CLUSTAL W (1.82) multiple sequence alignment ENST00000299035 ------------------------------------------SRQPSVETLDSPTGSHVE ENSMUST00000015358 MDRPVAAAAAASAASCEGAGGPGPGPGASWRPSRVAGGASASSRHPSIETLDSPTGSHVE SINFRUP00000140882 ------------------------------------------------------------ ENSMUST00000034396 -----------------------MEKSSSCESLGAQLPAARLPSEDS---LSSASTSHSE ENST00000322626 ----------PRRLLQPFPVLPLPRDGEELELRESWLPAGGGSAAQRGLLVQCLHFSFRE SINFRUP00000141969 ------------------------------------------------------------ ENST00000306167 ------------------------------------------------------------ ENSMUST00000061970 ------------------------------------------------------------ ci0100149543 ------------------------------------------------------------ CG9115-RA -------------------------------------------------------MDPSA ENST00000299035 WCKQLIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPLFPGE-SIKAIVKDVMY ENSMUST00000015358 WCKQLIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPLFPGE-SIKAIVKDVIY SINFRUP00000140882 -------------------------------------------------------KDVMY ENSMUST00000034396 NSVHTKSASAISSDSISTSADNFSPDLRVLREANKLAEMEEPALLPGE-NIKDMAKDVTY ENST00000322626 FSAY-KISFCVSSDSISTSADNFSPDLRVLRESNKLAEMEEPPLLPGE-NIKDMAKDVTY SINFRUP00000141969 ----------------------------VLRDSDK----EEPQLLPNE-TVQNLALDITY ENST00000306167 ------MASASTSKYNSHSLENES-IKRTSRDGVNRDLTEAVPRLPGE-TLIT-DKEVIY ENSMUST00000061970 ------MASASASKYNSHSLENES-IKKVSQDGVSQDVSETVPRLPGE-LLIT-EKEVIY ci0100149543 -------------MDSSKNGQEVPKNEIVETNVSNAARSDMEPLVPGEQVYIALLKDVTY CG9115-RA SLADKLASKTASSNSLDSSSKSSSLGSKHGGGENGILRDTPFGYLEGE-EDQDQKNDVTY :: * ENST00000299035 ICPFMGAVSGTLTVTDFKLYFKN---VERDPHFILDVPLGVISRVEKIG-AQSH-----G ENSMUST00000015358 ICPFMGAVSGTLTVTDFKMYFKN---VERDPHFVLDVPLGVISRVEKIG-AQSH-----G SINFRUP00000140882 ICPFSGLMNGTLTITDYKMHFTS---VERESQFILDINLGAISRLETIS-VPNL-----G ENSMUST00000034396 ICPFTGAVRGTLTVTSYRLYFKS---MERDPPFVLDASLGVISRVEKIGGASSR-----G ENST00000322626 ICPFTGAVRGTLTVTNYRLYFKS---MERDPPFVLDASLGVINRVEKIGGASSR-----G SINFRUP00000141969 FCPFIGALRGTVTVTNYRLFFKC---MDRDPTFVLDLPLGVLSRVEKVGGASSR-----G ENST00000306167 ICPFNGPIKGRVYITNYRLYLRS---LETDSSLILDVPLGVISRIEKMGGATSR-----G ENSMUST00000061970 ICPFNGPIKGRVYITNYRLYLRS---LETDSALILDVPLGVISRIEKMGGATSR-----G ci0100149543 LCPYMGAISGQLIITNYKLHFSKPSMPEKETSFVVEVPLCTISRVEKVGGATTASRATDG CG9115-RA VCPYRGPVFGALTITNYRLYFRSLPLRDQEPPVVVDVPLGVIARVEKIGGATSR-----G .**: * : * : :*.:::.: : :. .::: * .: *:*.:. . . * ENST00000299035 DNSCGIEIVCKDMRNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYKEKF---- ENSMUST00000015358 DNSCGIEIVCKDMRNLRLAYKQEEQRKLGIFENLNKHAFPLSNGQVLFAFNYKEKF---- SINFRUP00000140882 ENTRGLELVCKDMRSPRFAYKTD-SSQPDIIEVLSKHAFPLCHNLPLFAFLYKEQF---- ENSMUST00000034396 ENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAFEYKEVF---- ENST00000322626 ENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVF---- SINFRUP00000141969 ERGS-YLLVCK------------------------------------------------- ENST00000306167 ENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKF---- ENSMUST00000061970 ENSYGLDITCKDLRNLRFALKQEGHSRRDMFEILVKHAFPLAHNLPLFAFVNEEKF---- ci0100149543 RNPYGLEVGCKDMRVLRFVMRQESRQRRMVYEKLQELCFPVSNKMPFFAYIYKEEYPE-- CG9115-RA ENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAAANSVNG . ** : : : : : : :: ENST00000299035 --PINGWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVA ENSMUST00000015358 --PVNGWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVA SINFRUP00000140882 --PVDGWKVYDPTSEYKRQGLPNESWTISKINSTYELCDTYPSILVIPTNISDEDIKQVS ENSMUST00000034396 --PENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVA ENST00000322626 --PENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVA SINFRUP00000141969 -------------------GIPNESWRITKVNDHYDLCDTYPSTLVVPVNIPDEELKRVA ENST00000306167 --NVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVA ENSMUST00000061970 --NVDGWTVYNPVEEYRRQGLPNHHWRISFINKCYELCETYPALLVVPYRTSDDDLRRIA ci0100149543 --EANGWMMYSAKAEYHRQGLPVEGWRFTKANSKYELCDTYPQLLVVPSPASDDDLKQVS CG9115-RA NGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVA : *:* . * : *. * :*::** .:* *: : ::: ENST00000299035 AFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIF ENSMUST00000015358 AFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLTIF SINFRUP00000140882 LFRAKHRIPVLSWIHPESQATIVRCSQPLVGPSDRRCKEDERFLQIIMDANAQSHKLTIF ENSMUST00000034396 SFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIF ENST00000322626 SFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIF SINFRUP00000141969 AFRAKGRIPVLSWIHPESQATVTRSSQPMVGVNGKRSKEDEKFLQAIMDANAQSHKLFIF ENST00000306167 TFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIY ENSMUST00000061970 TFRSRNRLPVLSWIHPENKMVIMRCSQPLVGMSGKRNKDDEKYLDVIRETNKQTSKLMIY ci0100149543 QFRSRSRIPVLSWIHPESQATITRCSQPLVGIGNKRSRDDERYVHLILEANPHAHKLLIF CG9115-RA QFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIM **:: *:*****::*..: .: *.***:** ..:* :** :: * ::* : *: * ENST00000299035 DARQNSVADTNKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPS--IDEA ENSMUST00000015358 DARQNSVADTNKAKGGGYENESAYPNAELIFLEIHNIHVMRESLRKLKEIVYPS--IDES SINFRUP00000140882 DARQSSVAVTNKAKDGGYESETFYPNVELNFLEIPNIHVMRESLRKMKDVVYPT--IDEA ENSMUST00000034396 DARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPT--IEET ENST00000322626 DARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPN--IEET SINFRUP00000141969 DARPSVNAAANKMKGGGYESEDAYQNAELFFLDIHNIHVMRESLRKLKDVVYPN--IEDS ENST00000306167 DARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPN--VEES ENSMUST00000061970 DARPSVNAVANKATGGGYESDDAYQNSELSFLDIHNIHVMRESLKKVKDIVYPN--IEES ci0100149543 DARPQANAVANVARGGGYEKSEAYTTSELIFCDVHNIHVMRESLRKLQDTCFAQNPNEDK CG9115-RA DARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPT--TDDS *** . * :* .****.. * . *: * :: *********:*::: :. :: ENST00000299035 RWLSNVDGTHWLEYIR------------MLLAGAVRIADKIESGKTSVVVHCSDGWDRTA ENSMUST00000015358 HWLSNVDGTHWLEYIR------------VLLAGAVRIADKIESGKTSVVIHCSDGWDRTS SINFRUP00000140882 RWHSSVDQTHWLEYIR------------LLLSGAAKIADKLESGKTSVVVHCSDGWDRTA ENSMUST00000034396 HWLSNLESTHWLEHIK------------LILAGALRIADKVESGKTSVVVHCSDGWDRTA ENST00000322626 HWLSNLESTHWLEHIK------------LILAGALRIADKVESGKTSVVVHCSDGWDRTA SINFRUP00000141969 HWLSNLESTHWLEHIK------------LILAGALRIADKVESGKTSVVVHCSDGWDRTS ENST00000306167 HWLSSLESTHWLEHIK------------LVLTGAIQVADKVSSGKSSVLVHCSDGWDRTA ENSMUST00000061970 HWLSSLESTHWLEHIKAISMPPAVSLCQLVLTGAIQVADQVSSGKSSVLVHCSDGWDRTA ci0100149543 HWLSNLEQTQWLHHTK------------VILAAATRIADRVESGKSSVLVHCSDGWDRTA CG9115-RA KWQTAIDNTLWLKHIR------------CILAGAVRIVDKVETMSTSVVVHCSDGWDRTA :* : :: * **.: : :*:.* ::.*::.: .:**::*********: ENST00000299035 QLTSLAMLMLDSYYRTIKGFETLVEKEWISFGHRFALRVGHGNDNHADADRSPIFLQFVD ENSMUST00000015358 QLTSLAMLMLDSYYRTIKGFEALIEKEWISFGHRFALRVGHGDDNHADADRSPIFLQFID SINFRUP00000140882 QLTCLAMLMLDSYYRTLRGFQVLVEKEWISFGHKFSARVGHGDENHANAERSPLFVQFID ENSMUST00000034396 QLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFID ENST00000322626 QLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFID SINFRUP00000141969 QLTSLSMLMLDGYYRTIRGFEVLLEKEWLSFGHRFQLRIGHGDKNHTDADRSPVFIQFVD ENST00000306167 QLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFID ENSMUST00000061970 QLTSLAMLMLDSFYRTIEGFEILVQKEWISFGHKFASRIGHGDKNHADADRSPIFLQFID ci0100149543 QLTSLSMIMLDSYYRTLDGFIVLIEKEWLSFGHKFQQRIGHGDKNHSDSERSPVFLQFID CG9115-RA QLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNKHSDADRSPVFLQFID ***.*:*::** .**:: ** *::***:****:* *:***:.:*::::***:*:**:* ENST00000299035 CVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRFKEDVYTKTISLWSYIN ENSMUST00000015358 CVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRIKEDVYTNTISLWSYIN SINFRUP00000140882 CVWQMTRQFPSAFEFNELFLFAVLDHLYSCLFGTFLYNSEQERTAKEVQTKTVSLWSYIN ENSMUST00000034396 CVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYIN ENST00000322626 CVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYIN SINFRUP00000141969 CVWQLTRQFPSAFEFNEYFLVTILDHLYSCLFGTFLCNCEQQRMKEEIPKRTVSLWSYIN ENST00000306167 CVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLIN ENSMUST00000061970 CVWQMSKQFPTAFEFNEGFLITVLDHLYSCRFGTFLFNCDSARERQKLTERTVSLWSLIN ci0100149543 CVWQMTQQFPTAFEFNEYLLILILEHLYSCLFGTFLYNCDRERRKEEVKKRTKSLWSLVH CG9115-RA SVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHIN .***:::** .****** :*. :::***** ***** * : * :.: .* ***: :: ENST00000299035 SQLDEFSNPFFVN---YENHVLYPVASLSHLELWVNYYVRWNPRMRPQMP--IHQNLKEL ENSMUST00000015358 SQLDEFSNPFFVN---YENHVLYPVASMSHLELWVNYYVRWNPRMRPQMP--IHQNLKEL SINFRUP00000140882 SQPEDFTNPFYVD---YEHHVLYPVVSSRHLELWSSYYARWNPRMRPQVP--VHQSLKEL ENSMUST00000034396 SQLEDFTNPLYGS---YSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEP--IHSRYKEL ENST00000322626 SQLEDFTNPLYGS---YSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEP--IHNRYKEL SINFRUP00000141969 SQLEEFTNPLYVN---YSNHVLFPAVSLRHLELWVGYYIRWNPRMRPQEP--VHQRHKDL ENST00000306167 SNKEKFKNPFYTK---EINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMEL ENSMUST00000061970 SNKDKFKNPFYTK---EINRVLYPVASMRHLELWVNYYIRWNPRVKQQQPNPVEQRYMEL ci0100149543 KRKEEYLNALYVSA--YQNHVLLPVPAVRHLDFWSNNYARWNPKMKSQEP--IQERHKEL CG9115-RA SSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHG--CQRTREL . :.: *.:: . . ** * : : :* . * **** : : . :* ENST00000299035 LAVRAELQKRVEGLQREVATRAVSSSSERGSSPSHSATSVHTSV ENSMUST00000015358 LAIKAELQKRVEDLQREMATRTISSSSERGSSPTHSATPVHTSV SINFRUP00000140882 LFLRAELQRRVEELQREASAHSLSSSEHTPSPTHTSGTPLHTAV ENSMUST00000034396 LAKRAELQRKVEELQREISNRSTSSS-ERASSPAQCVTPVQTVV ENST00000322626 LAKRAELQKKVEELQREISNRSTSSS-ERASSPAQCVTPVQTVV SINFRUP00000141969 LAKRAELQKRVDELQREVTNRSASSSSERAGSPTRSITPVQTFV ENST00000306167 LALRDEYIKRLEELQLANSAK-LSDPPTSPSSPSQMMPHVQTHF ENSMUST00000061970 LALRDDYIKRLEELQLANSAK-LADAPASTSSSSQMVPHVQTHF ci0100149543 LKIRDYLKKKVEDLERQLAAKQLSPSGGPKLTVHSDAEPLAV-- CG9115-RA LSKQDQLFKLVNELRLKSNNR-----SNSMQTTTRLASPMH--- * : : :: *. : . : .