CLUSTAL W (1.82) multiple sequence alignment ENST00000294353 GKEAEAWAKPGAAARRSLLEPPRRLSLGAGSGPARRRTQDGGCMPEDQAGAAMEEASPYS ENSMUST00000043616 ------------------------------------------------------------ SINFRUP00000138538 ----------------------------------------------------QDDASPAA ENSMUST00000043793 ------------------------------------------------------------ SINFRUP00000129048 --------------------------------------------------ALQECEGPQA ENSMUST00000044751 ----------------------------------------------------MASDTPES ENST00000291900 ----------------------------------------------------MASDTPES CG12084-RA -----------------------------------------MSCKVRLMEDGSLDEEPLT ENST00000294353 LLDICLNFLTTHLEKFCSARQD-GTLCLQEPGVFPQEVADRLLRTMAFHG------LLND ENSMUST00000043616 ------------------------------------------------------------ SINFRUP00000138538 LTDLCLTFLSQNLERFCATRPD-GSLSFRDAILFPQELADQLLAKMATEG------LLND ENSMUST00000043793 ------------------------------------------------------------ SINFRUP00000129048 LCDLCLSQVCCSLPALCRGRTD-GSMCFSWAPVFPQEVADQLMHTMAAKG------LLND ENSMUST00000044751 LMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDQLVNEYVELVSAACTFEPHE ENST00000291900 LMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDRLVNEYVELVNAACNFEPHE CG12084-RA LKEIAYQKLCNNLDIISSHRPDGQRG-LNPGIVLPNEICDGFLENYQRFN-----RPLDD : : : : .: : :: ENST00000294353 GTVGIFR-GNQMRLKRACIRKAKIS-------AVAFRKAFCHHKLVELDATGVNADITIT ENSMUST00000043616 ------------------------------------------------------------ SINFRUP00000138538 STVGIFRNCEHLRLRRACIRTARIS-------AEAFRKALCPHRLLELDAARVNADLTIP ENSMUST00000043793 ------------------------------------------------------------ SINFRUP00000129048 TTVGIFRDGGTLRLRRATVRRCPLS-------PNAFLLALCPHRLQELDASWASGGLTGA ENSMUST00000044751 TFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKSLQTLRSFR ENST00000291900 SFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKSLQTLRSFS CG12084-RA SVIRLFEDTHRTSLKIVNLRNSTLSSIGLETLMRHKLFALSLWYCDMISVGSHHLLAHYG . :: : : : : : ENST00000294353 DIISGLGSNKWIQQNLQCLVLNSLTLS-L----EDPYERCFSRLSGLRALSITNVLFYNE ENSMUST00000043616 ------------------------------------------------------------ SINFRUP00000138538 DILQGLATNKYCQESLQRLVLTGLTMSSL----EEPTQYRFSTLRGLRSLSLGNVDFYDS ENSMUST00000043793 -----------IQKNLQCLVLDSVSIP------PNSGLVALSHFTGLHTLSVANVSFCNE SINFRUP00000129048 AIVSGLASNPECRSSLQRLSLDGLRLDWESLVEDAGTRVGFSSLRGLRTLKLANTDLSDA ENSMUST00000044751 HSLVSLSLSGCAN-IFYEEDNPGGCEDECLVNPTCQVLVKDFTFEGFSRLRFLNLGRMID ENST00000291900 HTLVSLSLFGCTN-IFYEEENPGGCEDEYLVNPTCQVLVKDFTFEGFSRLRFLNLGRMID CG12084-RA DSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLN-GVVMHHRLQFAHL-HDLG : : . : . ENST00000294353 DLAEVASLPRLESLDISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELK ENSMUST00000043616 ------------------------------------------------------------ SINFRUP00000138538 GLVDVCSLPRLESLDLSNTSVTNLTPLLGLKERLRSLTLHQLKRLEMSTAQLLGVIGKLD ENSMUST00000043793 DLVSVSQLPNLGSLDISNTLVTNISALLSCKNRLRSLTMHYLKCLAMNSPQVLAVIRQLK SINFRUP00000129048 ALADVCSLPHLESLDISCSGVSNLSPLLDCKNTLRHLIAHRLQRLHMAPSGLTFVLRQLD ENSMUST00000044751 GIPVESLLRPLNSLAALDLSGIQTSDATFLTQWKDSLMSLVLYNMDLSDDHIR-VIVQLH ENST00000291900 WVPVESLLRPLNSLAALDLSGIQTSDAAFLTQWKDSLVSLVLYNMDLSDDHIR-VIVQLH CG12084-RA HLDLTSCVLANFSLEALGS--------------LPNLHTLILFNVWPIANQLH-AICCLR : : : : : : : : : ENST00000294353 HLNHLDISDDKQFTSD---------IALRLLEQKDILPNLVSLDVSGRKHVTDKAVEAFI ENSMUST00000043616 ------------------------------------------------------------ SINFRUP00000138538 VLQHLDISDDKQFTSD---------VARQLLGQTGILPALVSLDVSGRKQVTDAAVKTFV ENSMUST00000043793 CLLHLDISDHQQLRSD---------LAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFL SINFRUP00000129048 ALRHLDFSEDHVAEDDGSGEDVNEAVRQLLEGGPELLPSLVSLDISGQKKISEAAVRTFV ENSMUST00000044751 KLRHLDISRDRLSS-YYKFK----LTRKVLSLLVQKLGNLMSLDISGHMILENCSISKTD ENST00000291900 KLRHLDISRDRLSS-YYKFK----LTREVLSLFVQKLGNLMSLDISGHMILENCSISKME CG12084-RA RLCTLDISISSSGNGHGTYD----LPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATKES : : : : : : : : ENST00000294353 QQR--------------------------PSMQFVGLLATDAGYSEFLTGEGHLKVSGEA ENSMUST00000043616 ------------------------------------------------------------ SINFRUP00000138538 EER--------------------------PGMTFVGLLATDAGFSDFLSGEGNLKVTGEA ENSMUST00000043793 QHR--------------------------PAMRFVGLLYTDAGYSDFFTAKQGLKVAGGA SINFRUP00000129048 ETR--------------------------GGLVFMGLLATGTSTCDILSTKKNLKVTGAA ENSMUST00000044751 EEAGQTSTEPSKSSIMPFRALK-------RPLQFLGLFETS---LCRLTHIPAYKVSGDK ENST00000291900 EEAGQTSIEPSKSSIIPFRALK-------RPLQFLGLFENS---LCRLTHIPAYKVSGDK CG12084-RA TTTSGMQQSPKMEQHFALTDIPGLASRTQRPLQFLGLYHTAH-WACKRHDIPALEVAGDA : :: : : ENST00000294353 NETQIAEALKRYSERAFFVREALFHLFSLTHVME--KTKPEILKLVVTGMRNHPMNLPVQ ENSMUST00000043616 --------------------------------ME--KTKPDILKLVVTGMRNHPMNLPVQ SINFRUP00000138538 NEMQICEALRRYSEREGFVREALFHLFSLTHVME--KPRPDILKLVVLGMKNHPATLNVQ ENSMUST00000043793 NMSQISEALSRYRNRSCFVKEALFRLFTETLSLR--AVLPVMLKLVAIGMRNHPLDLPVQ SINFRUP00000129048 NEDQVCEALRRYRDRQCFVREALVHLYNLIADTD--KPRPDILKLVLAAMQSHRSSLHVH ENSMUST00000044751 NEEQVLNAIEAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDKNIQ ENST00000291900 NEEQVLNAIEAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDRNIQ CG12084-RA NEQQILTAARYYHD-RPVLLTRVLNDLYHLFRFENCKDIHTALDVVLSAMDRHLKFKHMQ : : . *.:* .: * :: ENST00000294353 LAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKN------CLLSLCS ENSMUST00000043616 LAASACVFNLTKQDLALGMPVRLLADVTHLLLKAMEHFPNHQQLQKN------CLLSLCS SINFRUP00000138538 LAASACVFNLTKQDLAAGMPVRLLSTVTQLLLEAMRTFPNHQQLQKN------CLLSLCS ENSMUST00000043793 FTASACALNLTRQELARGMPVRLLAEITDLLFKATKNFPYYQQLQKN------CLLSLTS SINFRUP00000129048 VIATACVFSLTTQDLAEAMPLSLLGAAVAQLLHAMKTFPNHQQVSHQWCFCQQMLLSFHH ENSMUST00000044751 VTGSAALFYLTNSEYRSEQSVKLRRQVIQVVLNGMES-YQEVTVQRN------CCLTLCN ENST00000291900 VTGSAALFYLTNSEYRSEQSVKLRRQVIQVVLNGMES-YQEVTVQRN------CCLTLCN CG12084-RA ISGSATLFYIVKGRDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRN------GYLTLTQ . .:* : :. * ::.. . : :: *:: ENST00000294353 DRILQDVPFNRQVIALELKVGQNRMFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLS ENSMUST00000043616 DRILQDVPFN-------------RQFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLS SINFRUP00000138538 DRILQEVPFNR----VSERSLLIVRFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLS ENSMUST00000043793 SRILMDVPFDR----QVKIGHHLTVFDAAKLALRWVCRRESPKLRTMAVSITSILALKLS SINFRUP00000129048 PWCLCVTPSFQ--------LWSPFRYSAATLVINWLSSHEDATLQRMAVAVICLLVSKLS ENSMUST00000044751 FSIPEELEFQY-------------RRVNELLLGILSPTRQDESIQRIAVHLCNALVCQVD ENST00000291900 FSIPEELEFQY-------------RRVNELLLSILNPTRQDESIQRIAVHLCNALVCQVD CG12084-RA FHMPVDVLFEY-------------ERLIKILLHGVSKTEQEGFVQRIAIYLLNTLACQVD * .:. :: :*: : *. ::. ENST00000294353 TEQTAQLGTELFI-VRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQ ENSMUST00000043616 TEQTAQLGAELFI-VRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQ SINFRUP00000138538 TEQTAQLGAEMFI-VKQLLHIVRQKATQVMVDATLKFTLSALWNLTDESPTTCRHFIENQ ENSMUST00000043793 PEEMGQLQEELIMAIKELLTIIRQKLAENLDDVTFLFTLKALWNLTDECPLACKYFMENE SINFRUP00000129048 AEETAQFSGDVSI-MKQLLAIVQQKAMVGALDSSLKFALTALWNLTDEMPSAGRSFIECR ENSMUST00000044751 NDHKEAVGKMGFV--VTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFLNFN ENST00000291900 NDHKEAVGKMGFV--VTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFLNFN CG12084-RA GRQKLFLGELGVV--STMFTLIKDRLTRSVFDDVMEVAWSTMWNVTDETAINCKRFLDGR . . : : :: :::.: * : .: .::**:*** . . *:: . ENST00000294353 GLELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHS--VEVE ENSMUST00000043616 GLELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHS--VEVE SINFRUP00000138538 GLELFIKVLESFPNESSIQQKVLGLLNNIAEVGELHGELMVQGFLDHIRTLLHS--QEVE ENSMUST00000043793 GLATVIRVLETFS-ISVIQSKVLGLLNNVAEVRELSSKLVTEDVIERIISLLHS--SNLE SINFRUP00000129048 GLELYQEVLESYYGEPSIQQKILGLLNNLAEVQELQPDLLDEDLLEHVLSLLQDTQLDME ENSMUST00000044751 GKKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIE ENST00000291900 GMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIE CG12084-RA GMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARLLDSLSDGIE * *. : : :::***.*:*** * .*: . .:. . **.. :* ENST00000294353 VS----------------------------YFAAGIIAHLISRGEQAWTLSRSQR--NSL ENSMUST00000043616 VS----------------------------YFAAGIIAHLISRGEQAWTLSRSQR--NSL SINFRUP00000138538 VS----------------------------YFAAGILAHLTSRGEKAWTLSPQLR--SSL ENSMUST00000043793 VS----------------------------FLAAGVLAHLTCDR-QHWLSRDLQR--TDL SINFRUP00000129048 VR----------------------------YFAGGILAQLASRP-QAWTLNWFTFGLHAL ENSMUST00000044751 V----------------------------SYNACGVLSHIMFDGPEAWGVCEPQR--AEV ENST00000291900 V----------------------------SYNACGVLSHIMFDGPEAWGVCEPQR--EEV CG12084-RA VGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSR--EHV * : * *::::: . * : ENST00000294353 LDDLHSAILKWPTPECEM---VAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSR ENSMUST00000043616 LDDLHSAILKWPTPECEM---VAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSR SINFRUP00000138538 LEQLHDVIMKWPPPECEM---VAYRSFNPFFPLLECFHTPGVQLWAAWAMQHVCSKNAAR ENSMUST00000043793 LRYLHLAIQNWPSSRCDMSVLVTYRSFKAFSPLLVNFSQPEVQRWALWAIHHVCSKN--- SINFRUP00000129048 LPSQHAAIPTWTPIGREM---VSYRSFQPFCPLLQSSQPPGVQLWAVWAIHLVCSHNTSH ENSMUST00000044751 EDRMWAAIQSWDINSRRN---INYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDK ENST00000291900 EERMWAAIQSWDINSRRN---INYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDK CG12084-RA LERMVAAIQRWNIKSERN---INYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEK .* * : ****:.: *: * * ** **: : . ENST00000294353 YCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILDSLEKHIVRHGRPPPCKKQPQARLN ENSMUST00000043616 YCSMLIEEGGLQHLYNIKEHEQTDPYVQQIAVAILDSLEKHIVRHGRPPPCKKQPQARLN SINFRUP00000138538 YCSMLLEEGGLEQLELVHTHPQTHADVKFLAKSILESLHNHRARTGQPAP---------- ENSMUST00000043793 ------------------------------------------------------------ SINFRUP00000129048 YCSMLEKEGVAELLKSLSAGPDTHPDPKGLADSILRMLDEHQSR---------------- ENSMUST00000044751 YCPLLIKEGGMPLLRDLIKMATARQETKEMARKVIEHCSNFREENMDTSR---------- ENST00000291900 YCPLLIKEGGMPLLRDIIKMATARQETKEMARKVIEHCSNFKEENMDTSR---------- CG12084-RA YCKLVEQENGIQILNELIEHESPYCEIKRIARLVIEQCDSGSERMVVDG----------- :: : : : ::