CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000057572 PGRRDRTGVADSGGGHAVQSSPRPITRRTKPALGSDGVRVTMESALTARDRVGVQDFVLL ENST00000263078 -----------------------------------------MESALTARDRVGVQDFVLL SINFRUP00000160392 -----------------------------------------MESALTARDRVGVQDFLLL SINFRUP00000145776 -----------------------------------------MESSLNARDRVGIQDFVLL SINFRUP00000155069 -----------------------------------------MEGALTARDRVGIQDFVLL ci0100140769 -----------------------------------------MEGALTARDRVGVQDLVLL CG9155-RC -----------------------------------------METGLHERDRAGVQDFVLL ** .* ***.*:**::** ENSMUST00000057572 ENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPP ENST00000263078 ENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPP SINFRUP00000160392 ENHNSEAAFIENLRRRLRENLIYTYIGSVLVSVNPYKELEIYSKQQMERYRGISFYEISP SINFRUP00000145776 DAHTSESAFLDNLRKRFHENLIYTYIGTLLVSVNPYKELDIYSKKQMDTYMGVNFFELPP SINFRUP00000155069 DETT-EVAFLGNLQKRFSKDLIYTYIGTLLVSVNPYKDLDIYNKKDMELYKGVNFFELPP ci0100140769 EDYQSETAFLHNIKKRFKEKLIYTYIGSVLISVNPYQQLGFYSPYHMEKYQGVNFYEMPP CG9155-RC ENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPP : * **: *:::*: :.******* :*:*****::* :*. .:. * . *:*:.* ENSMUST00000057572 HLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRL ENST00000263078 HLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRL SINFRUP00000160392 HIYALSDNTYRAMRTERKDQCILISGESGAGKTEASKKILLYYSVTCPTNDRMASLGECL SINFRUP00000145776 HIYALADNVFRTMQSEYNNHFILISGESGAGKTEASKKILQFYAVSCPSTRLLNNIRDRL SINFRUP00000155069 HIYALADNAYQTMLAEFNNHFILISGESGAGKTEASKKILQYYAVSCPSTALLNTVRDKM ci0100140769 HVYAIGDNTYRSMRNEASDQCILISGESGSGKTEASKYILQYLSVCSASNDNVEHIKGRL CG9155-RC HIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKL *::*: *..:::: * .: ::******:*****:* :* : : . : : ENSMUST00000057572 LQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGE ENST00000263078 LQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGE SINFRUP00000160392 LQSIPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFRGAPVGGHILNYLLEKSRVVHQNHGE SINFRUP00000145776 LLSNPVLEAFGNAKTLKNDNSSRFGKYMDIQFDHQGGAVGGHILSYLLEKSRVVHQNHGE SINFRUP00000155069 LMSNPVLEAFGNAKTLKNDNSSRFGKYMDIQFDSQGDAVGGHILNYLLEKSRVVHQNHGE ci0100140769 LQSNPILEAFGNAKTHRNDNSSRFGKYMDIEFDHKGAPVGGHILNYLLEKSRVVHQASGE CG9155-RC LKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE * * *:********* :************::** :* .:**:**.********* * ** ENSMUST00000057572 RNFHVFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVMRKALSVI ENST00000263078 RNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVI SINFRUP00000160392 RNFHIFYQLLDGADNNLLNQLDLERNPQKYQYLVKGNCPRISSVSDKNNWKAVMKALSVI SINFRUP00000145776 RNFHIFYQLVEGGEEDLLRWLGLERNCKHYSYLVQGDCAKVSSINDKSDWKIVRKALSVI SINFRUP00000155069 RNFHIFYQIVEGGDDHLLRQLGLERDPQKYNYLTQGQCAIVSSINDRNDWKTVKNALQIM ci0100140769 RNFHIFYQLLEGADEELLSRLMLQKTPDKYFYTSQGKCAKVSSINDRRDFLAVQKALKVL CG9155-RC RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVI ****:***:: *.:: * * *:: . * * .* :: :.* .: : :** :: ENSMUST00000057572 DFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTEN--QLKYLTRLLGVEGTTLREA ENST00000263078 DFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTEN--QLKYLTRLLSVEGSTLREA SINFRUP00000160392 GFTEEEVQNLLRIVGSILHLGNAQFGEGEGGETYITTEP--EISTLAKLLAVDGSALGEA SINFRUP00000145776 EFSESDIEDLFGIIASVLHLGNIKFDVDSEGYASLNNSSNNEMHWVSKLLGIPTEVLHRG SINFRUP00000155069 NIDEINTKDLFGIVASVLHLGNVCFDSDGTGQAVLRDS--AELHWVSNLLGVDAPSLQEG ci0100140769 EFSPKNIDELLSIVASVLHLGNVSFSANEEGHATVDREH--EIQKIANLLGCQFEQLLQA CG9155-RC DFTKEEQREIFGIVASILHLGNVGFT-EVEGNAKVNSRD--LVVTAARLLGVNASELEAA : : ::: *:.*:***** * . : : : :.**. * . ENSMUST00000057572 LTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWR ENST00000263078 LTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWR SINFRUP00000160392 LTHKKLKAKGEEVISPLSFEQALSARDALAKTVYRRTFNWLVEKINQSLAPKDELHRSSK SINFRUP00000145776 LTHRKIEAKTEEVFSPFSEDHAVYARDALAKAVYGRTFNWLVNKINESLANKD-----SS SINFRUP00000155069 LTYRKIEAKTDQVFSPFTVDHALYARDALAKAIYGHTFTWLVNKINASMENKD-----SS ci0100140769 LTHRTIEANKEKMESPLTVEQALYARDALSKAIYGRMFNWLVLKLNGSLTSKD-----RM CG9155-RC LTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETR---AS **::.: *. : : **:. : * *****:*::* : *.*** ::* *: *: ENSMUST00000057572 STTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQ ENST00000263078 STTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQ SINFRUP00000160392 SSTLIGLLDIYGFEVLQCNSFEQFCINYCNEKLQQLFIELTLKSEQEEYETEGIAWETVK SINFRUP00000145776 RKTVIGLLDIYGFEVFNVNSFEQFCINYCNEKLQQLFIQLTLKSEQEEYEMEGIEWEPVP SINFRUP00000155069 QKTVIGLLDIYGFEVFCVNSFEQFCINYCNEKLQQLFIQLTLKAEQEEYQAEDIEWEPVQ ci0100140769 RKNVIGLLDIYGFEIFKSNSFEQFCINFCNEKLQQLFIELTLKQEQEEYRAEGIEWEPVE CG9155-RC RNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVE ..::*:*******:: *********:**********:**** **:**. *.* * .* ENSMUST00000057572 YFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKPHPHFLTHKLADQK ENST00000263078 YFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQR SINFRUP00000160392 YFDNKIICDLVEEKHKGIISILNEECLRPGETCDMSFLEKLEDTLGNHPH-ITHKLANGK SINFRUP00000145776 YFNNKIICELVEAKHRGIISLLDEECLLPGEASDLTFLAKMEEKIGSHPHFVTHKLADQK SINFRUP00000155069 FFNNKIICDLVEEKHRGIISILDEECLRPGDATDLTFLERLEENMGNHPHFVSHKLADKM ci0100140769 YFNNKIICDLVEERHQGIIDILDEECLRPGEATDNTFLSKLEETVGKHPHFITHALGDSK CG9155-RC YFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAH :*:**:**:*:* :.:***.:*:**** **:. * :** :: :.: * * : * . ENSMUST00000057572 TRKSLDRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSMNPIMAQCFDKSELS ENST00000263078 TRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELS SINFRUP00000160392 TRRVMSREEFRLLHYAGEVNYNVNGFLDKNNNFLNRNLKEVMCKSDNQILRACFHREEAM SINFRUP00000145776 TRKTLERGEFRLLHYAGEVSYSVVGFLDKNNDLLYRSGKEVMRQSKNAIIKLCFPSTESD SINFRUP00000155069 TRKTLERGDFRLLHYAGEVTYCVVGFLDKNNDLLYRNLKDLICQSKNAIVKECFSTLDRD ci0100140769 MRKTIGYEEFRLVHYAGEVTYSVKGFLDKNNDLLYRDLKVTMSVSKNEIVKEAFPATELT CG9155-RC IKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELR :: : :***:******.* * *******::* *. * : : * *: .* : ENSMUST00000057572 DKKRPE--TVATQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLG ENST00000263078 DKKRPE--TVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLG SINFRUP00000160392 DQKRQEMVTAATNFKNSLMKLMEILMSKEPSYVRCIKPNDAKQPGKFDDVLVRHQVKYLG SINFRUP00000145776 SKKRPE--TVVTQFKNSLTGLTEILLSKEPWYVRCIKPNEAKQPGRFDDVLVRHQVKYLG SINFRUP00000155069 SRRRPE--TVATQFKSSLLKLTEILVAKEAWYIRCLKSNESKHPGQFDEVLIRHQVKYLG ci0100140769 KLKRPE--TVGSQFRTSLNRLMDILMSKEPSYVRCIKPNDAKMADRFDETLVRHQVKYLG CG9155-RC SLKRPE--TAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLG . :* *::*. ::*: ** * :** .**. *:**:*.*: : .. *:: *: ******* ENSMUST00000057572 LMENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPMWAGR--PQDGVAVLVRHLGYKPEEY ENST00000263078 LLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGR--PQDGVAVLVRHLGYKPEEY SINFRUP00000160392 LMENLRVRRAGFAYRRRFEAFLQRFKPLCPETWPNWHGR--LEDGVSTLVNHLGYKEEEY SINFRUP00000145776 LMEHLRVRRAGFAYRRKYEVFLQRYKPLCPDTWPNWKGT--AAEGVKRLIVHLGYKRDEY SINFRUP00000155069 LMEHLRVRRAGFAYRRKFDVFLKRYKPLCPATWPHWTGM--PADGVEVLVQHLGYLPNEY ci0100140769 LMENLRVRRAGFAYRRTHDIFLNRYKSLCPETWPHYDGP--SRKGVDVLCKYLDYKEGEY CG9155-RC LMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKY *:*:************ .: **:*:*.*. *** : * ** * *.: :* ENSMUST00000057572 KMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWW ENST00000263078 KMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWW SINFRUP00000160392 QLGRTKIFIRFPKTLFRTEDALQAKKPDIALILQTSWRGYRERSKYQRIRHAVIVIQSAW SINFRUP00000145776 KMGRTKIFIRHPRTLFATEDAFQVCKHKLATRIQAKYKGYRMKGDYQRQREAATRIENCW SINFRUP00000155069 KMGRTKIFIRHPRTLYATEDAFEKCKHELATRLQAKYKGYRAHGEFRKQKEAATKIESCW ci0100140769 RLGKTKVFIRFPRTLFATEDAFQIRKHELATTIQSVFRGWRQKKKFTTMRNAVTLLSSQW CG9155-RC RVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYC ::*.**:*** *:**: ***: : : .:* :*: ::* : .: : . :.. ENSMUST00000057572 RGTLGRRKAAKRKWAAQTIRRLIRGFILRHSPRCPENAFFLDHVRASFLLNLRRQLPRNV ENST00000263078 RGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRRQLPQNV SINFRUP00000160392 RGMKARRRAKTRRQAAELIRRFIKGFIYRHEEYCPENDYFLDHVRCSFLKKLRQNLPKSV SINFRUP00000145776 RGLMARKEREKRAWAVKVIKRFIKGFITRNQPLCTDNSEYLAYVRYSYLTRLRENLPKTV SINFRUP00000155069 RGAQARKERERRAWAVKVIRQFIKGYMSRGQAKTTDNSEYLAFVRQNYLNRLRNNLPKTV ci0100140769 KKILAQRLKAKRKKATLDIRKFILGFMTRLKPRCPENADFLDYVRYSYLMRAKESLPASV CG9155-RC RRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKV : .:: * *. *: :* *:: * * :: .: :* . ..** .* ENSMUST00000057572 LDT-SWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDN ENST00000263078 LDT-SWPTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDN SINFRUP00000160392 LDK-SWPTPPPSLVEASENLRNLHMRNMVIKYCKRVQPEWKKQMKQKVIASEIFKDQKDG SINFRUP00000145776 LEKDSWLTPPPIMQEASQLLKKLYIRHMVRKYVGEVTPQRKAQLQLKLQTSSMFKGKKEN SINFRUP00000155069 LDKTTWLPAPAVLAETSELLRKLHYRLMVRRYVRGLTPQKKAQFQLKFITSCVFKGKKDS ci0100140769 LDK-SWIHSPAALEETGKLLQQLNMKNLMLKYVKGVSPQRKAMMEEKVLASAIFRQKKKG CG9155-RC LDK-SWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNN *:. :* .* *:. *:.* : * : *: * :: * :. :*: :*.. ENSMUST00000057572 YPQSVPRLFISTRLGTEEISPR---VLQSLGS-EPIQYAVPVVKYDRKGYKPRPRQLLLT ENST00000263078 YPQSVPRLFISTRLGTDEISPR---VLQALGS-EPIQYAVPVVKYDRKGYKPRSRQLLLT SINFRUP00000160392 YPQTVGRLFLDTRLEPEQISLK---VLQTLGN-DKVQYGVPVTKYDRRGFKPRPRQLLLT SINFRUP00000145776 YPFSVCRPFVDTRIGVEDINIK---VLQMIQH-EHIKYSVPVVKYDRNRFRPRLRQLVFT SINFRUP00000155069 YPQSVAQPFMDTRISEQDINIR---VLQTIRN-EHIKYGVPVIKYHRNGFKPRARQLVLT ci0100140769 YDESVANPFQD-KPRVEQLKPK---MLATIDSGEQALYCCSVTKYDRHGYHPRARTLIIT CG9155-RC YASSVSTWFQEDRIPKEHIQRVNDFVASTFGS-EQLKYQSFCTKFDRHGYKSRDRFILLS * :* * . : :.:. : : : * *:.*. ::.* * :::: ENSMUST00000057572 PSAVVIVE--DAKVKQRIDYANLTGISVSSLSDSLFVLHVQREDNKQKGDVVLQSDHVIE ENST00000263078 PNAVVIVE--DAKVKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIE SINFRUP00000160392 NTFAVLVD--RTKIKQRLDYSALRGISVSSLSDGVFVLHMPNEDSKQKGDVVLQCNYVIE SINFRUP00000145776 QEAAYLVE--EAKIKQRISHSSLKGVSVSNLSDNFLILHVTCDDIKQKGDLVLQCDYLFE SINFRUP00000155069 QTAAYVVE--EAKIKQRVLYTVLKGVSVSNLTDSIIVFHITCEDPKQKGDLVLQCDHLFE ci0100140769 SGATYLFDSKDGKLKQKISHNELRGISTSSLGDNVFVLHAPS-DNKEKGDAIVQSTFVIE CG9155-RC NKAIYVLDGKTYKQKHRLPLDKID-FTLTNHNDDLMVIRIPLDLKKDKGDLILIIPRIIE :.: * *::: : .: :. *..:::: *:*** :: ::* ENSMUST00000057572 TLTKTALSADRVNNININ-QGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVVAPRL ENST00000263078 TLTKTALSANRVNSININ-QGSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAVVAPRL SINFRUP00000160392 VVTKLGLMACKVNYVNVS-PGSVRFAVARGKEGIIDFVRGSELKVAKGKRGHLLV----- SINFRUP00000145776 ALTKLSVIANKQKSIHVV-QGSARFDIHPGREGFVDFKSGQESTVYRAKNGHLMV----- SINFRUP00000155069 LLTKLCVIANKQNAVKVV-QGSVKIEIQPGKESAVDFSAGQEPMIYKAKNGHLMV----- ci0100140769 TITKLARIAKKDQDVKIVDNSSILHDMTGGKQGRIDYVVGNEVSVTKTKTGLVVVAPAR- CG9155-RC FSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAEPGVVRDK-GHLVIIGTQ- * . . : : .* *: . :* * * : : * * : : ENSMUST00000057572 NSR ENST00000263078 NSR SINFRUP00000160392 --- SINFRUP00000145776 --- SINFRUP00000155069 --- ci0100140769 --- CG9155-RC ---