CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000160368 -------------------------------------------------- Q90WI3_Brachydanio_rerio ----------------------------MWWKVGLVLVMFWGLTSSKDRE SINFRUP00000142897 -------------------------------------------------- ENST00000265014 ---------------------------MALVLGSLLLLGLCGNSFSGGQP ENSMUST00000030972 ---------------------------MALVFSALLLLGLCGKISSEGQP ENSMUST00000028855 ------------------------------MTRSPGLMVPLLGLSLGLAL ENST00000317620 ------------------------------MKHTLALLAPLLGLGLGLAL ci0100139703 -------------------------------------------------- CG7740-RB MGEVAATVEPLAAVKSKSMRSRKRRQRRRRQIAYLAICGLSVAIFGFALA SINFRUP00000160368 -------------------------------------------------- Q90WI3_Brachydanio_rerio EHRESPPRTAMLRAPVETLDFGFVPSVVYETHAYYEPGPMGILFHMVHAF SINFRUP00000142897 -------------------------------------------------- ENST00000265014 SSTDAPKAWN-----------YELPATNYETQDSHKAGPIGILFELVHIF ENSMUST00000030972 AFHNTPGAMN-----------YELPTTKYETQDTFNAGIVGPLYKMVHIF ENSMUST00000028855 SLPEAVTDDCGSLGRVEHLAFARVPRTRELAPLVRASGPLNSLYGTVRRF ENST00000317620 SQLAAGATDCKFLGPAEHLTFTPAARARWLAPRVRAPGLLDSLYGTVRRF ci0100139703 -------------------------------------------------- CG7740-RB TLIRPTTAQADADPGSWRKGYVGHGTTHEQLGQPHWPPVQYTVYRPTTNY SINFRUP00000160368 ---------PPDMIVKVIQQNMGGIKIEEWRKPENVVLLLQWVYYEVG-- Q90WI3_Brachydanio_rerio LYVVQPNPFPKDLIVKMVQQNMGGIKGDDYKKPENVVLLLQTIYYELG-- SINFRUP00000142897 ----------------------------------------QAIYYEIG-- ENST00000265014 LYVVQPRDFPEDTLRKFLQ-KAYESKID-YDKPETVILGLKIVYYEAG-- ENSMUST00000030972 LNVVQPNDFPLDLIKKLIQNKNFDISVD-SKEPEIIVLALKIALYEIG-- ENSMUST00000028855 LSVVQLNPFPAELIKTLLN-------------DPSSVKTDEVVRYEAG-- ENST00000317620 LSVVQLNPFPSELVKALLN-------------ELASVKVNEVVRYEAG-- ci0100139703 --------------------------------------------FEAG-- CG7740-RB TKAPPPPTSAMNPIFNFTHFLYDKVLYRDEPIPEGYIVVKNSDTLSLGPK : . : . * SINFRUP00000160368 ---------------FLICTTVGVLLLVVTPIIGACFCVCR-CCENCGGE Q90WI3_Brachydanio_rerio ---------------FIVLSVLGVFFVLLMPIVGLCFCVCR-CCENCGGE SINFRUP00000142897 ---------------FLVCAAVGLLFAILLPVVGLFFCMCR-CCDNCGGE ENST00000265014 ---------------IILCCVLGLLFIILMPLVGYFFCMCR-CCNKCGGE ENSMUST00000030972 ---------------VLICAILGLLFIILMPLVGCFFCMCR-CCNKCGGE ENSMUST00000028855 ---------------YVVCAVIAGLYLLLVPITGLCFCCCR-CRQRCGGR ENST00000317620 ---------------YVVCAVIAGLYLLLVPTAGLCFCCCR-CHRRCGGR ci0100139703 ---------------FMACFVAGCLFIILVPLVGAIMCCCRTCCDNCGGE CG7740-RB VEENDWRDLLAHYWMVLIWVVILVVLIIVIPFIAVCYCCFC-CCRRCRQG : . :: * . * * .* SINFRUP00000160368 MHQRQRKNADCQRGFFTASLIATSVLII---VGVVIAYAANHNMSLHVKS Q90WI3_Brachydanio_rerio MHQRQKKNGDCLRGFYMATLIATSVFLA---VGVTVAYVANQNITSQIKS SINFRUP00000142897 MHQRQRKNADCRRGLLGTLLFSTSLVIT---IGVLCAYAANQNLSSQVKN ENST00000265014 MHQRQKENGPFLRKCFAISLLVICIIIS---IGIFYGFVANHQVRTRIKR ENSMUST00000030972 MHQRQKQNAPCRRKCLGLSLLVICLLMRQVNLGIIYGFVANQQTRTRIKG ENSMUST00000028855 VKT-EHKAMACERGTLMIFLLLTTLVLL---IGMVCAFATNQHTHSQTGP ENST00000317620 VKT-EHKALACERAALMVFLLLTTLLLL---IGVVCAFVTNQRTHEQMGP ci0100139703 MIQSKSRVQSKWRYCFFASLLIITVFIM---IPCVFVFLTNEWVTQVVKV CG7740-RB CPPCTSKQDAQRRFCCGICLLILIIGLI---FGIIIAFVTNKMIDSGFAE . * *: : : . : :*. SINFRUP00000160368 TRRLINTNIRDLKTFANNTPSQIDYLMGQYITAKNKVLSELDN-----IG Q90WI3_Brachydanio_rerio TRRLVSTNIRDLKAFANYTPAQIDYLTAQYTTAKNKVLSDLDN-----IG SINFRUP00000142897 IRRYVNSNMRDLHTFANDTPMVRVTFFRLCTSAEGDFKVMFVL-----IM ENST00000265014 SRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNS-----IN ENSMUST00000030972 TQKLAKSNFRDFQTLLTETPK-------QYTNTKNKAFSDLDG-----IG ENSMUST00000028855 SVKAVPETLLSLRGLVSDVPEELRAIAEQFSVPQKQVSKELDG-----VG ENST00000317620 SIEAMPETLLSLWGLVSDVPQELQAVAQQFSLPQEQVSEELDG-----VG ci0100139703 IPDKTVKVFNDFSSYLELIPTQFNFIVNQYYTLDQGLSTDIQSKCFFSLI CG7740-RB TSETMKRGSEDTCTYLKDVADHVHHLMMYNYEEMETHVLDQLT------- . . . : SINFRUP00000160368 PLLGGRIHSQLEKEVVP---SLDGALRMAGAMRETKEALENVSSALEVLQ Q90WI3_Brachydanio_rerio TLLGGQIHNKLESEVVP---ALDHALRMTAAMRETKESLESVSTSLETLQ SINFRUP00000142897 VFLT--------------------ILMFDSAMRETKEALENSSMGLEVLQ ENST00000265014 SVLGGGILDRLRPNIIP---VLDEIKSMATAIKETKEALENMNSTLKSLH ENSMUST00000030972 SVLGGRIKDQLKPKVTP---VLEEIKAMATAIKQTKDALQNMSSSLKSLQ ENSMUST00000028855 ENLGNVIHNRLKSTVYP---VLASVHSLGQALQVSIDHLRALNTTSVELQ ENST00000317620 VSIGSAIHTQLRSSVYP---LLAAVGSLGQVLQVSVHHLQTLNATVVELQ ci0100139703 SPISTLILPKMKETLIVNTYEFNQRCLFSPDADKSLTELVSIQQSTDVLI CG7740-RB -HAHRHIFLDLSDTSESN--SLAEMERVLENMPEALELMRQVEKMEKDLR : : : . : : . * SINFRUP00000160368 EATGRLKASLSDERASLSNTLSDPACTNG----AVSHTCSSVRATLAQLG Q90WI3_Brachydanio_rerio EGTGRLQVSLQSERASLSNTLNDWACSNE----DVTHTCNSIRGTLNQLA SINFRUP00000142897 EGTGKLGFNLSLVR-SINRTLSDPGCHDEKSDATTAQLCRNIRQSLSQLQ ENST00000265014 QQSTQLSSSLTSVKTSLRSSLNDPLCLVH----PSSETCNSIRLSLSQLN ENSMUST00000030972 DAATQLNTNLSSVRNSIENSLSSSDCTSD----PASKICDSIRPSLSSLG ENSMUST00000028855 EAQRHLEPPVQAHRERLLALLQDSWCHEEN--------CKRVLSQAGALQ ENST00000317620 AGQQDLEPAIREHRDRLLELLQEARCQGD---------CAGALSWARTLE ci0100139703 NGSNNLDSQLSSLRSRMASSLNTTECRGD-------MYCRGVLISIDSLT CG7740-RB FYGSQLRDGVRGIKRDVNFAVAN-LCQLQ--------MCQKFLISSNIEH * : : : : * * SINFRUP00000160368 ANA----DFSRLADVNQALANVNVIL-GTDLSNIVQKGYSSFNDTPRLVK Q90WI3_Brachydanio_rerio LSA----NFNGLPDVEAPLANLDAVL-KTDLSNIVQKGYSSFNDTPQLVR SINFRUP00000142897 ISA----NFTRLPNVNSQLERMKDVL-KMDLSIIVQKGFSSLNDTPHMVT ENST00000265014 SNP----ELRQLPPVDAELDNVNNVL-RTDLDGLVQQGYQSLNDIPDRVQ ENSMUST00000030972 SSL----NSSQLPSVDRELNTVTEVD-KTDLESLVKRGYTTIDEIPNTIQ ENSMUST00000028855 LGA----DFSQTPPVDDVLHRLKDVP-ETNFSSMVQEEKATFNNLPLLVQ ENST00000317620 LGA----DFSQVPSVDHVLHQLKGVP-EANFSSMVQEENSTFNALPALAA ci0100139703 TGG----DFSALQSVQAQITEINDTLTQYDINAEINKVMKQLNDIPELVT CG7740-RB IDSSQCLHFDNLPNTKEFVEGMENIV-ASEYYAIPQRGLSRLKKVSDKVK . . .. : : : :. :. . SINFRUP00000160368 EQTRNIVSG---VKSMLDKIGTEINSFAKMFPVESSLANFTTFLNLQQKT Q90WI3_Brachydanio_rerio EQTKGIVSALPKVKGLLDKSGAEIIGFTKMFPVEPALQNFSKFLTDSQKN SINFRUP00000142897 EQTRSVVEN---VQTLMDDIGKNISSFSKIFPVQSCLSNFTIFISHVHAK ENST00000265014 RQTTTVVAG---IKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESY ENSMUST00000030972 NQTVDVIKD---VKNTLDSISSNIKDMSQSIPIEDMLLQVSHYLNNSNRY ENSMUST00000028855 VQAVSVVKD---VKKALAEQPEGLRMLAQAFPGSEAASRWSQALEGLEQR ENST00000317620 MQTSSVVQE---LKKAVAQQPEGVRTLAEGFPGLEAASRWAQALQEVEES ci0100139703 NGSANVTKS-----NTLATINETMSKAISQLPLSSLDPLKQEMENINSTI CG7740-RB TQLSFVVPP---MMRDLTKGRTIFREHATNVR-NIVEGVLSDIHIKTLHS : : : . . SINFRUP00000160368 VESYYPQLDQMDFYRWIGCVGALCMVVLVLAFNILGLLCGTCGYDRQATP Q90WI3_Brachydanio_rerio IEAYYPQIDQLDFYRWIGCVLICCLVVLVLAFNFLGLLCGSCGYDKNSTP SINFRUP00000142897 IEDHYPEIDRMDFYRWIGCITLCCMVVLVLAFNYLGLLCGTLGYDKHASP ENST00000265014 IHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATP ENSMUST00000030972 LNQELPKLEEYDSYWWLGGLIVCFLLTLIVTFFFLGLLCGVFGYDKHATP ENSMUST00000028855 SRPYLQEVQQYETYRWILGCVLCSAILLVVICNLLGLSLGIWGLFAREDP ENST00000317620 SRPYLQEVQRYETYRWIVGCVLCSVVLFVVLCNLLGLNLGIWGLSARDDP ci0100139703 YSIAYDYSTKYDIYRYAAGIVLGSIVALICALYLLGMLCGGCGFKSDRNP CG7740-RB TKSFEDVYERFGHDRNVVSLIVCLLILLVLFILIFALLCGCFGR-RRTGY . : :: :.: * * SINFRUP00000160368 TTRGCLSNTGGNLLMAGVGFSFIFAWVLMGVVTTLFVVGGNVEKLLCEPL Q90WI3_Brachydanio_rerio TTRGCLSNTGGNLLMASVGFSFIFSWVLMGVVVTTFIVGGNIEKLVCEPL SINFRUP00000142897 TTRGCISNTGGTMLIAGVGISFIFSWVLMGLVTIIFLAGGNMEKLVCEPF ENST00000265014 TTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPY ENSMUST00000030972 TRRGCVSNTGGIFLMAGVGFGFLFCWILMILVVLTFVVGANVEKLLCEPY ENSMUST00000028855 SHSETKGEAGARLLMAGVAFSFLFAVPLILLVFVTFLVGGNVQTLVCRSW ENST00000317620 SHPEAKGEAGARFLMAGVGLSFLFAAPLILLVFATFLVGGNVQTLVCQSW ci0100139703 ADRSTLSNCGGISIMAGVGVSFIFGWILMLLVTLTFTVGGHGERYVCQNL CG7740-RB GDECCSKSTGATCLLLAILLIFCVFSFIALVGLFYFMLGMVTYQGACAPL . *. :: .: . * . : : * * * SINFRUP00000160368 ANRQLFKIIDTPFLVHPAKKNFLPGMLFQNPNIDLTLGSMYSDCYENSGL Q90WI3_Brachydanio_rerio ANRQIFKIIDTPYMVHPTKKNFLPGMLFQDPNIDLTIGSMYRDCYENNGL SINFRUP00000142897 HTK---EVVDTPYLVHPDWKNFIPGYLYNDSDMELTAESFYSTCKDNRGI ENST00000265014 TSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGT ENSMUST00000030972 ENKKLLQVLDTPYLLKEQWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGI ENSMUST00000028855 ESGELYEFADTPGNLPPSMNLSYLLGLKKN----ISIVQAYRQCKAGAVL ENST00000317620 ENGELFEFADTPGNLPPSMNLSQLLGLRKN----ISIHQAYQQCKEGAAL ci0100139703 EYP-YEGIKFLDDVLWKTYGSLLGIKLYTDSYVPLDFSGVLTACEGNSSI CG7740-RB RDQENNTLFRQLDASIDLNHYLPPSESNKEVVQPLKMSSAIKACHANQTI . . : * . SINFRUP00000160368 YHALQLETMFNINSFLNRTV-------YNKDLAKVFENVQVDLQGISLLE Q90WI3_Brachydanio_rerio YSALQLETKFNFNKFLNATV-------FNPEIGNIFNNVNVDLQGMLLLE SINFRUP00000142897 YSALRLDKVFNVSSFLNTTM-------FTKDVVARLNSVKIDLRGIILLE ENST00000265014 YGTLHLQNSFNISEHLNINE-------HTGSISSELESLKVNLN-IFLLG ENSMUST00000030972 YAAFQLENVVNVSDHFNIDQ-------ISENINTELENLNVNIDSIELLD ENSMUST00000028855 WKVLQLNDSYDLDKHLDIKQAREPLHPYTHKIQQELQSFQVDLKELDLLS ENST00000317620 WTVLQLNDSYDLEEHLDINQ-------YTNKLRQELQSLKVDTQSLDLLS ci0100139703 YTALQLEELFNVTEFIQSATEN------LNSFKTQLSDLTVDLSSLKAYT CG7740-RB FDMMRQHNIYDINDLTRIKVMS-----HSQENTDSIKVFDEDLSTVVLLT : :: . :. . . :. . : : SINFRUP00000160368 QAGRDALINFANSGIGYIDYDSYLAELNKGVTLVDLLTFSADLEAQADQL Q90WI3_Brachydanio_rerio QEGKDNLIDFANTGIGDIDYQAYLTEVNKGVTVVDLLSYANELDAQADNL SINFRUP00000142897 AEGKQNLLDFSEAGLLEINYADYLEEV----------------------- ENST00000265014 AAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSL ENSMUST00000030972 NTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFASTLEAKANQL ENSMUST00000028855 PTARQDLEALQRSGLEKIHYRGFLVQIQKPVVNTDMWQLAQELEGLAQAQ ENST00000317620 SAARRDLEALQSSGLQRIHYPDFLVQIQRPVVKTSMEQLAQELQGLAQAQ ci0100139703 PEIANALNALKQTGLDGINFDSYLNATAQGITTVNFTFYAQFLNNSADNM CG7740-RB KEERDELKTAGESKLAKYHSSLYMPSLCTQFTPMNLNALSEQLYKLSNDL * : . :: : : SINFRUP00000160368 PRGALENALK---GHASSIRQIHRDQVLPMEREMSTLSQSIKQLQRTS-- Q90WI3_Brachydanio_rerio PRGALENALK---GHASSIRQIHKDQVVPMEQAMSNLNQSIRQLEKTS-- SINFRUP00000142897 -------------------------------------------------- ENST00000265014 PPGNLRNSLK---RDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTG-- ENSMUST00000030972 PEGKLKQAFL---LDVQNIRAIHQHLLPPVQQSLNTLRQSVWTLQQTS-- ENSMUST00000028855 NDSLLRQQLR---EEARELRSLYQEKVVPQESLVTKLNFSVKTLESLA-- ENST00000317620 DNSVLGQRLQ---EEAQGLRNLHQEKVVPQQSLVAKLNLSVRALESSA-- ci0100139703 TN--LATEIR---KFSYEVTLIQTMYVDPLTPALNTLTTDINSLQKTA-- CG7740-RB EYPAYGWAKVSFWNEGLNTKAFYRNFVPKLTSLVEKMKANLKKIDELISY : : : : : : SINFRUP00000160368 --SDLPVKVTNILSAIDAAEYLIAHNASHVVKQETRGYMQSLVGYFRQYT Q90WI3_Brachydanio_rerio --RELPVKVTNVLNAIEAAEYLISNNASHVVKQESDKFIKKIIGYFSQYT SINFRUP00000142897 -------------------------------------------------- ENST00000265014 --NGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYL ENSMUST00000030972 --NKLPEKVKKILASLDSVQHFLTNNVSLIVIGETKKFGKTILGYFEHYL ENSMUST00000028855 --PSLQVNTSDFLDSVTRLKGELPVQINHILRNATECFLTREMGYFSQYV ENST00000317620 --PNLQLETSDVLANVTYLKGELPAWAARILRNVSECFLAREMGYFSQYV ci0100139703 --TGLNASIDETAAALQTLDSVIQTNGSALVSVEINKYADTLILSVNQYA CG7740-RB ENHDFTNTIKILTATAINSEQFIQTRGKDYINALGGNLTNSIDQMIDDYI : : : . SINFRUP00000160368 QWVKNSLSGEVAPCKPISNMVD-SMEIVACSFIIDSVNTFWFGLGGCSIL Q90WI3_Brachydanio_rerio EWVKHSLAMEVAQCKPISNIVD-SAEIVACSFIVDSVNTFWFGLGGCCVL SINFRUP00000142897 -------------------------------------------------- ENST00000265014 QWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVF ENSMUST00000030972 HWVFYAITEKMTSCKPMATAMDSAVNGILCGYVADPLNLFWFGIGKATVL ENSMUST00000028855 TWVRAEVTQRIATCQPFSTALD-NGHVILCDMMADPWNAFWFCLGWCTFF ENST00000317620 AWVREEVTQRIATCQPLSGALD-NSRVILCDMMADPWNAFWFCLAWCTFF ci0100139703 AWFLDQVTNHFGQCYPVVLVYN-QFVSILCSYFMDILNGLWFCLGWITFF CG7740-RB DMIIKEANESVGHCAPLSYIYY-RGVDLICHRIVDPINGFWVGILLCALL . . . . . : . : .: SINFRUP00000160368 LIPSIIFSIKLAKYYRRMD---------------TEDVFEE--------- Q90WI3_Brachydanio_rerio LIPSIIMSVKLAKFYRRMD---------------TEDVFDDGSENWS--- SINFRUP00000142897 -------------------------------------------------- ENST00000265014 LLPALIFAVKLAKYYRRMD---------------SEDVYDDVETIPMKNM ENSMUST00000030972 LLPAVIIAIKLAKYYRRMD---------------SEDVYDDVETVPMKNL ENSMUST00000028855 LIPSIIFAVKTSKYFRPIR---------------KRLSSTSSEETQLFHI ENST00000317620 LIPSIIFAVKTSKYFRPIR---------------KRLSSTSSEETQLFHI ci0100139703 LIPGAIFGMKLAKYYRRLQ---------------DMESYNE--------- CG7740-RB FLPILFVAHRLMCLYKKIYPYLATVGAAGVVEGGSDYLYDAYSERDREHV :: :. : SINFRUP00000160368 -------------------------------------------------- Q90WI3_Brachydanio_rerio -------------------------------------------------- SINFRUP00000142897 -------------------------------------------------- ENST00000265014 ENGNNGYHKDHVYGIHNPVMT----------------------------- ENSMUST00000030972 EIGSNGYHKDHLYGVHNPVMT----------------------------- ENSMUST00000028855 PRVTSLKL------------------------------------------ ENST00000317620 PRVTSLKL------------------------------------------ ci0100139703 -------------------------------------------------- CG7740-RB PLANVPKKRRKAYERRREQQDYFEDASPSVSRGNRSGGDRGGGGGDGAPG SINFRUP00000160368 ------------------------------------------------ Q90WI3_Brachydanio_rerio ------------------------------------------------ SINFRUP00000142897 ------------------------------------------------ ENST00000265014 ------------------------------------------------ ENSMUST00000030972 ------------------------------------------------ ENSMUST00000028855 ------------------------------------------------ ENST00000317620 ------------------------------------------------ ci0100139703 ------------------------------------------------ CG7740-RB SSSMRYNDMAPTHWDHEPPRYHNPPAAPPSSEYERPPPYYYPGASEQD