CLUSTAL W (1.82) multiple sequence alignment ENST00000322739 MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDL ENST00000256797 MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDL ENSMUST00000033153 MARPVQRFQLWSPLGFLLQLVT-LLGKLGPQVQSVRPESLLFVSTLDGSLHALNKQTGDL SINFRUP00000138363 ----------------------------GGVRSVTLPESLLFVSTLDGSLHAVSKQTGDI ENST00000225768 ---------RIISTLRVFYIS---LQIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSI ENSMUST00000001059 ------MPARWLLLLLALLLPPPGPGSFGRTSTVTLPETLLFVSTLDGSLHAVSKRTGSI SINFRUP00000136357 ------------------------------------------------------------ CG4583-RA --------------------------------MDAKESDFITISNLQSYPPIVAEHQEN- ci0100130623 ------------------------------------------------------------ :: : : : : ENST00000322739 KWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSS ENST00000256797 KWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSS ENSMUST00000033153 KWTVKDDPIIQGPMYVTEMAFLSDPADGSLYVLGTQKQQGLMKLPFTIPELVHASPCRSS SINFRUP00000138363 KWTLREDPIIQVPVYVTEPGFLPDPNDGSLYVLGGKHMEGLMKLPFTIPELVQSAPCRSS ENST00000225768 KWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSS ENSMUST00000001059 KWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSS SINFRUP00000136357 ------------------------------------------------------------ CG4583-RA ---------------VQVPHFLPDPRDGSIYQLG--QMGSLKKLPYTIPQLVANAPCRSS ci0100130623 ------------------------------------------------------------ : :: : :: : : : : : :: ENST00000322739 DGVFYTGRKQDAWFVVDPESGETQMTL--------TTEG-----PSTPRLYIGRTQYTVT ENST00000256797 DGVFYTGRKQDAWFVVDPESGETQMTL--------TTEG-----PSTPRLYIGRTQYTVT ENSMUST00000033153 DGVFYTGRKQDAWFVVDPESGETQMTL--------TTEG-----LSTPQLFIGRTQYTVS SINFRUP00000138363 DGILYTGKKHDVWFVVDPETGEKQTSL--------TTSSSESICPNTPLLYIGRTEYMVT ENST00000225768 DGILYMGKKQDIWYVIDLLTGEKQQTL--------SSAFADSLCPSTSLLYLGRTEYTIT ENSMUST00000001059 DGILYMGKKQDIWYVIDLLTGEKQQTL--------SSAFADSLCPSTSLLYLGRTEYTIT SINFRUP00000136357 ------------------------------------------------------------ CG4583-RA DGILYSGKKSDTWYMVDPKTGRREKVMGFGDATVDGKEGEQIGWATSRAIYLGRTQYTVM ci0100130623 ------------------------------------------------------------ :: :: : : : : ENST00000322739 MHDPRAP---ALRWNTTYRRYSAP--PMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWT ENST00000256797 MHDPRAP---ALRWNTTYRRYSAP--PMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWT ENSMUST00000033153 MHDLRTP---ALRWNTTYRRYSAP--LLNGSPGKYMSHLTSCGMGLLLTVDPGSGIVLWT SINFRUP00000138363 MFDTKTQ---ELRWNATYNDYSAP--PYDEKQDYKMAHLVSSGDGLVVTVDRESGDVLWS ENST00000225768 MYDTKTR---ELRWNATYFDYAAS--LPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWI ENSMUST00000001059 MYDTKTR---ELRWNATYFDYAAS--LPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWI SINFRUP00000136357 --------------------------------------FASNGDGLVVTVDSDSGDVQWV CG4583-RA MYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHGKFLWQ ci0100130623 ------------------------------------------------------------ : : :: : . ENST00000322739 QDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDT ENST00000256797 QDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDT ENSMUST00000033153 QDLGVPVTGIYTWHQDGLHQLPHLTLARDTLHFLVLRWGHIRLPASSYQDTATQFSSLDT SINFRUP00000138363 QNYGSPVVGVYLYSGDTLRHAPHVSLALETLRFLTF--------------SANNLADARS ENST00000225768 QNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVG-RITKWKYPFPKETEAKS ENSMUST00000001059 QNYASPVVAFYVWQGEVLRKVVHINVAVETLRYLTFMSGEVG-RITKWKYPFPKETEAKS SINFRUP00000136357 QNYNSPVVAIYIWQREGLRKVAHTNVAVETLRYLTFMSGEVG-RITQWKYPFPKEKKPKN CG4583-RA RDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILE--------------ESKTGNVNTV ci0100130623 ------------------------------------------------------------ : : : : ENST00000322739 QLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPST ENST00000256797 QLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPST ENSMUST00000033153 QLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTLQVSGEREGSPST SINFRUP00000138363 TLKWSYQFVKEFLTFIYSHVMCTV------------------------------------ ENST00000225768 KLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPST ENSMUST00000001059 KLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPST SINFRUP00000136357 KFLATLYVGKYSTSLYASPSLVHDGVTVVPRGSTFPMLGGPDSQ-ETEEDK-ECVITPST CG4583-RA KLFQSLYVGEHQKGLYALPSLVDKNTPRISTAPPIKLLDGPTGDQNSNQETDPRTIYIND ci0100130623 ------------------------------------------------------------ : . : : ENST00000322739 AVRYPSSSVA------LPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAP ENST00000256797 AVRYPSGSVA------LPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAP ENSMUST00000033153 AVRYPSGSVA------LPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAETRASEDLHAP SINFRUP00000138363 ------------------------------------------------------------ ENST00000225768 DVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKK ENSMUST00000001059 DLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKR SINFRUP00000136357 SVKFNAALRKRNRVNFMSNYLLLIGHHETPPEAHTKILEKFPDSFPRAQGNIIPPTTDKK CG4583-RA VLQEHAGIMLG---HYNMPNEGNGNLQLSPTTASSKVVQSLATIHNYNDGYGLLANNEKN ci0100130623 ------------------------------------------------------------ ENST00000322739 AFFLELLSLSREK---------LWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWI ENST00000256797 AFFLELLSLSREK---------LWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWI ENSMUST00000033153 PVFFELLNLRRE------------DPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWV SINFRUP00000138363 ------------------------------------------------------------ ENST00000225768 SFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWV ENSMUST00000001059 SFEEVINIVGQTSDNTPTTVSQDVEEKLARAPAKPEAPVDSMLKDMATIILSTFLLVGWV SINFRUP00000136357 AEEKVNDSGMDDAPPPPLPDTSIQEPGTAGRSVRPEAPVDSMLKDMATIIFSTFLLAGWV CG4583-RA AADIGVQTDPELVEIG---IDQRTNGNTINRTKTIILQNSNKVQAFINEWFMEHPSGKVH ci0100130623 ------------------------------------------------------------ ENST00000322739 LFVMRQQQPQVVEKQQETPLAPADFAH-------------------ISQDAQSLHSGATR ENST00000256797 LFVMRQQQPQVVEKQQETPLAPADFAH-------------------ISQDAQSLHSGASR ENSMUST00000033153 LYLMRQQQ--------QSPSAPAGPPD-------------------LSQDAQGQLSRDIL SINFRUP00000138363 ------------------------------------------------------------ ENST00000225768 AFIITYPLSMHQQQQLQHQQFQKELEK-IQLLQQQQQQLPFHPPGDTAQDGELLDTSGPY ENSMUST00000001059 AFIITYPLSVHQQRQLQHQQFQKELEK-IQLLQQQQ--LPFHPHGDLTQDPEFLDSSGPF SINFRUP00000136357 AFVITYPKSVHKQQQLQHQEFQRQMEERLELLQRQQPFLSADIGLGLGQDSDYLEVVRAR CG4583-RA QILIVIVLGMIALFWYTCSTMRELQKQ--------------------SENGSKTFAIAQN ci0100130623 ------------------------------------------------------------ ENST00000322739 RSQKRLQSPSKQA----------------------QPLDDPEAEQLTVVGKISFNPKDVL ENST00000256797 RSQKRLQSPSKQA----------------------QPLDDPEAEQLTVVGKISFNPKDVL ENSMUST00000033153 QDQRRFQSPSEPA----------------------QPPHDPEAGQPTVVGKISFNPKDVL SINFRUP00000138363 --------------------------------------ESPRARCTICSLRCSFN----- ENST00000225768 SESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVL ENSMUST00000001059 SESSGTSSPSPSPRASNHSLHPSSSASRAGTSPSLEQDDEDEETRMVIVGKISFCPKDVL SINFRUP00000136357 SESSDHSSPNVTPRASNHS---NLSVSEHGSSP-YEHEEGEEESSVVRVGNVSFRPKEVL CG4583-RA GSNGSTGSNGSNAN---------------------AEDLVDLGNGQVRVGKISFSTNEVL ci0100130623 ---------------------------------------------LVHVGRISIDPVDIL . *: ENST00000322739 GRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQF ENST00000256797 GRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQF ENSMUST00000033153 GRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQF SINFRUP00000138363 --------EFRGNFDGRDVAVKRILPECVEVAEREVQLLRASDTHPNVIRYFCTERDRLF ENST00000225768 GHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQF ENSMUST00000001059 GHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQF SINFRUP00000136357 GHGAEGTIVYKGQFDNRAVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQF CG4583-RA GKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQF ci0100130623 GRGSEGTIVYKGYFDGRSVAVKRVVPECFSFADREVALLRESDEHAHVIRYFCMERDAQF ::* *: * *****:: **. .. *** **: ** * :*:**** *:. * ENST00000322739 HYIALELCRASLQE-----------YVENPD--LDRGGLEPEVVLQQLMSGLAHLHSLHI ENST00000256797 HYIALELCRASLQE-----------YVENPD--LDRGGLEPEVVLQQLMSGLAHLHSLHI ENSMUST00000033153 HYIALELCQASLQEVSDILSLPHLMYVESPD--LDRWGLEPTTVLQQMMSGLAHLHSLHI SINFRUP00000138363 TYIAIELCAATLQQ-----------YVEDPA--RFP-ELSPVSLLEQTMCGLSHLHSLNI ENST00000225768 QYIAIELCAATLQE-----------YVEQKD--FAHLGLEPITLLQQTTSGLAHLHSLNI ENSMUST00000001059 QYIAIELCAATLQE-----------YVEQKD--FAHLGLEPITLLHQTTSGLAHLHSLNI SINFRUP00000136357 QYIAIELCAASLQE-----------YVERKD--FERRGLEPVMLLQQTMSGLAHLHSLNI CG4583-RA RYIAVELCAATLQD-----------YTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDI ci0100130623 QYIALEQCSNTLQE-----------YVENPQ-YKCSTGLDATTVLYQAMHGLDHLHQLKI ***:* * :**: *.* :. :* * ** ***.*.* ENST00000322739 VHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQ ENST00000256797 VHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQ ENSMUST00000033153 VHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQ SINFRUP00000138363 VHRDLKPRNILLSAPNALGQVRALISDFGLCKKIPDGRSSFSLRSGIPGTEGWIAPEVLR ENST00000225768 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS ENSMUST00000001059 VHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS SINFRUP00000136357 VHRDLKPHNILVSMPNAHGRVRAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEVLS CG4583-RA VHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMR ci0100130623 VHRDVKPSNILISVPGKLGKQRVVISDFGLCKKLVPGRVSFSHRSGTAGTDGWIAPEMIL ****:** *:*:: *. * :.::********: *: *** :** .**:**:***:: ENST00000322739 LLPPDS--------------------------PTSAVDIFSAGCVFYYVLSGGSHPFGDS ENST00000256797 LLPPDS--------------------------PTSAVDIFSAGCVFYYVLSGGSHPFGDS ENSMUST00000033153 -LPPDS--------------------------PTSAVDIFSAGCVFYYVLSGGSHPFGES SINFRUP00000138363 -DTPGN--------------------------KTVAVDVFSAGCVFYFVISRGQHPFGDT ENST00000225768 EDCKEN--------------------------PTYTVDIFSAGCVFYYVISEGSHPFGKS ENSMUST00000001059 EDCKDN--------------------------PTYTVDIFSAGCVFYYVISEGNHPFGKS SINFRUP00000136357 EDCKDN--------------------------PTCAVDIFSAGCVFYYVVSQGSHPFGKS CG4583-RA SQRTVRHDFYYYPTLLLHHHKNFLKSMSFNYLQTTAVDIFSLGCVYYYVLSGGHHAFGDN ci0100130623 DKRYRM---------------------------TQAVDIFSMGCVFYYVICG-KHPFGDS * :**:** ***:*:*:. *.**.. ENST00000322739 LYRQANILTGAPCLAHLEEEVHDK----VVARDLVGAMLSPLPQPRPSAPQVLAHPFFWS ENST00000256797 LYRQANILTGAPCLAHLEEEVHDK----VVARDLVGAMLSPLPQPRPSAPQVLAHPFFWS ENSMUST00000033153 LYRQANILSGDPCLAQLQEETHDK----VVALDLVRAMLSLLPQDRPSAGWVLAHPLFWS SINFRUP00000138363 LRRQVNILAGEYSLLHFKQGLHED----IIAQNLIEQMIAAAAETRPSCSCVLKHPFFWS ENST00000225768 LQRQANILLGACSLDCLHPEKHED----VIARELIEKMIAMDPQKRPSAKHVLKHPFFWS ENSMUST00000001059 LQRQANILLGACNLDCFHSDKHED----VIARELIEKMIAMDPQQRPSAKHVLKHPFFWS SINFRUP00000136357 LQRQANILLGTYSLDYLQTDKHGD----IVARDLIEQMLSVEPYKRPSAESLLKHPFFWS CG4583-RA LKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWD ci0100130623 ISRQARIVNGDYSLNELSTFESAE-----EAIDLIKRMLQTDPVMRPKSATILKHPLFWD : **..*: * : . : * :*: *: . ** . : **:**. ENST00000322739 RAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRD----NWHEHISMPLQTDLRKFR ENST00000256797 RAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRD----NWHEHISMPLQTDLRKFR ENSMUST00000033153 RAKELQFFQDVSDWLEKEPDQGPLVSALEAGSYKVVRE----DWHKHISAPLQADLKRFR SINFRUP00000138363 PERQLLFFQDVSDRIEKEPADSPIVLTLENGGRAVVRT----NWRMHISVPLQIDLRRFR ENST00000225768 LEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKM----DWRENITVPLQTDLRKFR ENSMUST00000001059 LEKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVKM----DWRENITVPLQTDLRKFR SINFRUP00000136357 LEKELQFFQDVSDRIEKEPLDGPIVRQLERGGRAVVKG----DWREHITVPLQTDLRKFR CG4583-RA EPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLD----DWNVHLDPMITDDLRKYR ci0100130623 AVKTLQFFEDVSDRIEKEPLDSATMQQLDRDSLNDIQNGIPRDWIYHLCEPLQDDLHKFR : * *::**** :** . : *: .. : :* :: : **:::* ENST00000322739 SYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRS ENST00000256797 SYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRS ENSMUST00000033153 SYKGTSVRDLLRAMRNKKHHYRELPAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRT SINFRUP00000138363 TYKGNSVRDLLRAMRNKKHHYHELPSEVQETLGELPDGFINYFTSRFPRLLMHTYEALHI ENST00000225768 TYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMEL ENSMUST00000001059 TYKGGSVRDLLRAMRNKKHHYRELPVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMEL SINFRUP00000136357 SYKGGSVRDLLRAMRNKKHHYRELPADVQETLGSIPDDFVSYFTSRFPHLLLHTYLAMRS CG4583-RA GYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSI ci0100130623 SYKAGSVRDLLRAIRNKKHHYRELPDEVKRSLGSVPDEFLSYFTSRFPRLLTHTYLSMAC * . ********:*******:**. .:. ** :* * *:..***:*: *:: :: ENST00000322739 CASESLFLPYYPP------------------------------DSEARRPCPGATGR--- ENST00000256797 CASESLFLPYYPP------------------------------DSEARRPCPGATGR--- ENSMUST00000033153 CASESLFLPYYPP------------------------------ALEARR--PDATKS--- SINFRUP00000138363 CSHERLFHPYYL------------------------------------------------ ENST00000225768 CSHERLFQPYYFH------------------------------EPPEPQPPVTPDAL--- ENSMUST00000001059 CRHERLFQTYYWH------------------------------EPTEPQPPVIPYAL--- SINFRUP00000136357 CASERPFLPYYSS------------------------------AEP-------------- CG4583-RA CSNEPIFKPYYSAGYLFTRPWYFDADDALFPMLMLDPKPLPKIGSPKKTPSPASSQAQQL ci0100130623 CRLEATFEPYYMSEEVEVNGDGNDVDGSNLQALAARKRFSLKNRSPRISESSSCSEADSK * * * .** ENST00000322739 ------------------------------------------------------------ ENST00000256797 ------------------------------------------------------------ ENSMUST00000033153 ------------------------------------------------------------ SINFRUP00000138363 ------------------------------------------------------------ ENST00000225768 ------------------------------------------------------------ ENSMUST00000001059 ------------------------------------------------------------ SINFRUP00000136357 ------------------------------------------------------------ CG4583-RA KQRKGL-----------YNFRKPNDELPIPGVGLQRNLELDGQSLEPDGKRDVFANFKFR ci0100130623 DKKSNKKLKPVEVTPPRSSHSSISSTISGSYAEVVANTLRNGQEHEPPAVAVVPDTEKDS ENST00000322739 ------------------------------------------------------------ ENST00000256797 ------------------------------------------------------------ ENSMUST00000033153 ------------------------------------------------------------ SINFRUP00000138363 ------------------------------------------------------------ ENST00000225768 ------------------------------------------------------------ ENSMUST00000001059 ------------------------------------------------------------ SINFRUP00000136357 ------------------------------------------------------------ CG4583-RA RYSKPGNNRNYNGGHKEAQDKEKYVIWTLPPSTQD------------------------- ci0100130623 DEQEQLSMDNGIAQASEQLPDDDSISLKIDEPKSDEVKLPAAVEDAESPEQEVEEKEEKV ENST00000322739 ----------------------------------- ENST00000256797 ----------------------------------- ENSMUST00000033153 ----------------------------------- SINFRUP00000138363 ----------------------------------- ENST00000225768 ----------------------------------- ENSMUST00000001059 ----------------------------------- SINFRUP00000136357 ----------------------------------- CG4583-RA ----------------------------------- ci0100130623 GEEETKTKSKHKRRRRLKKNKNKSIPIIDEVNAVS