CLUSTAL W (1.82) multiple sequence alignment ENST00000262971 ----------------------------------------------MAAELVEAKNMVMS ENSMUST00000005064 ----------------------------------------------MAAELVEAKNMVMS ENST00000324794 RRRPRRLKRRPVQDGAGGGGGRGGGSVVGGSGSGCGGSGGGARGWYKMADFEELRNMVSS ENSMUST00000058127 -------------------------------------------------------NMVSS SINFRUP00000130297 ------------------------------------------------------------ ENSMUST00000034976 ------------------------------------------------------KQMVMS ENST00000249636 ---------------GGAGRGGARPARGAGLAAAPGEVHCACADRRKMADSAELKQMVMS SINFRUP00000136070 ------------------------------------------------------------ ENSMUST00000029743 --------------------------------------------------------MVMS CG8068-RI ---------MRKTRSQTARTQAENAATSSSPGHQSTSSAPIAVNPFDSTKYKECEQMVQM ENST00000262971 FRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKNSEPA ENSMUST00000005064 FRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKSAEPG ENST00000324794 FRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLS ENSMUST00000058127 FRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLC SINFRUP00000130297 ------------------------------------------------------------ ENSMUST00000034976 LRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPA ENST00000249636 LRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPA SINFRUP00000136070 ------------------------------------------------------------ ENSMUST00000029743 FRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPS CG8068-RI LRVVELQKILSFLNISFAGRKTDLQSRILSFLRTN-LELLAPKVQEVYAQSVQEQNATLQ ENST00000262971 PQPHRP---------LDPLTMHSTYDRAGAVPRTPLAGPNIDYPVLYGKYLN-------G ENSMUST00000005064 PQAPRP---------LDPLALHS-------MPRTPLSGPTVDYPVLYGKYLN-------G ENST00000324794 DLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQ ENSMUST00000058127 DLSTIKSSVFSLDGSSSPVEPDLPVAGIHSLPSTSITPHSPSSPVGSVLLQDTKPTFEMQ SINFRUP00000130297 -------------------------------------------------------SMNLQ ENSMUST00000034976 DLSIPN----------VHSSPMPPTLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELP ENST00000249636 DLSIPN----------VHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELP SINFRUP00000136070 ------------------------------------------------------------ ENSMUST00000029743 DLSLLS----------LPPGTSP------------------------------------- CG8068-RI YIDPTR----------MYSHIQLPPTVQPNPVGLVGSGQGVQVPGGQMNVVG-GAPFLHT : ENST00000262971 LGRLPAKTLKPEVRLVKLPFFNMLDELLKPTELVPQNNEK-LQESPCIFALTPRQVELIR ENSMUST00000005064 LGRLPTKTLKPEVRLVKLPFFNMLDELLKPTELVPQSAEK-LQESPCIFALTPRQVEMIR ENST00000324794 QPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQR-FQEKFFIFALTPQQVREIC ENSMUST00000058127 QPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQR-FQEKFFIFALTPQQVREIC SINFRUP00000130297 PPVPVIHPVHPDVQMKPLPFYDVLDVLIKPSSLGAGTPQRYHQEKYFVFALTPQQVREVC ENSMUST00000034976 HLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQR-FRETCFAFALTPQQVQQIS ENST00000249636 HLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQR-FRETCFAFALTPQQVQQIS SINFRUP00000136070 ---------------------------------ASDNSQR-YQETCLAFALTPQQVQQIS ENSMUST00000029743 -------PVHPDVTMKPLPFYEVYGELIRPTTLASTSSQR-FEEAHFTFALTPQQLQQIL CG8068-RI HSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQR-VQEVPFYFTLTPQQATEIA : : : : : : :: : . :: .* *:***:* : ENST00000262971 NSRELQPGVKA---VQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGV ENSMUST00000005064 NSRELQPGVKA---VQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGV ENST00000324794 ISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGI ENSMUST00000058127 ISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGI SINFRUP00000130297 ISRDFLPGGRRDYMVQIQLRFCLSETSCPQEDNYPNGLCIKVNGKIFPLPGYVPPAKNGM ENSMUST00000034976 SSMDIS-GTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGV ENST00000249636 SSMDIS-GTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGV SINFRUP00000136070 SSMDIS-GTKCDFSVQVQLRFCLSETSCPQEDHFPPNLCVKVNGKPCNLPGYLPPTKNGV ENSMUST00000029743 TSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGA CG8068-RI SNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNV . :. . : :*: **:* :*** *** :* .: :*** . :*. *. : . ENST00000262971 EPKRPCRPINLTHLMYLSSAT-NRITVTWG-NYGKSYSVALYLVRQLTSSELLQRLKTIG ENSMUST00000005064 EPKRPCRPINLTHLMYLSSAT-NRITVTWG-NYGKSYSVALYLVRQLTSSDLLQRLKTIG ENST00000324794 EQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKG ENSMUST00000058127 EQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKG SINFRUP00000130297 EQKRQGRPLNITSLVRLSSAVPNQISVTWSPEIGKTYSLSVYLVRQLTSPLLLQRLRMKG ENSMUST00000034976 EPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRTYSMAVYLVKQLSSTVLLQRLRAKG ENST00000249636 EPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAKG SINFRUP00000136070 EPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRSYSMAVYLVKQQSSSVLLQRLRAKG ENSMUST00000029743 EPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKG CG8068-RI EPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKG * ** **:*:* **.:. * * : * : :.*.:::***:: :: ***::: * ENST00000262971 VKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVF ENSMUST00000005064 VKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVF ENST00000324794 IRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAAL ENSMUST00000058127 IRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAAL SINFRUP00000130297 IRNPDHSRALIKEKLTADPDSEIATTSLRVSLICPLGKMRLTVPCRAVTCSHLQCFDAAL ENSMUST00000034976 IRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATL ENST00000249636 IRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATL SINFRUP00000136070 IRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLMIPCRALTCSHLQCFDATL ENSMUST00000029743 IRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPVGKMRLTVPCRALTCAHLQSFDAAL CG8068-RI VKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASL :: .: :.*:**** *.*.*:*** ::*** **: **:: :**** **:***.*** : ENST00000262971 YLQMNEKKPTWMCPVCDKPAPYDQLIIDGLLSKILSE---CEDADEIEYLVDGSWCP--I ENSMUST00000005064 YLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSE---CEGADEIEFLAEGSWRP--I ENST00000324794 YLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILND---CSDVDEIKFQEDGSWCP--M ENSMUST00000058127 YLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILND---CSDVDEIKFQEDGSWCP--M SINFRUP00000130297 YLQMNEKKPTWICPVCDKKAAYESLIIDGLFLEILND---CSDKDEIQFQQDGTWCP--M ENSMUST00000034976 YIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKY---CTDCDEIQFKEDGSWAP--M ENST00000249636 YIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKY---CTDCDEIQFKEDGTWAP--M SINFRUP00000136070 YIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFVEILNS---CTDCDEIQFKEDGSWAP--M ENSMUST00000029743 YLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNS---CSDCDEIQFMEDGSWCP--M CG8068-RI YLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGL *:****:**** ****** * *: *::** : ::* . **: :*:* . : ENST00000262971 RAEKERSCSP--------------------------QGAILVLGPSDANG-------LLP ENSMUST00000005064 RAEKEPSCSP--------------------------QGPILVLGTSDANG-------LAP ENST00000324794 RPKKEAMKVS-SQPCTKIES---------SSV---LSKPCSVTVASEASKKKVDVIDLTI ENSMUST00000058127 RPKKEAMKVT-SQPCTKVES---------SSV---FSKPCSVTVASDASKKKIDVIDLTI SINFRUP00000130297 KPKKESFKVP-TPLFQKIE----------------------------------------- ENSMUST00000034976 RSKKEVQEVT-ASYN-GVDG-------CLSST---LEHQVASHNQSSNKNKKVEVIDLTI ENST00000249636 RSKKEVQEVS-ASYN-GVDG-------CLSST---LEHQVASHHQSSNKNKKVEVIDLTI SINFRUP00000136070 KSKKEVQEVSTASYNNGLDDS------CQTSTGPDHRSPLSSSHSNSSNGKTVEVIDLTL ENSMUST00000029743 KPKKEASEVC-PPPGYGLDG---------------LQYSAVQEGIQPESKKRVEVIDLTI CG8068-RI RSETQILDTP-SKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTL :.:.: : ENST00000262971 APSVNGSG---------------------ALGSTG-GGGPVGSMENGKPGADVVDLTLDS ENSMUST00000005064 ASSTPGIGSG-----------------LSGPGSAGSGAGAAGSLENGKTGADVVDLTLDS ENST00000324794 ESSSDEEEDP-----------PAKRKCIFMSETQS--SPTKGVL--MYQPSSV-RVPSVT ENSMUST00000058127 ESSSDEEEDP-----------PAKRKCIFMSETQS--SPTKGVL--MYQPSSV-RVPSVT SINFRUP00000130297 ------------------------------------------------------------ ENSMUST00000034976 DSSSDEEEEE----------PPAKRTCPSLSPTSP-LSN-KGILSLPHQASPVSRTPSLP ENST00000249636 DSSSDEEEEE----------PSAKRTCPSLSPTSP-LNN-KGILSLPHQASPVSRTPSLP SINFRUP00000136070 DSSSEDEGQESPQPPPPPLPPPPKRACPSMSPTSPPVIN-KGVLNMHHQASPVSRTPSMP ENSMUST00000029743 ESSSDEEDLP-----------PTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMG CG8068-RI SDSDDDMPLA-------------KRRPPAKQAVASSTSNGSGGGQRAYTPAQQPQQSESP ENST00000262971 SSSSEDEE---------------------------------------------------- ENSMUST00000005064 SSSSEDED---------------------------------------------------- ENST00000324794 SVDPAAIP---PSLTDYSVPFHHTPISSMSSDLPGEQRR--------------------- ENSMUST00000058127 SVDPAAIP---PSLTDYSVPFHHTPVSSMSSDLPGLDFLS----------------LIPV SINFRUP00000130297 ------------------------------------------------------------ ENSMUST00000034976 AVDTSYIN--TSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAA-AAVS ENST00000249636 AVDTSYIN--TSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAA-AAVS SINFRUP00000136070 AVDTSYIPPVPPLIQDYR-PYYHTPN--DLSELNFFSFLQGDNHQVRKLQGGSEFNLSIL ENSMUST00000029743 TLGSDFLS--SLPLHEYP---PAFPLGADIQGLDLFSFLQTESQHYGPSV------ITSL CG8068-RI EQQASRQSPEKQTVSEQQLQQQQHEQPATAAVHAS------------------------- ENST00000262971 --------------------------EEEEEEEDEDEEGPRPKRRCPFQKGLVPAC---- ENSMUST00000005064 --------------------------EDEDDDEDEDE-GPRPKRRCPFQKGLVPAC---- ENST00000324794 --------------------------NDINNELKLGTSSDTVQQ---------------- ENSMUST00000058127 DPQ-------YC---------PPMFLDSLTSPLTASSTSVTTTSPHESSTHVSSSSSRSE SINFRUP00000130297 ------------------------------------------------------------ ENSMUST00000034976 DDQDLLHSSRFFPYTSS-----QMFLDQLSAGGSTSLPA-TNGSSSGSNSSLVSSNS-LR ENST00000249636 DDQDLLHSSRFFPYTSS-----QMFLDQLSAGGSTSLPT-TNGSSSGSNSSLVSSNS-LR SINFRUP00000136070 NVHSGLNVNKFRPVATSSSSSSQLYLNQTGGSSGTSLNAPTNGAGSSGGGSLVSSGN-LR ENSMUST00000029743 DEQDTLG--HFFQYRGTP----SHFLGPLAPTLGSSHRSSTPAPPPGRVSSIVAPGSSLR CG8068-RI ------------------------LLESLAAAVADQKHFQLLDLAAVAAAAAATASSGQS ENST00000262971 ----------------------------------------------- ENSMUST00000005064 ----------------------------------------------- ENST00000324794 ----------------------------------------------- ENSMUST00000058127 TGVIT-----------------------------SSGRNIPDIISLD SINFRUP00000130297 ----------------------------------------------- ENSMUST00000034976 ESHG-----HG-----------VASRSSADT--ASIFGIIPDIISLD ENST00000249636 ESHS-----HT-----------VTNRSSTDT--ASIFGIIPDIISLD SINFRUP00000136070 DAHSAYSSLHSGSHSVHTHPGVVASRSSAEAAVAAIYGGIPDVISLD ENSMUST00000029743 EGHG-------------------GPLPSGPS----LTGCRSDVISLD CG8068-RI QNAGP------------------------------------------