CLUSTAL W (1.82) multiple sequence alignment O42317_Cyprinus_carpio -------------------------------------------------- ENST00000304374 -------------------------------------------------- ENSMUST00000038101 -------------------------------------------------- ENST00000231683 -------------------------------------------------- ENST00000305905 MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGA ENSMUST00000028810 MTFRDILSVTFEGPRASSSTGGSGAGGGAGTVG----PEGPAVGGVPG-A ENSMUST00000043164 -------------------------------------------------- ENST00000271357 -------------------------------------------------- Q90X46_Brachydanio_rerio -------------------------------------------------- SINFRUP00000149305 -------------------------------------------------- SINFRUP00000141555 -------------------------------------------------- ENST00000286603 -------------------------------------------------- ENSMUST00000062028 -------------------------------------------------- ENST00000322241 -------------------------------------------------- CG6989-RA -------------------------------------------------- O42317_Cyprinus_carpio ------MRAPRSG-----------AQHARPNRAAG--------------- ENST00000304374 ------MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTA ENSMUST00000038101 ------MEPNGTVHS--------CCLDSIALKVTIS-------------- ENST00000231683 ------MAPNGTASS--------FCLDSTACKITIT-------------- ENST00000305905 GGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVG ENSMUST00000028810 TGGSAVVGTGSGEDNQSSTAEAG-AAASGEVNGSAAVGGLVVSAQGVGVG ENSMUST00000043164 ------MSLNSSLSYR--------KELSNLTATEGGEGGAVS------EF ENST00000271357 ------MSLNSSLSCR--------KELSNLTEEEGGEGGVIIT-----QF Q90X46_Brachydanio_rerio --------MNGSKNG---------TAVANSTNGLD-DNGLMVL-----ES SINFRUP00000149305 ---EPSGPFLTSEHNDTGS-TAALTPIPSTPSRQMGFPLRPSHIKDLTGI SINFRUP00000141555 MMAVRPAPVLAGLPNLT---TTVWTTNPTVPADVGVVTSSQSQIKDLFGL ENST00000286603 ---MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLR-DVASESVAL ENSMUST00000062028 ---MESSPIPQSSGNSSTLGRALQTPGPSTASGVPELGLR-DVASESVAL ENST00000322241 ------------------------MANSTGLNASEVAG--------SLGL CG6989-RA -------------------------------------------------- O42317_Cyprinus_carpio ELTRALILWTLLGNALVCATVVRFRHLRAKVTHVFIASLAVSDLLVAVLV ENST00000304374 CLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLV ENSMUST00000038101 VVLTTLIFITVAGNVVVCLAVSLNRRLRS-LTNCFIVSLAATDLLLGLLV ENST00000231683 VVLAVLILITVAGNVVVCLAVGLNRRLRN-LTNCFIVSLAITDLLLGLLV ENST00000305905 VFLAAFILMAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATV ENSMUST00000028810 VFLAAFILTAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSAAV ENSMUST00000043164 IAIIIITVLVCLGNLVIVVTLYKKSYLLT-LSNKFVFSLTLSNFLLSVLV ENST00000271357 IAIIVITIFVCLGNLVIVVTLYKKSYLLT-LSNKFVFSLTLSNFLLSVLV Q90X46_Brachydanio_rerio VSIIIIAILACLGNLVIVVTLYKKPYLLT-PSNKFVFSLTSSNLLLSVLM SINFRUP00000149305 CIMVTLNVLALVANTAVLIVVVKSPHLRK---FAFVGHLCAVDLLCAVLL SINFRUP00000141555 FCMVTLNLIALLSNTGVMVAIARAPHLKR---FAFVCHLCGVDLLCAILL ENST00000286603 FFMLLLDLTAVAGNAAVMAVIAKTPALRK---FVFVFHLCLVDLLAALTL ENSMUST00000062028 FFMLLLDLTAVAGNAAVMAVIAKTPALRK---FVFVFHLCLVDLLAALTL ENST00000322241 ILAAVVEVGALLGNGALLVVVLRTPGLRD---ALYLAHLCVVDLLAAASI CG6989-RA -----------------MDSIIRYNDVRK--------------------- . . : : : : : :: : O42317_Cyprinus_carpio MPWKAVAE---VAGFWPFG-AFCNIWVAFDIMCSTASILNLCVISVDRYW ENST00000304374 MPWKAVAE---VAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYW ENSMUST00000038101 MPFSAIYQ---LSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYC ENST00000231683 LPFSAIYQ---LSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYC ENST00000305905 LPFSATME---VLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYV ENSMUST00000028810 LPFSATME---VLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYV ENSMUST00000043164 LPFVVTSS---IRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYY ENST00000271357 LPFVVTSS---IRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYY Q90X46_Brachydanio_rerio LPFVVASS---VRRDWMFGVVWCNFTALLHLLVSSSSMLTLGAIAIDRYY SINFRUP00000149305 MPLGIVATSP-YFAGVGFTMLECRLYIFINIILIAASIFTITAISVERYY SINFRUP00000141555 MPLGIISSSP-FFSTVAFTVLECQVYIFLNVFLISLTILTITAVNVERYF ENST00000286603 MPLAMLSSSA-LFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYY ENSMUST00000062028 MPLAMLSSSA-LFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYY ENST00000322241 MPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYR CG6989-RA ---------------WNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYY : : * . . : : : : ** O42317_Cyprinus_carpio AISSPFRYERKMTPRVSFVMIGAAWTLSVLISFIPVQLDWHKTDAG---- ENST00000304374 AISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGG ENSMUST00000038101 AVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTR--- ENST00000231683 AVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS--- ENST00000305905 GVRHSLKYPAIMTERKAAAILALLWVVALVVSVG-PLLGWKEPVPPD--- ENSMUST00000028810 GVRHSLKYPAIMTERKAAAILALLWAVALVVSVG-PLLGWKEPVPPD--- ENSMUST00000043164 AVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLP-PLFGWSSVEFDE--- ENST00000271357 AVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLP-PLFGWSSVEFDE--- Q90X46_Brachydanio_rerio AVLYPMIYPMKITGNRAVLAIVYIWLHSLVGCLP-PLFGWSSFEFDR--- SINFRUP00000149305 YIVHPMRYEVRMTLRLTAAVLAMVWIASCGLGLL-TVFGWPDYGGLGS-- SINFRUP00000141555 YIVHPMRYEVKMTINLAVGVMLLIWVKSALLALV-SVFGWPAYGHQSS-- ENST00000286603 YVVHPMRYEVRMTLGLVASVLVGVWVKALAMASV-PVLGRVSWEEGAP-- ENSMUST00000062028 YVVHPMRYEVRMTLGLVASVLVGVWVKALAMASV-PVLGRVYWEEGAP-- ENST00000322241 LIVHPLRPGSRPPP---VLVLTAVWAAAGLLGAL-SLLGPPPAPPPAP-- CG6989-RA AIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQ-- : .: . : * . :. O42317_Cyprinus_carpio AAEPN---------------ASDADSCDSSLSRVYAISSSLISFYIPVAI ENST00000304374 LDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI ENSMUST00000038101 ------------------GGND-TFKCKVQVNEVYGLVDGMVTFYLPLLI ENST00000231683 ------------------KGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLI ENST00000305905 -----------------------ERFCGITEEAGYAVFSSVCSFYLPMAV ENSMUST00000028810 -----------------------ERFCGITEEVGYAIFSSVCSFYLPMAV ENSMUST00000043164 --------------------FKWMCVAAWHQEPGYTIFWQIWCALFPFLI ENST00000271357 --------------------FKWMCVAAWHREPGYTAFWQIWCALFPFLV Q90X46_Brachydanio_rerio --------------------FKWTCTVSWHKEISYTAFWVTWCCLLPLVA SINFRUP00000149305 ----------------IGAAHCSLHWMHSDHRRVFSVIFSVACFCLPAVV SINFRUP00000141555 ----------------IAAAHCSLHASHSRLRGVFAVLFTVVCFLLPAVV ENST00000286603 ----------------SVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLL ENSMUST00000062028 ----------------SVNPGCSLQWSHSAYCQLFVVVFAVLYFLLPLIL ENST00000322241 ----------------------ARCSVLAGGLGPFRPLWALLAFALPALL CG6989-RA ------------------FVIQNPTQCSFVVNKYYAVISSSISFWIPCTI : :* O42317_Cyprinus_carpio MIVTYTRIYRIAQVQIRRIASLER-----------------------AAE ENST00000304374 MIVTYTRIYRIAQVQIRRISSLER-----------------------AAE ENSMUST00000038101 MCVTYYRIFKIAREQAKRINHIS--------------------------- ENST00000231683 MCITYYRIFKVARDQAKRINHIS--------------------------- ENST00000305905 IVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAH ENSMUST00000028810 IVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNP ENSMUST00000043164 MLVCYGFIFRVARVKARKVHCGTVVTVEEDS------------QRSGRKN ENST00000271357 MLVCYGFIFRVARVKARKVHCGTVVIVEEDA------------QRTGRKN Q90X46_Brachydanio_rerio MLVCYGVIFRVARIKARKVYCGSVVVSQEESS----------SQNNGRKN SINFRUP00000149305 IFAVYCSVYKVARVAARQHGP-LPLWTNS-Q----------SKHRSDSIN SINFRUP00000141555 ILAVYCAVYKVARSAALQLVPTVPAWANANL----------AKNRSDSIN ENST00000286603 ILVVYCSMFRVARVAAMQHGP-LPTWMET------------PRQRSESLS ENSMUST00000062028 IFVVYCSMFRVARVAAMQHGP-LPTWMET------------PRQRSESLS ENST00000322241 LLGAYGGIFVVARRAALRPPRPAR-------------------------G CG6989-RA MIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQP-SGEALSGSGSSKT : * :: *. O42317_Cyprinus_carpio HAQSRRS--DRSLHRSLKTSFQRETKVLKTLSVIIGVFVCCWLPFFVLNC ENST00000304374 HAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNC ENSMUST00000038101 ---------------SWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFV ENST00000231683 ---------------SWKAATIREHKATVTLAAVMGAFIICWFPYFTAFV ENST00000305905 GMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLP ENSMUST00000028810 GTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLP ENSMUST00000043164 SSTSTSSSGSRRNALQGVVYSANQCKALITILVVIGAFMVTWGPYMVVIT ENST00000271357 SSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIA Q90X46_Brachydanio_rerio SNTSTSSSGSRK----SLIYSGSQCKAFITILVVLGTFLTTWGPYVVVIS SINFRUP00000149305 SQTTIITTTPNTPRRTVCDWPFGGSKAAFTLVVIVGQFLVCWLPYFAFHI SINFRUP00000141555 SQTTMIGAAHSLPQRLSPERAFSGGKAALTLVFIVGQFLLCWLPFFIFHL ENST00000286603 SRSTMVTSSG--APQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHL ENSMUST00000062028 SRSTMVTSSG--AHQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHL ENST00000322241 SRLRSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACL CG6989-RA LTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYT *. . * * * *: O42317_Cyprinus_carpio VVPFCRREP--------CVTDTTFDVFVWFGWSNSSLNPVIYA-FNAEFR ENST00000304374 MVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQ ENSMUST00000038101 YRGLRGDDA---------VNEVVEGIVLWLGYANSALNPILYATLNRDFR ENST00000231683 YRGLRGDDA---------INEVLEAIVLWLGYANSALNPILYAALNRDFR ENST00000305905 LGSLFPQLK---------PSEGVFKVIFWLGYFNSCVNPLIYPCSSREFK ENSMUST00000028810 LGSLFPQLK---------PSEGVFKVIFWLGYFNSCVNPLIYPCSSREFK ENSMUST00000043164 SEALWGKNC---------VSPTLETWATWLSFTSAICHPLIYGLWNKTVR ENST00000271357 SEALWGKSS---------VSPSLETWATWLSFASAVCHPLIYGLWNKTVR Q90X46_Brachydanio_rerio TEALLGKNS---------VSPQVETLVSWLSFTSAVCHPLIYGLWNKTVR SINFRUP00000149305 HQMLSQMHS---------TSEELEDGVTWLAYSSFSLNPFFYGLLNRQIR SINFRUP00000141555 HMSLTGSLQ---------SPGDLEEVVTWLAYSSFAVNPFFYGLLNRQIR ENST00000286603 YVALSAQPI---------STGQVESVVTWIGYFCFTSNPFFYGCLNRQIR ENSMUST00000062028 YVALSAQPI---------SAGQVENVVTWIGYFCFTSNPFFYGCLNRQIR ENST00000322241 APAAR--------------AAEAEAAVTWVAYSAFAAHPFLYGLLQRPVR CG6989-RA LSMTCEECQ---------VPDIVVSILFWIGYFNSTLNPLIYAYFNRDFR *..: :*.:* . .: O42317_Cyprinus_carpio RAFSSLLRC-----RTPVETVNASNALVSYN------REAASAC------ ENST00000304374 KVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAY------ ENSMUST00000038101 MAYQQLFHCKLASHNSHKTSLRLNNSLLSRS------QSREGRW------ ENST00000231683 TGYQQLFCCRLANRNSHKTSLRSNASQLSRT------QSREPRQ------ ENST00000305905 RAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGA ENSMUST00000028810 RAFLRLLRCQCRRRRRR--LWSLRPPLASLDRRPALRLCPQPAHRTPRGS ENSMUST00000043164 KELLGMCFGDRYYRESFVQRQRTSRLFSISNRITDLGLSPHLTALMAGG- ENST00000271357 KELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGG- Q90X46_Brachydanio_rerio KELLGMCFDDRYYRESFVIRHRTSRLFSISNRITDLGMSPHLTAMLVGGG SINFRUP00000149305 EELCKLRRCYSARP--VELAASSHEGTGNENFLQFLHRTSCTVETQASAA SINFRUP00000141555 EQLVKFHRCCSTQA--TEIGASSHEGSLQENLLQFFQRSSKSTEAPSGCV ENST00000286603 GELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRP ENSMUST00000062028 GELSKQFVCFFKAAPEEELRLPSREGSIEENFLQFLQGT---SENWVSRP ENST00000322241 LALGRLSRRALPGPLRACTPQAWHPRALLQCLQRPPEGPAVGPSE----- CG6989-RA EAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTT O42317_Cyprinus_carpio ---VNIIPNVVD------------ETLDRMSQLSRG---GD--------V ENST00000304374 ---IHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWEL ENSMUST00000038101 ---QEEKP--------------------LKLQVWSG-------------T ENST00000231683 ---QEEKP--------------------LKLQVWSG-------------T ENST00000305905 PLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQL ENSMUST00000028810 P-SPHCTPRPGLRRHAG---GAGFGLRPSKASLRREWRLLGPLQRPTTQL ENSMUST00000043164 QSLGHSSSTGDTGFSYS------QDSGTDVMLLEDGTSEDNPPQHCTCPP ENST00000271357 QPLGHSSSTGDTGFSCS------QDSGTDMMLLEDYTSDDNPPSHCTCPP Q90X46_Brachydanio_rerio QLLGRGSSTGDTGFSYT------QDSG----------------------- SINFRUP00000149305 TPSPRSTLDQTGP----------------------------------NGF SINFRUP00000141555 GSHPQNTADRS--------------------------------------V ENST00000286603 LPSPK--QEPP-A----------------------------------VDF ENSMUST00000062028 LPSPK--REPPPV----------------------------------VDF ENST00000322241 --APEQTPELAGG------------------------------------- CG6989-RA PSHRRQSQMQQQRLAAGGSRLGGQLAAAAKDGRESKDAKDTGKDAGKGKS O42317_Cyprinus_carpio DLDGAVHANGIL-------------------------------------- ENST00000304374 DCEGEISLDKITPFTPNGFH------------------------------ ENSMUST00000038101 ELTHPQGSPVR--------------------------------------- ENST00000231683 EVTAPQGATDR--------------------------------------- ENST00000305905 RAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYE ENSMUST00000028810 RAKVSSLSHKFRSGGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYE ENSMUST00000043164 KRRSSVTFEDEVEQIK---------------------------------- ENST00000271357 KRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAK Q90X46_Brachydanio_rerio -RPSAV-------------------------------------------- SINFRUP00000149305 RIPGQIPEE----------------------------------------- SINFRUP00000141555 KVPGLVPVE----------------------------------------- ENST00000286603 RIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLES----------- ENSMUST00000062028 RIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAPSPRLES----------- ENST00000322241 RSPAYQGPPESSLS------------------------------------ CG6989-RA NVDCLAGDDVQEIQIEIPMEYINKWNKNNNAAASTASSHV---------- O42317_Cyprinus_carpio -------------------------------------------------- ENST00000304374 -------------------------------------------------- ENSMUST00000038101 -------------------------------------------------- ENST00000231683 -------------------------------------------------- ENST00000305905 LADYSNLRETDI-------------------------------------- ENSMUST00000028810 PGDLSNLRETDI-------------------------------------- ENSMUST00000043164 -------------------------------------------------- ENST00000271357 INLFGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLA Q90X46_Brachydanio_rerio -------------------------------------------------- SINFRUP00000149305 -------------------------------------------------- SINFRUP00000141555 -------------------------------------------------- ENST00000286603 -------------------------------------------------- ENSMUST00000062028 -------------------------------------------------- ENST00000322241 -------------------------------------------------- CG6989-RA -------------------------------------------------- O42317_Cyprinus_carpio ---- ENST00000304374 ---- ENSMUST00000038101 ---- ENST00000231683 ---- ENST00000305905 ---- ENSMUST00000028810 ---- ENSMUST00000043164 ---- ENST00000271357 AEQR Q90X46_Brachydanio_rerio ---- SINFRUP00000149305 ---- SINFRUP00000141555 ---- ENST00000286603 ---- ENSMUST00000062028 ---- ENST00000322241 ---- CG6989-RA ----