CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000142194 -------------------------------------------------- SINFRUP00000158032 -------------------------------------------------- ci0100145491 -------------------------------------------------M ENST00000255977 MAEAATPGTTATTSGAGAAAATA--------------------------- ENSMUST00000031985 MAEAAAPGTTATTSGAGAAAAAV--------------------------- ENST00000325367 -------------------------------------------------- Q9DFG7_Brachydanio_rerio ------------HASADAWAAAS--------------------------- Q8JFF3_Seriola_quinqueradiata ---------------MAEAAAAS--------------------------- ENST00000314520 MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPH ENSMUST00000000449 -------------------------------------------------- ENST00000314352 -------------------------------------------------- Q90WG5_Seriola_quinqueradiata -------------------------------------------------- Q91457_Seriola_quinqueradiata -------------------------------------------------- Q90WG4_Seriola_quinqueradiata -------------------------------------------------- ENST00000229766 -------------------------------------------------- CG7184-RA -------------------------------------------------- SINFRUP00000142194 -------------------------------------------------- SINFRUP00000158032 -------------------------------------------------- ci0100145491 LLLYIGSLIVCSVKFGSKHHRRNQDNKPKMASSGQNTPCHNSQPWTKKVL ENST00000255977 AAASPTPIPTVTAPSLGAGGGGGGSDGSGGG-------------WTKQVT ENSMUST00000031985 AAASLTSIPTVAAPSPGAGGGGGGSDGSGGG-------------WTKQVT ENST00000325367 --------------------------------------------WTKQVT Q9DFG7_Brachydanio_rerio TAAP----------------------AVIGG-------------WTKHVT Q8JFF3_Seriola_quinqueradiata TAAS----------------------GVIGG-------------WTKHVT ENST00000314520 AARGWAPFPVAPVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQII ENSMUST00000000449 -------------------------------------------MSTKQVT ENST00000314352 -------------------------------------------------- Q90WG5_Seriola_quinqueradiata ---------------------------------------------TKQVT Q91457_Seriola_quinqueradiata ---------------------------------------------TKQVT Q90WG4_Seriola_quinqueradiata -------------------------------------------------- ENST00000229766 -------------------------------------------------- CG7184-RA ----------------------------MSAVTSSDTAISGMALGRSQTI SINFRUP00000142194 -------------------------------------------------- SINFRUP00000158032 -------------------------------------------------- ci0100145491 CRYFLHGACKFGSECSYSHDTKAQA--NMVCRYYQSGHCSYGDRCR-YDH ENST00000255977 CRYFMHGVCKEGDNCRYSHDLSDSP-YSVVCKYFQRGYCIYGDRCR-YEH ENSMUST00000031985 CRYFMHGVCKEGDNCRYSHDLSDSP-YGVVCKYFQRGYCVYGDRCR-YEH ENST00000325367 CRYFKYGICKEGDNCRYSHDLSDRL-CGVVCKYFQRGCCVYGDRCR-CEH Q9DFG7_Brachydanio_rerio CRYFMHGLCKEGENCRYSHDLSSCK-QTMICKFFQKGCCAFGDRCR-YEH Q8JFF3_Seriola_quinqueradiata CRYFMHGLCKEGDNCRYSHDLTNSKPAAMICKFFQKGNCVFGDRCR-FEH ENST00000314520 CRYYIHGQCKEGENCRYSHDLSGRK-MATEGGVSPPGASAGGGPST-AAH ENSMUST00000000449 CRYFMHGVCREGSQCLFSHDLANSK-PSTICKYYQKGYCAYGARCRQYDH ENST00000314352 -------------------------------------------------- Q90WG5_Seriola_quinqueradiata CRYFLHGVCREGSRCLFSHDLNNSK-PSTICKFYQRGVCAYGERCR-YDH Q91457_Seriola_quinqueradiata CRYFLHGVCREGSRCLFSHDLNNSK-PSTICKFYQRGVCAYGERCR-YDH Q90WG4_Seriola_quinqueradiata -------------------------------------------------- ENST00000229766 -------------------------------------------------- CG7184-RA CRYYVRGICRFGELCRFSHDLSRGR-------------PECEEQVATDVL SINFRUP00000142194 -------------------------------------------------- SINFRUP00000158032 -------------------------------------------------- ci0100145491 IKPDKGRKTIKAKYPTDS---------IIIDSTKYENSLTG--------- ENST00000255977 SKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEA--------E ENSMUST00000031985 SKPLKQEEVTATDLSAKPSLAASSSLSSGVGSLAEMNSGEA--------E ENST00000325367 SKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTNEA--------E Q9DFG7_Brachydanio_rerio TKPSKQDEVPSSKPSMPLTAAP------LAGTPEPVSDGPG--------G Q8JFF3_Seriola_quinqueradiata CKPAKNEELPAP-QMLPLPSAS------LAGPSDPEPSGPT--------P ENST00000314520 IEPPTQEVAEAPPAASSLSLPV-------IGSAAERGFFEA--------E ENSMUST00000000449 TKPPAAAGGAVGPAPNPSPSSGLHSPHPSPDIATSVMRTHSNEPGKREKK ENST00000314352 -------------------------------------------------- Q90WG5_Seriola_quinqueradiata IKPSSRGGGGGAPEDQAGGGGAGGGGAGIGGAGGGPSVRGG------MKK Q91457_Seriola_quinqueradiata IKPSSRGGGGGAPEDQAGGGGAGGGGAGIGGAGGGPSVRGG------MKK Q90WG4_Seriola_quinqueradiata -------------------------------------------------- ENST00000229766 -------------------------------------------------- CG7184-RA PKPSTSSSSTIGSRSASISSQQRNWANAPVFVPSQKRYTAH--------- SINFRUP00000142194 -------------------------------------------------- SINFRUP00000158032 -------------------------------------------------- ci0100145491 --------------ADWANAVEFVPGKEYSPRTSNTYSS-----ALKEGL ENST00000255977 SRNSNFATVG-AGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEE ENSMUST00000031985 SRNPSFPTVG-AGSEDWVNAIEFVPGQPYCGRTAPSCTEVPPQGSVTKEE ENST00000325367 SRNSNFATVV-AGSEDWANAIEFVPGQPYCGRTVPSCTEAPLQGSVTKEE Q9DFG7_Brachydanio_rerio TTGAQEKPQG-SGAVDWVNAAEFVPGQPYCGRADPVLCEGPGP-LIEEEY Q8JFF3_Seriola_quinqueradiata VPGAQ----------DWVNAAEFVPGQPYCGRAEQAKVESSVP-LIEEFD ENST00000314520 RDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQ----SSE ENSMUST00000000449 TLVLRDRNLTGLAEDKTPPSKVNNPGGCSDPQTSPEMKPHSYLDAIRTGL ENST00000314352 ---------SGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIRSGL Q90WG5_Seriola_quinqueradiata NLVLRDR---VLGVDRVDR-MFGAPADSMWSDVSTAAAPHSYVEAIRTGL Q91457_Seriola_quinqueradiata NLVLRDR---VLGVDRVDR-MFGAPADSMWSDVSTAAAPHSYVEAIRTGL Q90WG4_Seriola_quinqueradiata -------------------------------------------------- ENST00000229766 -------------------------------------------------- CG7184-RA --------------EQSEFETTVDPEAVMEAQAGASYDTLAPGVSWAEVV SINFRUP00000142194 -------------------------------------------------- SINFRUP00000158032 -------------------------------------------------- ci0100145491 ESSTSTDKYN----------DLCPFALNGECVNGENCAY-VHGLLCDMCC ENST00000255977 SEKEQTAVET--------KKQLCPYAAVGECRYGENCVY-LHGDSCDMCG ENSMUST00000031985 SEKEPTTVET--------KKQLCPYAAVGECRYGENCVY-LHGDSCDMCG ENST00000325367 SEEEQTAVET--------KKQLCPYAAVGQCRYGENCVY-LHGDLCDMCG Q9DFG7_Brachydanio_rerio EK-EQANKEM--------KKQLCPYAAVGECRYGLNCAY-LHGDVCDMCG Q8JFF3_Seriola_quinqueradiata SYPAPDNKQL--------RKQLCPYAAVGECRYGINCAY-LHGDVCYMCG ENST00000314520 TERKQMAVGS--------GLRFCYYASRGVCFRGESCMY-LHGDICDMCG ENSMUST00000000449 DDLEASSSYS-------NEPQLCPYAAAGECRFGDACVY-LHGDMCEICR ENST00000314352 DDVEASSSYS-------NEQQLCPYAAAGECRFGDACVY-LHGEVCEICR Q90WG5_Seriola_quinqueradiata DASAQDQATPPVCGPSQNLPQLCPYAANGHCFYEENCTY-LHGDLCEVCG Q91457_Seriola_quinqueradiata DASAQDQATPPVCGPSQNLPQLCPYAANGHCFYEENCTY-LHGDLCEVCG Q90WG4_Seriola_quinqueradiata -------------------------------------------------- ENST00000229766 -------------------------------------------------- CG7184-RA GGPSSLNKED-------------YGEENSSCAWGEFSAYPIHMELCEMCD SINFRUP00000142194 ---------------------------------QDNPDETCSICMENIYE SINFRUP00000158032 ---------------------------------KKEPDVTCSICMENIYE ci0100145491 LYILHPSDVLQQEKHKEECIKYHEEDMLESFKVAESREIACGICMEVVWE ENST00000255977 LQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYE ENSMUST00000031985 LQVLHPVDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYE ENST00000325367 LQVLHPMDAAQRSQHIQACIEAHEKDMEFSFAVQRSKDKVCGICMEVVYE Q9DFG7_Brachydanio_rerio LQVLHPSDTSQRSQHIRACIEAHEKDMEISFAIQRSKDMMCGVCMEVVFE Q8JFF3_Seriola_quinqueradiata LQVLHPTDNNQRSEHTKACIEAHEKDMEISFAIQRSKDMMCGVCMEVVFE ENST00000314520 LQTLHPMDAAQREEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYE ENSMUST00000000449 LQVLHPFDPEQRKAHEKMCMSTFEHEMEKAFAFQASQDKVCSICMEVILE ENST00000314352 LQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILE Q90WG5_Seriola_quinqueradiata LQVLHPHDSEQRRAHEKMCLAAFEADMEKAFAAQLSQDKVCSICMEVVVQ Q91457_Seriola_quinqueradiata LQVLHPHDSEQRRAHEKMCLAAFEADMEKAFAAQLSQDKVCSICMEVVVQ Q90WG4_Seriola_quinqueradiata ------------------------------------QDKVCSICMEVVVQ ENST00000229766 ----------------------------------DSRDVVCGICMDKVWD CG7184-RA QYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIME : *.:*:: : : SINFRUP00000142194 RKLPKHKTFGILPNCVHAFCEPCIVTWRRMDR-YRPDVVKGCPVCRVRSD SINFRUP00000158032 MK----KTFGILPNCVHAFCEPCIVTWRRMDR-YRPDVVKGCPVCRVRSD ci0100145491 KADEKDRKFGILENCNHTFCLDCIRKWRSAKA-FNNTVVKACPQCRVSSS ENST00000255977 KANPSERRFGILSNCNHTYCLKCIRKWRSAKQ-FESKIIKSCPECRITSN ENSMUST00000031985 KANPSERRFGILSNCNHTYCLKCIRKWRSAKQ-FESKIIKSCPECRITSN ENST00000325367 KANPNEHRFGILSNCNHTFCLKCIRKWRSAKE-FESRIVKSCPQCRITSN Q9DFG7_Brachydanio_rerio KTNPSERRFGILSNCCHCYCLKCIRKWRSAKQ-FESKIIKSCPECRITSN Q8JFF3_Seriola_quinqueradiata KANPSERRFGILSNCSHCYCLKCIRKWRSAKQ-FESKIIKSCPECRITSN ENST00000314520 KANPNDRRFGILSNCNHSFCIRCIRRWRSARQ-FENRIVKSCPQCRVTSE ENSMUST00000000449 KASASERRFGILSNCSHTYCLSCIRQWRCAKQ-FENPIIKSCPECRVISE ENST00000314352 KASASERRFGILSNCNHTYCLSCIRQWRCAKQ-FENPIIKSCPECRVISE Q90WG5_Seriola_quinqueradiata KANPSDRRFGILSSCCHTFCLACIRKWRCTRT-FSNTIIKSCPECRVVSE Q91457_Seriola_quinqueradiata KANPSDRRFGILSSCCHTFCLACIRKWRCTRT-FSNTIIKSCPECRVVSE Q90WG4_Seriola_quinqueradiata KANPSDRRFGILSSCCHTFCLACIRKWRCTRT-FSNTIIKSCPECRVVSE ENST00000229766 KPE-AQRVFGILPNCTHAHCLGCLRTWRKNRQDFPLDVIKACPQCRVHSS CG7184-RA KAG-REKRFGILPNCNHIFCLECIRTWRQAKQ-FENKITRACPECRVCSD : **** .* * .* *: ** : : :.** **: *. SINFRUP00000142194 YYVPSESMMEG-EEKEQLIISTKQRCREDFCSFFDQS-GFCPFEEDCRY- SINFRUP00000158032 FYVPSESMMEG-EEKEQLIISTKQRCREDFCSFFDQS-GFCPFEEDCRY- ci0100145491 FVTPSERWIEDKEEKKKLIQGYKDHLSNKACKYFDQGRGKCPFGANCFYL ENST00000255977 FVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYK ENSMUST00000031985 FVIPSENWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGGNCFYK ENST00000325367 FVIPSEYWVEEKEEKQKLIQKYKEAMSNKACKYFDEGRGSCPFGENCFYK Q9DFG7_Brachydanio_rerio LVIPSEYWVEDKEEKQQLIQKYKDGMGTKPCRYFDEGRGTCPFGANCFYK Q8JFF3_Seriola_quinqueradiata FVIPSEYWVEDKDDKQKLIQKYKDGMGSKPCRYFDEGRGTCPFGSNCFYK ENST00000314520 LVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYK ENSMUST00000000449 FVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYR ENST00000314352 FVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYR Q90WG5_Seriola_quinqueradiata FVIPSVYWVEDQEDKDHLIDLFKSGVSKKACKYFDQGRGSCPFGGKCLYL Q91457_Seriola_quinqueradiata FVIPSVYWVEDQEDKDHLIDLFKSGVSKKACKYFDQGRGSCPFGGKCLYL Q90WG4_Seriola_quinqueradiata FVIPSVYWVEDQEDKDHLIDLFKSGVSKKACKYFDQGRGSCPFGGKCLYL ENST00000229766 YIIPHKFWVSKGAQKEQLIRNFKARTSQIRCRFFVRGNGRCPFKSECIYL CG7184-RA FVCPSAFWMETKEEKDKLLNDYRAALGAKDCKYFKKGEGKCPFGNKCFYK * :. .*..*: : * :* .. * *** * * SINFRUP00000142194 -------------------------------------------------- SINFRUP00000158032 -------------------------------------------------- ci0100145491 HAYSDGRKQDRSKIQTRNVVDSNGRAGHLDLNTIWDMLGDEDSHAEDHAR ENST00000255977 HAYPDGRREE----PQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDND ENSMUST00000031985 HAYPDGRREE----PQRQKVGTSSRYRAQRRSHFWELIEEREN-NPFDND ENST00000325367 HMYPDGRREE----PQRQQVGTSSRNPGQQRNHFWEFFEEGANSNPFD-D Q9DFG7_Brachydanio_rerio HAFPDGRLEEPQ--PQRRQNGSNGRNRNTRRTHLWDLLDERENSDSFDNE Q8JFF3_Seriola_quinqueradiata HAFPDGRLEEAQ--PQRRQTGSNSRNRNSRRTPLWDIYDERESTDSFDNE ENST00000314520 HEYPEGWGDE--------PPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSI ENSMUST00000000449 HAYPDGRLAEPE--KPRKQLSSEGTVRFFNSVRLWDFIENRETRQVPSTD ENST00000314352 HAYPDGRLAEPE--KPRKQLSSQGTVRFFNSVRLWDFIENRESRHVPNNE Q90WG5_Seriola_quinqueradiata HAFPDGTRAEPD--RPRKQLSSEGNVRFMNSVRLWDFIEEREQRSVPPLP Q91457_Seriola_quinqueradiata HAFPDGTRAEPD--RPRKQLSSEGNVRFMNNVRLWDFIEEREQRSVPPL- Q90WG4_Seriola_quinqueradiata HAFPDGTRAEPD--RPRKQLSSEGNVRFMNSVRLWDFIEEREQRSVPPLP ENST00000229766 HQLP-------------AKAGTS--------------------------- CG7184-RA HALPNGDIVDVGLPKRTRKLQSQNEIIDLLDIYLWDYVD-RRDYHWLEMI SINFRUP00000142194 -------------------------------------------------- SINFRUP00000158032 -------------------------------------------------- ci0100145491 LMNLLDDDADLFDLFYLLGDDTMSSGDEYSFEYPYHYNGGEDFFTDSD-- ENST00000255977 EEEVVTFELGEMLLMLLAAGGDDE-LTDSEDEWDLFHDELEDFYDLDL-- ENSMUST00000031985 EEEVVTFELGEMLLMLLAAGGDDE-LTDSEDEWDLFHDELEDFYDLDL-- ENST00000325367 EEEAVTFELGEMLLML---------------------------------- Q9DFG7_Brachydanio_rerio DEEMVRFELSEMLLMLLAAGTDDD-VTDSEDEWDLFHEELDDYYELYL-- Q8JFF3_Seriola_quinqueradiata DEEMVTFELSEMLLMLLAAGTDDEEVIIRPPSCATSSGRLDPTVTRYRKA ENST00000314520 KKELVVLRLASLLFKRFLS--LRDELPFSEDQWDLLHYELEEYFNLIL-- ENSMUST00000000449 --DVDVTELGDLFMHLSGVESSEP-------------------------- ENST00000314352 --DVDMTELGDLFMHLSGVESSEP-------------------------- Q90WG5_Seriola_quinqueradiata ALDDDMAELRELFMQMSGPSHDGPETPPTADQ------------------ Q91457_Seriola_quinqueradiata ----------------AGPR------------------------------ Q90WG4_Seriola_quinqueradiata ALDDDMAELRELFMQMSGPSHD---------------------------- ENST00000229766 -------------------------------------------------- CG7184-RA SSDITSSESSDYSDED---------------------------------- SINFRUP00000142194 - SINFRUP00000158032 - ci0100145491 - ENST00000255977 - ENSMUST00000031985 - ENST00000325367 - Q9DFG7_Brachydanio_rerio - Q8JFF3_Seriola_quinqueradiata C ENST00000314520 - ENSMUST00000000449 - ENST00000314352 - Q90WG5_Seriola_quinqueradiata - Q91457_Seriola_quinqueradiata - Q90WG4_Seriola_quinqueradiata - ENST00000229766 - CG7184-RA -