CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000033672 MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPSRGWAPPGPSPSSGALDLL ENST00000276070 MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLL ENST00000275286 ------------------------------------------------------------ SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA MEEISSLDSFGADSNARPESATPRSEEQQDQDRQQTAPAASETLDTPASPPAEDAAAQES ENSMUST00000033672 DTPSGLEKDPGGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDSGEQTLEPGPGCQ ENST00000276070 DTPAGLEKDPG-VLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQ ENST00000275286 ------------------------------------------------------------ SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA KPPPSKEADDDFEQISEGSLDADDNQSRDKAASTPADPVDAEEPAEEPTPNEEPQGGEDE ENSMUST00000033672 TPEVMPPDPGAGASPPSPEGLLEPLAPDSPIILESPHIEEEIPP-LATRRRGSPGQEEEH ENST00000276070 TPEVVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARRGSPGQEEEL ENST00000275286 ------------------------------------------------------------ SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA QPQTEAVRVDPQEEPEEAEEETDALQATAEEVEAAAAEADAVDGGPASPEAMDVDEGEVD ENSMUST00000033672 TQGQPQSPNAPPSPSVGETLGDGINSSQSKPGVCTPTAHPSLPGDGLTGKEIEKPPERVQ ENST00000276070 PQGQPQSPNAPPSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGDGLTAKASEKPPE--R ENST00000275286 ----------------------------------MNKMLPSVP----------------- SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA AEGEAEQEAEDDAALDREATDDVDMQSVGADSHQAEDAEPPEGRDEVDTSLEEQENGQDP ENSMUST00000033672 KRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSMA ENST00000276070 KRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVS ENST00000275286 ------------------------------------------------------------ SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA DEREKDAAADEDDPDAEGDAESEQVDENAEETGEAEHGDDTVENVLEPEESDVCLIPDDQ ENSMUST00000033672 QRAGRSSMGTKMSCAHCRTPLQKGQTAYQRKGLP--------------QLFCSSSCLTTY ENST00000276070 QRAGRSAVGTKMTCAHCRTPLQKGQTAYQRKGLP--------------QLFCSSSCLTTF ENST00000275286 ------ATAVRVSCSGCKKILQKGQTAYQRKGST--------------QLFCSTLCLTGY SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA ETEVTEAEKELARENAEKAAEEEEAEERQAKTPDNDRKSPADAAADPEDDSAAAVDATDV ENSMUST00000033672 SKK------PLGRKTCTFCKKEIWNTKDSVVVQTGPGGSFHEFCTSVCLSLYEAQQQRPI ENST00000276070 SKK------PSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPI ENST00000275286 TVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKK-KPI SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA SPTTPTADGVAAAANEEEAGGDVPDPDEPTAEESSSAGAGEPGSTPKIIISWIVGSVQKC ENSMUST00000033672 PQSGDPADA-------------TRCSICQKTGEVLHEVSNGSVVHRLCSDSCFSKFRANK ENST00000276070 PQSGDPADA-------------TRCSICQKTGEVLHEVSNGSVVHRLCSDSCFSKFRANK ENST00000275286 VTINTNSIS-------------TKCSMCQKNAVIRHEVNYQNVVHKLCSDACFSKFRSAN SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA KQCGDEKNCGFRYRSPEESEEMDKEKENDKAEENAEEGEEEEARQKPAAPSGFEYICDTA ENSMUST00000033672 GLKTNCCDQCGAYIYARPGGLGPELLFHDGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTL ENST00000276070 GLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTL ENST00000275286 NLTMNCCENCGGYCYSGSGQ--CHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSL SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA CVDALLEDQPGKYFVRRKKFLVEEVVREEGAAEAEASADGEGGDAEEEATPANTQDCLQC ENSMUST00000033672 CKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDR ENST00000276070 CKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDR ENST00000275286 RSSAEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDG SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA KDKTRCKYFIKQDQDCFYICNDDCFNLLNAEEPDKFKLKRHSIRVRNIGATTLQPPQNSP ENSMUST00000033672 TVYQFCSPSCWTKFQ----------------------------HTSPEGG---------- ENST00000276070 TVYQFCSPSCWTKFQ----------------------------RTSPEGG---------- ENST00000275286 SIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSTVSAGGGSTSAVSPTS SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA TKRTDGSVVARTVEEAETARLDRIESFRRRCADCEADINTDEKQLMWETMDFCNEVCLGS ENSMUST00000033672 -------------------------IHLSCHYCHSLFSGKPEVLEW-------------- ENST00000276070 -------------------------IHLSCHYCHSLFSGKPEVLDW-------------- ENST00000275286 ISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDY-------------- SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA YQRTIGSTCETCKQEVSSIALGKYCVRFGFDVRQFCCAGCLNTFKKGLKTCSCCQKDISG ENSMUST00000033672 -----------QDQVFQFCCRDCCEDFKRLRG-----VVSQCEHCRQEKLLHEKLRFSGV ENST00000276070 -----------QDQVFQFCCRDCCEDFKRLRG-----VVSQCEHCRQEKLLHEKLRFSGV ENST00000275286 -----------KGKMFQFCGKNCSDEYKKINN-----VMAMCEYCKIEKIVKETVRFSGA SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA GQEGFLAPVGDKDQFKDFCSQSCLRRYESMCNPRRKLRTDVCGVCNNQKPVRVEMLLEDR ENSMUST00000033672 EKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDG-STWDFCSEDCKTKY ENST00000276070 EKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDG-STWDFCSEDCKSKY ENST00000275286 DKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGG-KVEEFCCEECMSKY SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA EHYFCSNPCFSAFKFVSNVNADPCAMCSKYFERRSAESYTIYNEQQSPKVFCSRVCINVY ENSMUST00000033672 LLWYCKAARCHACKRQGKLLETIHWRG--------------------------------- ENST00000276070 LLWYCKAARCHACKRQGKLLETIHWRG--------------------------------- ENST00000275286 TVLFYQMAKCDACKRQGKLSESLKWRG--------------------------------- SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA IIVNRHIVSCQWCKVKKYNFDMIYQIGGPHDQETLTCSINCLTMHGVSCNISARAVTKCD ENSMUST00000033672 -----------------QIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSSE---- ENST00000276070 -----------------QIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSPE---- ENST00000275286 -----------------EMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAAS---- SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA NCSNFNTPQYHLTMSDASMRNFCTYQCVMQFQNQFARAPLTLDSDLPPSSAGSSKSQQQS ENSMUST00000033672 ------------------------------------------------------------ ENST00000276070 ------------------------------------------------------------ ENST00000275286 ------------------------------------------------------------ SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA NRGNKNAAPFPTGLPKRVKLKLSHTGKGGVGGKKSGSGTMLPVISTVQSLASGETEARIG ENSMUST00000033672 -----------------------SKP------QTPSQTKVE--NNHTVRTPDENGN---- ENST00000276070 -----------------------SKP------QTPSQTKVE--NSNTVRTPEENGN---- ENST00000275286 -----------------------AGPPSLRKDSTPVIANVVSLASAPAAQPTVNSNSVLQ SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 ------------------------------------------------------------ CG5965-RA NLTVRRKRGRPRESGTSSPPLSMPGVHPPAQRGRPRKHAVDYSARSPSPTMSGGSSHMGI ENSMUST00000033672 --LGKTPVK-RATPSVPTPPPPPPPATPR---KNKAAMCKPLMQNRGVSCKAEMKSKGSQ ENST00000276070 --LGKIPVKTRSAPTAPTPPPPPPPATPR---KNKAAMCKPLMQNRGVSCKVEMKSKGSQ ENST00000275286 GAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQ SINFRUP00000156790 ------------------------------------------------------------ SINFRUP00000131303 ------------------------------------------------------------ ENSMUST00000006851 --------------------------------------------------------MVGT CG5965-RA PVRRNTTTTMDFGPATVTETKIITVPPYPKAVRNVNISCKPLTVTQGEQCSPDVR--DCA ENSMUST00000033672 TEEWK--PQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTEKIVE ENST00000276070 TEEWK--PQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVE ENST00000275286 TEDTPSQPQIIVVPVPVPVFVPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTE SINFRUP00000156790 --------EEVVHTLAANTLFSAQLMNGNIHIPVAVQ---GYSN-TTQSL-IWDPQQQ-V SINFRUP00000131303 --------EEVVQ-----TLFPAQFMNGNIHIPVAVQTVGGTYN-TPQSVHIWDPNQQ-Q ENSMUST00000006851 TSVVKNSHEEVVQTLAN-SLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQ CG5965-RA TQTEKDYSNKVLIPVPVPIFVPQPMYMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILK : :: : :.. : **.. . : ENSMUST00000033672 TIEELKVKIPSNPLEADILAMAEMIAEAEEL------------------------DKASS ENST00000276070 TIEELKVKIPSNPLEADILAMAEMIAEAEEL------------------------DKASS ENST00000275286 SIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTKIFEKDQGST SINFRUP00000156790 LHTQGLTGQETQQLQVQAQMLSSTHSHHGTI----------------------------- SINFRUP00000131303 ALVE---DEQGQQLHLQVKIITR------------------------------------- ENSMUST00000006851 QQTAQEQTPPPQQQQQQLQVTCS------------------------------------- CG5965-RA EIKKIQDKMPEDPLEAELLMMAEMVAEEKHESDSDSDNEIKPDPGLVALQYQNSLESVAQ . . : ENSMUST00000033672 DLCDLVSNQS--AEGLLEDCDLFGTARDDVLAMAVKMANVLD-EPGQDLEADFPKNPLDI ENST00000276070 DLCDLVSNQS--AEGLLEDCDLFGPARDDVLAMAVKMANVLD-EPGQDLEADFPKNPLDI ENST00000275286 YSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDP SINFRUP00000156790 ----------------NTDLCDCTILTGLLLCGVCLQGQTVVAEVDGQGQQQV------- SINFRUP00000131303 ----------------------------LILIHVFLIPGQGHIEAKAQAEP--------- ENSMUST00000006851 ----------------------------------AQTVQVAEVEPQSQPQP--------- CG5965-RA QQQQQQVVDVSGAGHNPYGDDMLQIALKMATGDYDNHHQTSTVDLETSMTANTISSQSPM : . ENSMUST00000033672 NPSVDFLFDCGLVGPEDVSTEQDLPRAMRKGQKRLMLSESCSRDSLSSQPSCTG------ ENST00000276070 NPSVDFLFDCGLVGPEDVSTEQDLPRTMRKGQKRLVLSESCSRDSMSSQPSCTG------ ENST00000275286 ---LNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSIVAVEPRSLIQGAFQGCSVS----- SINFRUP00000156790 -----------------QVQELLLPTTLKPEE---------------------------- SINFRUP00000131303 ------------------PAEILVPDCLKPEE---------------------------- ENSMUST00000006851 ------------------SPELLLPNSLKPEE---------------------------- CG5965-RA GHDGMGQMGVHHLDQQHHMLDATQRTARGRKRGVGVVMDPPNRNSRSPVKRQRGGEMDHS . ENSMUST00000033672 ---------------------LNYSYGVNAWKCWVQSKYANGETS--------------- ENST00000276070 ---------------------LNYSYGVNAWKCWVQSKYANGETS--------------- ENST00000275286 ------------------GMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPR SINFRUP00000156790 --------------------------GLEVWQLWAQRKNAELEKSD-------------- SINFRUP00000131303 --------------------------GLEVWCLWARRKNEELEQQG-------------- ENSMUST00000006851 --------------------------GLEVWKNWAQTKNAELEKDA-------------- CG5965-RA ALQQQSQQAQQPQEKPDAQMFLKYTFGVNAWKQWVMTKNADIEKSS-------------- *::.* *. * . * ENSMUST00000033672 --------------KGDELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYE ENST00000276070 --------------KGDELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYE ENST00000275286 SDPLGSTQDHALSQESSEPGCRVRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYD SINFRUP00000156790 -------------KNRLAPIGRRQALRFQEDLVSCAVAELCMGLSLMTTEARGMEGETYE SINFRUP00000131303 -------------NTKLAPIGRRQPLRFQEDLVSSAVAELNLGLSLMTQEARGLDEQPFS ENSMUST00000006851 -------------QNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYD CG5965-RA ----------------------MRRRPFKTELLQMTADELNYSLCLFVKEVRKPNGTEYA : :: ::: : ** .*. : * : : ENSMUST00000033672 PDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFS-RVE ENST00000276070 PDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFS-RVE ENST00000275286 PDSILYLCLGIQQYLFENGRIDNIFTEPYSR-FMIELTKLLKIWEPTILPNGYMFS-RIE SINFRUP00000156790 ADVLYYVFLCIQKYMFDNGRVDDIFSDQYYTRFAHSLHQILEPWRPSLHPLGYIIPSHVT SINFRUP00000131303 SDVLYYVFLCIQKYLSENGRVDDIFADPYYVPFCESLHKILDGWKPGVSPMGHIIPSHVT ENSMUST00000006851 PDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVT CG5965-RA PDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLDEVARKFSVLYNDSQYIVT-RVE .* : *: * **:*: *.*: :** : * * * : :.. :: ENSMUST00000033672 EEHLWECKQLGVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKC--TTPRG ENST00000276070 EEHLWECKQLGVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKC--TTPRG ENST00000275286 EEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTR-----TLKY SINFRUP00000156790 EEMLWECKQLGAHSPSTLLTTLMFFNTKYFHLKTVDQHLKVAFSKVLRHTRK---SPNNP SINFRUP00000131303 EEMLWECKQLGAHSPATLLTTLMYFNTKYFRLTTPEQHLKVAFTKVLRHTRK---NPTNA ENSMUST00000006851 EEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKK---SPSNP CG5965-RA EEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFSHIMKHWKRSSQNSKVP ** ********.:** .**.**::****.* * . :*::::*:::::: : . ENSMUST00000033672 TTKVVSIRYYAPVRQRKGR----DTGPGKRKREDET--ILEQRENRMNPLRCPVKFYEFY ENST00000276070 TTKVVSIRYYAPVRQRKGR----DTGPGKRKREDEAP-ILEQRENRMNPLRCPVKFYEFY ENST00000275286 STKMTYLRFFPPLQKQESEPDKLTVGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFY SINFRUP00000156790 KDKSTSIRYLKST----------ERFIGQKVTDDMYS---EQLEDTENPLRCPIKLYDFY SINFRUP00000131303 KDKTTSIRLLKG-----------QHGAGQKGTDDMYD---EQAEDLENPLRCPIKLYDYY ENSMUST00000006851 KDKSTSIRYLKALG---------IHQTGQKVTDDMYA---EETENPENPLRCPIKLYDFY CG5965-RA GSRNVLLRFYPP-----------QAGLDANPRKKKVY---EQQENEENPLRCPVRLYEFY : . :* . .. * *: ******:::*::* ENSMUST00000033672 LSKC----------PESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILA ENST00000276070 LSKC----------PESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILA ENST00000275286 LSKC----------SESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILM SINFRUP00000156790 LFKC----------PQSAKGRNDTFYLTPEPVVAPNSPIWYSTQPVPKEQLEQMLARILA SINFRUP00000131303 LFKWQVTLRSFNLIPQSIKGRNDAYYMMPETVVAPNSPMWYSSQPLTSQQVEQMLSRIIA ENSMUST00000006851 LFKC----------PQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILV CG5965-RA LSKC----------PESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKM * * .:* : ***.:*: ** .:**:*** .: : ** *: ENSMUST00000033672 VREIYEELGRPGEEDLD----- ENST00000276070 VREIYEELGRPGEEDLD----- ENST00000275286 VREVHEELAKAKSEDSDVELSD SINFRUP00000156790 VREIQEAI-------------- SINFRUP00000131303 VREIQEII-------------- ENSMUST00000006851 IREIQEAIAVANATTMH----- CG5965-RA VKEINIALLTT----------- ::*: :