CLUSTAL W (1.82) multiple sequence alignment ENST00000222584 MSDQKKEEEEEAAAAAAMATEGGKT---------------SEPENNNKKP ENSMUST00000026367 -------------------------------------------------- SINFRUP00000161029 -------------------------------------------------- ENSMUST00000050182 MSDQDHSMDEVTAVVKIEKDVGGNNGGSGNGGGAAFSQTRSSSTGSSSSS ENSMUST00000028518 -------------------------------------------------- SINFRUP00000149501 -------------------------------------------------- Q90WU2_Fundulus_heteroclitus -------------------------------------------------- SINFRUP00000149404 -------------------------------------------------- CG5669-RA ---MLQYKSAASAATSAPPATPLAAGGSSKATIPPNGASAAASQTQVHGA ENST00000222584 KTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQN ENSMUST00000026367 ------DSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQN SINFRUP00000161029 ---------------------------------QAQIVVDTAGGQALV-- ENSMUST00000050182 GGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTG------- ENSMUST00000028518 ----------------ALDVDGGGGGGGHGEYLQQQQQQQQQHGNGAAAA SINFRUP00000149501 -------------------------------------------------- Q90WU2_Fundulus_heteroclitus -------------------------------------------------- SINFRUP00000149404 -------------------------------------------------- CG5669-RA PGTPTMQQIINIHQMPPQFAGGAVAGNGQNAGMPQNMFQIVQPMPMQTVN ENST00000222584 QPQQLELVTTQLAG--NAWQLVASTPPASKENNVSQPASSSSSSSSSNNG ENSMUST00000026367 QPQQLELVTTQLAG--NAWQLVASTPPASKENNVSQPASSSSSSSSSNNG SINFRUP00000161029 -PQQLELVPAQFTG--NGWQIITTAPTMAKET-SNQPVAVTVATTLAND- ENSMUST00000050182 ---ELDLTAAQLSQGANGWQIISSS-SGATPTSKEQSGNSTNGSESSKNR ENSMUST00000028518 AAQTGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIP--GAATSSGQ SINFRUP00000149501 --------STQLTGT-DRWEVL--TPTSEKDESG-MIQIQSQGIFTSNGQ Q90WU2_Fundulus_heteroclitus ----TDMSAIRLTGS-DRWEVL--TPVSSTKEDQGVIHIPNSGIVTSNGQ SINFRUP00000149404 ---TTDMSAIQMTGS-DRWEVV--TPVSAGKEDHGVVHVPNSGIVTSNGQ CG5669-RA IDGQEAIFIPNLNAQLATAQAVNFNGQQAFITPNGQILRAPQMAANPAAS : .: : : . ENST00000222584 SASPTKTKSGNSSTPGQFQVIQVQNP--SGS-VQYQVIPQLQTVEGQQIQ ENSMUST00000026367 SSSPTKTKSGNPSTPNQFQVIQVQNP--SGS-VQYQVIPQLQTVEGQPIQ SINFRUP00000161029 -SSPGGTNS-SPATQQQFQIIQVQNLPSAGSGVQYQVIPHLQTADGQQIH ENSMUST00000050182 TVSGGQYVVAATPNLQNQQVLTGLPG--VMPNIQYQVIPQFQTVDGQQLQ ENSMUST00000028518 YVLPLQNLQNQQIFSVAPGSDSSNGT---VSNVQYQVIPQIQSTDAQQVQ SINFRUP00000149501 YVLPLQNLQSQSVFVTSGTDTSSATS---VPNIQYQVIPQIQTADGQLSF Q90WU2_Fundulus_heteroclitus YVLPIGSLPSQPIYVIASGNEATANG---VSGIQYQVIPQIHNADGTLAG SINFRUP00000149404 YVLPIGSLPSQPVYVTAAGNEVTANG---VSGIQYQVIPQIQNPDGTLAG CG5669-RA NCIQLQQLNGLGQEQTQLITIPGTNIQIPVTNLIQQQQQAQQVHQGTVQQ . : * : :. ENST00000222584 INPTSSSSLQ-----DLQGQIQLISAGNNQAILTAANRTASGNILAQNLA ENSMUST00000026367 INPTSSSSLH-----DSQGQIQLISA------------------------ SINFRUP00000161029 ISPAQTAPIG-----ALPEQVQLIQTQS-PSQTQAILQPANQQAILTSSA ENSMUST00000050182 FAATGAQVQQ-----DGSGQIQIIPGAN---------QQIIPNRGSGGNI ENSMUST00000028518 IGFTGSSDNGG-INQENS-QIQIIPGSN-----------QTLLASGTP-P SINFRUP00000149501 S--TSNMEGAG-LAQDATGQIHILPDGS-----------QTLNVSSAANI Q90WU2_Fundulus_heteroclitus FS-TQGLDGG-------TGQVHLLQDGS-----------QSNMGISCS-T SINFRUP00000149404 FS-AQGLDDG-------TGHIQLLQDGS-----------QGNIGISCA-T CG5669-RA QAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANGLLGN : ENST00000222584 NQTVPVQIRPGVSIPLQLQTLPGT--------------QAQVVTTLPINI ENSMUST00000026367 ---VPLQIRPGVSIPLQLQTLPGT--------------QAQVVTTLPINI SINFRUP00000161029 NQTVPLQIRPAQSFPLQLQTLQGS--------------QAPVMTTVPINI ENSMUST00000050182 IAAMPNLLQQAVPLQGLANNVLSG--------------QTQYVTNVPVAL ENSMUST00000028518 ANIQNLIPQTGQVQ-VQGVAIGGSS----------FPGQTQVVANVPLGL SINFRUP00000149501 LNNQNLISQTGNVQQIQGVSIGSST----------FNNQGQVVTNVPVGL Q90WU2_Fundulus_heteroclitus TAATDLLTQAGQVQSIQGVSLAGG---------------SVYASTV--GL SINFRUP00000149404 TGATDLLTQAGQVPSIQGLPLAGG---------------SAYTGTVPVGL CG5669-RA ISNISNLLGGGQSIKLENGQLQMRPQLVQFPAPAMPQQQQTVAVQIPVQT . : : : ENST00000222584 GG-----VTLALPVINNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTN ENSMUST00000026367 GG-----VTLALPVINNVTAGGGTGQVGQPTTTTDSGTSNGNQLVSTPTT SINFRUP00000161029 GG-----MTLALPVINNVG-GAGAVQLIQAADGTLS-VANGNQLVTTAVP ENSMUST00000050182 NG-----NITLLPVN-SVS-AATLTPSSQAGTISSSGSQESSSQPVTSGT ENSMUST00000028518 PG-----NITFVPIN-SVDLDSLGLSGS-SQTMTAGINADGHLINTGQAM SINFRUP00000149501 PG-----NITFVPIN-SVDLDSLGLSG--AQTIATGVTADGQLIMANQPV Q90WU2_Fundulus_heteroclitus PG-----NITFVPIN-SVDLESLGLTGAQTVPIATGVTPEGQLIMSGQPL SINFRUP00000149404 PS-----NITFVPIN-SLDLESLGLTGAQTVPIATGVTAEGQLIMSGQAL CG5669-RA ANGQTIYQTVHVPVQAAATSSGGLQNLMQAQSLQMPSASQMQIIPQFSQI . :*: . . : ENST00000222584 TTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSE ENSMUST00000026367 STAPASTMPESPSSSTTCTTTASTTLTSSDTLVSSADTGQYASTSASSSE SINFRUP00000161029 GPAPG------TASSGSTAVADGDSASDGTQMVSVGTEGAQADAQVQSSE ENSMUST00000050182 AISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQG ENSMUST00000028518 DSSDNSERTGERVSPDVN-ETNADTDLFVP-TSSS----SQLPVTIDSTG SINFRUP00000149501 DGSQNLVKTDNHLSQTLPVNANANREIYVP-TSSSQ---SQLHIPVSESA Q90WU2_Fundulus_heteroclitus E-SQSQDGGSKQSLVTVS-DAGGNQEMYVPTTSSSSSNASQLPATIDGTG SINFRUP00000149404 E-SQGQDASAKQHLVTVS-NASNNPELYVPTTTSSN---TSLPETIDGTG CG5669-RA AQIVTPNGQIQQVQLAMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQ . ENST00000222584 RTIEESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQI-----VGQ ENSMUST00000026367 RTIEEPQTPAATESEAQSSSQLQSNGIQNAQDQSNSLQQVQI-----VGQ SINFRUP00000161029 ---------------ADSQTQNQANGLQSQTDATGTVQQVIVGQ---VGH ENSMUST00000050182 QTPQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQ-------- ENSMUST00000028518 ILQQNTNSLTTTSGQVHSS-DLQGNYIQSPVSEETQAQNIQVS----TAQ SINFRUP00000149501 LLTQDTSLSSVTTAQTNSSSGLQDGFIQ-----ENQDQNIQVS----SAQ Q90WU2_Fundulus_heteroclitus VLTQATAVSAGVSDPPSTENFNSHNHLQ--------QMQVSSS----SAT SINFRUP00000149404 VLTQATAVSAGVSDPSSSANFNSHNHLQ--------QIQVSSA----NAT CG5669-RA AQQQQQAQQQQAQQQQQQQVQAQHQQLLQAISDASAGGQLPPNQPITITN . : : ENST00000222584 PILQQIQIQQPQQQIIQAIPPQSFQLQSGQ--TIQTIQQQPLQNVQ-LQA ENSMUST00000026367 PILQQIQIQQPQQQIIQAIPPQSFQLQSGQ--TIQTIQQQPLQNVQ-LQA SINFRUP00000161029 QFVQQIQLQ-PQAQ----SPGQVQGQQQPQ--HIQTLQLAPGQTLQPIQA ENSMUST00000050182 --QQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQ-LQA ENSMUST00000028518 PVVQHLQLQDSQQPTSQAQIVQGITPQTIHG-VQASGQNISQQALQNLQL SINFRUP00000149501 PIIQ---LQQVPIQTTNGQVIQSVTPG--------------GQGLQNVQL Q90WU2_Fundulus_heteroclitus TISQPILQLSGDGQ---AQVAQGQDLSG------------AGQTMQSVQL SINFRUP00000149404 TISQPILQLSGDSQAQVAQVAQGQDLNAA-----------AGQTLQSVQL CG5669-RA AQGQQLTVIPAQLRPNAPTAPTPAPAGVPTPMQMPNLQALPIQNIPGLGQ * : * : : ENST00000222584 V-------------N-PTQVLIRAPTLTPSGQISWQTVQVQNIQSLSN-L ENSMUST00000026367 V-------------N-PTQVLIRAPTLTPSGQISWQTVQVQNIQSLSN-L SINFRUP00000161029 F-------------QNPAQVLIRTPTLSPSGQLTWQTLQLP--SSVSL-Q ENSMUST00000050182 V-------------QNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQA ENSMUST00000028518 Q-------------LNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQ SINFRUP00000149501 --------------INPGTFIIQAQTVTPSGQIQWQTFQVQGVQNLQNLQ Q90WU2_Fundulus_heteroclitus --------------VNPGTFLIQAQTVTATGQIQWQTFQVQGVQSLQGLQ SINFRUP00000149404 --------------VNPGTFLIQAQTVTATGQIQWQTFQVQGVQSLQGLQ CG5669-RA VQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQSPTQ .: : . * *. : . . ENST00000222584 QVQNAGLSQQLTITPVSSSGGTTLAQIAP--------------------- ENSMUST00000026367 QVQNAGLSQQLTITPVSSSGGTTLAQIAP--------------------- SINFRUP00000161029 SGLGAAVPQQLTLAPVA--GGTPMGGGGL--------------------- ENSMUST00000050182 QTITLAPMQGVSLGQTSSSNTTLTPIASA--------------------- ENSMUST00000028518 IQN--TAAQQITLTPVQT-----LTLGQV--------------------- SINFRUP00000149501 LPT--TPHQQITLAPVQT-----LSLG----------------------- Q90WU2_Fundulus_heteroclitus LPQGQGQAQQLTLAPVQT-----LPLG----------------------- SINFRUP00000149404 LPQGQGQTQQLTLAPVQT-----LPLG----------------------- CG5669-RA MITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQQIKFLHTESNSLS :: ENST00000222584 --------------VAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQV ENSMUST00000026367 --------------VAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQV SINFRUP00000161029 --------------VSLSGAPLTLSAAQINPGSGVQTVSIAGLGAAGVQV ENSMUST00000050182 --------------ASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQV ENSMUST00000028518 --------------AAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQL SINFRUP00000149501 ---------------------STPVSIGTGQIPNLQTVTVN-----SVAL Q90WU2_Fundulus_heteroclitus -------------------------QAGQVSLPNLQTVTVNSVTQTGVQY SINFRUP00000149404 -------------------------QTGQVSLPNLQTVTVNSVSQ-GVQY CG5669-RA SLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQI . .: : . ENST00000222584 QGVP---VTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSP ENSMUST00000026367 QGVP---VTITSVAG-------------------------------AVSP SINFRUP00000161029 QGVP---LTITGIQGQPQGQDGVKVQSS---PVTVAVG-------NVASG ENSMUST00000050182 HQLPGLPLAIANTPGDHGTQLG----------------------LHGSGG ENSMUST00000028518 HPGENADSPADIRIKEEEPDPEEWQLSG-----------------DSTLN SINFRUP00000149501 NEGE-ADTLGDIQIKEE-PD---WQLST-----------------DSTLN Q90WU2_Fundulus_heteroclitus AQGEEARSPSGIQIKEE-PDSEEWQLSG-----------------DSTLN SINFRUP00000149404 THGEDAKSPTGIHIKEE-PDSEEWQLSG-----------------DSTLN CG5669-RA TIAPTGGQVVSVTTQARGATASIRSTNTSTTTITTPSQ------SHLNMN : ENST00000222584 DQLTQVHLQ-QGQQTSDQEVQPGKRLRRVACSCPNCREGEGRGSNEPGKK ENSMUST00000026367 DQLTQVHLQ-QGQQTSDAEVQPGKRLRRVACSCPNCREGEGRGSSEPGKK SINFRUP00000161029 SSMSPEQLG-SVQSSSEQDGPPNKRLRRVACSCPNCRDGEGRNSGDPTKK ENSMUST00000050182 DGIHDETAGGEGENSSDLQPQAGRRTRREACTCPYCKDSEGRASGDPGKK ENSMUST00000028518 TNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTN-LGKK SINFRUP00000149501 TSDLSHLRGRLVDED-DQIGQEGKRLRRVACTCPNCKESGGRGSS-TGKK Q90WU2_Fundulus_heteroclitus PSDLSNLRGPMGDEDMEAAGGDGKRLRRVACTCPNCKESGGRGSG-VGKK SINFRUP00000149404 PSDLNNLN-MMGDGDMEMQS-EGKRLRRVACTCPNCKESGGRGSG-MGKK CG5669-RA ISVASVGGAATGGGGGTATGEPKPRLKRVACTCPNCTDGE----KHSDKK * :* **:** * :. ** ENST00000222584 KQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDEL ENSMUST00000026367 KQHVCHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDEL SINFRUP00000161029 KQHICHMEGCGKVYGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDEL ENSMUST00000050182 KQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDEL ENSMUST00000028518 KQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDEL SINFRUP00000149501 KQHICHIAGCGKVYGKTSHLRAHLRWHSGERPFVCSWMLCGKRFTRSDEL Q90WU2_Fundulus_heteroclitus KQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDEL SINFRUP00000149404 KQHICHIAGCGKVYGKTSHLRAHLRWHSGERPFVCNWMFCGKRFTRSDEL CG5669-RA RQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDEL :**:**: ** ****************:*****:*.* *********** ENST00000222584 QRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQN------------- ENSMUST00000026367 QRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQN------------- SINFRUP00000161029 QRHRRTHTGEKRFECPECSKRFMRSDHLSKHIKTHQN------------- ENSMUST00000050182 QRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQN------------- ENSMUST00000028518 QRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQN------------- SINFRUP00000149501 QRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQN------------- Q90WU2_Fundulus_heteroclitus QRHRRTHTGEKKFVCSECSKRFMRSDHLAKHIKTHQN------------- SINFRUP00000149404 QRHRRTHTGEKKFVCMECSKRFMRSDHLAKHIKTHQN------------- CG5669-RA QRHRRTHTGEKRFQCQECNKKFMRSDHLSKHIKTHFKSRSGVELIELSIK ***:*******:* * ** *:*******:**:*** : ENST00000222584 --KKGGGTALAIVTS-----------------GELDS------SVTEVLG ENSMUST00000026367 --KKGGGTALAIVTS-----------------GELDS------SVTEVLG SINFRUP00000161029 --KKGG-AALAIITT-----------------EDMEE------DAPEGLG ENSMUST00000050182 --KKGGPGVALSVGT-----------------LPLDSGAGSEGTATPSAL ENSMUST00000028518 --KKVIHSSSTVLASV-------------EAG---------RDDALITAG SINFRUP00000149501 --KKGMNSGGSVVASM-------------ESTG-------SSDSIIATAG Q90WU2_Fundulus_heteroclitus --KKGGGPPSTSPP---------------------------TTDAVITAD SINFRUP00000149404 --KKG--IPVTSPP---------------------------TADAVITSD CG5669-RA QETKGGNAPKSISTVNGIVTIEIPGGGSAAAGSGASSVAATVAGSTVTPG .* ENST00000222584 -SPRIVTVAAISQDS------------NPATPNVSTNMEEF--------- ENSMUST00000026367 -SPRIVTVAAISQDS------------NPATPNVSTN------------- SINFRUP00000161029 TSPHIVAVATLSRDS------------DPATPTTSNHLEE---------- ENSMUST00000050182 ITTNMVAMEAICPEG------------IARLANSGINVMQVTELQSINIS ENSMUST00000028518 GTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVT-VSGNETM SINFRUP00000149501 GTTLILTNIQQGSSN-----------AQDILANAEIPLQLVTTVAASEVM Q90WU2_Fundulus_heteroclitus GTTLILQTAT----------------AHDLVANQEIPLQLVT-VAPGEVL SINFRUP00000149404 GTTLILQTTG----------------GHDHVGNQEIPLQLVT-VAPSEVM CG5669-RA GATIVQLPTVEASGGGDSFGDDEDDEEDDELTEEDDEDEELDEDDMDDCE :. : ENST00000222584 ------------------------------- ENSMUST00000026367 ------------------------------- SINFRUP00000161029 ------------------------------- ENSMUST00000050182 GNGF--------------------------- ENSMUST00000028518 E------------------------------ SINFRUP00000149501 E------------------------------ Q90WU2_Fundulus_heteroclitus E------------------------------ SINFRUP00000149404 E------------------------------ CG5669-RA DEEDDEDPELDSGDEVKMTIAVSEPGDNSSN