CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000154730 ------------------------------------------------------------ SINFRUP00000160735 ------------------------------------------------------------ ENST00000263459 ------------------------------------------------------------ ENSMUST00000003313 ------------------------------------------------------------ ENSMUST00000001115 ------------------------------------------------------------ ENST00000230673 ------------------------------------------------------------ SINFRUP00000146838 ------------------------------------------------------------ ENSMUST00000001112 ------------------------------------------------------------ ENST00000322270 KPLAPSPPGSGSPAAAGAPASEPLSEVSHGIDSGLPGGRALRRELRARGEGDGAKKNRGD ci0100151190 ------------------------------------------------------------ CG17998-RA ------------------------------------------------------------ SINFRUP00000154730 ------------------------------------------------------------ SINFRUP00000160735 ------------------------------------------------------------ ENST00000263459 ----------------------------------------------CGRQGGLLAPPAPA ENSMUST00000003313 ------------------------------------------------------------ ENSMUST00000001115 ------------------------------------------------------------ ENST00000230673 ------------------------------------------------------------ SINFRUP00000146838 ------------------------------------------------------------ ENSMUST00000001112 ------------------------------------------------------------ ENST00000322270 SAAAVTAGTRRGRAAPSPRPDRSPAGEGLRRRRRRRPWWQWWRRSSLPGSCPELEERVVP ci0100151190 ------------------------------------------------------------ CG17998-RA ------------------------------------------------------------ SINFRUP00000154730 -------------------------------------------------GGGGKRKGRSK SINFRUP00000160735 ------------------------------------------------------------ ENST00000263459 AAAAARAAAAAAAAPQALTAPPAGSVADRRLSMELENIVANTVLLKAREGGGGKRKGKSK ENSMUST00000003313 -------------------------------------------------GGGGKRKGKSK ENSMUST00000001115 ---------------------------------ELENIVANTVLLKAREGGGGNRKGKSK ENST00000230673 --------------------------------MELENIVANTVLLKAREGGGGNRKGKSK SINFRUP00000146838 -------------------------------------------------GGGGNRKGKSK ENSMUST00000001112 -------------------------------------FVANNLLLKARLG-FNKQTGRSK ENST00000322270 GELCTGAAASPPVPPPQSPRSRRIRRRRRRQDMELENIVANSLLLKARQGGYGKKSGRSK ci0100151190 --------------------------------MELENIVANTVYLKAREGGGGKRKGKSK CG17998-RA --------------------------------MELENIVANTVYLKAREGGSDSNKGKSK SINFRUP00000154730 KWKEILRFPHISQCVSP----DRSYLSVCERQPIGRLLFRLFCET-RVNLDLCIQLLDAM SINFRUP00000160735 ------------------------------------------------------------ ENST00000263459 KWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCET-RPGLECYIQFLDSV ENSMUST00000003313 KWKEILKFPHISQCEDLRRTIDRDYYSLCDKQPIGRLLFRQFCET-RPGLECYIQFLDLV ENSMUST00000001115 KWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCAT-RPELTRCTAFLDGV ENST00000230673 KWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCAT-RPELSRCVAFLDGV SINFRUP00000146838 KWKQMLQFPHISMCEELRQNTEKDYSTLCERQPIGRLLFRQFCDT-RPELRCCVKFLDAV ENSMUST00000001112 KWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRLLFRQFCDT-KPDLKRCIEFLDAV ENST00000322270 KWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDT-KPTLKRHIEFLDAV ci0100151190 KWREMMKFPHISLTEDLRRTIEPEYTSICEDQPIGQRLFQLFCET-QSELSICRECLEQM CG17998-RA KWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRELFRLFCENKRPVYFRYITFLDEV :: : : : : :: : : : SINFRUP00000154730 VRSAAHTHAHTVSRPPVLFSPALTSGRP--RAHGTA------------------------ SINFRUP00000160735 ------------------------------------------------------------ ENST00000263459 AEYEVTPDEKLGEKGKEIMTKYLTPKSP--VFIAQVGQDLVSQTEEKLLQKPCK------ ENSMUST00000003313 AEYEITPDENLGAKGKEIMTKYLTPKSP--VFIAQVGQDLVSQTEKKLLQSPCK------ ENSMUST00000001115 SEYEVTPDEKRKACGRRLMQNFLSHTGP--DLIPEVPRQLVSNCAQ--RLEQGP------ ENST00000230673 AEYEVTPDDKRKACGRQLTQNFLSHTGP--DLIPEVPRQLVTNCTQ--RLEQGP------ SINFRUP00000146838 VRQKKGYGNFVCVCVCPCSCPWYLTRTS--VIMITLWLVLIKGCLLKLRLELGVG----- ENSMUST00000001112 AEYEVTIEEEQREFGLAIFSRFFKEKSE--VPLPEIPPDIVKECKWN-LKQNSP------ ENST00000322270 AEYEVADDEDRSDCGLSILDRFFNDKLA--APLPEIPPDVVTECRLG-LKEENP------ ci0100151190 RNYEETLLEDRRQVAQTVFDKYLKERTSNGVLPPTVTNEMIDAIEERLKAPPECD----- CG17998-RA VKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDAETQEELLLNSSNANPTET SINFRUP00000154730 ------------------------------------------------------------ SINFRUP00000160735 ------------------------------------------------------------ ENST00000263459 ------------------------------------------------------------ ENSMUST00000003313 ------------------------------------------------------------ ENSMUST00000001115 ------------------------------------------------------------ ENST00000230673 ------------------------------------------------------------ SINFRUP00000146838 ------------------------------------------------------------ ENSMUST00000001112 ------------------------------------------------------------ ENST00000322270 ------------------------------------------------------------ ci0100151190 ------------------------------------------------------------ CG17998-RA AETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVK SINFRUP00000154730 -------------------------------------------------------DVVFW SINFRUP00000160735 ------------------------------------------------------------ ENST00000263459 ------------------------------------------------------ELFSAC ENSMUST00000003313 ------------------------------------------------------ELFSAC ENSMUST00000001115 ----------------------------------------------------CKDLFQEL ENST00000230673 ----------------------------------------------------CKDLFQEL SINFRUP00000146838 ------------------------------------------------CE--SPDLYVLF ENSMUST00000001112 ----------------------------------------------------SQNVFEEC ENST00000322270 ----------------------------------------------------SKKAFEEC ci0100151190 ------------------------------------------------QEELNQDLFSEC CG17998-RA CQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSGGKDIFAQC SINFRUP00000154730 L-RAVHEYLRGAPFADYQNSMFFDRFLQWKMLERQPVTKDTFRQYRVLGKGGFGEVCACQ SINFRUP00000160735 --RALHKYLRGEPFSQYQNSMYFDRFLQWKMVERQPITKHGFRQYRVLGKGGFGEVWACQ ENST00000263459 A-QSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQ ENSMUST00000003313 A-QSVHDYLKGDPFHEYLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQ ENSMUST00000001115 T-RLTHEYLSTAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQ ENST00000230673 T-RLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQ SINFRUP00000146838 FPRLIHDYLSMAPFADYLDSMYYNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQ ENSMUST00000001112 A-GIVCKYLSETPFEEYQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQ ENST00000322270 T-RVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQ ci0100151190 S-SAITNYLSGQPFKEFCDSIYFSRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQ CG17998-RA V-NAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQ :* ** :: .* :: ::**** :* :*:* . ** ************ *** SINFRUP00000154730 VRATGKMYACKKLEKKRIKKRKGESMALNEKVILENVNSRFVVSLAYTYETKDALCLVLT SINFRUP00000160735 VRATGMMYACKKLEKTHIKKRRGEAMALNEKQILEGLSSRFVVNLAYAYETKHALCMVLT ENST00000263459 VRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLT ENSMUST00000003313 VRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLT ENSMUST00000001115 VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT ENST00000230673 VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT SINFRUP00000146838 VRATGKMYACKKLEKKRIKKRKGESMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT ENSMUST00000001112 VRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLT ENST00000322270 VRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLT ci0100151190 VRSSGKMYACKRLEKKRIKKRKGEAMALNEKQILESVNSRFVVSLGYAYETKDALNLVLT CG17998-RA VRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLT **::* *****:*:*.:****:**:*.* ** **: : * ***.*.*:****.** :*** SINFRUP00000154730 IMNGGDLKFHIYNMG-TPGFDRERVQFYAAQICCGLEHLHRESIVYRDLKPENILLDDNG SINFRUP00000160735 MMSGGDLNFHIYNIG-EPGLSEDRVQFYAAQVCCGLMHLHNESILYRDLKPENILLDDNG ENST00000263459 IMNGGDLKFHIYNMG-NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG ENSMUST00000003313 IMNGGDLKFHIYNMG-NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG ENSMUST00000001115 LMNGGDLKFHIYHMG-QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHG ENST00000230673 LMNGGDLKFHIYHMG-QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHG SINFRUP00000146838 LMNGGDLKFHIYHMG-ESGFDEKRAVFYSAEICCGLEDLHRERIVYRDLKPENILLDDHG ENSMUST00000001112 IMNGGDLKYHIYNLG-DPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHG ENST00000322270 IMNGGDLKFHIYNLG-NPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRG ci0100151190 IMNGGDLKFHIHNMG-APGFSIHRAIFYSAEITCGLHDLHKQRIVYRDLKPENILLDDHG CG17998-RA IMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHG :*.****::**:::* .*: *. **:*:: *** .*:.: :*** ********* * SINFRUP00000154730 NIRISDLGLAIKVPAGELIRGRVGTVGYMAPEVIRNERYSMSPDWWGLGCLIYEMTAGRS SINFRUP00000160735 HIRISDLGLAVRLTDGKLVHGRVGTLGYMAPEVIGRKHYGVSADWWGLGCLIYEMTAGKP ENST00000263459 HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQS ENSMUST00000003313 HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQS ENSMUST00000001115 HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVRNERYTFSPDWWALGCLLYEMIAGQS ENST00000230673 HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQS SINFRUP00000146838 HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIEGQS ENSMUST00000001112 HIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHS ENST00000322270 HIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHS ci0100151190 HIRISDLGLAVRIPSGEKIKGRVGTVGYMAPEVVRNERYEMSPDWFGLGCIIYEMIAGQA CG17998-RA HVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQA ::******** .:. *. ::*****:******:: .::* .*.*::.:**::*** *:. SINFRUP00000154730 PFRARKERVKREEVERRVHEEEEEYD-DKFTEDTKAICRLLLNKDPKRRLGCL--LDGAS SINFRUP00000160735 PFRAHGEHHSTSEMERRILSDQEEYG-EKFSLDVKQICSLLLTKKPNHRLGCQ--SSGGK ENST00000263459 PFRGRKEKVKREEVDRRVLETEEVYS-HKFSEEAKSICKMLLTKDAKQRLGCQ--EEGAA ENSMUST00000003313 PFRGRKEKVKREEVDRRVLETEEVYS-SKFSEEAKSICNMLLTKDSKQRLGCQ--EEGAA ENSMUST00000001115 PFQQRKKKIKREEVERLVKEVAEEYT-DRFSSQARSLCSQLLSKDPAERLGCR--GGGAR ENST00000230673 PFQQRKKKIKREEVERLVKEVPEEYS-ERFSPQARSLCSQLLCKDPAERLGCR--GGSAR SINFRUP00000146838 PFQQRKKKIKREEVEKLVREVEEEYS-SKFSEDAKSLCKMLLAKDPKVRLGCQ--GNGAS ENSMUST00000001112 PFRKYKEKVNREELERRVKNETEEYS-ERFSEDAKSICSMLLIKDPSKRLGCQ--RDGVS ENST00000322270 PFKKYKEKVKWEEVDQRIKNDTEEYS-EKFSEDAKSICRMLLTKNPSKRLGCR--GEGAA ci0100151190 PFRKRKEKVKREEVDRRVKEDTESYDDEKFTEEAKSICSMLLKKDVKDRLGCRN-GSCAS CG17998-RA PFRMRKEKVKREEVDRRVKEDPEKYS-SKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQ **: :: . .*::: : . * * :*. :.: :* ** *. **** SINFRUP00000154730 GVVAQSFFR--NINFKRLEAG---IVEPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDQTD SINFRUP00000160735 DVQSHPFFK--KINFRMLEAG---LVEPPFKPDPRHVYCSDVLDIDEFSTLRGVTLDQMD ENST00000263459 EVKRHPFFR--NMNFKRLEAG---MLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTD ENSMUST00000003313 EVKRHPFFR--NMNFKRLEAG---MLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTD ENSMUST00000001115 EVKEHPLFK--KLNFKRLGAG---MLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTD ENST00000230673 EVKEHPLFK--KLNFKRLGAG---MLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTD SINFRUP00000146838 EVKAHPIFR--SINFKRLEAG---MLEPPFIPDPQAIYCKDVLDIEQFSTVKGVDLEPKD ENSMUST00000001112 AVKQHPIFK--DINFSRLEAN---MLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTND ENST00000322270 GVKQHPVFK--DINFRRLEAN---MLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTAD ci0100151190 DVKAHPFFK--NINFKRLETGKAPFGNPPFD-KPHAVYAKDVLDIEQFSTVKGVTIDGKD CG17998-RA DVMAHPFFHSTQLNWRRLEAG---MLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESD * :..*: .:*: * :. : :*** .*: :*. ::*** :**.::*: :: * SINFRUP00000154730 TDFYAKFATGSVSIPWQNEMIETECFRDLNLFGPQGSRPPDLDWDH-PPELPRRSLLDRI SINFRUP00000160735 KYFYAKFNTGSVPITWQNEIIDTGCFEELNVFGANGSRSPDLDRCQ-SPDSPRRNLLRRI ENST00000263459 DDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNH-PPEPPKKGLLQRL ENSMUST00000003313 DDFYSKFSTGSVPIPWQNEMIETECFKELNVFGPNGTLSPDLNRSQ-PPEPPKKGLFHRL ENSMUST00000001115 QDFYQKFATGSVSIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPTAPPKKGLLQRL ENST00000230673 QDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRL SINFRUP00000146838 ESFYSKVSTGSVSIPWQNEMIETGCFAELNVFYQDGTVPPDLDWRGQPSPPPKQGLLQRL ENSMUST00000001112 EIFYAEFATGSVTIPWQNEMIESGCFKDLNENEDDLSSLEKYKMCS-SILRPKRNFFRRL ENST00000322270 EDFYARFATGCVSIPWQ------------NEADDRIWVFQRHQQK--------------- ci0100151190 NDFYAKFSTGSVSIPWQNEMCETSVYKDLNVFNADGSPTPDLTPYDQQSNPPKKGFFSRL CG17998-RA TNFYTKFNTGSVSISWQNEMMETECFRELNVFGPEECPTPDLQINAAPEPDKAGCFPFRR ** .. **.*.*.** : :* : SINFRUP00000154730 FRR--------------------------------- SINFRUP00000160735 FRR--------------------------------- ENST00000263459 FKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS ENSMUST00000003313 FRRQHQSNSKSSPTPKTSCNHRINSNHINSNSTGSS ENSMUST00000001115 FSRQDCCGNCSDSEEELPTRL--------------- ENST00000230673 FSRQDCCGNCSDSEEELPTRL--------------- SINFRUP00000146838 FGRQVSG----------------------------- ENSMUST00000001112 FRRTGCLNIALSEEREPTEH---------------- ENST00000322270 ------------------------------------ ci0100151190 FGRQ-------------------------------- CG17998-RA KKKQPARTQPIPIPEHLLTTSHSVSSTTVES-----