MWIQVRTMDGKETHRVDSLSKLTKVDELRQKIMELFKVE ci0100139112 ---------------------MWIRVRTMDGKRSEQVDGLSKLTKIEDLRELIMEKFSVE SINFRUP00000155873 -------------------------------QINELVD--CRDVSIGAWFEACIEKVTRA ci0100152860 ---------------------MQIFVKTLTG--KTITLEVEASDSIDNVKAKIQDKEGIP ci0100139520 ---------------------------------------------------------GIP CG11624-RA ---------------------MQIFVKTLTG--KTITLEVEPSDTIENVKAKIQDKEGIP : : : : : : ENSMUST00000025739 PECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDS-SLPSTSKQNDAQVKPSSHNPP ENST00000276893 PECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQ--IEAKPCSNSPP ENSMUST00000001258 PQLQRLFYRGKQMEDGHTLFDYDVRLNDTIQLLVRQSLALPLSTKERD--SELSDSDSGY ENST00000262952 PGLQRLFYRGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERD--SELSDTDSGC SINFRUP00000162015 PERQRLFYRGKQMEDGHTIFDYNVGLNDIVQLLVRQKAPPTEENKNKDKEAELSDSDSGC ci0100139112 PSLQRLFFRGKQLEDGYSLFDYDVGLNALVQLLERKVIKEVETQQENETPASPSDTDSGI SINFRUP00000155873 PKGLITPTKGK----------------------VGRPPKRTNGKLEAEQ-GQTTDTNKNI ci0100152860 PDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASD ci0100139520 PDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASD CG11624-RA PDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSD * ** : : : : :: . ENSMUST00000025739 KVKKTARGGSSSQPSTSAR--------TCLIDPGFGLYKVNELVDARDVGLGAWFEAHIH ENST00000276893 KVKKAPRVGPSNQPSTSAR--------ARLIDPGFGIYKVNELVDARDVGLGAWFEAHIH ENSMUST00000001258 GVGHSESDKSSTHGEGAAEAD----DKTVWEDTDLGLYKVNEYVDVRDNIFGAWFEAQVV ENST00000262952 CLGQSESDKSSTHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVV SINFRUP00000162015 GSTQSESDKNSTHGEVEDRVML--FCEPVETQDIFLCSKINDLIDARDLNMGAWFEAQIV ci0100139112 ETAENVQEVV----------------EDIPSTSCEGLYKINALIDAQDTDVGAWFEAKVV SINFRUP00000155873 VALNPESNGAST----------------------------------------SQTDSTAA ci0100152860 SIDNVKAKIQDKEG-------------------------------IPPDQQRLIFAGKQL ci0100139520 SIDNVKAKIQDKEG-------------------------------IPPDQQRLIFAGKQL CG11624-RA TIENVKAKIQDKEG-------------------------------IPPDQQRLIFAGKQL . : : . ENSMUST00000025739 SVTRASDGHSRGKTPLKNGSSYKRTNGNVNHNSKENTNKLDNVPSTSNSDSVAADEDVIY ENST00000276893 SVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIY ENSMUST00000001258 QVQKRALSEDEP---------------------------------CSSSAVKTSEDDIMY ENST00000262952 RVTRKAPSRDEP---------------------------------CSSTSRPALEEDVIY SINFRUP00000162015 NVTKMAKTPKE------------------------------------GAGEEEAEEEIFY ci0100139112 NVTKDKT------------------------------------------------EGLDY SINFRUP00000155873 SETKERE------------------------------------------------EDAVY ci0100152860 EDGRTLSDYNIQ-----------------------------------------KESTLHL ci0100139520 EDGRTLSDYNIQ-----------------------------------------KESTLHL CG11624-RA EDGRTLSDYNIQ-----------------------------------------KESTLHL : . ENSMUST00000025739 HIEYDEYPESGILEMNVKDLRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEIT ENST00000276893 HIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEIT ENSMUST00000001258 HVKYDDYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEIC ENST00000262952 HVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEIS SINFRUP00000162015 HVKFEDYPENGVIQLLGKDVRPRARTVYQWHQLESGMIVMVNYNPDDPKERGYWYDAEIQ ci0100139112 HIKFDDYGDDGVKVVGEKLIRPRARKLLEWNEIEVTSKVMANYNMDHPKERGFWYDCVVL SINFRUP00000155873 HIKYEDYPENGVVAMQPIHVRPRARTLLRWDQLQVGMRVMVNYNLETPEERGFWFDAEVQ ci0100152860 VLRLRGGMQIFVKTLTGKTITLEVEASDSIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDG ci0100139520 VLRLRGGMQIFVKTLTGKTITLEVEASDSIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDG CG11624-RA VLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDG :. : : : ... .::: . : : ENSMUST00000025739 TLKTISRTKKEVRVKVFLGGSEGTLNDCRVMSVDEIFKIEKPG--AHPISFADGKFL--- ENST00000276893 TLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPG--AHPLSFADGKFL--- ENSMUST00000001258 RKRQT-RTARELYGNIRLLNDSQ-LNNCRIMFVDEVLMIELPK-ERRPLIASPSQPPPAL ENST00000262952 RKRET-RTARELYANVVLGDDS--LNDCRIIFVDEVFKIERPG-EGSPMVDNPMR----- SINFRUP00000162015 RKRET-RTLREIYAKIILGDAGDSLNDCRIIFLTEIYKIEEVG-SLGDVPAGSESP---- ci0100139112 DKKNK-RKKNELTVQLLLGENRT-LEPCKITFVEEVFVIETVGSESGPLSADTAVAR--- SINFRUP00000155873 TVNQTSRTSKELRVKILLGGPGDVIGDCKVQFLDEIYQVEKPG--SRALSAADGQFK--- ci0100152860 RTLSDYNIQKESTLHLVLRLRGG-MQIFVKTLTGKTITLEVEA--SDSIDNVKAKIQ--- ci0100139520 RTLSDYNIQKESTLHLVLRLRGG-MQIFVKTLTGKTITLEVEA--SDSIDNVKAKIQ--- CG11624-RA RTLSDYNIQKESTLHLVLRLRGG-MQIFVKTLTGKTITLEVEP--SDTIENVKAKIQ--- . .* :: * : : :* : ENSMUST00000025739 ---RKNDPECDLCGGDPDKTCHMCSCHKCGEKRDPNMQLLCDECNMAYHIYCLSPPLDKV ENST00000276893 ---RRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKV ENSMUST00000001258 RNTGKSGPSCRFCKDDENKPCRKCACHVCGGREAPEKQLLCDECDMAFHLYCLKPPLTSV ENST00000262952 ---RKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSV SINFRUP00000162015 -LKRSNGPECKDCKDNPNVTCRSCNCKVCGIKQDPDKQLLCDECDMAYHIYCLNPPLTSI ci0100139112 --KTEKEADCGHCRDNPDKDCKECGCHVCGEKRAFDKTLLCDECNLPFHTFCLNPPLDNL SINFRUP00000155873 ---RKTGPECKHCKADPDAECRFCSCCVCGGKQDAHMQLLCDECNMAFHIYCLSPPLATI ci0100152860 --------DKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKT ci0100139520 --------DKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKT CG11624-RA --------DKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKT . : : * . .: : : . ENSMUST00000025739 PEEEYWYCPSCKTDSSEVVKAGERLKLSKKKAKMPSASTESRRDWGRGMACVGRTKECTI ENST00000276893 PEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTI ENSMUST00000001258 PPEPEWYCPSCRTDSSEVVQAGEKLKESKKKAKMASATSSSRRDWGKGMACVGRTTECTI ENST00000262952 PSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTI SINFRUP00000162015 PEDEDWYCPGCRNDSSEVVLAGEKLRESKKKSKMASASSSSQRDWGKGMACVGRTKECTI ci0100139112 PEEDDWYCPLCCQDRSKVVKAGEKLKENKKKNKMKSMTSDTQRDWGKGMACVGRSKICTI SINFRUP00000155873 PDDEDWYCPTCKNDTSEVVKAGEKLKASKKKAKMPSATTESQRDWGKGMACVGRTKECTI ci0100152860 LTGKTITLEVEASDSIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTL ci0100139520 LTGKTITLEVEASDSIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTL CG11624-RA LTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTL * . * * : : . : : .: : *: :: . .*: ENSMUST00000025739 VPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFEDEVDR ENST00000276893 VPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEV-- ENSMUST00000001258 VPANHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDN ENST00000262952 VPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDH SINFRUP00000162015 VPSNHYGPIPGVPVGSQWKFRVQVSESGVHRPHVAGIHGRSNDGSYSLVLAGGYEDDVDD ci0100139112 VPSNHFGAIPGVPVGSLWKFRVQVSESGIHRPHVSGIHGKENEGAYSIVLAGGYEDDEDD SINFRUP00000155873 VPSNHYGPIPGVPVGTTWKFRVQVSEAGVHRPHVGGIHGRSNDGSYSLVLAGGFEDEVDR ci0100152860 HLVLRLRGGMQIFVKTLTGKTITLEVEASDSIDNVKAKIQDKEGNF-------------- ci0100139520 HLVLRLRGG--------------------------------------------------- CG11624-RA HLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLE : : : : : ENSMUST00000025739 GDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKP ENST00000276893 ----------------------------LTEL---------------------------- ENSMUST00000001258 GNYFTYTGSGGRDLSGNKRTAGQSSDQKLTNNNRALALNCHSPINEK-GAEAEDWRQGKP ENST00000262952 GNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDWRSGKP SINFRUP00000162015 GNEFTYTGSGGRDLSGNKRTAEQSCDQTLTHMNRALALNCNVPVNDKVGAEAKNWKDGKP ci0100139112 GDEFTYTGSGGRDLSGNKRTAEQSCDQVLTKNNMAIARTCDVKADAKNGAEAKDWKKSRP SINFRUP00000155873 GDEFTYTGSGGRDLSGNKRIGEHCFDQTLTHMNRALALNCDAPLNDKDGAESRNWREGKP ci0100152860 ------------------------------------------------------------ ci0100139520 ------------------------------------------------------------ CG11624-RA DGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEG : ENSMUST00000025739 VRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWT ENST00000276893 ------------------------------------------------------------ ENSMUST00000001258 VRVVRNMKGGKHSKYAPAEGNRYDGIYKVVKYWPERGKS-GFLVWRYLLRRDDTEPEPWT ENST00000262952 VRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKS-GFLVWRYLLRRDDDEPGPWT SINFRUP00000162015 VRVVRSCKGRKHSKYAPEEGNRYDGIYKVVKYWPEKGKS-GFLVWRYLLKRDDDEPAPWT ci0100139112 IRVVRNYKGAKHSDYAPEEGNRYDGLYKVVKYWPEKGKS-GFIVWRYLFRRDDKEPAPWT SINFRUP00000155873 VRVVRSSKGRRISKYAPEEGNRYDGIYKVVKYWPEIGKC-GYLVWRYLLRRDDQEPAPWT ci0100152860 ------------------------------------------------------------ ci0100139520 ------------------------------------------------------------ CG11624-RA IPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEP : : : : ENSMUST00000025739 SEGIERSRRLCLRLQYPAGYP-----------SEKEGKKTKGQSKKQGSEATKRPASDDE ENST00000276893 ------------------------------------------------------------ ENSMUST00000001258 REGKDRTRQLGLTMQYP--EGYLEALAN----KEKSRKRPAKALEQGPSSSKTGKSKQKS ENST00000262952 KEGKDRIKKLGLTMQYP--EGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKWKR SINFRUP00000162015 RDGKERIKKLGLIMQYP--AGYQ---------KEKENKNEVEVEEGTPSKAKRKRKSQES ci0100139112 KAGKKRSKELGITIKYP--EGYL---------EAQAQKLANEEAAGPKKKGKRSLSNDDA SINFRUP00000155873 PEGMERTKKLGLTVQYP--PGYL---------AAMANKTKKEACTRPGRGGRKLPPVVEP ci0100152860 ------------------------------------------------------------ ci0100139520 ------------------------------------------------------------ CG11624-RA SDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQI ENSMUST00000025739 CPGDSKVLKASDSTDAVEAFQLTPQQQRLIREDCQNQKLWDEVLASLVEGPN----FLKK ENST00000276893 ------------------------------------------------------------ ENSMUST00000001258 TGPTLSSPRASKKSKLEP-YTLSEQQANLIKEDKGNAKLWDDVLTSLQDGPYQ--IFLSK ENST00000262952 K----SAGGGPSRGRVPA-PDIQENQGGALQS----------------HGPAE--QPHQR SINFRUP00000162015 SKS--SPAKTPKKVKVEE-YKLTREQKALIKNDTANKKVWDEAMQSLSLGPK----FLSK ci0100139112 S----TPKSTPKKIKINE-FEVSQELMKMIKTDKLNSKLWSEGLKSRKEGQT---KFYQI SINFRUP00000155873 P---------SKKVKIEESFVLSEQQQQLIREDTANKKLWDEALDSLKEGPN----FLRK ci0100152860 ------------------------------------------------------------ ci0100139520 ------------------------------------------------------------ CG11624-RA FVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQK ENSMUST00000025739 LEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYVMVLNET ENST00000276893 ------------------------------------------------------------ ENSMUST00000001258 VKEAFQCICCQELVFRPVTTVCQHNVCKDCLDRSFRAQVFSCPACRFELDHSSPTRVNQP ENST00000262952 GQEQRQAVE--------------------------------------------------- SINFRUP00000162015 VEEVFLCICCQEVVDQPITTECQHNVCRECLQRSFKAEVYTCPACRHDLGKNYSMAVNKS ci0100139112 IQDLFMCVCCQDVVHQPITTPCKHNLCKTCLQRSFKADIYSCPVCREDLEKEN-IDINIP SINFRUP00000155873 MEQTFMCVCCQELAFQPITTICTHNVCKTCLQRSFRAKVYTCPACRHDLGKDYIMTQNTT ci0100152860 ------------------------------------------------------------ ci0100139520 ------------------------------------------------------------ CG11624-RA ESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAG : : : : : ENSMUST00000025739 LQTLLDLFFPGYSKGR---------------- ENST00000276893 -------------------------------- ENSMUST00000001258 LQTILNQLFPGYGSGR---------------- ENST00000262952 -------------------------------- SINFRUP00000162015 LQDILNQLFPGYNNGR---------------- ci0100139112 LQKVLLKLFPGYTSGR---------------- SINFRUP00000155873 LQKLLDQFFPGYSKGR---------------- ci0100152860 -------------------------------- ci0100139520 -------------------------------- CG11624-RA KQLEDGRTLSDYNIQKESTLHLVLRLRGGIQA :