CLUSTAL W (1.82) multiple sequence alignment ENST00000265985 ------------------------------------------------------------ ENSMUST00000025729 ------------------------------------------------------------ ENST00000310430 MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPR SINFRUP00000143424 ------------------------------------------------------------ SINFRUP00000138445 ------------------------------------------------------------ ci0100148048 ------------------------------------------------------------ CG4719-RA ------------------------------------------------------------ ENST00000265985 ------------------------------------------------------------ ENSMUST00000025729 ------------------------------------------------------------ ENST00000310430 HGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNP SINFRUP00000143424 ------------------------------------------------------------ SINFRUP00000138445 ------------------------------------------------------------ ci0100148048 ------------------------------------------------------------ CG4719-RA ------------------------------------------------------------ ENST00000265985 --------------------------------------MSGRRCAGGGAAC----ASAAA ENSMUST00000025729 ------------------------------------------------------------ ENST00000310430 AGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAG----PGTGV SINFRUP00000143424 -----------------------------------------------GAAS----PIDGG SINFRUP00000138445 ----------------------------------------------SGGGN----PCSG- ci0100148048 --------------------------------------MSGRRNTVSGAAYSLPTRSDRA CG4719-RA -------------------------------------------MANSSRSRAILSVNLDA ENST00000265985 EAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL ENSMUST00000025729 EAVEPSARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL ENST00000310430 PAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLL SINFRUP00000143424 SSIGGAFRELFEACRNGDVSRVKRLVDSVNVNAKDMAGRKSTPLHFAAGFGRKDVVEHLL SINFRUP00000138445 -AANGAFRELFEACRNGDVSRVKKLVDAVNVNAKDMAGRKSTPLHFAAGFGRKDVVDHLL ci0100148048 TNSHSTARDLFDACRNGDLNKVKKLVTTQNVNARDLEGRKSTPLHFAAGFGRKDVVEHLL CG4719-RA VMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLL . *:*::**:.*:: :**:*: . .**::* ****:*******:**::**:.** ENST00000265985 QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKID ENSMUST00000025729 QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLQHGADPNARDNWNYTPLHEAAIKGKID ENST00000310430 QMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKID SINFRUP00000143424 QTGANVHARDDGGLIPLHNACSFGHAEVVSLLLCHGADPNARDNWNYTPLHEAAIKGKID SINFRUP00000138445 RTGANVHARDDGGLIPLHNACSFGHSEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKID ci0100148048 QCGANVHAQDDGGLIPLHNACSFGHAEVVQLLLTRGADPNSRDNWNYTPLHEAAIKGKLD CG4719-RA NSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVD . **.::* *:*** ****.*****:*** *** **.**: ************ ***:* ENST00000265985 VCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT ENSMUST00000025729 VCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGDYKKDELLESARSGNEEKMMALLT ENST00000310430 VCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT SINFRUP00000143424 VCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT SINFRUP00000138445 VCIVLLQHGADPNIRNTDGKSALDLAEPSAKAVLTVVERCNMCLCSCRSGNEEKLMALLT ci0100148048 VCVVLLQSGGDPHIKNADNKTALDLAEPSAKVVLSGEFKKDELLEAARGGNEEQLMDLLT CG4719-RA VCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLT **:.*** *.: *:*:: ::.*:**: ::: **: : : * :.*.* *:::: *** ENST00000265985 PLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYE ENSMUST00000025729 PLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLHHGADVHAKDKGDLVPLHNACSYGHYE ENST00000310430 PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYE SINFRUP00000143424 PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHFE SINFRUP00000138445 PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYE ci0100148048 PLNVNCHASDGRKSTPLHLAAGYNRVRIVNLLLKQGADVHAKDKGGLVPLHNACSYGHFE CG4719-RA PLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFD ************:************: **::** :**********.************:: ENST00000265985 VTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAP ENSMUST00000025729 VTELLVKHGACVNAMDLWQFTPLHEAASKNRIEVCSLLLSYGADPTLLNCHNKSAIDLAP ENST00000310430 VTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAP SINFRUP00000143424 VTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLLNCHSKSAVDMAP SINFRUP00000138445 VTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLLNCHSKSSVDMAP ci0100148048 VTELLIKHGANVNAMDLWQFTPLHEAASKNRVEVCSLLLAHGGDPTTVNCHSKTAVDVAP CG4719-RA VTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAP **:**:: ** *** *** **********.*:*******: *.*** :***.*:::* ** ENST00000265985 TPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPK ENSMUST00000025729 TAQLKERLSYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPK ENST00000310430 TPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPK SINFRUP00000143424 TPELKDRLTYEFKGHSLLQAAREADVAKVKKTLALEIISFKHPQTNDAALHCAVASAHPK SINFRUP00000138445 TPELKERLTYEFKGHSLLQAAREADVAKAKKSLVLEIINFKHPHTHETALHCAVASPHPK ci0100148048 NRQLQEKLVYEFKGHSLLDAARQADLTRVKKHLTSDSILFCHPHTHDSPLHCAVGSPYPK CG4719-RA TRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGK . :*:::: :*:***.**:*.*:.*::: ** : : : * :* : ::.** *. * * ENST00000265985 RKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLH ENSMUST00000025729 RKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDVVEVVVKHEAKVNALDSLGQTSLH ENST00000310430 RKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALH SINFRUP00000143424 RKQVTELLLRKGANINDKNKDFMTPLHVAAERAHNDILEVLQKHGAKVNAVDTLGQTALH SINFRUP00000138445 RKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLQKHGAKVNALDTLGQTALH ci0100148048 RRQVTELLIRKGASLNDKNKEFLAPLHIAADKAHIDVLEVLLKNGAKVNILDCLGQTALH CG4719-RA RKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLH *:*: *** ***: *:*.* *::***:*:: * * :**: *: **:* :* ****.** ENST00000265985 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE ENSMUST00000025729 RAAHCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGASLGHSEADRQLLE ENST00000310430 RAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLE SINFRUP00000143424 RAALAGHIQTCKLLLSYGADPAIVSLQGFTAAQMGNEAVQQILNENIPTRNSDVDYRFLE SINFRUP00000138445 RAALAGHLQTCRLLLGYGADASLVSLQGFTAAQMGNEAVQQILSGVILSVSLLLLRLNRT ci0100148048 RAAQLGLSQVCIVLLNHGVDPTIMSLQGFTAAQMATETIQQLL-------------QLLD CG4719-RA RCARD--EQAVRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKN-----PPDSETHLLE *.* *. :**.:. *. ::**:*:** *:..: : ::* ENST00000265985 AAKAG--DVETVKKLCTVQ--SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA ENSMUST00000025729 AAKAG--DVETVKKLCTVQ--SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA ENST00000310430 ASKAG--DLETVKQLCSSQ--NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA SINFRUP00000143424 AAKAG--DLDTVQQLCSPQ--NVNCRDLEGRHSTPLHFAAGYNRVAVVEYLLHHGADVHA SINFRUP00000138445 CCLRGSSNPPCLQSLCTAQ--NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA ci0100148048 AAKAG--DLEVVKKLCSVH--NVNCRDMEGRLSTPIHFAAGYNRVAVVEYLLQHGADVHA CG4719-RA AAKAG--DLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYA .. * : :: : : .*****::** ***:*****:***.**::**.***:*:* ENST00000265985 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH ENSMUST00000025729 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH ENST00000310430 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH SINFRUP00000143424 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH SINFRUP00000138445 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH ci0100148048 KDKGGLVPLHNACSYGHYEVTELLVKHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH CG4719-RA ADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKH *******************:****:*** ***:*****************:******:* ENST00000265985 GADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRD ENSMUST00000025729 GADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRD ENST00000310430 GADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRD SINFRUP00000143424 GADPTKKNRDGNMPLDMVKDGDTDIQDLLRGDAALLDAAKKGCLARVQKLCSPENINCRD SINFRUP00000138445 GADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVQKLCSPDNINCRD ci0100148048 GADPHKKNRDGNTPLDLVKEGDLDIQDLLRGDVALLDAAKKGCLARVQKLCTPSNINCRD CG4719-RA GADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRD **** ****** * *:**:.* *: :**** ********* ****::* :*..:**** ENST00000265985 TQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY ENSMUST00000025729 TQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY ENST00000310430 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY SINFRUP00000143424 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY SINFRUP00000138445 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY ci0100148048 QQGRNSTPLHLAAGYNNAEVAEYLIEHGADVNAQDKGGLIPLHNASSYGHVEIAALLIKS CG4719-RA AQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKH ***:************ * ****:::******************:****:::****** ENST00000265985 NACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL ENSMUST00000025729 NACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL ENST00000310430 NTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL SINFRUP00000143424 NTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTALDLATADDIRALL SINFRUP00000138445 NTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL ci0100148048 NASVNATDRWAFTPLHEAAQKGRTQLCTLLLAHGADPTMKNQEGQTPLDLATQEDVRCLL CG4719-RA KTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLL :: *****:*.****************:********. :*******.::*.: :*: .** ENST00000265985 TAAMP----PSALPSCYKPQVLNGVRSPGATADALS---------SGPSSPSSLSAA--S ENSMUST00000025729 TAAMP----PSALPTCYKPQVLSGVRGPGATADALS---------SGPSSPSSLSAA--S ENST00000310430 IDAMP----PEALPTCFKPQAT------VVSASLIS----------PASTPSCLSAA--S SINFRUP00000143424 IDAMP----PDALPSCFKPQAT------VVSSSVIS----------PASTPSCLSAS--S SINFRUP00000138445 IDAMP----PDALPSCLKPQAT------VVSASVVSTGAAGGVVISPSPSPSCLSAA--S ci0100148048 IDAAP----QTATVSSTSKQAT-----------------------------QSSSNS--N CG4719-RA QDAMATSLSQQALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGAS * . * :. . . : : . ENST00000265985 SLDNLSGSFSELSSVVSSS----GTEGASSLEKKEVP------GVDFSITQFVRNLGLEH ENSMUST00000025729 SLDNLSGSFSELSAVVSSS----AAEGATGLQRKEDS------GIDFSITQFIRNLGLEH ENST00000310430 SIDNLTGPLAELAVGGASN----AGDGAAGTERKEGE----VAGLDMNISQFLKSLGLEH SINFRUP00000143424 SIDNLAGPLTELAAAAVSTGSTGVADGATGSDRKEGE----MTMLDINISQFLKSLGLEH SINFRUP00000138445 SIDNLTTPLGELAVGGAAG----SVDVTSVSDRKEGEGTDVRSLLDMTINQFLKSLGLEH ci0100148048 AVDDEDGEATAASHSIALD-----PNASTG---------------EVAVLQLLDRLSLCQ CG4719-RA MILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLP---DADTITNVSGFLSSQQLHH : . : : : : : :: * : ENST00000265985 LMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQG--LNPYLTLN ENSMUST00000025729 LMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQG--LNPYLTLN ENST00000310430 LRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQG--TNPYLTFH SINFRUP00000143424 LRDIFEREQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQG--ANPYLTFH SINFRUP00000138445 LRDIFQREQISLDVLADMGHEELKEIGINAYGHRHKLIKGIERLLGGQQG--GNPYLTFH ci0100148048 YHEMFDKEKITPDVLADMGHTELKDIGITAFGHRHKIIKAAERLALAAADGAVDPMSDIN CG4719-RA LIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLR-STTG------IGNN ::*: *:*: *:*.:*** :**::*:.*:*.***::*. :* . . : ENST00000265985 ------TSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC ENSMUST00000025729 ------NSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGVFNRYNILKIQKVC ENST00000310430 ------CVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVV SINFRUP00000143424 ------CASQGTILIDLAPDDKEYQSVEEEMQSTIREHRDGGNAGGVFSRYNIIKV---- SINFRUP00000138445 ------CSSQGTVLIDLATDDKEFQSVEEELQSTIREHRDGGNAGGVFSRYNIIKIQKVV ci0100148048 SIAFSRPTQQGSIIIDLKPEDKEFQSVSEEMQTTIREHKDGGVAGGVYKSYNIIKVQKVQ CG4719-RA -------VNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQ ::::** .:***: :*.**:*:*:***:*.* *** :. **:::: : ENST00000265985 NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYF ENSMUST00000025729 NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYF ENST00000310430 NKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYF SINFRUP00000143424 ------------------------------------------------------------ SINFRUP00000138445 NKKLRERYAHRQKEIADENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYF ci0100148048 NKRLRERWNHRRIEVGEENHNHSNDRMLFHGSSFINAIVQKGFDERHAYIGGMFGAGIYF CG4719-RA NRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYF : : ::: :: :: : : :: : : ENST00000265985 AENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPG ENSMUST00000025729 AENSSKSNQYVYGIGGGTGCPIHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPG ENST00000310430 AENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPG SINFRUP00000143424 ------------------------------------------------------------ SINFRUP00000138445 AENSSKSNQYVYGIGGGTGCPTHKDRSCYVCHRQMLFCRVTLGKSFLQFSAMKMAHAPPG ci0100148048 AENSSKSNQYVYGINGGTGCPMHKDRSCYICHRQMIFCRVTLGKSFLQFSAMKMAHAPPG CG4719-RA AEHSSKSNQYVYGIGGGIGCPSHKDKSCYVCPRQLLLCRVALGKSFLQYSAMKMAHAPPG : : : ::: : : :: : : ENST00000265985 HHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVDG-------- ENSMUST00000025729 HHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIVRPEGMVDG-------- ENST00000310430 HHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT SINFRUP00000143424 ----------------------------------------------------- SINFRUP00000138445 HHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIVKPE------------- ci0100148048 HHSVIGRPSVGGLSHAEYVIYRGEQAYPEYLITYQIVKPPDETSTSQA----- CG4719-RA HHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQIVKPDDSSSGTEDTR--- : : :: :: ::