CLUSTAL W (1.82) multiple sequence alignment ENST00000201886 PCGARPCSRVEPPPPPPPPQLQPPRQARPRRAMSDYSTGGPPPGPPPPAGGGGGAGGAGG ENSMUST00000057643 ------------------------------------------------------------ SINFRUP00000137517 ------------------------------------------------------------ ENSMUST00000039254 ------------------------------------------------------------ ENST00000302073 ------------------------------------------------------------ SINFRUP00000143074 ------------------------------------------------------------ ENST00000294623 ------------------------------------------------------------ ENSMUST00000029668 ------------------------------------------------------------ ci0100137634 ------------------------------------------------------------ CG8912-RB ------------------------------------------------------------ ENST00000201886 GPPPGPPGAGDRGGGGPGGGGPGGGSAGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKI ENSMUST00000057643 -----------------------------PSQLPGGCGPGICK----DAMQPTRQIAVKI SINFRUP00000137517 ------------------------------------------------------------ ENSMUST00000039254 ------GPGAEWEAGPGEPSDGGGGGLGYGGAGAGAERSGGHEGGFVDALHRVRQIAAKI ENST00000302073 ------------------------------------------------------------ SINFRUP00000143074 ------------------------------------------------------------ ENST00000294623 --------MADYSTVPPPSSGSAGGGGGGGGG-------GGVNDAFKDALQRARQIAAKI ENSMUST00000029668 --------MADYSTVPPPSSGSAGGGGGG-----------VVNDAFKDALQRARQIAAKI ci0100137634 ------------------------------------------------------------ CG8912-RB MSDFQQQGINQSQALAQAIQRAKQIAAKIQPSQQGGGTAGPSPPSSGGGPGFKRINDDGD ENST00000201886 GGDAATTVNNSTPDFGFGGQKRQLEDGDQPESKKLASQGDSISS----QLGPIHPPP-RT ENSMUST00000057643 GGGAATTN------FGLGGQKRQLEDGDQTDSKKLSSQGDSTGS----QLGPIHPP--RT SINFRUP00000137517 ------------------------------------------------------------ ENSMUST00000039254 D--SIP---------HLNNSTPLVDPSVYGYGVQKRALDDGVGN----QLGALVHQR--A ENST00000302073 -----------------------MPP---------------IGN----QLGALVHQR--T SINFRUP00000143074 ------------------------------------------------------------ ENST00000294623 G--GDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGT----QLPPMHQQQ-RS ENSMUST00000029668 G--GDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVPPQNDSFGA----QLPPMHQQQSRS ci0100137634 --------------MGDAPNKRPLEDGEEPGPKKLATPQTSAANSEQIEFDNLGMQQNPD CG8912-RB SGPESKRSLGSPEYANNSSNMSSGSGGGGGGGGGPGGASITQAIAQAAAVAARLAASAGT ENST00000201886 SMTEEYRVPDGMVGLIIGRGG-EQINKIQQDSGCKVQISPDSGGLPERSVSLTGAPESVQ ENSMUST00000057643 SMTEEYRGPDHMVGLIIGRDG-EQINK-QQDSSCEVQISPDSGGLPERSMSLTGAPESVQ SINFRUP00000137517 ----------------------------------------DTAGLPERRVSLTGPPDAIQ ENSMUST00000039254 VITEEFKVPDKMVGFIIGRGG-EQISRIQAESGCKIQIASESSGIPERPCVLTGTPESIE ENST00000302073 VITEEFKVPDKMVGFIIGRGG-EQISRIQAESGCKIQIASESSGIPERPCVLTGTPESIE SINFRUP00000143074 -------------------------------------VFSDSGGLMERPCSLTGTPESIE ENST00000294623 VMTEEYKVPDGMVGFIIGRGG-EQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQ ENSMUST00000029668 VMTEEYKVPDGMVGFIIGRGG-EQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQ ci0100137634 IMSDTIRLPDDLVGLIIGRGG-ENIMRMQRETGCRIQITQSIPGTKERPCTLSGTQEQIE CG8912-RB SCEEQIRLPESVAGAFMGRSSNDTITHIQAESGVKVQVMQD----QDRVIMLRGQRDTVT . :* * * : : ENST00000201886 KAKMMLDDIVSRGRG---GPPGQFHDNANGGQ----NGTVQEIMIPAGKAGLVIGKGGET ENSMUST00000057643 KAKMM-DDIVSQGHD---PPPGQFHDNTNGG-----NGTVQEIMIPAGKAGLVIGKGGET SINFRUP00000137517 RAKALIDDIVSRGHE---SPNGQ-------------PGSMHEMIIPAGKAGLIIGRGGET ENSMUST00000039254 QAKRLLGQIVDRCRN---GPGFHNDMDG--------NSTIQELLIPASKVGLVIGKGGET ENST00000302073 QAKRLLGQIVDRCRN---GPGFHNDIDS--------NSTIQEILIPASKVGLVIGRGGET SINFRUP00000143074 HAKRLLVQIVDRCRN---GPGFHGDGEG--------GASVQEMLIPASKVGLVIGRGGDT ENST00000294623 SAKRLLDQIVEKGRP---APGFHHGDGP--------GNAVQEIMIPASKAGLVIGKGGET ENSMUST00000029668 SAKRLLDQIVEKGRP---APGFHHGDGP--------GNAVQEIMIPASKAGLVIGKGGET ci0100137634 VCRNMLNEIISRSQAGTLGSNFNLSQGGLGGMGDGGMEKSIEIAVPPDKCGLIIGKGGET CG8912-RB KGREMIQNMANRAGGGQVEVLLTINMPPPGPS---GYPPYQEIMIPGAKVGLVIGKGGDT : :: :: .: *: :* * **:**:**:* ENST00000201886 IKQLQERAGVKMILIQDGSQNTNVDKPLRIIGDPYKVQQ---------------ACEMVM ENSMUST00000057643 IKQLQERAGVKMILIQNGSQNTNVDKPLRIIGDPK--QQ---------------ACEMVM SINFRUP00000137517 IKQLQERAGVKMILIQDGSQPPNIDKPLRIIGDPYKVQQ---------------AKEMVN ENSMUST00000039254 IKQLQERTGVKMVMIQDGPLPTGADKPLRITGDPFKVQQ---------------AREMVL ENST00000302073 IKQLQERTGVKMVMIQDGPLPTGADKPLRITGDAFKVQQ---------------AREMVL SINFRUP00000143074 IKQLQERAGVKMMMIQDGPMPTGADKPLRISGDPYKVQRSEVTPPFLLLFFLQAARELVL ENST00000294623 IKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQ---------------AKEMVL ENSMUST00000029668 IKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQ---------------AKEMVL ci0100137634 IKMLQQSLGVKMLLIQDSTDNIGQSKPLRITGPQLNVDV---------------CVCILM CG8912-RB IKQLQEKTGAKMIIIQDGP-NQELIKPLRISGEAQKIEH---------------AKQMVL ** **: *.**::**:.. ***** * :: . :: ENST00000201886 DILRERDQGGFGD-RNEYGSRIGGGI---------------DVPVPRHSVGVVIGRSGEM ENSMUST00000057643 DILQERDQGGFGD-LNEYGSGVGGGI---------------DAPVPRHSVGVVIGRSGEM SINFRUP00000137517 EILRERDHAGFGE-RTEYGSRMGGG------------------AVPRHSVGVVIGRNGEM ENSMUST00000039254 EIIREKDQADFRGVRSDFTSRAGGGS--------------IEVSVPRFVVGIVIGRNGEM ENST00000302073 EIIREKDQADFRGVRGDFNSRMGGGS--------------IEVSVPRFAVGIVIGRNGEM SINFRUP00000143074 EVIRDKD-GDFRSGRTDFGARLGGSN--------------IDVPVPRFAVGIVIGRNGEM ENST00000294623 ELIRDQG--GFREVRNEYGSRIGGNEG-------------IDVPIPRFAVGIVIGRNGEM ENSMUST00000029668 ELIRDQG--GFREVRNEYGSRIGGNEG-------------IDVPIPRFAVGIVIGRNGEM ci0100137634 DLVSSFP---FIQ-PNMFGDDVNKTI----------------IPVPKAAVGVVIGKGGDM CG8912-RB DLIAQKDAQGQQQGGRGGGGGGGGPGMGFNNFNNGNGGESTEVFVPKIAVGVVIGKGGDM ::: . . :*: **:***:.*:* ENST00000201886 IKKIQNDAGVRIQFKQ-DDGTGPEKIAHIMGPPDRCEHAARIINDLLQS---LRSGPPGP ENSMUST00000057643 IKKIQND---RIQFEQ-DDGTGPKKIAPIMGPPNRCKPAARIINDLLQSL--LRSGPLGP SINFRUP00000137517 IKKIQSDAGVKIQFKP-DDGTGPEKMALIMGPPDRCEHAASIITDLLQSVRAREEGGQGP ENSMUST00000039254 IKKIQNDAGVRIQFKP-DDGISPERAAQVMGPPDRCQHAARIINELILTA---------Q ENST00000302073 IKKIQNDAGVRIQFKP-DDGISP------------------------------------- SINFRUP00000143074 IKKIQNDAGVRIQFKA-DDGISPERVAMVMGQPDRCQHAVHLINELIQTA---------Q ENST00000294623 IKKIQNDAGVRIQFKP-DDGTTPERIAQITGPPDRCQHAAEIITDLLRSV---------Q ENSMUST00000029668 IKKIQNDAGVRIQFKP-DDGTTPDRIAQITGPPDRCQHAAEIITDLLRSV---------Q ci0100137634 INQIQNVTGTRVQFKP-EDPTLPERMCSVMGPKEGVDAAIRRIHEIIQNVQ--ERNRGGS CG8912-RB IRKIQTECGCKLQFIQGKNDEMGDRRCVIQGTRQQVDDAKRTIDGLIENVMQRNGMNRNG *.:**. ::** .: : : :: ENST00000201886 PGG-PGMPPGGRGRGRGQGNWGP----------PGGEMTFSIPTHKCGLVIGRG-GENVK ENSMUST00000057643 PEV-PGMLPGGRGRGGGQGNWATESS-------PGREMTFSIPPLKCGLVIGRD-RENVK SINFRUP00000137517 PGAGPGMPSGGQGHGRGQGSWGG-------------EMAFSVPAHKCGLVIGRG-GENVK ENSMUST00000039254 EREILGGLTVTRGRGRGRSDWSVGTPG------GVQEITYTVPADKCGLVIGKG-GENIK ENST00000302073 ------------------------------------------------------------ SINFRUP00000143074 ERDGFSS-ALRGGRVRGRGDWTVGSPG------PLQEVTYTISADKCGLVIGKG-GETIK ENST00000294623 AGNPGGPGPGGRGRGRGQGNWNMGPPG------GLQEFNFIVPTGKTGLIIGKGRGETIK ENSMUST00000029668 AGNPGGPGPGGRGRGRGQGNWNMGPPG------GLQEFNFIVPTGKTGLIIGKGRGETIK ci0100137634 GGGGGGSGGGHPGGMGGFGQWEGPNMGRGGRGMGMASEEHLVPANKTGLVIGKG-GDTIK CG8912-RB NGGGGGPGGDSGNSNYGYGYGVNHAQG------GREEITFLVPASKCGIVIGRG-GETIK : ::: : ENST00000201886 AINQQTGAFVEISRQLPPNGDPNFKLFIIRGSPQQIDHAKQLIEEKIEGP---------- ENSMUST00000057643 AINQQTGTFVEISRQLQPNRDPNFKLFAIQ-SPQQTDHAKQLIEEKIEGP---------- SINFRUP00000137517 SINQQTGAFVKMTHQPPPNGDPNFKLFTIRGTPQQIDHAKQLIEEKIEAP---------- ENSMUST00000039254 SINQQSGAHVELQRNPPPNTDPNLRIFTIRGAPQQMEVARHLIDEKVGGAS--------L ENST00000302073 ------------------------------------------------------------ SINFRUP00000143074 SINQQSGAHVELQRNPPPSTDHNTRVFTIRG----------------------------- ENST00000294623 SISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGGPVNPLGPPVPH ENSMUST00000029668 SISQQSGARIELQRSPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGGPVNPLGPPVPH ci0100137634 QINMQSGAHAEIQRNPPPGSDLNYKTFIIKGTPEQIKMARQLIQEKVDAGP--------- CG8912-RB LINQQSGAHTEMDRN--ASNPPNEKLFKSKGTTDQVEAARQMISEKINMELNVISRKPIG : : : :: : ENST00000201886 ----LCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAG---------------GPPP ENSMUST00000057643 ----LCPVGPGPGGPGPARPMGPFNPGPFNQ----VHPHAG---------------GPP- SINFRUP00000137517 ----LCPVG---GGPGPGGPMGPYNPNPYNPGPPDGAPYGA---------------APGA ENSMUST00000039254 GAPAAFGQSPFSQPPAAPHQKGVWGSVPPAITKDSSVTHS------------------GP ENST00000302073 ------------------------------------------------------------ SINFRUP00000143074 ------------------------------------------------------------ ENST00000294623 GPHGVPGPHGPPGPPGPGTPMGPYNPAPYNPGPPGPAPHG------------------PP ENSMUST00000029668 GPHGVPGPHGPPGPPGPGTPMGPYNPAPYNPGPPGPAPHG------------------PP ci0100137634 --GGSSNGQMHGGHMGGQPPMSNFGPPPHQQGGYGGLPPAAGYGHPSHNPLQGPPQAPQA CG8912-RB GGPGGGGGNSGGGQNNSHHNQQQGGYGGQNQMQGGDPNSGAG-----------YQQQPWG ENST00000201886 HQYPPQGWGNTYPQWQPPAPHDPSKAAAAAADPNAAWAAYYSHYY-QQPPGPVPGPAPAP ENSMUST00000057643 HQYLPQRWGNTYPQWQPPAPHDPNKAAAEATDPNAT--SYVSHYY-QQPPGPVPGPDPAP SINFRUP00000137517 PQYYPQGWGENYQQWQDPGSQVPNKAAA---DQNAAWEAYYAQYYGQQQEGAMAAQAPG- ENSMUST00000039254 PAFLTQGWGSTYQAWQQPTQQVPSQQ---------------------------------- ENST00000302073 ------------------------------------------------------------ SINFRUP00000143074 ------------------------------------------------------------ ENST00000294623 APYAPQGWGNAYPHWQQQAPPDPAKAGTDPNSAAWAAYYAHYYQQQAQPPPAAPAGAPTT ENSMUST00000029668 APYAPQGWGNAYPHWQQQAPPDPAKAGADPNSAAWAAYYAHYYQQQAQPPPAAPAGAPAT ci0100137634 PQSYQQPWGNQFQQWNSPTVSAPQQNGADPTKPVADSSNAAAWQTYLQMYG---AQAQAY CG8912-RB GPYGQQGWDPSGQQQQMAMANQGGSAAGGASGGQDYSAQWIEYYKQMGCHREAEMIEQQM ENST00000201886 AAPPAQGEPPQPP-----------------PTGQSDYTKAWEEYYKKIGQQPQ-----QP ENSMUST00000057643 AAPPAQGEPQRPPPCL------------PPPIGQSDYTKAWEEYYT-------------- SINFRUP00000137517 AAAPAPGHQSQAG---------------QTTGGQPDYTKAWEEYYKKMGINQC-----MY ENSMUST00000039254 ----------SQP-----------------QNSQPDYSKAWEDYYKKQ------------ ENST00000302073 ------------------------------------------------------------ SINFRUP00000143074 ------------------------------------------------------------ ENST00000294623 TQTNGQGDQQNPA-----------------PAGQVDYTKAWEEYYKKMG----------- ENSMUST00000029668 TQTNGQGDQQAPA-----------------PAGQVDYTKAWEEYYKKMG----------- ci0100137634 QQPAAAAAVSAAP------------------ASQPDYSKQWDEYLKQNAAAVAEQRQQLT CG8912-RB KAKQAGGSSGPVQQQQPQQQQQSQQQTGGAGAGGADYSAQWAEYYRSVGKIEEAEAIEKT ENST00000201886 G-----------APPQQDYTKAWEEYYKKQAQVATGGGPGAPPGS-QPDYSAAWAEYYRQ ENSMUST00000057643 ------------APPQHDYTKAWKEYRSKHRWSLVGG-SWSTPGS-QPDYSASWAEYYKQ SINFRUP00000137517 P-----------TSGFKLFVPSAQPAGGSAAASVSAVSTAGTAAAGQQDYSAAWAEYYRQ ENSMUST00000039254 ----------------------------------SHPTSAAPQASSPPDYTMAWAEYYRQ ENST00000302073 -------------------------------------------------------EYYRQ SINFRUP00000143074 ---------------------------------------------------------SAQ ENST00000294623 ---------------------------------QAVPAPTGAPPGGQPDYSAAWAEYYRQ ENSMUST00000029668 ---------------------------------QAVPAPAGAPPGGQPDYSAAWAEYYRQ ci0100137634 L-----------AAPAAAAAIQQQQVAAPAAAAPAASAAVQPATTQAADYSAAWAEYYRQ CG8912-RB LKNKQNGSGGQSSTPNPSQGGSGQQQPNPAAAAAAAAAAAAAAGGYGQSMTPTQYAQYSQ * ENST00000201886 QAAYYG--QTPGPGGPQPPPTQQGQQQAQ------------------------------ ENSMUST00000057643 QTAYYAYYAWIDPGGPQPPPTQQGHQQAS------------------------------ SINFRUP00000137517 QAAYYGQ-GGQAPG--QVPAPQQGQQ--------------------------------- ENSMUST00000039254 QAAFYGQTLGQAQAHSQ------------------------------------------ ENST00000302073 QVAFYGQTLGQAQAHSQEQ---------------------------------------- SINFRUP00000143074 QMDVARQLIDDKIG--------------------------------------------- ENST00000294623 QAAYYAQTSPQGMPQHPPAPQCRFDPASIELAL-------------------------- ENSMUST00000029668 QAAYYAQTSPQGMPQHPPAPQGFANHARSHHHLY------------------------- ci0100137634 YYAMHGQAGYAAAAAAAGQAPAPT----------------------------------- CG8912-RB YYAAAAAAGGQPQGAPQPGGGQSGGPPGNYPGNYPGAGYGGYPGAPGQQQQKSHKNDNH