CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000040895 ------------------------------------------------------------ ENST00000303622 ------------------------------------------------------------ SINFRUP00000146277 ------------------------------------------------------------ ci0100151427 ------------------------------------------------------------ CG30132-RB ------------------------------------------------------------ ENSMUST00000027929 ------------------------------------------------------------ ENST00000294888 RGSPPPPGSPSTPHPASLAAPPAPGNRLARSPPSLLSAYPGGAAAGSGSPSSSSASSSLF ENST00000294247 ------------------------------------------------------------ ENST00000262891 ------------------------------------------------------------ ENSMUST00000032556 ------------------------------------------------------------ SINFRUP00000150307 ------------------------------------------------------------ ENSMUST00000040895 ----------------------------ARGRCSPAAQSWAVLFSPWRCAESKRNKMSTR ENST00000303622 --------------------------------------------------------MSTR SINFRUP00000146277 ------------------------------------------------------------ ci0100151427 ------------------------------------------------------------ CG30132-RB ------------------------------------------------------------ ENSMUST00000027929 ------------------------------------------------------------ ENST00000294888 PPPGPLVAPPRGLREPLAPALCSRPHPFPVAPRGPHHSPAGETPARPRCPHKMSARTPLP ENST00000294247 ------------------------------------------------------------ ENST00000262891 -----------------------------------------------------MSSRTVL ENSMUST00000032556 ------------------------------------------------------------ SINFRUP00000150307 ------------------------------------------------------------ ENSMUST00000040895 TPLPTVNERDTENHISHGDGRQEVTSRTGRSGARCRNSIASCADEQPHIGNYRLLKTIGK ENST00000303622 TPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGK SINFRUP00000146277 ------------------------------------------------------------ ci0100151427 ---------MSRSATEDRGGSGDGLRSHRNPSNHMQRSRMATGDDQPHIGQYRILKTIGK CG30132-RB ----------------------MQMRSS---------APMRWRATEEHIGKYKLIKTIGK ENSMUST00000027929 ---------HTSVDGYTETHIPPAKSSSRQNLPRCRNSITSATDEQPHIGNYRLQKTIGK ENST00000294888 TVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGK ENST00000294247 -------------------------------MIRGRNSATSA-DEQPHIGNYRLLKTIGK ENST00000262891 APGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGK ENSMUST00000032556 ------------------------SWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGK SINFRUP00000150307 ----------HTSLSVSRS-EKGTGWSSRSLGARCRNSIALCSDEQPHIGNYRLLKTIGK ENSMUST00000040895 GNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKL----FREVRIMKILNHPNIVKLFE ENST00000303622 GNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKVRLVQYICLFFFRVLSSP-AVKLFE SINFRUP00000146277 ------------------------------------------------------------ ci0100151427 GNFAKVKLARHVLTGREVAIKIIDKKQLNTSSLQKL----FREVRIMKHLDHPNIVKLYE CG30132-RB GNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKL----FREVRIMKMLDHPNIVKLFQ ENSMUST00000027929 GNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL----FREVRIMKILNHPNIVKLFE ENST00000294888 GNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL----FREVRIMKILNHPNIG---- ENST00000294247 GNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL----FREVRIMKVLNHPNIVKLFE ENST00000262891 GNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFR----EVRIMKGLNHPNIVKLFE ENSMUST00000032556 GNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFR----EVRIMKGLNHPNIGKISL SINFRUP00000150307 GNFAKVKLARHILTGREVGLMITCCKRHVKSCLFLFF----------------FFKQFIL ENSMUST00000040895 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLK ENST00000303622 VIETEKTLYLIMEYASGG--KNIFIYIGFFFFLPFKKIHNHTAHMVQYCHQKRIVHRDLK SINFRUP00000146277 ----------------------------------------QILSAVQYCHQKHIVHRDLK ci0100151427 VIENSKQLLLVMEYANGGEVFDYLVAHGRMKEKEARAKFRQIVSSVQYLHSKNIVHRDLK CG30132-RB VIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK ENSMUST00000027929 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLK ENST00000294888 ------------------EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLK ENST00000294247 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQVVSAVQYCHQKFIVHRDLK ENST00000262891 VIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLK ENSMUST00000032556 FRSVWTTALMVISRG--GEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLK SINFRUP00000150307 LSNLCKERVLICSHSSSGEVFDYLVAHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLK : *:* *.* *:***** ENSMUST00000040895 AENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG ENST00000303622 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG SINFRUP00000146277 AENLLLDADMNIKIADFGFSNEFSVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG ci0100151427 AENLLLDADMNIKIADFGFSNEFTPGHKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG CG30132-RB AENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG ENSMUST00000027929 AENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG ENST00000294888 AENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG ENST00000294247 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG ENST00000262891 AENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLG ENSMUST00000032556 AENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLG SINFRUP00000150307 AENLLLDADSNIKIADFGFSNEFSVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLG *******.: *************: * ****************************:**** ENSMUST00000040895 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQ ENST00000303622 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ SINFRUP00000146277 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPGKRGTLEQ ci0100151427 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEHLLRKFLVLNPTKRGTLTS CG30132-RB VILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLET ENSMUST00000027929 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQ ENST00000294888 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQ ENST00000294247 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ ENST00000262891 VILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQ ENSMUST00000032556 VILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQ SINFRUP00000150307 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEGILRRFLVLNPAKRCSLEQ *************** .*:************:********* :*:::*:*** ** :* ENSMUST00000040895 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT ENST00000303622 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT SINFRUP00000146277 IMKDRWINTGSEEEELKPFIQPDLDIRDQARIDLMVVMGYCKDDIADSLSKMKYDDITAT ci0100151427 VMQDKWMNIGHEDEPLKPYVDAPFQENDEGRLQSMIDMGYNKEEVENSIRTRAYDDSFAT CG30132-RB IMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFAT ENSMUST00000027929 IMKDRWMNVGHEEEELKPYSEPELDLSDAKRIDIMVTMGFARDEINDALVSQKYDEVMAT ENST00000294888 IMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMAT ENST00000294247 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT ENST00000262891 IMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTAT ENSMUST00000032556 IMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTAT SINFRUP00000150307 IMKDKWINIGHEGDELKAHIEPVEDFNDTSRIDIMVGMGFTREEIRDSLNTQKYNEVTAT :* *:*:* * * : **.. :. : * * : :: **: :.:: :: *:: ** ENSMUST00000040895 YLLLGRKSAELDASDS----SSSSNLSLAKVRPNSDLSNSTGQ-SPHHKGQRSVSSSQKQ ENST00000303622 YLLLGRKSSELDASDS----SSSSNLSLAKVRPSSDLNNSTGQ-SPHHKVQRSVFSSQKQ SINFRUP00000146277 YLLLGHK--------------------VAEVRDRQHSNNSLSN-FSHHRGSASSTTSSKQ ci0100151427 YLLLGTKPSELSDPSASRSSSALSLKQVGQPSPSNQQTRKVHRSVSANQKPRRVSTENSK CG30132-RB YLLLGRKSTDP-ESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTK ENSMUST00000027929 YILLGRKPPEFEGGES-LSSGSLCQR----SRPSSDLNNSTLQSPAHLKVQRSISANQKQ ENST00000294888 YILLGRKPPEFEGGES-LSSGNLCQR----SRPSSDLNNSTLQSPAHLKVQRSISANQKQ ENST00000294247 YLLLGYKSSELEG-------DTITLK----PRPSADLTNSSAPSPSH-KVQRSVSANPKQ ENST00000262891 YLLLGRKTEEGGDRGA----PGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQ ENSMUST00000032556 YLLLGRKTEEGGDRGA----PGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQ SINFRUP00000150307 YLLLGRKK--------------------HASSSSSSGAASS--SAGPKAQR-SASTYHRQ *:*** * : : : ENSMUST00000040895 RRYSDHAG----------PAIPSVVAYPKRSQTSTADSDLK-EDGIPSRK---------- ENST00000303622 RRYSDHAG----------PAIPSVVAYPKRSQTSTADSDLK-EDGISSRK---------- SINFRUP00000146277 RRYSEQA------------ACPSSAALPSRGGQASVQAEVKREVGGQSKK---------- ci0100151427 KSFNNLRYRICFSIFSDHRSEGGLAAGSFSFEQNLVRVNFTRSMPRDKMRIVRNYLENQR CG30132-RB PSR---------------RASSGVGP------TNAAATVAAATGAVGAVNPSNNY--NAA ENSMUST00000027929 RRFSDHAG----------PSIPPAVSYTKRPQANSVESEQKEEWGKDTARRLGSTTVGSK ENST00000294888 RRFSDHAG----------PSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSK ENST00000294247 RRFSDQAAG---------PAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKASST----- ENST00000262891 RRHSDFCGP------------SPAPLHPKRSPTSTGE-AELKEERLPGRKA--------- ENSMUST00000032556 RRHSDFCGP------------SPAPLHPKRSPTSTGD-TELKEERMPGRKA--------- SINFRUP00000150307 RRHSDFCGPG-----------VSTTTHPKRSPSGVSEGVGLKEERLSVRKP--------- . ENSMUST00000040895 --SSSSAVGGKGIAPASPMLGNAGNPNKADIPERKKSPAVPSSNTASGGMTRRNTYVCSE ENST00000303622 --SSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSE SINFRUP00000146277 --SDTAETG-------SPLLGNATNPNMADVLGRRRVLATPTS--ASSSMSRRNTYVCTE ci0100151427 ASVSTASSYASAQAKQALLASTAANPNKAEIPS-NQRPETAKTW-KNNDMTRRNTYVCTD CG30132-RB GSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASAT----QKMLTTADTTLNSP ENSMUST00000027929 SEVTASPLVGPDRKKSTASPSNN-VYSGGSMARRNTYVCERSTD-RYAALQNGRDSSLTE ENST00000294888 SEMTASPLVGPERKKSSTIPSNN-VYSGGSMARRNTYVCERTTD-RYVALQNGKDSSLTE ENST00000294247 AKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASL-GQASIQNGKDSLTMP ENST00000262891 SCSTAGSGSRGLP-PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTE ENSMUST00000032556 SCSAVGSGSRGLP-PSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTE SINFRUP00000150307 STSTIGS--RNIPTPSSPMVSSAHNPNKAEIPDRRKDINSTTNNIPASAMTRRNTYVCTD . . . . : ENSMUST00000040895 RCAADRHSVIQNGKENS------------------------------------------- ENST00000303622 RTTADRHSVIQNGKENSLTEMFAYAASPASVCTSTCRLRHQKSMSMSASGHPKMMLPPID SINFRUP00000146277 RGAADQHAPLQNGKDSS------------------------------------------- ci0100151427 RKGDKAALVQVDELYIFLPLGAISCCSP------------QEETSVRPRHHKTQSSTAVP CG30132-RB AKP--RTATKYDPTNGNRTVSGTSGIIP------------RRSTTLYEKTSSTEKTNVIP ENSMUST00000027929 MSA--SSMSSAGSTVASAGPSARPRHQK------------SMSTSGHPIKVT-LPTIKDG ENST00000294888 MSV--SSISSAGSSVASAVPSARPRHQK------------SMSTSGHPIKVT-LPTIKDG ENST00000294247 GSR--ASTASASAAVSAARP---RQHQK------------SMSASVHPNKASGLPPTESN ENST00000262891 RPGAERPSLLPNGKENSS------------------------------------------ ENSMUST00000032556 RPGSERPSLLPNGKENSS------------------------------------------ SINFRUP00000150307 RANADRHSLLQNGKETSS------------------------------------------ . ENSMUST00000040895 ---------AIPDERTP-VASTHSISSATTP-DRI-----RFPRGTASRSTFHG-QPRER ENST00000303622 SEGDNFKAITIPDQRTP-VASTHSISSAATP-DRI-----RFPRGTASRSTFHG-QPRER SINFRUP00000146277 -------SATTPPQRSAGGSSTHSVSGGAAPSERP-----RFPRGTASRSTFHGGQLRER ci0100151427 PIPTVVNSEEPEHRPTIAPGARSSIHARHSQTSAT-----PFPRNARERRTYHGPQTQER CG30132-RB AETNLFD------RLRMASAVKSSRH---------------FPRNVPSRSTFHSGQTRAR ENSMUST00000027929 SEAYRPG---AAQRVPAASPSAHSISAS--TPDRT-----RFPRGSSSRSTFHGEQLRER ENST00000294888 SEAYRPG---TTQRVPAASPSAHSISTA--TPDRT-----RFPRGSSSRSTFHGEQLRER ENST00000294247 CEVPRPRQVTAPQRVPVASPSAHNISSSGGAPDRT-----NFPRGVSSRSTFHAGQLRQV ENST00000262891 ----------GTPRVPPASPSSHSLAPPSGERS-------RLARGSTIRSTFHGGQVRDR ENSMUST00000032556 ----------GTSRVPPASPSSHSLAPPSGERS-------RLARGSTIRSTFHGGQVRDR SINFRUP00000150307 ----------LSHRLPPASPSTHSIAGASAASSSSSTPSSRLSRGTTVRSTFHGGQIRDR . . :.*. * *:*. * : ENSMUST00000040895 R------TATYNGPPASPSLS----------------HEATPLSQTRSRGSTNLFSKLTS ENST00000303622 R------TATYNGPPASPSLS----------------HEATPLSQTRSRGSTNLFSKLTS SINFRUP00000146277 R------SATYNGPPASPSLS----------------HDTTPLSQSRSRGSTNLFSKLTS ci0100151427 TR-R---TATYNGPPPPTSPSVSECMPGAMASGRDSNTTSRGGPSGSREGASGFLSKLSS CG30132-RB NN-T---ALEYSG-------------------------TSGASGDSSHPGRMSFFSKLSS ENSMUST00000027929 R------SAAYNGPPASPS------------------HETGAFAHARRGTSTGIISKITS ENST00000294888 R------SVAYNGPPASPS------------------HETGAFAHARRGTSTGIISKITS ENST00000294247 RDQQ---NLPYGVTPASPS------------------GHS----QGRRGASGSIFSKFTS ENST00000262891 RAGGGGGGGVQNGPPASPTLA----------------HEAAPLPAGRPRPTTNLFTKLTS ENSMUST00000032556 RAGSGSGGGVQNGPPASPTLA----------------HEAAPLPSGRPRPTTNLFTKLTS SINFRUP00000150307 RPPS-------HAPPGSPTPS----------------HDASPLPHARTRATTNLLSKLTS : .:::*::* ENSMUST00000040895 KLTR---------------SRNVSSEQKDEN--------------REAKPRSLRFTWSMK ENST00000303622 KLTRRLPTEYERNGRYEGSSRNVSAEQKDEN--------------KEAKPRSLRFTWSMK SINFRUP00000146277 RLTR---------------SHNVSGDQKEEPG------SPAVPPLKESKPRSLRFTWSMK ci0100151427 KFNRS---------------TSRGVP----------------EAEKDSKPRSLRFTWSMK CG30132-RB RFSKR---------------PT--------------------IADEAAKPRVLRFTWSMK ENSMUST00000027929 KFVRRDPSEGEASGRADTARGSSGDP-----------KERDKDEGKEAKPRSLRFTWSMK ENST00000294888 KFVRR---------------STSGEP-----------KERDKEEGKDSKPRSLRFTWSMK ENST00000294247 KFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMK ENST00000262891 KLTRRVADE----------PERIGGP--EVT------SCHLPWDQTETAPRLLRFPWSVK ENSMUST00000032556 KLTRSPCTDGGVEVLAPLPPCLILAPCCPLL------SCHLPWDKTETAPRLLRFPWSVK SINFRUP00000150307 KLTR---------------------------------SRHLSGHQKASEPRTPRCGWDVR :: : : ** * *.:: ENSMUST00000040895 TTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGH-AENLVQWEMEVCKLPR-- ENST00000303622 TTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGH-AENLVQWEMEVCKLPR-- SINFRUP00000146277 TTSSMEPQDMMREIRKVLDTNNCDYEQRERFLLLCVHGDGH-ADNLVQWEMEVCKLPR-- ci0100151427 TTSAMEPKEMMKEIRKVLDANSCDYEQREKYLLFCVNGHGH-ADNLVQWEMEVCKLPR-- CG30132-RB TTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPN-TDSLVQWEIEVCKLPR-- ENSMUST00000027929 TTSSMDPNDMLREIRKVLDANTCDYEQKERFLLFCVHGDAR-QDSLVQWEMEVCKLPR-- ENST00000294888 TTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDAR-QDSLVQWEMEVCKLPR-- ENST00000294247 TTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPG-HEDFVQWEMEVCKLPR-- ENST00000262891 LTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPR-- ENSMUST00000032556 LTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPR-- SINFRUP00000150307 VRSPRDPAEVVLALREAAQGCGCQVHLAGPFLLSCTHGVAG---ARVAFEAEVCQLPSGL *. * :: :*:. * . ::* * :* :* ***:** ENSMUST00000040895 LSLNGVRFKRISGTSIAFKNIASKIANELKL ENST00000303622 LSLNGVRFKRISGTSIAFKNIASKIANELKL SINFRUP00000146277 LSLNGVRFKRISGTSIAFKNIASKIANELRL ci0100151427 LSLNGVRFKRISGTSIAFKNIASKIANELKL CG30132-RB LSLNGVRFKRISGTSIGFKNIASRIAFDLKL ENSMUST00000027929 LSLNGVRFKRISGTSIAFKNIASKIANELKL ENST00000294888 LSLNGVRFKRISGTSIAFKNIASKIANELKL ENST00000294247 LSLNGVRFKRISGTSMAFKNIASKIANELKL ENST00000262891 PGLRGVLFRRVAGTALAFRTLVTRISNDLEL ENSMUST00000032556 PGLRGVLFRRVAGTALAFRTLVTRISNDLEL SINFRUP00000150307 GQSSGVRFKRLWGAPLAFRDIATKVSKELEL ** *:*: *:.:.*: :.:::: :*.*