CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000004683 ------------------------------------------------------MATPAG ENST00000326646 ------------------------------------------------------------ SINFRUP00000164524 ------------------------------------------------------------ ENST00000263724 -------------------------------------------------------MADPE ENSMUST00000039450 -------------------------------------------------------MANPE SINFRUP00000146027 ------------------------------------------------------------ ENSMUST00000011152 ------------------------------------------------------MPGDEE SINFRUP00000165235 ------------------------------------------------------------ CG8743-RA MQSYGPGAQTAPAVKRRTDSYEAAQQQQQSPESDEEYVNTRILRRQVQLQSTPVAPVVPM ENSMUST00000004683 RRASETERLLTPNPGYGTQVGTSPAPTTPTEEEDLRRRLKYFFMSPCDKFRAKGRKPCKL ENST00000326646 -----------------------MTPSQPTRGSSCTRPSSMLWTS---TWRCLT---CHW SINFRUP00000164524 ------------------------------EEECLRRKLKYFFMSPCDKYYAKGRKPYKL ENST00000263724 VVVSSCSSHEEENRCNFNQQTSPS--EELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKL ENSMUST00000039450 VLVSSCRARQDESPCTFHPSSSPS--EQLLLEDQMRRKLKFFFMNPCEKFWARGRKPWKL SINFRUP00000146027 ------------------------------------------------------------ ENSMUST00000011152 TLDLPAWNRVPDLTWGPHHRSAMASLDSEVREECLREDLKFYFMSPCEKYRARRQIPWKL SINFRUP00000165235 ---------------------------------DLRRRLKYYFMNPCEKYQARRRKPWKL CG8743-RA PISAGSGTAPPSVDGREEQPEFPGSSAASYQEERMRRKLQFFFMNPIEKWQAKRKFPYKF ENSMUST00000004683 MLQVVKILVVTVQLILFGLSNQLVVTFREENTIAFRHLFLLGY-SDGSDDTFAAYTQEQL ENST00000326646 AGMRMSVVGVTLGPMAQGLLSASGTTTEATWTRPTTHLTLIRW-WLLTASRWIPPSGPLR SINFRUP00000164524 ILQLLKIIIVTAQLVMFGLSNQVVVTFKEENTMTFKHLFLKDY-DESSDASFAVYTQNDV ENST00000263724 AIQILKIAMVTIQ----------------------------------------------- ENSMUST00000039450 AIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGY-MDRMDDTYAVYTQSEV SINFRUP00000146027 ------------------------------------------------------------ ENSMUST00000011152 GLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGF-SGVDEDDYSCSIYTQE SINFRUP00000165235 MLQILKIALITAQLVSFGLSNEMMVTFKDDNLMTFRHLFLKGY-KDHHSGSYALYTKSDV CG8743-RA VVQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGWDSSREVESYPPAVGPFA ENSMUST00000004683 Y----QAIFYAVDQYLILPEISLG---RYAYVRGGGGPWANGSALALCQRYYHRGHVDPA ENST00000326646 P----PATISPSWKAAPVTRTSRSNSTSTACSLEGGPGWG-----RQHTRHSHPSNYFPK SINFRUP00000164524 Y----EHIFYAVDQYLALPETTVG---CYAYVYDVGVNGS---ALSLCQQYYKRGRIDPA ENST00000263724 --------------YLQLYNVSVG---NHAYENKGTKQSA----MAICQHFYKRGNIYPG ENSMUST00000039450 ----YDQIIFAVTQYLQLQNISVG---NHAYENKGTKQSA----MAICQHFYRQGTICPG SINFRUP00000146027 ------------FQYGNLYNITLG---NHEYEKNGDSYSP----LTLCQTFYRNGSVYAG ENSMUST00000011152 NTYESIFFAIKQASYRHLKNISLA---TLGYGESEDNRTG----LKVCKQHYKTGAMFSS SINFRUP00000165235 Y----DHIFFIIDKYINLQNLTVG---NLAHELVDGDYAP----LSVCQELYRKSCVFPG CG8743-RA LYLKSEFFDTVQYAVNGYANVSRSIG-PYDYPTPNNTMPP----LKLCLQNYREGTIFGF . : . : : . ENSMUST00000004683 NDTFDIDPR--VVTDCIQVDPPDRPPDIPSEDLDFLDGSASYKNLTLKFHKLINVTIHFQ ENST00000326646 VGTGPPRPRWCLLGEHFPCQLQSQHVAGDAGTWGRKGPEDAPDPHPSLLPRLVNVTIHFR SINFRUP00000164524 NDTFNIDPH--IITALKQLLVTAERLRSWFSPRTQTTVLDISVNNPFSLYRFINITIDFQ ENST00000263724 NDTFDIDPE--IETECFFVEPDE--------PFHIGTPAENKLNLTLDFHRLLTVELQFK ENSMUST00000039450 NDTFDIDPE--VETECFLVEPDE--------ASHLGTPGENKLNLSLDFHRLLTVELQFK SINFRUP00000146027 NETFEIDAE--VDTDCVEFYPD-----------HHPSPEEVMSHFPLHFKRLVSVTVTFV ENSMUST00000011152 NETLNIDSD--IETDCIHLDLQV--------LTTEPEDWAQTSFFRLDFYRLVQVDISFA SINFRUP00000165235 NDTFAIDPR--TDKDCISIHPRQ--------PLHGPP-----VNLSLDFRRLLSVSVTLT CG8743-RA NESYIFDPH--IDEVCERLPPNV--------TTIGVENYLRQRDVEVNFASLVSAQLTFK : . : :: : : ENSMUST00000004683 LKTINLQSLIN-NEIPDCYTFS--ILITFDNKAHSGRIPIRLETKTHIQECK-HPSVSRH ENST00000326646 LKTINLQSLIN-NEIPDCYTFS--VLITFDNKAHSGRIPISLETQAHIQECK-HPSVFQH SINFRUP00000164524 LKAINLQTIIN-SEIPDCYTFY--ITIIMDNKAHSGKVKIRLETRATIKECK-DPSVSGQ ENST00000263724 LKAINLQTVRH-QELPDCYDFT--LTITFDNKAHSGRIKISLDNDISIRECK-DWHVSGS ENSMUST00000039450 LKAINLQTVRH-QELPDCYDFT--LTITFDNKAHSGRIKISLDNDISIKECK-DWHVSGS SINFRUP00000146027 LKAINLQTIRY-RELPDCYDFT--VIITFNNNAHSGRIKIEMDQDVSISECR-DWEIIGA ENSMUST00000011152 LKGIDLQAVHS-REIPDCYLFQNTASITFDNTAHSGKIKIYLNSEANIEECK-NMNISGS SINFRUP00000165235 LKTINLQTVLH-HELPDCYDFR--ITIIFDNHAHSGKIMVEVENDMRIYECR-DWNVEGK CG8743-RA IKTVNFKANGGPLSAPDCFRFD--ISITFNNRDHDGQMLLSLDAEATRLKCHGATDFISD :* ::::: . ***: * * ::* *.*:: : :: :*: . ENSMUST00000004683 GD--NSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVVFMWRRRGREISLWERLEF ENST00000326646 GD--NSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEF SINFRUP00000164524 X--------------------------KSVWA-----------------------DRFEF ENST00000263724 IQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEF ENSMUST00000039450 IQKNTHYMMIFDAFVILTCLASLVLCARSVIRGLQLQQEFVNFFLLHYKKEVSASDQMEF SINFRUP00000146027 SSQVLYLTEVFDCVIILTCIASFILCTRSVLTGIRLQCEYSQYCRNSSGKDAPWSDKLEF ENSMUST00000011152 TQRSTHYLLVFDVFVIMICLASLILCTRSIVLALRLRKRFLNFFLEKYKQRVCGADQWEF SINFRUP00000165235 SDKIDYRLLLLDSAVILVCFTSFVLCVRSVITGIQLQFEFGVFFHAHFHKAVTWSDRMEF CG8743-RA ANFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEF :: ::: : : ::: : : ** ENSMUST00000004683 VNGWYILLVTSDVLTISGTVMKIGIEAKNLAS--YDVCSILLGTSTLLVWVGVIRYLTFF ENST00000326646 VNGWYILLVTSDVLTISGTIMKIGIEAKNLAS--YDVCSILLGTSTLLVWVGVIRYLTFF SINFRUP00000164524 INGWYILLIISDILTITGSIIKIGIESKNMSS--YDLCGILLGTSTLLVWVGVIRYLTFF ENST00000263724 VNGWYIMIIISDILTIIGSILKMEIQAKSLTS--YDVCSILLGTSTMLVWLGVIRYLGFF ENSMUST00000039450 INGWYIMIIISDILTIVGSVLKMEIQAKSLTS--YDVCSILLGTSTMLVWLGVIRYLGFF SINFRUP00000146027 VNGWYILIIVSDTLSIIGSILKIEIENKVVTS--YDICSIFLGTGTMLVWIGVIRYMGYF ENSMUST00000011152 VNGWYVLVTISDLMTIIGSILKMEIKAKKLTN--YDVCSILLGTSTLFVWVGVIRYLGYF SINFRUP00000165235 VSGWYILIVVSDTLTIAGSALKVGIQTKYLTD--YDRCSILLGTATLLVWVGVIRYLGFF CG8743-RA VNFWYIMIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFF :. **::: .* : * *: :* *: : : :* *.::** ..::**.**:**: :* ENSMUST00000004683 HKYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLI ENST00000326646 HNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLI SINFRUP00000164524 QKYNILIVTLRAAFPNVIRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLI ENST00000263724 AKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLI ENSMUST00000039450 AKYNLLILTLQAALPNVMRFCCCAAMIYLGYCFCGWIVLGPYHEKFRSLNRVSECLFSLI SINFRUP00000146027 KKYNILILTLRAALPNVIRFICCAGIIYLGYCFCGWIVIGPYHEKFRTLNTVSECLFSLI ENSMUST00000011152 QTYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHEKFENLNIVAECLFSLV SINFRUP00000165235 KKYNILILTLRAAFPNVIRFCCCAAMMYLGYCFCGWIVLGPYHDKFQTLDKVTECLFSLL CG8743-RA KTYNVVILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLATTSECLFALI .**::* *:: : *.::** .. ::* *: ****:::**** **..* .:****:*: ENSMUST00000004683 NGDDMFVTFAAMQAQQGHSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPG ENST00000326646 NGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPG SINFRUP00000164524 NGDDMFVTFSGLQES---STLVWLFSQVYLYTFISLFIYMVLSLFIALITGAYETIK--- ENST00000263724 NGDDMFATFAKMQQK---SYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQ ENSMUST00000039450 NGDDMFSTFAKMQQK---SYLVWLFSRVYLYSFISLFIYMILSLFIALITDTYETIKHYQ SINFRUP00000146027 NGDDMFPTFKDMNQK---SSLVWVFSRIYLYTFVSLFIYMILSLFITIITDTYTTIKQLD ENSMUST00000011152 NGDDMFATFAQIQQK---SILVWLFSRLYLYSFISLFIYMVLSLFIALITDSYHTIKKYQ SINFRUP00000165235 NGDDMYATFLRLRDK---SYMVWLFSRLYLYSFISLFIYMVLSLFIALITDTYETIK--- CG8743-RA NGDDMFATFATLSSK---ATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTIKAYY *****: ** : . : :* *.::***:*:**:**::*****::* .:* *** ENSMUST00000004683 GTGTEKSELQAYIEQ-CQDSPTSGKFRRGSG--------SACSLFCCCGRDSPEDHSLLV ENST00000326646 GAGAEESELQAYIAQ-CQDSPTSGKFRRGSG--------SACSLLCCCGRDPSEEHSLLV SINFRUP00000164524 ------------------------------------------------------------ ENST00000263724 QDGFPETELRTFISE-CKDLPNSGKYRLEDD--------PPVSLFCCCKK---------- ENSMUST00000039450 QDGFPETELRKFIAE-CKDLPNSGKYRLEDD--------PPGSLLCCCKK---------- SINFRUP00000146027 QSGTPTSELQEFLSM-CNDLPNSGVYRLE------------------------------- ENSMUST00000011152 QHGFPETDLQKFLKE-SGSKDG---YQKQPS--------ALLSCLCCLRRRRSNDHLILI SINFRUP00000165235 ------------------------------------------------------------ CG8743-RA KDGFPTTDLKAFVGTRTAEDISSGVFMTDLDDFDQTSFLDVVKSICCCGRCGRHQEPAQP : : ENSMUST00000004683 N----------- ENST00000326646 N----------- SINFRUP00000164524 ------------ ENST00000263724 ------------ ENSMUST00000039450 ------------ SINFRUP00000146027 ------------ ENSMUST00000011152 D----------- SINFRUP00000165235 ------------ CG8743-RA NSGYTSLSSIMK