CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000007116 MDIASPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQ ENST00000264646 ---------------------------------------ALYVANFAKVQ SINFRUP00000138237 -------------------------------------------------- Q90WP4_Tetraodon_nigroviridis MVLTGKRSEKGPACWKRRVKSEYMRLRQLKRFRRADEIKSMFSTNRQKIM SINFRUP00000135359 ---TGKRSEKGPACWKRRVKSEYMRLRQLKRFRRADEIKSMFSTNRQKIV ENSMUST00000031698 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKIL ENST00000223193 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKIL ci0100147390 --------------WNKRVRQEYFSLRQQKRFQRSDKIKSAFTTNLSLIA CG6502-RA -----MNSTKVPPEWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWD--- ENSMUST00000007116 EKTQILNEEWKKLRVQPVQPMKPVSGHPFLKKCTIESIFPGFDSQDMLMR ENST00000264646 EKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMR SINFRUP00000138237 ----------------------------FLQMCTVEFGFPGFKAQAVAMR Q90WP4_Tetraodon_nigroviridis ERTDILNQEWKTRRIQPVHIMTSVGSLRGTRECTVDSSFSEFPRQVIPLK SINFRUP00000135359 ERTDILNQEWKTRRIQPVHIMTSVGSLRGTRECTVDSSFSEFPRQVIPLK ENSMUST00000031698 ERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDL-DFPAQVIPLK ENST00000223193 ERTEILNQEWKQRRIQPVHILTSVSSLRGTRE------------------ ci0100147390 EQLTELSSTLPEVKAXCVNADGSFDDRPITKSCVVKSSVHAYRDQAVPLY CG6502-RA EHNHNVQDLYCESKVWQAKPYDPPHVDCVKRAEVTSYNGIPSGPQKVPIC : : : ENSMUST00000007116 SLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEEL ENST00000264646 SLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEEL SINFRUP00000138237 PLSTIAGIPFMYSWSPLQHNFMVEDETFLHNIPYMGDDVLEQDEAFLEEL Q90WP4_Tetraodon_nigroviridis TLNAVASVPVMYSWSPLQQNFMVEDETVLHNIPYMGDEILDQDGTFIEEL SINFRUP00000135359 TLNAVASVPVMYSWSPLQQNFMVEDETVLHNIPYMGDEILDQDGTFIEEL ENSMUST00000031698 TLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEEL ENST00000223193 ----------------------VEDETVLHNIPYMGDEVLDQDGTFIEEL ci0100147390 TLNTVPSLPICYSWVPVHQNFMVEDETILHNIPYMGDEVLDEDGAFIEEL CG6502-RA VINAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEVLDKDGKFIEEL : : : ::*****.* *******:: ::* *:*** ENSMUST00000007116 INNYDGKVHGEEEMIPGSVLISDAVFLELVDALN-QYSDEEEDGHNDPSD ENST00000264646 INNYDGKVHGEEEMIPGSVLISDAVFLELVDALN-QYSDEEEEGHNDTSD SINFRUP00000138237 IDNYDG-VHGDREGG----FISDEIFKELVEALS-QYSDHEDE--EEEEA Q90WP4_Tetraodon_nigroviridis IKNYDGKVHGDRECG----FINDEIFVELVNALA-QYSDNEDEEEEEEHD SINFRUP00000135359 IKNYDGKVHGDRECG----FINDEIFVELVNALA-QYSDNEDDEEEEEHD ENSMUST00000031698 IKNYDGKVHGDRECG----FINDEIFVELVNALG-QYNDDDDDDDGDDPD ENST00000223193 IKNYDGKVHGDRECG----FINDEIFVELVNALG-QYNDDDDDDDGDDPE ci0100147390 IKNYDGKVHGDREGD----FINDELFLELVQSLN-QLNMQSKELSTEEEI CG6502-RA IKNYDGKVHGDKDPS----FMDDAIFVELVHALMRSYSKELEEAAPGTAT *.**** ***:.: ::.* :* ***.:* . . . .: ENSMUST00000007116 GKQDDSKEDLPVTRKRKRHAIE---------------------------- ENST00000264646 GKQDDSKEDLPVTRKRKRHAIE---------------------------- SINFRUP00000138237 GAASEVMRKKEDERMMRRSSVE---------------------------- Q90WP4_Tetraodon_nigroviridis -FKVDK-IDLCDSKKHPEDGRKDGLVN----------------------- SINFRUP00000135359 -YKVDK-LELCDS------------------------------------- ENSMUST00000031698 -EREEKQKDLEDNRD----------------------------------- ENST00000223193 -EREEKQKDLEDHRD----------------------------------- ci0100147390 DVVSDGNKDGETS------------------------------------- CG6502-RA AIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEE : . ENSMUST00000007116 ------------GNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRE ENST00000264646 ------------GNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRE SINFRUP00000138237 ------------VRDTSSSKKVPNDKIFTAIASMFPYKGTMEELKEKYKD Q90WP4_Tetraodon_nigroviridis ---------NEGRSGADGSKKFPSDKIFEAISAMFPDKGSTEELKEKYKE SINFRUP00000135359 ------------RTGADG-KKFPSEKIFEAISAMFPDKGSTEELKEKYKE ENSMUST00000031698 ------------DKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKE ENST00000223193 ------------DKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKE ci0100147390 ---------------NDPNSNLPCHQIFSSIADLFPDKGSVEDLIEKYKE CG6502-RA PLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIE .* ** :*: ** :* ::: *:* : ENSMUST00000007116 LTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFL ENST00000264646 LTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFL SINFRUP00000138237 LLEPPSTVKLLPLCTPNLDGPFAKSVQREQSLHSFHTLFCRRCFKYDCFL Q90WP4_Tetraodon_nigroviridis LTEQQMPGALPPECTPNIDGPHARSVQREQSLHSFHTLFCRRCFKYDCFL SINFRUP00000135359 LTEQQLPGALPPECTPNIDGPNARSVQREQSLHSFHTLFCRRCFKYDCFL ENSMUST00000031698 LTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFL ENST00000223193 LTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFL ci0100147390 LTEVSDPDKVVPDCTPNIDGSSAKSVARENALHSFHELFCRRCYKYDCFQ CG6502-RA LTEHQDP-ERPQECTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFL * * . ****:** *.** **.::**** ******:***** ENSMUST00000007116 HPFHATP--NVYKRKNKEIKIEPEPCGTDCFLLLEG---AKEYAMLH--- ENST00000264646 HPFHATP--NVYKRKNKEIKIEPEPCGTDCFLLLEG---AKEYAMLH--- SINFRUP00000138237 HPFHATP--NIYKRKNKEIHIETEPCGENCFLLQKG---AKEFVDQN--- Q90WP4_Tetraodon_nigroviridis HPFHATP--NTYKRKNLENLVDSKPCGLDCYMYLVQDGMASEYAAG--AE SINFRUP00000135359 HPFHATP--NTYKRKNLENLVDSKPCGLDCYMYLLQDGIASEYPAGGLAE ENSMUST00000031698 HPFHATP--NTYKRKNTETALDNKPCGPQCYQHLEG---AKEFAAALTAE ENST00000223193 HPFHATP--NTYKRKNTETALDNKPCGPQCYQHLEG---AKEFAAALTAE ci0100147390 HSHTYRPPAKVNRRKVLDVRAPTEVCGPNCFLNLDG---AMEFTLVT-SM CG6502-RA HRLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLIDG---MKEKLAAD--- * . : :*: : : *. .*: * ENSMUST00000007116 --NPRSKCSGRRRRRHPVVSASCSNASASAMAETKEGDSDRDTG------ ENST00000264646 --NPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTG------ SINFRUP00000138237 --MLRSQRSRRHRRQQRPNLSNCPGPSQSAE-ESKPGDSDHET------- Q90WP4_Tetraodon_nigroviridis RTKTPSKRPAGRRRGRQPNSSSRPSTPTVSS-ESKDADSDREGSKEDERE SINFRUP00000135359 RAKTPSKRAVGRRRGRQPNSNSRPSTPTVSS-ETK--------------- ENSMUST00000031698 RIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGE ENST00000223193 RIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGE ci0100147390 RHSSNKKLQQLRSGGGGSGSSSGSRPSTPTPSESETDTTEGFQS------ CG6502-RA -----SKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLT----- : . . : : ENSMUST00000007116 ---------NDWASSSSEANSRCQTPTKQKASPAPAQLCVVEAPSEPVEW ENST00000264646 ---------NDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEW SINFRUP00000138237 -------------TSSSEGNSRCQTPTKLR----PGEDDVTEQESSVVQW Q90WP4_Tetraodon_nigroviridis N-EKDEDDKKDENTSSSEGNSRCQTPVKMK---------LVGEA-EAVDW SINFRUP00000135359 ------------------GNSRCQTPVKMK---------LSGEA-EAVEW ENSMUST00000031698 NNDKEEEEKKDETSSSSEANSRCQTPIKMK---------PNIEPPENVEW ENST00000223193 NNDKEEEEKKDETSSSSEANSRCQTPIKMK---------PNIEPPENVEW ci0100147390 ---------VFYYKCDSFIEKDSSSLVKLED---------LPEQLREVEW CG6502-RA ------------VNSAAVAEINSIMAGMMN------------ITSTQCVW : . . * ENSMUST00000007116 TGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKES-LILKLP- ENST00000264646 TGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKES-LILKLP- SINFRUP00000138237 SGAEESLFRVLHGTYFNNFCSIARLIGTKNCKQVYEFAVKEV-LIHRVP- Q90WP4_Tetraodon_nigroviridis NGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIARAP- SINFRUP00000135359 NGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIARAP- ENSMUST00000031698 SGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVP- ENST00000223193 SGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAP- ci0100147390 DGAESTLFRVLHETLLTNFCAISKMIKTKNCQQVFAFALREASNLTNQPP CG6502-RA TGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVYEFAQKEDAEFSFED- **: :::**: . *:*:*:: : **.*:**: * :* : ENSMUST00000007116 --------TDELMNPAQKKKRKHRQGL--DKGLLRLLRLWAAHCR---KI ENST00000264646 --------TDELMNPSQKKKRKHRQ-----------EGLWAAHCR---KI SINFRUP00000138237 --------LVDGGISPQKKKRKHRHDITIDYKLFKLNICFSFLCRLWAKI Q90WP4_Tetraodon_nigroviridis --------AEDEDTPPRKKKRKHRL--------------WATHCR---KI SINFRUP00000135359 --------AEDEDTPPRKKKRKHRL--------------WATHCR---KI ENSMUST00000031698 --------TEDVDTPPRKKKRKHRL--------------WAAHCR---KI ENST00000223193 --------AEDVDTPPRKKKRKHRL--------------WAAHCR---KI ci0100147390 GASSLNPEHDNIEFSPPKKKRKHRL--------------WSLHAR---RV CG6502-RA --------LRQDFTPPRKKKKKQRL--------------WSLHCR---KI : .. ***:*:* : : :: : :: .*: :: ENSMUST00000007116 QLKKDNNSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCSPDCQNR ENST00000264646 QLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNR SINFRUP00000138237 QLKKDNSSNQVYNYQPCDHPDHPCDSSCPCVMTQNFCEKFCLCDHECQNR Q90WP4_Tetraodon_nigroviridis QLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCSSECQNR SINFRUP00000135359 QLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCSSECQNR ENSMUST00000031698 QLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNR ENST00000223193 QLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNR ci0100147390 QQKKDNSSSHVYNYQPCYHPGQPCDSSCQCVALGNYCEKFCQCASDCHNR CG6502-RA QLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNR * ***..*.:**** ** ** :*** .* *: *:***** * :*:** ENSMUST00000007116 FPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWD-CKVVSCKNCS ENST00000264646 FPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWD-CKVVSCKNCS SINFRUP00000138237 FPGCRCKTQCNTKQCPCYLAVRECDPDLCMTCGAADHWD-SKGVSCKNCS Q90WP4_Tetraodon_nigroviridis FPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD-SKNVSCKNCS SINFRUP00000135359 FPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD-SKNVSCKNCS ENSMUST00000031698 FPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD-SKNVSCKNCS ENST00000223193 FPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD-SKNVSCKNCS ci0100147390 FPGCRCKAQCNTKQCPCYLAVRECDSDLCTQCGADQFGENAWKCSCKNVL CG6502-RA FPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKL--TKITCKNVC *******:*****************.*** *** :. :*** ENSMUST00000007116 IQRGLKKHLLLAPSDVAGWGTFIKESVQ-KNEFISEYCGEL----ISQDE ENST00000264646 IQRGLKKHLLLAPSDVAGWGTFIKESVQ-KNEFISEYCGEL----ISQDE SINFRUP00000138237 IQRGLKKHLLLAPSDVAGWGTFIKEPVQ-KNEFISEYCGEL----ISQDE Q90WP4_Tetraodon_nigroviridis IQRGAKKHLLLAPSDVAGWGIFIKEPVQ-KNDFISEYCGEI----ISQDE SINFRUP00000135359 IQRGAKKHLLLAPSDVAGWGIFIKEPVQ-KNDFISEYCGEI----ISQDE ENSMUST00000031698 IQRGSKKHLLLAPSDVAGWGIFIKDPVQ-KNEFISEYCGEVRHTHYSQDE ENST00000223193 IQRGSKKHLLLAPSDVAGWGIFIKDPVQ-KNEFISEYCGEI----ISQDE ci0100147390 IQRGLHKHLLQAPSDVAGWGIYIKQDVANKNEFISEYCGEI----ISQDE CG6502-RA VQRGLHKHLLMAPSDIAGWGIFLKEGAQ-KNEFISEYCGEI----ISQDE :*** :**** ****:**** ::*: . **:********: **** ENSMUST00000007116 ADRRGKVYDKYMSSFLFNLNN------------DFVVDATRKGNKIRFAN ENST00000264646 ADRRGKVYDKYMSSFLFNLNN------------DFVVDATRKGNKIRFAN SINFRUP00000138237 ADRRGRIYDKYMSSFLFNLNNGNNHHYTLCLSVDFVVDATRKGNKIRFAN Q90WP4_Tetraodon_nigroviridis ADRRGKVYDKYMCSFLFNLNN------------DFVVDATRKGNKIRFAN SINFRUP00000135359 ADRRGKVYDKYMCSFLFNLNN------------DFVVDATRKGNKIRFAN ENSMUST00000031698 ADRRGKVYDKYMCSFLFNLNN------------DFVVDATRKGNKIRFAN ENST00000223193 ADRRGKVYDKYMCSFLFNLNN------------DFVVDATRKGNKIRFAN ci0100147390 ADRRGKVYDKYMCSFLFNLNN------------DFVVDATRKGNKIRFAN CG6502-RA ADRRGKVYDKYMCSFLFNLNN------------DFVVDATRKGNKIRFAN *****::*****.******** : : :***************** ENSMUST00000007116 HSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVG ENST00000264646 HSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVG SINFRUP00000138237 HSVNPNCYAKVVMVNGDHRIGIFAKRAILQGEELFFDYRYSQADALKYVG Q90WP4_Tetraodon_nigroviridis HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADARKYVG SINFRUP00000135359 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVG ENSMUST00000031698 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVG ENST00000223193 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVG ci0100147390 HSVNPNCYAKVMMVNGDHRIGIFANRPIQAGEELFFDYRYSQSDAMKYVG CG6502-RA HSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVG **:********:**.*********:*.* **********. :: *:** ENSMUST00000007116 IERETDVF ENST00000264646 IERETDVL SINFRUP00000138237 IEREVDVI Q90WP4_Tetraodon_nigroviridis IEREMEIA SINFRUP00000135359 IEREMEI- ENSMUST00000031698 IEREMEIP ENST00000223193 IEREMEIP ci0100147390 IEREMEPA CG6502-RA IEREMEIV **** :