CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000144229 ------------------------------------------------------------ SINFRUP00000139732 ------------------------------------------------------------ ENSMUST00000040500 --MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGVKLLFSLST ENST00000258767 --MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGVKLLFLY-- SINFRUP00000132799 --------------------------SSKKLKDVLDEFHGEGVLSKYNPEQP-------- ENST00000265022 ---MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEP-------- ENSMUST00000023578 ---MSEEQWVSLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLRQYDPHKP-------- ci0100132672 MAGTSDGEFVTLTPEEFERLQKYAEYSSKKLADVMAEFNDGGILSKYNKEKP-------- ENSMUST00000026414 ----MAKEKGLISPEDFAQLQKYIEYSTKRVSDVLKVFDD-GEMNRFCQGDA-------- CG18654-RB -------------------------MSAINIKHNGSWLPAVDGIKDNEGRRP------AT SINFRUP00000144229 ------------------------------------------------------------ SINFRUP00000139732 ------------------------------------------------------------ ENSMUST00000040500 IDFEGFKLFMKTFLEA-ELPDDFTAHLFMSFSNKFPHSSPNVKSKPALLSG--------- ENST00000258767 INFEGFKLFMKTFLEA-ELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSG--------- SINFRUP00000132799 IDYEGFQLFMATYLEN-DIPEELCRHLFTSFKSKTGGCSPNQSHGESSLLE--------- ENST00000265022 ISYDVFKLFMRAYLEV-DLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQ ENSMUST00000023578 ISYDVFKLFMRAYLEV-DLPQPLSTHLFLAFSQKPRQETPDHPKEGASSSEPNVSDY--- ci0100132672 IDYSGFKLFMETYLDT-DLSEDFCAHMFRSFQKSSNQPRTTSVGSCSDNIIKSMGGNAQT ENSMUST00000026414 IGYLGFEQFMKMYLEMEEVPHHLCWALFWSFHTSQVAAEKTKSKAN-------------- CG18654-RB LSLNKCTATALAVLQCSTPPIHSSSTLSFAADIKLLARKLSHFDPLT------------- SINFRUP00000144229 --------------------------------------------------VFLRDVSCYF SINFRUP00000139732 --------------------------------------------------VFLKDVSCYF ENSMUST00000040500 ----GLRMNKGAITPPRS-SPANT---------------------CSPEVIHLKDIVCYL ENST00000258767 ----GLRMNKGAITPPRTTSPANT---------------------CSPEVIHLKDIVCYL SINFRUP00000132799 ----RSQTEKHLLQ-RRSPSPHQSPLL------------------QPPQVVFLKDIVCYL ENST00000265022 NADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYL ENSMUST00000023578 NSDNAAKADEACAPDTESKTTKTQAPSKELEAAAPWEDPGALASSSDAPVVYLKDVVCYL ci0100132672 HDGKEVSEEDVAVTVLNPEDAFKAITSG---ITGNVDKPKQAIMPEEHETVHLKDIACYL ENSMUST00000026414 -------------------------------------------------VICLSDVYCYF CG18654-RB ------------------------------------------------LKVPLKDVVCYL : * *: **: SINFRUP00000144229 SVLEDGRPRDKLEFTFNLYDKDGNGLLDSTEVDRIIAQMMRAADYLGWDVTELRPVLKDM SINFRUP00000139732 SLLEDGQPRDKLEFAFKLYDRDGNGVLDSSEVDRIIAQMMHAAEYLGWDVSELRPVRRES ENSMUST00000040500 SLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEM ENST00000258767 SLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEM SINFRUP00000132799 SLLERGMPEDKLELCWSP------------------------------------QILKEM ENST00000265022 SLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEM ENSMUST00000023578 SLMETGRPQDKLEFMFRLYDSDENGLLDQAEMDQIVSQMLHVAQYLEWDPTELRPILKEM ci0100132672 SLLEGGRPEDKLQFVFKLYDTDGNGNLDSSEMERIVNQMMHVAEYLGWDVTELRPILEEM ENSMUST00000026414 TLLEGGRPEDKLEFTFKLYDMDRNGILDSTEVEKIILQMMRVAEYLDWDVSELRPILQEM CG18654-RB SLLEAGRPEDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEM :::* * *.***:: : : : :: :: : : : .: SINFRUP00000144229 MTAIDVDDSGTVTLEEWLKGGMNNVPLLVLLGLKMT--ERDGQHIWRLKHFNKPTYCSVC SINFRUP00000139732 ARARQFLHRRAGECARCLAT------LIVIFNHQMT--QTDGQHLWRMKHFNRPVYCNVC ENSMUST00000040500 MEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLC ENST00000258767 MEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLC SINFRUP00000132799 MEEIDYDRDGTVTLEEWIRGGLTTIPLLVLLGMDTN-IEEDGQHVWRLKHFNKPAYCNYC ENST00000265022 LQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFC ENSMUST00000023578 LQGMDYDKDGFVSLQEWINGGMTTIPLLVLLGMDDSGSKGDGRHAWTLKHFKKPTYCNFC ci0100132672 LQEIDYDGDGVVTLNEWIHGGLTTIPLLVLLGLETN-IKDDGSHAWRLKHFSLPAYCNFC ENSMUST00000026414 MREMDQDGSGSVSLDEWVRAGATTVPLLVLLGMDVT-MKDDGNHIWRPKRFTRLVYCNLC CG18654-RB MVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLC : . : *:*::. . . : ** * * *:*. .**. * SINFRUP00000144229 QSMLLGLGKQGLCCTCCKYTVHNQCANRNPEPCARTFVKSKKE--IGVAAHEWIRTDSSS SINFRUP00000139732 QSLLLGLRKQGLCCTCCKYTVHGRCANRNPAPCTRTYVKSKKE--IGVPAHDWVSGNCDS ENSMUST00000040500 LNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKKN--TDVMHHYWVEG-NCP ENST00000258767 LNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRN--TDVMHHYWVEG-NCP SINFRUP00000132799 HTMLLGVRKQGLCCSICKYTVHERCVSKDIAACISTYAKSRRH--TDAMQHVWMEG-NSP ENST00000265022 HIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRS--GEVMQHAWVEG-NSS ENSMUST00000023578 RAMLMGVGKQGLCCIYCKYTVHQRCVSKTIHGCVKTNSKAKRS--GEVMQHAWVEG-NSS ci0100132672 LTMLVGVGKQGLCCTFCKYTAHERCVNKVPANCIQTYVKSAKE--ASKLSHVWVEG-NNA ENSMUST00000026414 EQSIS-LGKQGLSCNFCKYIVHDHCAMKAQPCEVSTYAKSRKD--IGVQSHLWVRGGCHS CG18654-RB LNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLLHHWVEG-NCY : : *:**.* *** .* :*. : * *: : * *: SINFRUP00000144229 GKCQVCHKKIKT---LAGRRCVWCHEMRHDDCLFSGLSSCGCGALRDHILPPWAIYAVSK SINFRUP00000139732 KKCDKCQKKIKSFQGLTGKHCVWCHTMRHDECADQEPTECSCGLLRDHILPPWAIYPVIK ENSMUST00000040500 TKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASHLKPECDCGPLKDHILPPTTICPVVL ENST00000258767 TKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVL SINFRUP00000132799 TKCDRCHRSIKCYQGLTGLHCVWCQITLHNKCASHVKQECDGGSLRDHTLLPSYICPVVL ENST00000265022 VKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE--LSTLCDGGELRDHILLPTSICPITR ENSMUST00000023578 VKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE--LSTVCDGGELKDHILLPTSICPVSG ci0100132672 GPCDKCKKPIKCYQGLTGLHCRWCQATYHNKCASHTSAECNMGKMRAHILPPNCICPGLL ENSMUST00000026414 GRCDRCQKKIRTYHSLTGLHCVWCHLEIHDDCLQAVGPECDCGLLRDHILPPCSIYPSVL CG18654-RB GRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICPAVL *. *:: :: ::. * **: * * * * : * * . SINFRUP00000144229 VRKTAETPIQIVSSVSLLLAACLHPPFRVAH--------------TFYCQI-VPVADTHP SINFRUP00000139732 VHN--YLPIHTHTHRPNSARHTNRRDLLTCG--------------VNKCEISCPVANTHP ENSMUST00000040500 QTMPSAGASVPEERQSTAKKEKSSSQQPNKATDKNKMQRANSVTMDGQGLQITPVPGTHP ENST00000258767 QTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHP SINFRUP00000132799 VRSPPASTCLFPTEAASCGSELYSAPSN----------------------QINPLPGSHP ENST00000265022 DRPGEKSDGCVSAKGELVMQY-----------------------------KIIPTPGTHP ENSMUST00000023578 DRQGGKSDGSVAAKGELVTQY-----------------------------KIIPSPGTHP ci0100132672 VNEVTARDSIKGKQITKLFQIAAKHMKRMN-----------SMTWDGQGLQISPLPGTHP ENSMUST00000026414 VSGQECKHKTTDDTSLCTPEA----------------------------FRIEPVSNTHP CG18654-RB DRQRSVNQAHKKSQMHHHQAT--------------------------HFQITPPDELSCP * : * SINFRUP00000144229 LLVFVNPKSGGKQGERVLRKFQYLLNPRQVYNLSNGGPAPGLHFFRNLREYRILVCGGDG SINFRUP00000139732 LLVFVNPKSGGKQG--VLHKFQYLLNPRQVYNLSSGGPGPGLSFFRSLQDYRILVCGGDG ENSMUST00000040500 LLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLHFFRDVPDFRVLACGGDG ENST00000258767 LLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDG SINFRUP00000132799 LLVMVNPKSGGRQGE---RKFMLVTAFTSMYFLSP------LSFFHDVPDFRVLACGGDG ENST00000265022 LLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDG ENSMUST00000023578 LLVLVNPKSGGRQGERILRKFHYLLNPEQVFNLDNGGPTPG---YGQSSSLCPALVSEEN ci0100132672 LLVFINPKSGGKQGVRLLRKMQGLLNPRQVYDLCSGGPMPGLNFFHDVEDFRVLCCGGDG ENSMUST00000026414 LLVFINLKSGGKQGQSVLWKFQYILNPRQVFDLKD-GPEPGLRFFKDVPQFRILVCGGDG CG18654-RB LLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDG ***::* ****:** : *: : .:: * : :: . . :. SINFRUP00000144229 TVGWLLDAIDRENLQVRPPVAVLPLGTGNDLARCLRWGGGYEGSDLREILKEIEASKLVL SINFRUP00000139732 TVGWILDAIDKCNLLARPPVAVLPLGTGNDLARCLRWGGGYDGEDLTRILKDIEGSSPVQ ENSMUST00000040500 TVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIESSTEIM ENST00000258767 TVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIM SINFRUP00000132799 TVGWILDCIDKSNFAKHPPVAILPLGTGNDLARCLRWGGGYEGGSLLKFLRDIEHSTEVV ENST00000265022 TVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVM ENSMUST00000023578 TF------LYKANFTKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKEIEQSPLVM ci0100132672 TVGWVLDCIDKSQILHRPPVAILPLGTGNDLARCLRWGGGYEGTSVMKVLQQVENSQSVL ENSMUST00000026414 TVGWVLETIDKANFATVPPVAVLPLGTGNDLARCLRWGRGYEGENLRKILKDIELSKVVY CG18654-RB TVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVM *. :: : :. *.:.::*************** **:* .: ..: ... : : SINFRUP00000144229 MDRWSIQVIPNDPQ---------------------------------------------- SINFRUP00000139732 MDRWSVQVVADESQ---------------------------------------------- ENSMUST00000040500 LDRWKFEVTPNDKD---------------------------------------------- ENST00000258767 LDRWKFEVIPNDKD---------------------------------------------- SINFRUP00000132799 LDRWNINIIPDDKQ---------------------------------------------- ENST00000265022 LDRWHLEVIPREEV---------------------------------------------- ENSMUST00000023578 LDRWYLEVMPREEV---------------------------------------------- ci0100132672 MDRWNLNVKCEVETS--------------------------------------------- ENSMUST00000026414 LDRWFLEVIPQQNG---------------------------------------------- CG18654-RB LDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATS :*** .:: SINFRUP00000144229 ------------------------------------------------------------ SINFRUP00000139732 ------------------------------------------------------------ ENSMUST00000040500 ------------------------------------------------------------ ENST00000258767 ------------------------------------------------------------ SINFRUP00000132799 ------------------------------------------------------------ ENST00000265022 ------------------------------------------------------------ ENSMUST00000023578 ------------------------------------------------------------ ci0100132672 ------------------------------------------------------------ ENSMUST00000026414 ------------------------------------------------------------ CG18654-RB MGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRT SINFRUP00000144229 ------------------------------------------------------------ SINFRUP00000139732 ------------------------------------------------------------ ENSMUST00000040500 ------------------------------------------------------------ ENST00000258767 ------------------------------------------------------------ SINFRUP00000132799 ------------------------------------------------------------ ENST00000265022 ------------------------------------------------------------ ENSMUST00000023578 ------------------------------------------------------------ ci0100132672 ------------------------------------------------------------ ENSMUST00000026414 ------------------------------------------------------------ CG18654-RB AMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHK SINFRUP00000144229 ------------------------------------------------------------ SINFRUP00000139732 ------------------------------------------------------------ ENSMUST00000040500 ------------------------------------------------------------ ENST00000258767 ------------------------------------------------------------ SINFRUP00000132799 ------------------------------------------------------------ ENST00000265022 ------------------------------------------------------------ ENSMUST00000023578 ------------------------------------------------------------ ci0100132672 ------------------------------------------------------------ ENSMUST00000026414 ------------------------------------------------------------ CG18654-RB QQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHE SINFRUP00000144229 ------------------------------------------------------------ SINFRUP00000139732 ------------------------------------------------------------ ENSMUST00000040500 ------------------------------------------------------------ ENST00000258767 ------------------------------------------------------------ SINFRUP00000132799 ------------------------------------------------------------ ENST00000265022 ------------------------------------------------------------ ENSMUST00000023578 ------------------------------------------------------------ ci0100132672 ------------------------------------------------------------ ENSMUST00000026414 ------------------------------------------------------------ CG18654-RB DEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKV SINFRUP00000144229 --EEGDPVPYEIINNYFSIGVDASIAHRFHSMREKHPQRFNSRKKNKLRYFEFATSETIS SINFRUP00000139732 --AKGDPVPYEIINNYFSIGVDASIAHRFHTMREKHPQKFNSRMKNKLWYFEFATSETIS ENSMUST00000040500 --EKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFS ENST00000258767 --EKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFS SINFRUP00000132799 --EKGDPVPYNIVNNYFSIGVDASIAHRFHLMREKHPEKFNSRMKNKLWYFEFGTTETIS ENST00000265022 --ENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFA ENSMUST00000023578 --ENGDQVPYNIMNNYFSIGVDASIAHRFHMMREKHPEKFNSRMKNKLWYFEFGTSETFA ci0100132672 --EIGDPVPLSIMNNYFSIGVDASICRKFHVMREKHPEKFNSRMKNKLWYSAFGTTETFA ENSMUST00000026414 --EKSDPVPSQIINNYFSIGVVSGVGS-------GRREKCG--MKNKLWYFEFATSESIF CG18654-RB QSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFA . ** .*:*****:** :.: : . .: . ***: * :.*:*:: SINFRUP00000144229 ASCKKLKDCLAVECCGRPLD-LGNMCLEGIAVLNIPSMHGGSNLWGE---SKKADSLP-- SINFRUP00000139732 ASCKKLSESLTIECCGVPLD-LSSLSLEGVAVLNIPSMHGGSNLWGE---TKRADTKGGT ENSMUST00000040500 ATCKKLHESVEIECDGVQID-LINISLEGIAILNIPSMHGGSNLWGE---SKKKRSHRRI ENST00000258767 ATCKKLHESVEIECDGVQID-LINISLEGIAILNIPSMHGGSNLWGE---SKKRRSHRRI SINFRUP00000132799 ATCKKLNECIEVECDGITLD-LSNTSLEGIAVLNIPSMHGGSNLWGE---SKRRRNYNRM ENST00000265022 ATCKKLHDHIELECDGVGVD-LSNIFLEGIAILNIPSMYGGTNLWGE---NKKNRAVIRE ENSMUST00000023578 ATCKKLHDHIELECDGVEVD-LSNIFLEGIAILNIPSMYGGTNLWGE---TKKNRAVIRE ci0100132672 ASCKKLHDNLEVLVDGVKLESLSRNRFQGIAILNIPSVYGGTNLWGT---SKKMK----- ENSMUST00000026414 STCKKLEESVTVEICGKLLD-LSDLSLEGIAVLNIPSTHGGSNLWGD---TKRPHGDTCE CG18654-RB ASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGP ::**:* : : : * :: ::*:*:**** :**:**** *: SINFRUP00000144229 EAEEGR----------VITDPDLLKTISQDISDKRLEVVGLEGVIEMGQIYTGLKSAGHR SINFRUP00000139732 SQAEPD----------VITDPEILKVTSQGMTS---PPPSLQLIVKI--VITHKNQASML ENSMUST00000040500 EKKGSDKRP-------TLTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRR ENST00000258767 EKKGSDKRT-------TVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRR SINFRUP00000132799 SKKALDRIPSS-----TVTDAKELKFCVQ------------------------------- ENST00000265022 SRKG-------------VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRR ENSMUST00000023578 SRKS-------------VTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRR ci0100132672 KRDG--------------NKPVDLRYAVQEMGDKLLEVVGLEGAMEVGQIMAGLR-AGKR ENSMUST00000026414 INQALGSAAK------IITDPDILKTCVPDMSDKRLEVVGIEGAIEMGQIYTRLKSAGHR CG18654-RB FGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRR .. * : : : : : : SINFRUP00000144229 LAQTSQITIRLKRITPTQ------------------------------------------ SINFRUP00000139732 MAPQAKSSGFFTY----------------------------------------------- ENSMUST00000040500 LAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLIKRTR ENST00000258767 LAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKRTR SINFRUP00000132799 ------------------------------------------------------------ ENST00000265022 LAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFS---LRRK ENSMUST00000023578 LAQCSSVTIRTNKLLPMQVDGEPWMQPQCTIKITHKNQAPMMMGPPQKSSFFS---LRRK ci0100132672 LAQGSDIIINTNRLFPMQVDGEPWMQIPCTIHITHKNQVPMLMAHPGGQSSFFSCFRRSP ENSMUST00000026414 LAKCSEITFQTTKTLPMQIDGEPWMQAPCTIKITHKNQMPMLMGPPSNSYNFFGFWS--- CG18654-RB LAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLLCS- : SINFRUP00000144229 ------- SINFRUP00000139732 ------- ENSMUST00000040500 NRSKE-- ENST00000258767 NRSKE-- SINFRUP00000132799 ------- ENST00000265022 SRSKD-- ENSMUST00000023578 SRSKD-- ci0100132672 HEGIEEP ENSMUST00000026414 ------- CG18654-RB -------