CLUSTAL W (1.82) multiple sequence alignment ENST00000326270 -------------------------------------------------- ENST00000324442 -------------------------------------------------- ENSMUST00000015107 -------------------------------------------------- Q90ZY7_Brachydanio_rerio -------------------------------------------------- SINFRUP00000158137 -------------------------------------------------- Q90ZY6_Brachydanio_rerio MSVQSNSNSSGSLDGAPSCSQFSTGSPTPGSVSPLDIF-----APRRHKE SINFRUP00000140996 -------------------------------------------------- SINFRUP00000149375 -------------------------------------------------G ENST00000263815 ---MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREG ENSMUST00000038584 -------------------------------------------------- CG3068-RA -------------------------------------------------- ENST00000326270 ---------------------------------------QGPLNSESSNQ ENST00000324442 -MEELHSLDPRRQKLLEARFTGVG-------------VSKGPLNSESSNQ ENSMUST00000015107 -MEELHSLDPRRQELLEARFTGVG-------------VSKGPLNSESSNQ Q90ZY7_Brachydanio_rerio MMEELHSLDPRRQELLEARFTGVG-------------VAKGSGHNESSNQ SINFRUP00000158137 -------------------------------------------------- Q90ZY6_Brachydanio_rerio GMDELHSLDPRRQELLEARFIGAVSGNTGGSTGSASGGPKGLNNNECSSH SINFRUP00000140996 -MEELHSLDPRRQELLEARFTGAVTGNTVGSTGSTSGGAKGLAN-ESSNH SINFRUP00000149375 IMEELHSLDPRRQELLEARFMGGVSGNTGGSTGSTSGGTKALTNNECSNH ENST00000263815 AMDELHSLDPRRQELLEARFTGVASGSTG-STGSCSVGAKASTNNESSNH ENSMUST00000038584 -MDELHSLDPRRQELLEARFTGVATGSTG-STGSCSVGAKASTNNESSNH CG3068-RA -------------------------------------------------- : : : :: : ENST00000326270 SLCSVGSLSDKEVETPEKKQND-QRNRKRKAEPYETSQGKG--------- ENST00000324442 SLCSVGSLSDKEVETPKKKQND-QRNRKRKAEPYESSQGKG--------- ENSMUST00000015107 SLCSVGSLSDKEVETPEKKQND-QRNRKRKAEPYDTSQGKG--------- Q90ZY7_Brachydanio_rerio SLRSVGSLSDKELETPEKKSND-QRTRKRKGDPFD-SQGKG--------- SINFRUP00000158137 -------------------------------------------------- Q90ZY6_Brachydanio_rerio SFGSLGSSSDKESETPEKKHFESSRGRKRKVDNQSESSQ----------- SINFRUP00000140996 SYGSLGSSSDKESETPEKKPSESSRGRKRKADTYSESSQ----------- SINFRUP00000149375 SFGSLGSLSDKESETPEKKQSE-TRGRKRKPDIQSESSQVFKSFLLTLGN ENST00000263815 SFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGFPNLPVFQSL ENSMUST00000038584 SFGSLGSLSDKESETPEKKQSESSRGRKRKAESQNESSQ----------- CG3068-RA -------------------------------------------------- : : : ENST00000326270 --------------TPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQ ENST00000324442 --------------TPRGHKISDYFEFAGGSGPGTSPGRSVPPVARSSLQ ENSMUST00000015107 --------------TPRGHKISDYFE------------------------ Q90ZY7_Brachydanio_rerio --------------GGRGHKISDYFEFAGGSGTG---------------- SINFRUP00000158137 -------------------------------------------------- Q90ZY6_Brachydanio_rerio ----------GKSSG-RGPKISDYFDFQGGNG------------------ SINFRUP00000140996 ----------GKTST-RGPKISDYFDFQGGNG------------------ SINFRUP00000149375 FVFT------GKLNM-RGPKISDYFDFQAGNG------------------ ENST00000263815 AYWEMGRTAGGKSIGGRGHKISDYFEYQGGNG------------------ ENSMUST00000038584 ----------GKSIGGRGHKISDYFEYQGGNG------------------ CG3068-RA -------------------------------------------------- : : ENST00000326270 HSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQ ENST00000324442 HSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQ ENSMUST00000015107 --------RRAEQPLYGLDGSAAKEASEEQSALPTLMSVMLAKPRLDTEQ Q90ZY7_Brachydanio_rerio -----------TSPARGIPPVARSSPQHSLSNPP---------------- SINFRUP00000158137 -------------------------------------------------- Q90ZY6_Brachydanio_rerio -----------SSPVRGLPSVLRSPQN--SHSAPG--------------- SINFRUP00000140996 -----------SSPVRGLPPIRRSPQN--SHSAPG--------------- SINFRUP00000149375 -----------SSPVRGVPPAIRSPQNSHSHSTQV--------------- ENST00000263815 -----------SSPVRGIPPAIRSPQNSHSHSTPS--------------- ENSMUST00000038584 -----------SSPVRGIPPAIRSPQNSHSHSTPS--------------- CG3068-RA -------------------------------------------------- : ENST00000326270 LAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQ----KQISIQHRQTQ ENST00000324442 LAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQ----KQISIQHRQTQ ENSMUST00000015107 LAPRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQ----KQISIQHRQTQ Q90ZY7_Brachydanio_rerio ------------AAVQQGSPSSINSVNTDHSHTSTSHMPASIHTQHRASQ SINFRUP00000158137 ------------------------------------------------VQ Q90ZY6_Brachydanio_rerio ------------AIVRQNSSSPTSLCFMDHTM-------NLKQLSSRSVQ SINFRUP00000140996 ------------SIIRQNSSSPTSLCFADH---------NPKASSSKCVQ SINFRUP00000149375 ------------TAVRQNSSSPPSLTFGDHTI-------HPKQLAVKQVQ ENST00000263815 ------------SSVRPNSPSPTALAFGDHPIV------QPKQLSFKIIQ ENSMUST00000038584 ------------SSVRPNSPSPTALAFGDHPVV------QPKQLSFKITQ CG3068-RA -------------------------------------------------- ENST00000326270 SDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKY ENST00000324442 SDLTIEKISALENSKNSDLEKKEGRIDDLLRAICDLRRQIDEQQKMLEKY ENSMUST00000015107 SDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKY Q90ZY7_Brachydanio_rerio SELTMEKLAALESSKSSDLEKKEGRIDDLLRVNCDLRRQIDEQQKMLERC SINFRUP00000158137 TELTLLKLTALERDKNSDLEKKEGRIDDLLRANCDLRRQVDEQQKMLERY Q90ZY6_Brachydanio_rerio TDLTLLKLAALESNKNLDLEKKEGRIDDLLRANCDLRRQIDEQQKLLERF SINFRUP00000140996 TELTGLKLAALESNKSLDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKY SINFRUP00000149375 TDLTALKLAALESTKNLDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKY ENST00000263815 TDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKY ENSMUST00000038584 TDLTMLKLAALESTKNQDLEKKEGRIDDLLRANCDLRRQIDDQQKLLEKY CG3068-RA ---------------------MSHPSDHVLRP----------KENAPHRM : : : : . *.:** : : ::: .: ENST00000326270 KERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFT ENST00000324442 KERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTS-HGAKFT ENSMUST00000015107 KERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFT Q90ZY7_Brachydanio_rerio KERLNKCVTMSKKLLIEKSKQEKIACREKSMQDRLRLGHFTTVRHGASFT SINFRUP00000158137 KERLHKCVTMSKKLLIEKAKQEKMACRDKSMQDRLRLGHFTTVRHGASFT Q90ZY6_Brachydanio_rerio KERLNKCTTMSKKLLIEKSTQEKQSCREKSMQDRLRLGHFTTVRHGASYS SINFRUP00000140996 KERLNKCITMSKKLLIEKSTQEKQSCREKSMQDRLRLGHFTTVRHGASYT SINFRUP00000149375 KERLNKCITMSKKLLIEKSTQEKQACREKSMQDRLRLGHFTTVRHGASFT ENST00000263815 KERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFT ENSMUST00000038584 KERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFT CG3068-RA PEKSAAVHNMQKNLLLGKKPNSENMAPASKPLPGSSGALIRKPGLGGSNS *: .*.*:**: * :.: . .. . : . *.. : ENST00000326270 EQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPA---MGQAPPA ENST00000324442 EQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPA---MGQAPPA ENSMUST00000015107 EQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPA---MGQAPPA Q90ZY7_Brachydanio_rerio EQWTDGYAFQNLVKQQERVNGQREEIERQRKLLMKKKPPS---ASQTPPP SINFRUP00000158137 EQWTDGYAFQNLIKQQERVSSQREDMERQRKLLGKRKPAS---LAPTPPS Q90ZY6_Brachydanio_rerio EQWTDGYAFQNLVKQQEWINQQREEIERQRKLLAKRKPS--STPSSQSPT SINFRUP00000140996 EQWTDGYAFQNLIKQQEGINQQREDIERQRKLLAKRKPPNPASPSLSVVS SINFRUP00000149375 EQWTDGYAFQNLVKQQEWINQQREDIERQRKLLAKRKPPS-SSNSQALTA ENST00000263815 EQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPT-ANNSQAPST ENSMUST00000038584 EQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLGKRKPPT-ANNSQAPAT CG3068-RA IASSEGNNFQKPMVPS--VKKTTSEFAAPAPVAPIKKPES---LSKQKPT ::* **: : . :. .:: : :** . . ENST00000326270 TNEQKQRKS-KTNGAENETL----------TLAEYHEQEEIFKLRLGHLK ENST00000324442 TNEQKQWKS-KTNGAENETL----------TLKEYHEQEEIFKLRLGHLK ENSMUST00000015107 TNEQKQRKS-KTNGAENETL----------TLAEYHEQEEIFKLRLGHLK Q90ZY7_Brachydanio_rerio NLEPNKRKS-KSNGAENEML----------SLAEYHEQEEIFKLRLGHLK SINFRUP00000158137 T-EQNKRKS-RSTSQENEALSAPATFLCSLSLAQYHEQEEIFKLRIIHLK Q90ZY6_Brachydanio_rerio PNESKQRKTKAVNGADNDPFLKP-SLPTLLTVAEYHEQEEIFKLRLGHLK SINFRUP00000140996 TSEPKQRKTKVVNGNDSDPFLKP-TLPQLLTLAEYHEQEEIFKLRLGHLK SINFRUP00000149375 NSEPKQRKT-AMNGAENDPFLKP-TLPQLLTLAEYHEQEEIFKLRLGHLK ENST00000263815 NSEPKQRKNKAVNGAENDPFVRP-NLPQLLTLAEYHEQEEIFKLRLGHLK ENSMUST00000038584 NSEAKQRKTKAVNGAENDPFVRP-NLPQLLTLAEYHEQEEIFKLRLGHLK CG3068-RA AASSESSKE--------------------------------LGAASSSAE . :. * : : : : :: : ENST00000326270 KEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHL ENST00000324442 KEEAEIQAELERLERVRKLHIREVKRIHNEDNSQFKYHPTLNDRYLLLHL ENSMUST00000015107 KEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHL Q90ZY7_Brachydanio_rerio KEGAEIQVELERLERVRNPHIRELKRIHNEDNSQFKDHPTLNDRYLLLHL SINFRUP00000158137 KEEAEIQAELEQLERIRNLHIRELKRIHNEDNSQFKDHPTLNERYLLLHL Q90ZY6_Brachydanio_rerio KEEAEIQAELERLERVRNLHIRELKRINNEDSSQFKDHPTLNERYLLLHL SINFRUP00000140996 KEEAEIQAELERLERVRNLHIRELKRINNEDSSAFKDHPTLNERYLLLHL SINFRUP00000149375 KEEAEIQAELERLERVRNLHIRELKRINNEDSSQFKDHPTLNERYLLLHL ENST00000263815 KEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHL ENSMUST00000038584 KEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHL CG3068-RA KEKTKTETQPQKPKKTWELNNFDIG-----------------------RL ** :: :.: :: :: : : :: : : : ::::* ENST00000326270 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRI ENST00000324442 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRI ENSMUST00000015107 LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRI Q90ZY7_Brachydanio_rerio LGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRI SINFRUP00000158137 LGRGGFSEVFKAFDLTEQRYVAIKIHQLNKNWKEEKKQNYHKHACREYRI Q90ZY6_Brachydanio_rerio LGRGGFSEVYKAFDLFEQRYAAVKIHQLNKNWREEKKENYHKHACREYRI SINFRUP00000140996 LGRGGFSEVYKAFDLFEQRYAAVKIHQLNKNWREEKKENYHKHACREYRI SINFRUP00000149375 LGRGGFSEVYKAFDLIEQRYAAVKVHQLNKNWREEKKENYHKHACREYRI ENST00000263815 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRI ENSMUST00000038584 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRI CG3068-RA LGRGKFGNVYLAREKESQFVVALKVLFK----RQIGESNVEHQVRREIEI **** *.:*: * : .* .*:*: :: :.* .::. ** .* ENST00000326270 HKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH--KLMSEK ENST00000324442 HKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH--KLMSEK ENSMUST00000015107 HKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH--KLMSEK Q90ZY7_Brachydanio_rerio HKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH--KLMSEK SINFRUP00000158137 HKELDHPRIVKLYDYFSLDTDSFCTVLEYCDGNDLDFYLKQN--KLMTEK Q90ZY6_Brachydanio_rerio HKQLDHPRIVKLYDYFSLDTDTFCTVLEFCEGNDLDFYLKQH--KLMSEK SINFRUP00000140996 HKQLDHPRIVKLYDYFSLDTDTFCTVLEFCEGNDLDFYLKQN--KLMSEK SINFRUP00000149375 HKELDHPRIVKLYDYFSLDTDSFCTVMEYCEGNDLDFYLKQH--KLMSEK ENST00000263815 HKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQH--KLMSEK ENSMUST00000038584 HKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQH--KLMSEK CG3068-RA QSHLRHPHILRLYAYFHDDVR-IYLILEYAPQGTLFNALQAQPMKRFDER :..* **:*::** ** *. : ::*:. . * *: : * : *: ENST00000326270 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFG ENST00000324442 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLENGTACGEIKITDFG ENSMUST00000015107 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFG Q90ZY7_Brachydanio_rerio EARSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFG SINFRUP00000158137 EGRSIVMQIVNALKYLNQIHPPIIHYDLKPGNILLVNGTACGEIRITDFG Q90ZY6_Brachydanio_rerio EARSIVMQIVNALRYLNEIKPSIIHYDLKPGNILLVDGTACGEIKITDFG SINFRUP00000140996 EARSIVMQIVSALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFG SINFRUP00000149375 EARSIVMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFG ENST00000263815 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFG ENSMUST00000038584 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFG CG3068-RA QSATYIQALCSALLYLHERD--IIHRDIKPENLLLG---HKGVLKIADFG :. : : : .** **:: *** *:** *:** * ::*:*** ENST00000326270 LSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW ENST00000324442 LSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW ENSMUST00000015107 LSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW Q90ZY7_Brachydanio_rerio LSKIMDDDNYG-VDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW SINFRUP00000158137 LSKIMDDDSYS-SAGMDLTSQGAGTYWYLPPECFVMGKDPPKISNKVDVW Q90ZY6_Brachydanio_rerio LSKIMDDDSYG-VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW SINFRUP00000140996 LSKIMDDDNYG-VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW SINFRUP00000149375 LSKIMDDDNYG-VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW ENST00000263815 LSKIMDDDSYG-VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW ENSMUST00000038584 LSKIMDDDSYG-VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW CG3068-RA WSVHEPN---------SMRMTLCGTVDYLPPEMVQG----KPHTKNVDLW * : :.: .** ***** . :::**:* ENST00000326270 SVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAK ENST00000324442 SVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAK ENSMUST00000015107 SVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAK Q90ZY7_Brachydanio_rerio SVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAK SINFRUP00000158137 SVGVIFYQCLYGRKPFGHNLSQQDILQENTILKATEVHFPPKPTVTTDAK Q90ZY6_Brachydanio_rerio SVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPAKPVASNEAK SINFRUP00000140996 SVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPAKPQASTEAK SINFRUP00000149375 SVGIIFFQCLYGRKPFGHNQSQQDILQENTILKATDVQFPVKPVASNEAK ENST00000263815 SVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK ENSMUST00000038584 SVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK CG3068-RA SLGVLCFELLVGHAPFYSKN------YDETYKKILKVDYKLPEHISKAAS *:*:: :: * *: ** : :: ::* * .*.: : *. ENST00000326270 AFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGA ENST00000324442 ALIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGA ENSMUST00000015107 AFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGA Q90ZY7_Brachydanio_rerio AFIRRCLVYRKEDRIDVHQLASDPYLLPHIRKSVAATGNSSMAVASTSNS SINFRUP00000158137 AFIRRCLAYHKEDRLDVLQLASDPFLMPHIRKA----------------- Q90ZY6_Brachydanio_rerio AFIRRCLAYRKEDRSDVHQLGSDSYLLPHMRRSNSSGNLQAT----PASP SINFRUP00000140996 AFIRRCLAYRKEDRFDVHQLCSDSYLLPHMRRSNSSGSL----------- SINFRUP00000149375 AFIRRCLAYRKEDRIDVHQMSSDPYLLPHIRRSNSSGNLQTS-------- ENST00000263815 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTP ENSMUST00000038584 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMSGLTATPTP CG3068-RA HLISKLLVLNPQHRLPLDQVMVHPWILAHTQ------------------- :* : *. . :.* : *: ..:::.* : ENST00000326270 SNNSSSN- ENST00000324442 SNNSSSN- ENSMUST00000015107 SNNSSSN- Q90ZY7_Brachydanio_rerio SNSSASN- SINFRUP00000158137 -------- Q90ZY6_Brachydanio_rerio APSGIISY SINFRUP00000140996 -------- SINFRUP00000149375 -------- ENST00000263815 PSSSIITY ENSMUST00000038584 PSSSIITY CG3068-RA --------