CLUSTAL W (1.82) multiple sequence alignment ENST00000274140 VSLAFCQPLSLSLSPLLPLASSLAPERTHLPGPGSLLLSPPSFPARPREPRGCVTAAPPD ENST00000309387 ------------------------------------------------------------ SINFRUP00000130586 ------------------------------------------------------------ SINFRUP00000165209 ------------------------------------------------------------ ENSMUST00000043826 ------------------------------------------------------------ CG1317-RB ------------------------------------------------------------ ci0100148389 ------------------------------------------------------------ ENST00000274140 KMDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRF ENST00000309387 ------------------------------------------------------------ SINFRUP00000130586 ------------------------------------------------------------ SINFRUP00000165209 -------DICRVCRSEGTPDKPLYHPCVCTGSIKYIHQECLVQWLKHSRKEYCELCKHRF ENSMUST00000043826 -------DICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRF CG1317-RB MDDLSQGDICRVCRCEAQPDRPLFYPCICTGSIKYIHQDCLMLWMRYSHKEYCELCSYSF ci0100148389 MDD--DEDICRVCRSTAFPDRPLFHPCICTGSIRHIHQDCLLQWLRHSRKEYCELCKHKY ENST00000274140 AFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLF ENST00000309387 ------------------------------------------------------------ SINFRUP00000130586 ------------------------------------------------------------ SINFRUP00000165209 AFTPIYSPDMPSRLPIQDICAGLLTSVGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLF ENSMUST00000043826 AFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLF CG1317-RB SFQPIYAPDMPRVLPIKDVLVGLMSAVLEGARCWLHYTLVGLAWFGVVPLSAYRTYRYLF ci0100148389 TFKPIYSPDMPNRLPVRDLLKGFARSITSAVKCWVHYTLVAIAWLGVVPLTASRIYNCIF ENST00000274140 TG-SVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEH ENST00000309387 ------------------------------------------------------------ SINFRUP00000130586 ------------------------------------------------------------ SINFRUP00000165209 TG-SVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPQWLEQ ENSMUST00000043826 TG-SVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEH CG1317-RB RASSFDMILTLPFDIFSVENLASDAFRGCFVVTCTLLSFIGLVWLREQILHGGGPDWLER ci0100148389 AG-SVKVLLSLPMDMLSTKNITADILHGCVVVACTVSAFVCLVWLRVQIMNGDMPQWLMQ ENST00000274140 AAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEE ENST00000309387 ------------------------------------------------------------ SINFRUP00000130586 ------------------------------------------------------------ SINFRUP00000165209 HQPPPQNAAGQANEAAGQGVAHEPPAAQPAP--PDPPAQNEAEPEPPDVPPDQGDDPDLE ENSMUST00000043826 AAPPFNAAGHHQNEAPVGGNGAENPAADQPANPAGENAVLGENPDAQDGQAEEEEEDNEE CG1317-RB DDAPLQAAAANP---------APDPAAEAAPQPQDDNNNADDNEAP---APADNDGQDAQ ci0100148389 RQEEVEVI-------------EPQPHNNDREQEVNEPEANDGEVIVNNNNVDEVNVPNPE ENST00000274140 EDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNT ENST00000309387 ------------------------------------------------------------ SINFRUP00000130586 -----------------EDLNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNT SINFRUP00000165209 EEEGAAAEDADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNT ENSMUST00000043826 EDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNT CG1317-RB AQDAAPAAAAPVVDADADEQNWNPMEWDRAAEELTWERLLGLDGSLVFLEHVFWIISLNT ci0100148389 IIHEEPIADEVQENNDADNINWDAINWDRAADEPTWERFLGLDGSLLFLEHVFWVVALNT : :: : :::: :: :: : ENST00000274140 LFILVFAFCPYHIGHFSLVGLGFEEHVQ-ASHFEGLITTIVGYILLAITLIICHGLATLV ENST00000309387 ------------------------------------------------------------ SINFRUP00000130586 LFILVFAFCPYHVGHFSVVGLGLEDYMK-ASHFDGLITTILGYILLAGALIACHALASLV SINFRUP00000165209 LFILVFAFCPYHIGHFSVVGLGFEEYVQ-ASHFEGLITTIVGYILLAMTLILCHGLAALV ENSMUST00000043826 LFILVFAFCPYHIGHFSLVGLGFEEHVQ-ASHFEGLITTIVGYILLAITLIICHALATLV CG1317-RB MFIFTFAFCPYCVGNFILSSMDLLQPEKPLLHFHGLITTLFGYCCIGLTLVVLHFFSRVF ci0100148389 LFILVFAFCPYHLGHFILLSVDLNTYVV-ATRFEGVLTTLCGYVIVAAGFLLAHAALQIT :::: : : : : : : : : :: : : :: : ENST00000274140 KFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAP ENST00000309387 ------------------------------------------------------------ SINFRUP00000130586 RFQRSGRLLGVCYVVVKVSLLVVMEIGLFPLICGWWLDICSLEMFDATLKDREQSFDSAP SINFRUP00000165209 RFQRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDASLKDRELSFKSAP ENSMUST00000043826 KFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAP CG1317-RB RLRRVCWFIGLCYIVVKVSLLSVLEIGVLPLICGWWLDICSLPLLDASLKDRKESFKAAP ci0100148389 KLQWPGRVFGFCYIILKVGLLVLVEIGAFPLVCGLWLDICTLDLFDATISIRRDGYLASP : .: . ::: : :: :: : : :: : : : :: : ENST00000274140 GTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHL ENST00000309387 ---MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHL SINFRUP00000130586 GTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHL SINFRUP00000165209 GTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHL ENSMUST00000043826 GTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHL CG1317-RB GTSLFVHWMFGMVYVYYFAAFVSLLREVLRPGVLWIFRNVNDPDFSPIQEMIHVPIVRHI ci0100148389 GTCIFVHWLVGMVFVFYFATFLMLLREVLRPGALWFLRNLNDPDFNPIHEMIHLPIYRHC :*:**:.***:*:***:*: *********.**::**:*****.*::****:** ** ENST00000274140 RRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLP ENST00000309387 RRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLP SINFRUP00000130586 RRFILSVVVFGSIVLLMLWLPIRIIKLLFPTFLPYNVMLYSDAPVSELSVELLLLQVVLP SINFRUP00000165209 RRFILSVVVFGSIVLLMLWLPIRLIKLLLPTFLPYNVMLYSDAPVSELSLELLLLQVVLP ENSMUST00000043826 RRFILSVIVFGSIVLLMLWLPIRIIKSLLPNFLPYNVMLYSDAPVSELSLELLLLQVVLP CG1317-RB RRLVASAMIFGFAVLLMLWLPIRILQVVCPDFLPY--ALSGDS---AVNLQLLLLQIVLP ci0100148389 RRFLLSVIIFGITIVIIAWFPVKLIGYCIPNFLPYNGSAQYTSPVGEFPLQLLVLQFVLP **:: *.::** :::: *:*:::: * **** : : . ::**:**.*** ENST00000274140 ALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQE------------------ENEN ENST00000309387 ALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQE------------------ENEN SINFRUP00000130586 ALLEQGHTRQWLKKLVHAWTFTAGYVLDLHSYLLGDHE------------------DEDN SINFRUP00000165209 ALLEQGHTRQWLKGLVRAWTVSAGYLLDLHSYLLGEQE------------------DNDP ENSMUST00000043826 ALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQE------------------ENEN CG1317-RB GFFEQTQTRIWLKGLLRIWCTAVAWLLGIRSYLLPAPEPEPEIPAAGEEGVENAAGENEN ci0100148389 GLLEQGHTRIWLKGTIKLWSKVVGGMLGVKSYLLGDDE------------------QRVI .::** :** *** :: * .. :*.::**** * :. ENST00000274140 SANQQVNNN-------QHARNNNAIPVVGEGLHAAHQAILQQGGP--VGFQPYRRPLNFP ENST00000309387 SANQQVNNN-------QHARNNNAIPVVGEGLHAAHQAILQQGGP--VGFQPYRRPLNFP SINFRUP00000130586 ----QINNN-------LAGRHHNNRFPAGDGLHAAHQAILQXCGEYHLRCVVNRISVSLP SINFRUP00000165209 NQPVNNNNNNNAPPA-HHNNHNNPAPAVGEGLHAAHQAILQQGGP--VGFQPYHRPLRFP ENSMUST00000043826 SANQQVNNN--------QPARNNNAVPAGEGLHAAHQAILQQGGP--VGFQPYRRPLNFP CG1317-RB QEGEAADAAAQPPAPPPPPPPPVEPAPAPRNLAAAHQAIMQRDAP--VGFQPYDKPSLFA ci0100148389 LVPDDNNNN---------EPAENAGIPP---LHAQHGVANEWNMT-----QPYTAPNMFT : * * * . : : . :. ENST00000274140 LRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTA-------------------- ENST00000309387 LRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTA-------------------- SINFRUP00000130586 LQILLLVVFMCATLLLASLICLTLPVCAGRWLMSFWMGST-------------------- SINFRUP00000165209 FRIVLLIAFLCITLLVASLVCLTLPVFTGRWLMSFWTGSS-------------------- ENSMUST00000043826 LRRRLP-----------------------RWAPSHWQG---------------------- CG1317-RB LRLCALLALMCLSIVCAAMLTLTVPVYIGRRLMLIWSSQPDEKAAGAAAAEGAGEVVENL ci0100148389 ARLILLLCSVSISLTLVSAMVLYVPVTVGRFVFNRLFGVHG------------------- : : : : : : : : * . ENST00000274140 ---------------KIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSL ENST00000309387 ---------------KIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSL SINFRUP00000130586 ---------------LVHELYTAASGLYLCWLCIRGATMLLSWMPQGRSVIMIKVHEWTL SINFRUP00000165209 ---------------KIHELYTAACGLYVCWLSIRGVTVLLAWMPQGRTVIVHKVQEWTL ENSMUST00000043826 --------------------------LLSCVLCPVAFRKMMS--------------SWGF CG1317-RB DPIDPEGARKNERLLRSHELYTAELGGYLCWIVCRVVAAVVTLLPQGRAAIVDKIKHWVR ci0100148389 -----IITATGDKDMVMHELYTVAIGLYMCWLAVRVCFLLSTWAPRQWSAVRSKVVDVIS : * : : : : : ENST00000274140 MIMKTLIVAVLLAG---VVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKI ENST00000309387 MIMKTLIVAVLLAG---VVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKI SINFRUP00000130586 MLLKTIVVAVMLAG---LVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKI SINFRUP00000165209 MILKTLVVALLVAG---VIPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKI ENSMUST00000043826 IVHNIC------------------------------------------------------ CG1317-RB VALQYALPVLTLLGIFVLVPLLIGLLIELAVVIPLRVPLRKTPIHFLWEDWALGVLYCKI ci0100148389 TGVKAIILSVFICG---LIPLMMGVLFDLVVIIPLRVPAHQTPVIFLWQDWALGVLLFKL : : : : :: ::: ::: : :: : : : : :: : ENST00000274140 IAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVV ENST00000309387 IAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVV SINFRUP00000130586 IAAITLMGPQWWLKTVIEQVYANGIRNIDLHFIVQSLAAPVICILLLALSVPYTISRGIA SINFRUP00000165209 IAAITLMGPQWWLKTVIEQVYANGIRNIDLQFIIRKLAAPVISVLLLALCVPYVIAAGVV ENSMUST00000043826 ------------------------------------------------------------ CG1317-RB AIALTMMGPDWHLKRALDRAYMDGLRDFDLKFVMRDLAVPVVTTIGLALAIPYVMAHMMF ci0100148389 VTACLIFGPDNTIKTAIEEAYNQGLQRMSLKTTLTDTVFPVIKTLALCLTIPYVTGHIIP :: : : : : : : :: : : : : : ENST00000274140 PLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYE ENST00000309387 PLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYE SINFRUP00000130586 PLLGVQPETQMLVERRIYPFLLMVLVLLVLLSFQIRQFRRLYQHIKNDK----------- SINFRUP00000165209 PAVGVTPEMEILMQRRIYPFLLMVVLLIGILSFQIRQFKRLYEHIKNDKYLVGQRLVNYE ENSMUST00000043826 ------------------------------------------------------------ CG1317-RB PIFLADAYAQHVVARLVYPVSFIVVGSICILLFQIDQLKKLYLSIKVDKYLVGQRLVNYE ci0100148389 VIFSTNETLTAFFYWRTYPLMISCASFICFCIFEIKQFQRLCDRIKNERYLIGKRLIDYE . .. . : : : : : : : : ENST00000274140 RKSGKQGSSPPPPQSSQE----------------------------- ENST00000309387 RKSGKQGSSPPPPQSSQE----------------------------- SINFRUP00000130586 ----------------------------------------------- SINFRUP00000165209 RKSGRTSSVPP------------------------------------ ENSMUST00000043826 ----------------------------------------------- CG1317-RB HRKKQQQQQEEEKEQQRAARELRENQERDREREREQLVQELELAELL ci0100148389 PAERRT-----------------------------------------