CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000039303 ---------------MNSTLFSKVENHSIHYNASE-NSPLLAFENDDCHL ENST00000296533 ---------------MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHL ENSMUST00000042747 ---------------MEVLTNQPTPNKTSGK---SNNSAFFYFES--CQP ENST00000290426 ---------------MEVSLNHPASNTTSTK---NNNSAFFYFES--CQP SINFRUP00000164394 ------------------------------------SDLALFGHSDQCHM O73733_Brachydanio_rerio -------------MPSALFDMPLWQALLNSTLTHNQSNSSLFLLDVPCWQ O73734_Brachydanio_rerio ------------------------MEAN-ITNISSGTGQKSWVESNVCPP SINFRUP00000160783 -----------------------------------------WAETSQCPP O57463_Brachydanio_rerio ------------------------MERS-HLNNSS-----WLLEDPTCPA Q9YHX1_Gadus_morhua ----------------MEEAFDQFIMES-HPKANYSLIQLAWDQE-ECPS ENSMUST00000052164 --------------MNTSHFLAPLFPGSLQGKNGTNPLDSPYNFSDGCQD ENST00000305389 --------------MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQD CG7395-RA MANLSWLSTITTTSSSISTSQLPLVSTTNWSLTSPGTTSAILADVAASDE . ENSMUST00000039303 PLA--------VIFTLALAYGAVIILGVSGNLALIIIILK-QKEMRNVTN ENST00000296533 PLA--------MIFTLALAYGAVIILGVSGNLALIIIILK-QKEMRNVTN ENSMUST00000042747 PFL--------AILLLLIAYTVILIMGIFGNLSLIIIIFKKQREAQNVTN ENST00000290426 PSP--------ALLLLCIAYTVVLIVGLFGNLSLIIIIFKKQRKAQNFTS SINFRUP00000164394 SPV--------LTTFLILWYGVTMILGLLGNIGLICIITR-RKEKPNVTS O73733_Brachydanio_rerio SST--------MTLTLVLCYCLVLILGLLGNILLICIIMH-QRDPPNVTS O73734_Brachydanio_rerio SVS--------GTTLLIVAYSTVIAVGLVGNTCLVFIISR-QKEMRNVTN SINFRUP00000160783 SIG--------GATFWIVAYSAIIAIGLLGNAGLVFIIAR-QRELRNVTN O57463_Brachydanio_rerio SLS--------STTFLIVAYSTMLAVGLVGNTCLVVVITR-QKEMRNVTN Q9YHX1_Gadus_morhua SKS--------GTTFLILVYSTMIAVGIVGNSCLVFVIAR-QKEMHNVTN ENSMUST00000052164 SAE--------LLAFIITTYSIETILGVLGNLCLIFVTTR-QKEKSNVTN ENST00000305389 SVD--------VMVFIVTSYSIETVVGVLGNLCLMCVTVR-QKEKANVTN CG7395-RA DRSGGIIHNQFVQIFFYVLYATVFVLGVFGNVLVCYVVLR-NRAMQTVTN * :*: ** : : : .: ..*. ENSMUST00000039303 ILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQCVSITV ENST00000296533 ILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITV ENSMUST00000042747 ILIANLSLSDILVCVMCIPFTVIYTLMDHWVFGNTMCKLTSYVQSVSVSV ENST00000290426 ILIANLSLSDTLVCVMCIHFTIIYTLMDHWIFGDTMCRLTSYVQSVSISV SINFRUP00000164394 IFICNLSFSDILVCVFCLPFTVIYTIMDHWVFGSLLCRLVPFIQCVSVTV O73733_Brachydanio_rerio ILIANLSVSDILVSVFCLPFTVVYTLMDHWIFGALLCRLMPFVQCVSVTV O73734_Brachydanio_rerio ILIANLSCSDILMCVVCLPVTVIYTLMDRWILGETLCKVTPFVQCMSVTV SINFRUP00000160783 ILIANLSCSDILMCVVCLPVTVIYTLMDRWVLGEALCKVTPFVQCMSVTV O57463_Brachydanio_rerio IFIVNLSCSDILVCLVCLPVTIIYTLMDRWILGEALCKVTPFVQCMSVTV Q9YHX1_Gadus_morhua IFIANLSCSDILMCIFCLPVTLIYTLMDRWILGEALCKLTPFVQCISVTV ENSMUST00000052164 LLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFIQCMSVTV ENST00000305389 LLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTV CG7395-RA IFITNLALSDILLCVLAVPFTPLYTFMGRWAFGRSLCHLVSFAQGCSIYI ::* **: ** *:.:.. .* **:*. * :* :*:: .: * *: : ENSMUST00000039303 SIFSLVLIAVERHQLIINPRGWRPNNRHAYIGITVIWVLAVASSLPFVIY ENST00000296533 SIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIY ENSMUST00000042747 SIFSLVLIAIERYQLIVNPRGWKPRVAHAYWGIILIWLISLTLSIPLFLS ENST00000290426 SIFSLVFTAVERYQLIVNPRGWKPSVTHAYWGITLIWLFSLLLSIPFFLS SINFRUP00000164394 SVLSLVFIALERHQLIVNPAGWKPTITQAYIALILIWILACFTSSPFLAF O73733_Brachydanio_rerio SVLSLVLIALERHQLILHPSGWKPSVPQAYIAVLTVWLLACVTSLPFLAF O73734_Brachydanio_rerio SIFSLVLIALERHQLIIHPTGWTPAAGHSYLAVAVTWMVACFISLPFLSF SINFRUP00000160783 SIFSLVLIALERHQLILHPTGWSPAAGHSYLAVGLTWLVACFISLPFLSF O57463_Brachydanio_rerio SIFSMVLIALERHQLIIHPTGWKPVVRHSYLAVAVIWIIACFISLPFLSF Q9YHX1_Gadus_morhua SIFSLVLIAMERYQLIIHPTGWKPMVGQSYMAVGIIWVVACLISVPFLSF ENSMUST00000052164 SILSLVLVALERHQLIINPTGWKPSIFQAYLGIVVIWFVSCFLSLPFLAN ENST00000305389 SILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLAN CG7395-RA STLTLTSIAIDRYFVIIYPFHPRMKLSTCIGIIVSIWVIALLATVPYGMY * :::. *::*: :*: * . : *..: : * ENSMUST00000039303 QILTDEPFQN---------------------------------------- ENST00000296533 QVMTDEPFQN---------------------------------------- ENSMUST00000042747 YHLTNEPFHN---------------------------------------- ENST00000290426 YHLTDEPFRN---------------------------------------- SINFRUP00000164394 QLLTNDPYTT---------------------------------------- O73733_Brachydanio_rerio HLLTSEPYSL---------------------------------------- O73734_Brachydanio_rerio NILTNAPFQN---------------------------------------- SINFRUP00000160783 NVLTNDPFQN---------------------------------------- O57463_Brachydanio_rerio NILTNSPFHN---------------------------------------- Q9YHX1_Gadus_morhua TVLDNLPLQN---------------------------------------- ENSMUST00000052164 STLNDLFHYN---------------------------------------- ENST00000305389 SILENVFHKN---------------------------------------- CG7395-RA MKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYM : . ENSMUST00000039303 --VSL-----AAFKDKYVCFDKFPSDSHRLSYTTLLLVLQYFGPLCFIFI ENST00000296533 --VTL-----DAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFI ENSMUST00000042747 --LSLPT---DIYTHQVACVEIWPSKLNQLLFSTSLFMLQYFVPLGFILI ENST00000290426 --LSLPT---DLYTHQVACVENWPSKKDRLLFTTSLFLLQYFVPLGFILI SINFRUP00000164394 --YRAPFSYMPTSPHLEACLEHWPSPQHRLIFTTWLLLFQYCGPLLLVLL O73733_Brachydanio_rerio --FPAPLS------QLQVCLEVWPSQDHKLAYTTSLLLFQYCCPLLLMLL O73734_Brachydanio_rerio --ISLPFN---PFSDHVICMELWPSERNRLAYTTSLLLFQYCLPLLLILL SINFRUP00000160783 --ISLPAN---PFRDHLICMEKWPSNKHRLAYMTSLLVFQYCLPLVLVLL O57463_Brachydanio_rerio --LSLPFN---PFSDHFICIEQWPSEGNRLTYTTTLLLCQYCLPLALILV Q9YHX1_Gadus_morhua --LSLPF----PGQDHWLCTESWPTNSNRLAYTTSLLVFQYFLPLGLIAA ENSMUST00000052164 --HSKVVE---FLEDKVVCFVSWSSDHHRLIYTTFLLLFQYCIPLAFILV ENST00000305389 --HSKALE---FLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILV CG7395-RA QVMTAGSTGPEMPYVRVYCEENWPSEQYRKVFGAITTTLQFVLPFFIISI * :. : : : *: *: :: ENSMUST00000039303 CYFKIYIRLKRRN----NMMDK-----IRDSKYRSSETKRINIMLLSIVV ENST00000296533 CYFKIYIRLKRRN----NMMDK-----MRDNKYRSSETKRINIMLLSIVV ENSMUST00000042747 CYLKIVLCLRKRT----RQVDR-----RKENKSRLNENKRVNVMLISIVV ENST00000290426 CYLKIVICLRRRN----AKVDK-----KKENEGRLNENKRINTMLISIVV SINFRUP00000164394 CYVRVFVRLRHRK----DMLD----RARAPECQRMAHSRRINIMLVALIT O73733_Brachydanio_rerio CYLRIFLRLQRRE----RMLERQCSRNREDEHRRVMHSKRINVMLATLVA O73734_Brachydanio_rerio CYLRIFLRLRRRK----DMVEQ---ATEA-RQRKARGAQRVNAMLVVIVV SINFRUP00000160783 CYLRIFLRLKRRR----DMLE---------RSRRTRGAQRINVMLLAIVV O57463_Brachydanio_rerio CYFRIFLRLSRRK----DMVER---ARGG-RQKKAKGSKRVNAMLASIVA Q9YHX1_Gadus_morhua CYLSIFLRLRRRK----DMVER---ARDSSRDNRAKGSRRINVMLGSIVA ENSMUST00000052164 CYIRIYQRLQRQK----HVFHA---HACS---SRAGQMKRINSMLMTMVT ENST00000305389 CYARIYRRLQRQG----RVFHK---GTYS---LRAGHMKQVNVVLVVMVV CG7395-RA CYVWISVKLNQRARAKPG------SKSSRREEADRDRKKRTNRMLIAMVA ** : * :: . :: * :* ::. ENSMUST00000039303 AFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFY ENST00000296533 AFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFY ENSMUST00000042747 TFGACWLPLNIFNVIFDWYHEMLMSCHHDLVFVVCHLIAMVSTCINPLFY ENST00000290426 TFGACWLPR----------------------------ISSMSSLTG---- SINFRUP00000164394 AFAVCWLPLTIFNVVSDWDQEALPICNHNLLFSLCHLLAMSSTCINPIIY O73733_Brachydanio_rerio AFAVCWLPLNAFNVVADCDQEVLPVCNHNLLFSLCHLLAMSSTCVNPIIY O73734_Brachydanio_rerio AFALCWLPLNVFNTIFDWYHQALPACQHDVIFSACHLTAMASTCVNPVVY SINFRUP00000160783 AFALCWLPLNVFNTLFDWHHQVLPDCQHDAIFSACHLTAMASTCINPVVY O57463_Brachydanio_rerio AFALCWLPLNVFNTIFDWNHEAIPVCQHDAIFSACHLTAMASTCVNPVIY Q9YHX1_Gadus_morhua LFAVCWLPLNIFNTVFDWHHELMVSCQHNLIFSVCHLVAMASTCVNPVVY ENSMUST00000052164 AFAVLWLPLHVFNTLEDWYQEAIPACHGNLIFLMCHLLAMASTCVNPFIY ENST00000305389 AFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIY CG7395-RA VFGLSWLPINVVNIFDDFDDKSNEWRFYILFFFVAHSIAMSSTCYNPFLY *. *** . . .: : *: . .. ENSMUST00000039303 GFLNKNFQRDLQFFFNFCDF------------------------------ ENST00000296533 GFLNKNFQRDLQFFFNFCDF------------------------------ ENSMUST00000042747 GFLNKNFQKDLMMLIHHCWC------------------------------ ENST00000290426 --------------IMRC-------------------------------- SINFRUP00000164394 GFLNSNFRQEVKDVLLHCRC------------------------------ O73733_Brachydanio_rerio GFLNSNFRKDVASVVLHCHF------------------------------ O73734_Brachydanio_rerio GFLNTNFQKELKATLQRCNCG----------------------------- SINFRUP00000160783 GFLNSNFQKELKATLQRCQCS----------------------------- O57463_Brachydanio_rerio GFLNNNFQKELKSLLSRCRC------------------------------ Q9YHX1_Gadus_morhua GFLNSNFQKQLKATLSHCRC------------------------------ ENSMUST00000052164 GFLNINFKKDIKALVLTCHCR----------------------------- ENST00000305389 GFLNTNFKKEIKALVLTCQQS----------------------------- CG7395-RA AWLNENFRKEFKHVLPCFNPSNNNIINITRGYNRSDRNTCGPRLHHGKGD : : . . ENSMUST00000039303 -----RSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKISMND-NEKV- ENST00000296533 -----RSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI- ENSMUST00000042747 -----GEPQESYENIAMSTMHTDESKGSLKLAHIPTGI------------ ENST00000290426 -------------------------------------------------- SINFRUP00000164394 -----GPVEEECEHFPMSTVHMEVSRTSVLPNCKNNSV------------ O73733_Brachydanio_rerio -----QPLEDSYEHFPMSTMNTDVSRTSFR--LRNNSV------------ O73734_Brachydanio_rerio -----WGVPETYESFPLSTVATDVSKVSSMQHGSLIRSEQCAHC------ SINFRUP00000160783 -----NRTTESYESFPLSTVGSE--------------------------- O57463_Brachydanio_rerio -----WGPAESYESFPLSTVSTGITKGSILSNGSASTYQPHKKNSLEQKE Q9YHX1_Gadus_morhua -----WGAAERYENLPLSAVSTEVTKESHMSKGSISIHS----------- ENSMUST00000052164 -----SPRGES-EHLPLSTVHTDLSKGSMRMGSKSNFI------------ ENST00000305389 -----APLEES-EHLPLSTVHTEVSKGSLRLSGRSNPI------------ CG7395-RA GGMGGGSLDADDQDENGITQETCLPKEKLLIIPREPTYGNGTGAVSPILS ENSMUST00000039303 -------------------------------------------------- ENST00000296533 -------------------------------------------------- ENSMUST00000042747 -------------------------------------------------- ENST00000290426 -------------------------------------------------- SINFRUP00000164394 -------------------------------------------------- O73733_Brachydanio_rerio -------------------------------------------------- O73734_Brachydanio_rerio -------------------------------------------------- SINFRUP00000160783 -------------------------------------------------- O57463_Brachydanio_rerio SI------------------------------------------------ Q9YHX1_Gadus_morhua -------------------------------------------------- ENSMUST00000052164 -------------------------------------------------- ENST00000305389 -------------------------------------------------- CG7395-RA GRGINAALVHGGDHQMHQLQPSHHQQVELTRRIRRRTDETDGDYLDSGDE ENSMUST00000039303 -------------------------------------------------- ENST00000296533 -------------------------------------------------- ENSMUST00000042747 -------------------------------------------------- ENST00000290426 -------------------------------------------------- SINFRUP00000164394 -------------------------------------------------- O73733_Brachydanio_rerio -------------------------------------------------- O73734_Brachydanio_rerio -------------------------------------------------- SINFRUP00000160783 -------------------------------------------------- O57463_Brachydanio_rerio -------------------------------------------------- Q9YHX1_Gadus_morhua -------------------------------------------------- ENSMUST00000052164 -------------------------------------------------- ENST00000305389 -------------------------------------------------- CG7395-RA QTVEVRFSETPFVSTDNTTGISILETSTSHCQDSDVMVELGEAIGAGGGA ENSMUST00000039303 ------- ENST00000296533 ------- ENSMUST00000042747 ------- ENST00000290426 ------- SINFRUP00000164394 ------- O73733_Brachydanio_rerio ------- O73734_Brachydanio_rerio ------- SINFRUP00000160783 ------- O57463_Brachydanio_rerio ------- Q9YHX1_Gadus_morhua ------- ENSMUST00000052164 ------- ENST00000305389 ------- CG7395-RA ELGRRIN