CLUSTAL W (1.82) multiple sequence alignment


ENST00000270503         MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQG
SINFRUP00000139269      MSTPDPPIGGTPRPGPSPGPGPSPGAMMGPSPGPSPGSSHSMMGPSPGPPSTGHPQP--G
SINFRUP00000127987      ------------------------------------------------------------
ENST00000265773         ------------------------------------------------------------
CG5942-RC               MASPSPANSPMP---PPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHPGAYGH
                                                                                    

ENST00000270503         PGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGY
SINFRUP00000139269      PSGYGQENMHPLHKPIESMHEKSMSEESRFSQLKGLTVRQAGHSGMGPPPSPLDQHSQGK
SINFRUP00000127987      ------------------------------------------------------------
ENST00000265773         -----------MFQPIDGIHDKGIVEDIHCGSMKGTGMRPP-HPGMGPPQSPMDQHSQGY
CG5942-RC               PMQHGPPGQGPPGHHMPPHHQGMSPHMGMQMPPTGPNMSPYQTHGM-PPNAPTQPCIVSP
                                                                                    

ENST00000270503         PSPLGGSEHASSPVPASGP--SSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLH
SINFRUP00000139269      YGPSG-DQHTLGPNSRPGPPVSAGPGPSPGPNLGPSLGSGLDPAG--GTGPTPFNQNQLH
SINFRUP00000127987      ----------------------SGPAASGGPG-GVGGGTG---------GPTPFNQNQLH
ENST00000265773         MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH
CG5942-RC               GGPPGGPPPPERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVN
                                                               .             :.  *::

ENST00000270503         QLRAQIMAYKMLARGQPLPDHLQMAVQ----------------------------GKRPM
SINFRUP00000139269      QLRAQIMAYKMLTRGQPLPDHLQMAVQ----------------------------GKRPM
SINFRUP00000127987      QLRAQIMAYKMLARSQALPEHLQMAVQ----------------------------GKRPM
ENST00000265773         QLRAQILAYKMLARGQPLPETLQLAVQ----------------------------GKRTL
CG5942-RC               LLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPGPPIGPPGAPGGPPPGSQHAGQPPV
                         **:** **::*:*.:.:.  :* *:*                            *: .:

ENST00000270503         PGMQQQMPT----LPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPS
SINFRUP00000139269      PGMQQQ--------PIPSLGPGAGGGPVGGVLGPGLGPIGSGYSRAHGMMGPNMPPPGPS
SINFRUP00000127987      PGMQQQ--------QMPNMPPITG---PGGGPGAGAGPAQGNYNRPHGMVGASVVPPGAA
ENST00000265773         PGLQQQ-------------------------QQQQQQQQQQQQQQQQQQQQPQQQPP---
CG5942-RC               PPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQVGG
                        *  ***                                        :    .   *    

ENST00000270503         GVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAAS---
SINFRUP00000139269      GAPVGIQGQNQNGPPKSWPEGPMVNAAAPSNTPQKLIPPQPTGRPSPAPPSVPPAAS---
SINFRUP00000127987      GVPSAMPGQAINGPPKSWSDGPVVNAATPSNPPQKLIPTQPTGRPSPAPPSVPPAAS---
ENST00000265773         -QPQTQQQQQPALVNYNRPSGPGPELSGPS-TPQKLPVPAPGGRPSPAPPAAAQPPA---
CG5942-RC               PPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTL
                          *               .  *  .    .   : *    . *:*  ....         

ENST00000270503         PVMPPQTQSP----GQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIA
SINFRUP00000139269      PVMPPQTQSP----GQPVQPTPMMPYHTKQNRITPIQKPCGLDPVEILQEREYRLQARIT
SINFRUP00000127987      PVMPPQTHSP----GQPALPPPMM-LHPKQNRITPIQKPRGLDPVEILQEREYRLQARIA
ENST00000265773         AAVPGPSVPQ----PAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIA
CG5942-RC               PGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARIS
                        . :*  :             .*      * .**:.: ** ****: :***** *: ***:

ENST00000270503         HRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAY
SINFRUP00000139269      HRIAELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALDAKAY
SINFRUP00000127987      HRIQELENLPGSLPGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAY
ENST00000265773         HRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAY
CG5942-RC               LRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLY
                         *: **:.**.::. *** :*::**:***:******** *.* * ****:*****: * *

ENST00000270503         KRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQK
SINFRUP00000139269      KRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSITGKMQK
SINFRUP00000127987      KRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSITAKIQK
ENST00000265773         KRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQK
CG5942-RC               KRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLAR
                        **:*** ***** *********:* ******** *:* ::***.**::*:**.  .:: :

ENST00000270503         LTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDE
SINFRUP00000139269      LTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDE
SINFRUP00000127987      ATKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDE
ENST00000265773         LSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDE
CG5942-RC               MNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDE
                         .*** . ***:******* ****************************:***:**.****

ENST00000270503         YVANLTELVRQHKAAQVAKEKKKKKKKK--KAENAEGQTPAIGPDGEPLDETSQMSDLPV
SINFRUP00000139269      YVANLTELVRAHKAAQAGITPKLTDVRLSLQLEVAEGQAPAMGPDGEPLDETSQMSDLPV
SINFRUP00000127987      YVANLTELVRAHKAAQALKEKKKKKKKK--VIICSSGATALLGPDGEPLDETSQMSDLPV
ENST00000265773         YVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPV
CG5942-RC               YISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSG-EYIG-----IDEGSIVADMRV
                        *::***::*  **  *     :              .    :*     :** * ::*: *

ENST00000270503         KVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQAA
SINFRUP00000139269      KVIHVDSGNILTGVDAPKAGQLDTWLEMNPGYEVAPRSDSEDSEEEEEEEEEEEE----P
SINFRUP00000127987      KVIHVDSGKILTGIEAPKAGQLEAWLEMNPGYEVAPRSDSEDSGSEEEEEEEDEEEDQ-P
ENST00000265773         KVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEE-----
CG5942-RC               HVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWID--DEEDSCGSNDDHKPKVE-----
                        :* .  :*: * * :**   :*. **:*:**::     *.*:*  . ::.. . *     

ENST00000270503         QPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHA
SINFRUP00000139269      QPSSASMEDKKKITDPDSEDVSEVDVRHIIENAKQDVDDEYSG-AAFARGLQSYYAVAHA
SINFRUP00000127987      QPSSAMTEEKKKIPDPDSEDVSEVDVQHIIEHAKQDVDDEYSN-ASFNKCLNSYYAVAHA
ENST00000265773         --SSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSM-QYSARGSQSYYTVAHA
CG5942-RC               ----EQPTATEDATDKAQATGNDEDAKDLITKAKVE-DDEYRT------EEQTYYSIAHT
                                  :   *  .   .: *.:.:*  ** ::****          ::**::**:

ENST00000270503         VTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLM
SINFRUP00000139269      VTEKVEKQSTLLVNGQLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLM
SINFRUP00000127987      VTEKVEKQSTLLVNGQLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLM
ENST00000265773         ISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLM
CG5942-RC               IHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLM
                        : *:* :*:::::** **.**::****:*************************:*:****

ENST00000270503         EHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLL
SINFRUP00000139269      EHKRLNGPYLIIVPLSTLSNWVYEFDKWAPTVVKVSYKGSPAARRAFVPQLRSGKFNVLL
SINFRUP00000127987      EYKRLNGPFLIIVPLSTLSNWVYEFDKWAPSVVKVSYKGSPAARRAFVPILRSGKFNVLL
ENST00000265773         EHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLL
CG5942-RC               DRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLL
                        : *:: **:*********.**. **:****:*  :****:*  ** :   :*: ******

ENST00000270503         TTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNK
SINFRUP00000139269      TTYEYIIKDKQVLAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYLAPRRVLLTGTPLQNK
SINFRUP00000127987      TTYEYIIKDKQVLAKLRWKYMIVDEGHRMKNHHCKLTQVLNTHYLAPRRVLLTGTPLQNK
ENST00000265773         TTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNK
CG5942-RC               TTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNK
                        *****:**** :***::*****:*********************:** *:**********

ENST00000270503         LPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLL
SINFRUP00000139269      LPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLL
SINFRUP00000127987      LPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLL
ENST00000265773         LPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLL
CG5942-RC               LPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLL
                        *************:***************** ***:*:**********************

ENST00000270503         RRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMN
SINFRUP00000139269      RRLKKEVEAQLPEKVEYVINCDMSALQRVLYRHMQAKGVLLD-GSEKDKKGKGGTKTLMN
SINFRUP00000127987      RRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMN
ENST00000265773         RRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMN
CG5942-RC               RRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMN
                        ******** ***:****:*:*******::**:***:**:**  ****.*:****:*:***

ENST00000270503         TIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNH
SINFRUP00000139269      TIMQLRKICNHPYMFQQIEESFSEHLGFSGGIVQGPDLYRASGKFEVLDRILPKLRATNH
SINFRUP00000127987      TIMQLRKICNHPYMFQHIEVTN--------KLTHYPDLYRSSGKFELLDRILPKLRATNH
ENST00000265773         TIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNH
CG5942-RC               TIVQLRKLCNHPFMFQHIEEKYCDHTG-GHGVVSGPDLYRVSGKFELLDRILPKLKATNH
                        **:****:****:***:** .          :    :*** *****:********:****

ENST00000270503         KVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTR
SINFRUP00000139269      KVLLFCQMTSLMTIMEDYFAYRSFKYLRLDGTTKAEDRGMLLKTFNDPESEYFIFLLSTR
SINFRUP00000127987      KVLLFCQMTTLMTIMEDYFAYRNFKYLRLDGTTKAEDRGMLLKTFNDPASDYFVFLLSTR
ENST00000265773         RVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTR
CG5942-RC               RVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTR
                        :********  ***:***:.:* * *********:***. **:.**   *: *:******

ENST00000270503         AGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAA
SINFRUP00000139269      AGGLGLNLQSADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVSSVEEKILAA
SINFRUP00000127987      AGGLGLNLQSADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAA
ENST00000265773         AGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAA
CG5942-RC               AGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAA
                        *********:****:***********************:******** **.****:****

ENST00000270503         AKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDES--RHCSTGSGSASFAHTA
SINFRUP00000139269      AKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEV--WAPATHNQKMCFLMRC
SINFRUP00000127987      AKYKLNVDQKVIQAGMFDQKSSGYERRAFLQAILEHEEQDEVGKLFVVLGTKDMFHIYKN
ENST00000265773         AKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEE------------------
CG5942-RC               ARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEE------------------
                        *:****:*:************:. **: ***:**.:::::*                   

ENST00000270503         PPPAGVNPDLEEPPLK-EEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRK
SINFRUP00000139269      LP-------MCVCCIQ-EEDEVPDDETVNQMIARSEEEFDQFMRMDLDRRREEARNPRRK
SINFRUP00000127987      ISNFIVNGCLLSGIIQQEEDEVPDDETVNQMIARSEEEFEQFMRMDLDRRREEARNPKRK
ENST00000265773         ------------------EDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRK
CG5942-RC               -----------------EENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGR
                             :   :    :   *:****** :* **** ***:: * *** :*::*: .    :

ENST00000270503         PRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEE
SINFRUP00000139269      PRLMEEDELPTWIMKDDAEVERLTCEEEEEKMFGRGSRQRKEVDYSDSLTEKQWLKAIEE
SINFRUP00000127987      PRLMEEDDLPSWILKDDAEVERLTCEEEEEKMFGRGSRQRKEVDYSDSLTEKQWLKAIEE
ENST00000265773         PRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIED
CG5942-RC               ERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDD
                         **::*.:** *: *** ****:  : :*:.::*****:*::***:*:****:**:**::

ENST00000270503         GTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSR---DKDDESKKQKKRGRPPAEKL
SINFRUP00000139269      GTLEEVEEEVRHKKTTRKRRRDRDLDLPGPSSSLGGRGRGDRDDDGKRQRKRGRPPVEKL
SINFRUP00000127987      GNLEDIEEEVRHKKTSRKRKRDRDHDGGPATPSSSSSRVREKDEEGKKTKKRGRPPAEKL
ENST00000265773         GNLEEMEEEVRLKKRKRRRNVDKDP---------------AKEDVEKAKKRRGRPPAEKL
CG5942-RC               GAEFDEEEEEDDSKRKRRKRKNRKE---------------ESDDDSLILKRRRRQNLDKR
                        *   : ***   .* .*::. : .                  ::     ::* *   :* 

ENST00000270503         SPNPPNLTKKMKKIVDAVIKYKDS-----------------SSGRQLSEVFIQLPSRKEL
SINFRUP00000139269      SPNPPSLTKKMKKIVDAVIKYKDS-----------------ASGRQLSEVFIQLPSRKEL
SINFRUP00000127987      SPNPLSLTKKMKKIIDAVIKYKD------------------GNGRQLSEVFIQLPSRKEL
ENST00000265773         SPNPPKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGNSSGRQLSEVFIQLPSRKEL
CG5942-RC               S------KKQMHKIMSAVIKHNQD-------------------GRTLSEPFMKLPSRQRL
                        *     :.*:*: *:.:**::::                    ** *** *::****:.*

ENST00000270503         PEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQ
SINFRUP00000139269      PEYYELIRKPVDFRKIKERIRGHRYRSLGDLERDVMLLFQNAQTFNLEGSLIYEDSIVLQ
SINFRUP00000127987      PEYYELIRKPVDFRKIKERIRSHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQ
ENST00000265773         PEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQ
CG5942-RC               PDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQ
                        *:***:*::***::** :**.. :* .*.:**:*.* * :*** :* *.* ** ***.**

ENST00000270503         SVFTSVRQKIEKEDDSEGEES-----------------------EEEEEGEEEGSESESR
SINFRUP00000139269      SVFTSLRQKIDSDDISIVMLR-----------------------SSFDS-------APAR
SINFRUP00000127987      SVFTSVRQKIE-ENESEGDES-----------------------EEEEEDVDEGSESESR
ENST00000265773         SVFKSARQKIAKEEESEDESN-----------------------EEEEEEDEEESESEAK
CG5942-RC               KVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAA
                        .** . **:*     :                             .  .       : : 

ENST00000270503         SVKVKIKLGRK-EKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED--
SINFRUP00000139269      SVKVKIRLGRK-DKGSDRGKARSRRTGR-SRAKPVVSDDDSEDEQEE------------
SINFRUP00000127987      SVKVKIKLSRK-EKG-ERGSKVHRRRGRGARAKPVVSDDDTEEDQEEVR----------
ENST00000265773         SVKVKIKLNKKDDKGRDKGKG-KKRPNR-GKAKPVVSDFDSDEEQDEREQSEGSGTDDE
CG5942-RC               AVKMKLKLNKSLASAPATPTQSSSNVSS-GAATTSKKQTRRKRSQKKYTISDDDDDDMD
                        :**:*::*.:.  ..    .    . .  . *..  .:   . .*.: