CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000020264 ------------------------------------------------------------ ENST00000319449 ------------------------------------------------------------ ENST00000313047 ----------------------------------FLLYPGDG-GAGFGVRPPPQQQRSWR ENSMUST00000031229 --------------------------------MSALTPPTDMPTPTTDKITQAAMETIYL ci0100151782 -------MKRFRAKYGSESHQSISESEISEESELELLKPTVNIQSNREDMVYSSTKHRET CG31064-RB MSTDDLLVRRERSEDSQSSSVSIPVTPTTGGAAPAPSAPTSSLDRLRNTFRRTESISSQI ENSMUST00000047485 ------------------------------------------------------------ ENST00000312373 ------------------------------------------------------------ SINFRUP00000161098 ------------------------------------------------------------ ENSMUST00000006750 ------------------------------------------------------------ ENST00000225441 ------------------------------------------------------------ SINFRUP00000161588 ------------------------------------------------------------ SINFRUP00000145020 ------------------------------------------------------------ ENSMUST00000020264 ------------------------------------------------------------ ENST00000319449 ------------------------------------------------------------ ENST00000313047 T---------------------------------PPSPGSPLPFLLLSYPSGGGGSSGSG ENSMUST00000031229 C---------------------------------KFRVSMDGEWLCLRELDDISLTPDPE ci0100151782 N---------------------------------TDDMNDDLYPLRFGSSAQWDSQVVPR CG31064-RB FSHISTQFSNAAAAAASSEVIDGTTTYPYPDEPAPPVVPVAPDTVASASASSPSPSKLKA ENSMUST00000047485 ------------------------------------------------------------ ENST00000312373 -----------------------------------------MASRSLGGLSGIRGGGGGG SINFRUP00000161098 ------------------------------------------------------------ ENSMUST00000006750 ----------------------------------------------MEASFVQTTMALGL ENST00000225441 -----------GAPSDRGPSRDPATGLGLREGWGGSGRRQQWPHIWMEASFVQTTMALGL SINFRUP00000161588 ----------------------------------------------MESGCIQTAMAMGL SINFRUP00000145020 ----------------------------------------------MVSGCVQAAMAMGD ENSMUST00000020264 ----ATKDPTAVERANLLN----------------------------------------- ENST00000319449 ---------MMEERANLMH----------------------------------------- ENST00000313047 KHH--PNYLMANERMNLMN----------------------------------------- ENSMUST00000031229 PTHEDPNYLMANERMNLMN----------------------------------------- ci0100151782 SRYHSTSNMDLKENSSLYNSESLHSMPEYPTLCTLFPPSPPRFWGDAIYSELDDILAQPV CG31064-RB KRLKRARDTAEIERSNLVN----------------------------------------- ENSMUST00000047485 -KKSLSARNAAVERRNLIT----------------------------------------- ENST00000312373 GKKSLSARNAAVERRNLIT----------------------------------------- SINFRUP00000161098 ------------------------------------------------------------ ENSMUST00000006750 PSKKASSRNVIVERRNLIT----------------------------------------- ENST00000225441 SSKKASSRNVAVERKNLIT----------------------------------------- SINFRUP00000161588 TSKKASARSVGVERKNLIT----------------------------------------- SINFRUP00000145020 VSKKASARNVAVERKNLIT----------------------------------------- ENSMUST00000020264 ------------------------------------------------------------ ENST00000319449 ------------------------------------------------------------ ENST00000313047 ------------------------------------------------------------ ENSMUST00000031229 ------------------------------------------------------------ ci0100151782 SPVSSFTSVAPSCRYSDTNSETLKAMETLYLCNFKVSVDGDWLCLKEICDDNVTTPNYLI CG31064-RB ------------------------------------------------------------ ENSMUST00000047485 ------------------------------------------------------------ ENST00000312373 ------------------------------------------------------------ SINFRUP00000161098 ------------------------------------------------------------ ENSMUST00000006750 ------------------------------------------------------------ ENST00000225441 ------------------------------------------------------------ SINFRUP00000161588 ------------------------------------------------------------ SINFRUP00000145020 ------------------------------------------------------------ ENSMUST00000020264 ------MAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLK----------- ENST00000319449 ------MMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLK----------- ENST00000313047 ------MAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK----------- ENSMUST00000031229 ------MAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK----------- ci0100151782 SSAIRGMAKLSVKGLIESSLSAGHTLDSDHVPLQQFFVIIEYVLRQGLK----------- CG31064-RB ------ICKLVVKELLEQSLRYGRMLDSDHLPLQHFFIVIEHVLGHGLR----------- ENSMUST00000047485 ------VCRFSVKTLIDRSC--FETIDDSSPEFNNFAAVLEQILSHRLKALFILCFD--L ENST00000312373 ------VCRFSVKTLIDRSC--FETIDDSSPEFNNFAAILEQILSHRLK----------- SINFRUP00000161098 ------VFRFSVKTLLDRSC--TETVDDSSSEFVNFASILEHILSHRLKDRIFSTSFGWV ENSMUST00000006750 ------VCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACAP------- ENST00000225441 ------VCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACAP------- SINFRUP00000161588 ------VCRFSVKTLLEKYT--AEPIDDSSEEFINFAAILEHILSHRFKGNA-------- SINFRUP00000145020 ------VCRFSVKTLLEKYT--AEPIDDSSDEFINFAAILEHILSHRFK----------- : :: :* *:: . :* . : :* ::* * : :: : ENSMUST00000020264 ---GRKSFLS--YNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALM ENST00000319449 ---VKKSFIG--QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALM ENST00000313047 ---AKKTFLG--QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALM ENSMUST00000031229 ---AKKTFLG--QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALM ci0100151782 ---APKNFFM--PNKYFWPPLEAIEKFNSEASEITSSVRSLPGIRTHLGKGRAWLRLALM CG31064-RB ---PKKGLLG--PRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALM ENSMUST00000047485 SSEGQVTWFGYESPRSFWDYIRVACRKVSQN--CICSIENMENVSSSRAKGRAWIRVALM ENST00000312373 ---GQVTWFGYESPRSFWDYIRVACRKVSQN--CICSIENMENVSSSRAKGRAWIRVALM SINFRUP00000161098 FVVGQTSWFGYESPRSFWDYVRTACSKVPHN--CIRSIESMENVRSSKAKGRAWIRVALM ENSMUST00000006750 --AGPASWFSSDGQRGFWDYIRLACSKVPNN--CVSSIENMENISTARAKGRAWIRVALM ENST00000225441 --AGPVSWFSSDGQRGFWDYIRLACSKVPNN--CVSSIENMENISTARAKGRAWIRVALM SINFRUP00000161588 --AGSGSWFSSDGQRSFWEYIRLACGKVQNN--CIASIENIENISTSRAKGRAWIRVALM SINFRUP00000145020 ---GSGSWF--DGQRSFWDYIRVACPKVPNS--CISSIECMENISTSRAK-ATWIRVALM : : :: :. . *:. : : : .: :*: :*** ENSMUST00000020264 QKKMADYLRCLIIQRE-LLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDS ENST00000319449 QKKLADYLKVLIDNKH-LLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDS ENST00000313047 QKKLSEYMKALINKKE-LLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDS ENSMUST00000031229 QKKLSEYMKALINKKE-LLSEFYEVNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDS ci0100151782 QKKLADYFKILIDNKA-ILSEWYDDGALIMNDEATVLAGHLVGLNCIDANLCMKGDDLDN CG31064-RB QKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDS ENSMUST00000047485 EKHLSEYISTALRDFK-TTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDG ENST00000312373 EKHLSEYISTALRDFK-TTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDG SINFRUP00000161098 EKRLSEYISSALRDLR-TTRRFYDDGAIMLGEEAGLLADTLIGLNTIDFSFCLKGEGVDG ENSMUST00000006750 EKRMSEYITTALRDNR-TTRRFYDSGAIMLREEATVLTGMLIGLSAIDFSFCLKGEVLDG ENST00000225441 EKRMSEYITTALRDTR-TTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDG SINFRUP00000161588 EKRLSEYISTALRDTR-TTRRFYDDGAILLREEATVLTGMLIGLSAIDFSFCLKGEALDG SINFRUP00000145020 EKRLSEYIATALRDSR-TTRRFYVEGAILLREEATVLTGMLIGLGAIDFSFCLKGEQLDG :*::::*: : . :* *::: :* :: . *:**. :* .:*:* : :*. ENSMUST00000020264 QV-GVIDFSMYLK----NEEEIGN---------KERNVQIAAILDQKNYVEELNRQLNST ENST00000319449 QV-GVIDFSLYLK----DVQDLDG---------GKEHERITDVLDQKNYVEELNRHLSCT ENST00000313047 QV-GVIDFSMYLK----DGNSSKG---------TEGDGQITAILDQKNYVEELNRHLNAT ENSMUST00000031229 QV-GVIDFSMYLK----DGNSSKG---------SEGDGQITAILDQKNYVEELNRHLNAT ci0100151782 QE-MVIDYSLYMK----DGNHGNHGMFMEDDNVEDEESQMQKLMDQKNYLEERNRHLEDA CG31064-RB QQ-GVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNAT ENSMUST00000047485 TFPAVIDYTPYLK--------------------------FEQSSDSISSDEEELRTFGSS ENST00000312373 SFPAVIDYTPYLK--------------------------YIQSSDSISSDEEELRTLGSS SINFRUP00000161098 ASPAIIDFTPYLK--------------------------FIQSGDSISSDEEEMRTMGSS ENSMUST00000006750 KTPVVIDYTPYLK--------------------------FTQSYDYLT-DEEERHSAESS ENST00000225441 KTPVVIDYTPYLK--------------------------FTQSYDYLT-DEEERHSAESS SINFRUP00000161588 KSPAVIDYTPYLK--------------------------FTQSYDYLS-DEDDRHSVDSS SINFRUP00000145020 KSSAVIDYTPYLK--------------------------FTQSYDYLS-DDDDRRSIDSS :**:: *:: * . :: : : ENSMUST00000020264 VSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENELILMRTRQHLEVTKVD ENST00000319449 VGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQD ENST00000313047 VNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRK-------- ENSMUST00000031229 VNNLQTKVDLLEKSNTKLTEELAVANNRIITLQEEMERVKEESSYLLESNRK-------- ci0100151782 SVDLQKRSDHLEEENKSMLLEVEALKIQITELKNERVKMMDE------------------ CG31064-RB VGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNS---------- ENSMUST00000047485 DSESSTPENVG--PPLILDENTWFNKCKRVRQKYQLTLEQKG---YLEELLR-------- ENST00000312373 GSESSTPENVG--PPFLMDENSWFNKCKRVKQKYQLTLEQKG---YLEELLR-------- SINFRUP00000161098 GSESSTPDKMATAASIFTEQSNLVSKCKRFEQKYRMALEQKG---YLEELVR-------- ENSMUST00000006750 TSEDNSPEHPY--LPLVTDEDSWYNKWHKMEQKFRIVYAQKG---YLEELVR-------- ENST00000225441 TSEDNSPEHPY--LPLVTDEDSWYSKWHKMEQKFRIVYAQKG---YLEELVR-------- SINFRUP00000161588 NSEESIPEHPY--IPLVTDEESWSNKCRKMEQRFKIVYAQKASQGYLEELVR-------- SINFRUP00000145020 TSDDSIPEHPY--VPLVTDEESWSTKCRKMEQRFKIVNAQKG---YLEELVR-------- . . . : . . ENSMUST00000020264 VETELQTYKHSRQGLDEMYNDARRQLRDESQLRQDVENELSVQVGMKHEMELAMKLLEKD ENST00000319449 TKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKD ENST00000313047 ------GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKD ENSMUST00000031229 ------GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELELQISMRQEMELAMKMLEKD ci0100151782 --------KKDMTVTHQKTLEIQKQLKHETQMRMEVEKELELQMSLKSELDVAMKLLEKD CG31064-RB --------TGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKD ENSMUST00000047485 --------LRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNND ENST00000312373 --------LRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQL------- SINFRUP00000161098 --------LREAQLSEAMSKNKSLQQSLTDTHLTHTLEKEQLEFIILELQDQLTVLKNND ENSMUST00000006750 --------LRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPGD ENST00000225441 --------LRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSD SINFRUP00000161588 --------LRESQLKNVETDNKCLRTKVEELTVQSQQEKKELEAVVLELQAQLSALIPCD SINFRUP00000145020 --------LRESQLKNAELENKKLKARLEELQSRNLQEKKELEAVVLELQEQLTSLIPCD . :: .:: : : ENSMUST00000020264 IHEKQDTLIGLRQQLEEVKAINIEMYQRLQGSEDGLKEKN-------EIIARLEEKTNKI ENST00000319449 THEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKN-------EAITSFEGKTNQV ENST00000313047 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKS-------ELNSRLEEKTNQM ENSMUST00000031229 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKS-------ELNSRLEEKTNQM ci0100151782 IFAKQDGLVTLREQLDNVKAINMDVYNKLQAKSILEEEKN-------KTIAKLENETRSL CG31064-RB IHEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKT-------ELMTKLEVQKEDM ENSMUST00000047485 LRSRQ----ELTAHLTKQWPSPGALDVNAVALDTLLYRKHNK-QWYDKSYQSLDQLSAEV ENST00000312373 -----------------------------------------------KSYQSLDQLSAEV SINFRUP00000161098 LRSRQ----ELTAHLTNQWPSPVALDANAVALDTLLYRKNTEGQWEEKSVQSLGQASVDL ENSMUST00000006750 HAPLAQGSKELTTSLVNQWPSLSTLHRPEGASNSKLYRR--------HSFMSTEPLSAEA ENST00000225441 HAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRR--------HSFMSTEPLSAEA SINFRUP00000161588 SSHLS---KELSIPLVNEWSAIANNQG-----EVKLFRR--------RSFHSFEQFSAEL SINFRUP00000145020 PNHLS---KNLSIPLINQWPTLEPYNN-----EVKLFRR--------RSFPSTELLSVEI : : . . . ENSMUST00000020264 TTAMRQLEQRLQQAEKAQ-KEAEAEDEKYAQECLSQSDSLQRQISQKEQQLVQLETDLKI ENST00000319449 MSSMKQMEERLQHSERAR-QGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKS ENST00000313047 AATIKQLEQR-------------------------------------------------- ENSMUST00000031229 AATIKQLEQSEKDLVKQA-KTLNSAANKLIPKHH-------------------------- ci0100151782 AKKVSTLQQQIEEEERKT-LVAREQAGRYNQQLDDS-----------ENKRGALVTNLQI CG31064-RB ASTIDQLEKKWSHDKSNLGEILKTTSQTLTTQVTAS-----------EERAARAEAESRI ENSMUST00000047485 SLSQASLDPSHSQEGDGK------------------------------------------ ENST00000312373 SLSQTSLDPGQSQEGDGK------------------------------------------ SINFRUP00000161098 GLSRPSLERSRMLSPDLRPAVAHW------------------------------------ ENSMUST00000006750 SLSSDSQRLG-------------------------------------------------- ENST00000225441 SLSSDSQRLG-------------------------------------------------- SINFRUP00000161588 SLNSDSQKTD-------------------------------------------------- SINFRUP00000145020 SLDSDSQRIE-------------------------------------------------- ENSMUST00000020264 EKEWRQTLQEDLQKEKDVLSHLRHETQKVISLKKEFLNLQDENQQLKRIYQEQEQALQEL ENST00000319449 EKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEM ENST00000313047 ------------------------------------------------------------ ENSMUST00000031229 ------------------------------------------------------------ ci0100151782 EREWRQSLEDQVGKLEQEKMLLEERLSVMEQMREELRLVTTDRDDLRQTCHEQELTITDL CG31064-RB EREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEEL ENSMUST00000047485 ------------QDSLN---FIGEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDCLASP ENST00000312373 ------------QDTLN---VMSEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDYLASP SINFRUP00000161098 ------------GKSLNHAALLHSGKEETLSLRGLCGSPTSVTSYMSLACLKSNECLASP ENSMUST00000006750 ------------EAKRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSD ENST00000225441 ------------EGTRDEEPWGPIG--------------SSEPN---------------- SINFRUP00000161588 ------------GRPNGDAAWTSAGKDNTPSMLGLCGSLASLPSSKSLASLKSSECLVNI SINFRUP00000145020 ------------GTQNG-GAWCTE-KDYTPSMMGLCGSLASIPSCKSLASLKSSECLVNI : ENSMUST00000020264 GSKLCESKLKIDDIKEAN-----------KALQGL--------VWLKDKDATHCKLCEKE ENST00000319449 GLHLSQSKLKMEDIKEVN-----------QALKGH--------AWLKDDEATHCRQCEKE ENST00000313047 ------------------------------------------------------------ ENSMUST00000031229 ------------------------------------------------------------ ci0100151782 AGHLGRSKQDLGDLKEVH-----------KTMTSS--------QWESDRQVTSCTQCEKA CG31064-RB GIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACERE ENSMUST00000047485 TTELTSPGLTPS------------------------------------------------ ENST00000312373 TTEMTSPGLTPS------------------------------------------------ SINFRUP00000161098 ATEISSPGLTPS------------------------------------------------ ENSMUST00000006750 SPEG-SPALSPS------------------------------------------------ ENST00000225441 ------------------------------------------------------------ SINFRUP00000161588 STEP-SPALSPS------------------------------------------------ SINFRUP00000145020 STES-SPALSPS------------------------------------------------ ENSMUST00000020264 FSLSKRKHHCRNCGEIFCNACSDNELPLPSSP----KPVRVCDSCHAMLIQRCSSNMP-- ENST00000319449 FSISRRKHHCRNCGHIFCNTCSSNELALPSYP----KPVRVCDSCHTLLLQRCSSTAS-- ENST00000313047 ------------------------------------------------------------ ENSMUST00000031229 ------------------------------------------------------------ ci0100151782 FNLSRRKHHCRNCGLIYCNTCSDNTMPLASSA----KPVRVCDTCHTTLLQRFSASNSAA CG31064-RB FNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCYAAK----------- ENSMUST00000047485 ------------------------------------------------------------ ENST00000312373 ------------------------------------------------------------ SINFRUP00000161098 ------------------------------------------------------------ ENSMUST00000006750 ------------------------------------------------------------ ENST00000225441 ------------------------------------------------------------ SINFRUP00000161588 ------------------------------------------------------------ SINFRUP00000145020 ------------------------------------------------------------