CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000032413 ----------------------------------------PAARPCVRAAAALRRGRPGT ENST00000266517 MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGT SINFRUP00000160317 ------------------------------------------------------------ SINFRUP00000156844 ------------------------------------------------------------ ENST00000306755 -------------------------------------MAVPPSAPQPRASFHLRRHTPCP ENSMUST00000000167 -------------------------------------MAVPPSAPVPCSPFYLRRQEPCP SINFRUP00000165508 ------------------------------------------------------------ ci0100139234 ------------------------------------------------------------ ENSMUST00000025760 -------------------MKTKFCTGGEAEPSPLGLLLSCG-GNAAPTPGVGQQRDAAG ENST00000265689 -------------------MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAAS SINFRUP00000135201 ------------------------------------------------------------ ENSMUST00000023289 --------------------------------------------MAADGTGVVGGGAVGG ENST00000216113 --------------------------------------------------------VCSG ci0100150144 ------------------------------------------------------------ CG2201-RA -----------------MATNLQKATLEEIRHAAARICRDYLTGPWKVVTPESLVVKRIS ENSMUST00000032413 EGSSSLPAPAALVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLDVTVQDQEEQRCRD ENST00000266517 EGSTSLSAPAVLVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLNVTVQDQEEHRCRE SINFRUP00000160317 -----------------------------MANYIHVPDEAPAVPKIDVAVDESD---YRS SINFRUP00000156844 ------------------------------------------------------------ ENST00000306755 QCSWG---------------MEEKAAASASCREPPGPPRAAAVAYFGISVDPDD---ILP ENSMUST00000000167 QCSWS---------------MEEKAVASAGCWEPPGPPR-AAVPCFSVTVEQDD---ILP SINFRUP00000165508 ------------------------------------------------------------ ci0100139234 -----------------------------------MSRIQNPVLKVNTIVDTEN---ATD ENSMUST00000025760 ELESKQLGGRTQPLA--------LPPPPPPPLPLP---PPPSPPLADEQPEPRTRRRAYL ENST00000265689 DLESKQLGGQQPPLA--------LPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYL SINFRUP00000135201 ------------------------------------------------------------ ENSMUST00000023289 GLPKDGLQDAKCPEP--------IPNRRR----------------ASSLSR-DAQRRAYQ ENST00000216113 GLS-NLLFRCSLPDH--------LPS-------------------VGEEPR-EVLLRLYG ci0100150144 ------MASALLPKR--------KPGPDD-------------MDMVKENIRVDVVSRAYQ CG2201-RA GGLSNFLYYVSLPDLNDYDELDEQKQQQEDIIGATATVTNRSGVFIHDDESAAKAVGVTL ENSMUST00000032413 GALSLLRHLRPHWDPREVTLQLFTDGITNKLIACYVGDTME---------DVVLVRIYGN ENST00000266517 GALSLLQHLRPHWDPQEVTLQLFTDGITNKLIGCYVGNTME---------DVVLVRIYGN SINFRUP00000160317 GALKLIKELRPNWKPSEVKIKFFTDGITNKLLGCYVGAVMQ---------DVVLVRIYGN SINFRUP00000156844 ----------------------FTDGTTNKLVGCYLEDSPE---------DVVLVRVYGN ENST00000306755 GALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVEEDMQ---------DCVLVRVYGE ENSMUST00000000167 GALRLIRELRPHWKPEQVRTKRFKDGITNKLLACYVEEDMR---------DCVLVRVYGE SINFRUP00000165508 ----------------------FTEGLTNKLIGCFVGSLQEN--------DCVLVRLYGR ci0100139234 GAFKILKLVRPEWDIENITLKVFSNGITNKMFGFHHLENKD---------DTVLVRINGN ENSMUST00000025760 WCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDE---PRKVLLRLYGA ENST00000265689 WCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDE---PRKVLLRLYGA SINFRUP00000135201 -----------------------RGGLSNKLFLCSLPDGTDTVGDE---PRSILLRLYGA ENSMUST00000023289 WCREYLGGAWRRARPEELSVCPVSGGLSNLLFRCSLPNHVPSVGGE---PREVLLRLYGA ENST00000216113 AILQKSQLWWEEGEPSCVSLCHFA-----------------------------LAPLLSI ci0100150144 LCKEYLDGPWSQISIHEFEITTLGGGLTNKLYICNLPPKYRSNDNDSCYPNTVLLRLYGL CG2201-RA MARELINNDDVADAAPGATQAHKRQRCDSNSRECSSSKRLHAPKQQ---PREVLLRIYGQ :* : . ENSMUST00000032413 KTEL-------------------LVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQ ENST00000266517 KTEL-------------------LVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQ SINFRUP00000160317 KTEL-------------------LVDRENEVKSFRVLHAHRCAPRLYCTFNNGLCYEFLE SINFRUP00000156844 KTEL-------------------IVDRDNELKSFQVLHANGCAPHLYCTFQNGICYEFIH ENST00000306755 RTEL-------------------LVDRENEVRNFQLLRAHSCAPKLYCTFQNGLCYEYMQ ENSMUST00000000167 RTEL-------------------LVDRENEVRNFQLLRAHGCAPKLYCTFQNGLCYEYVQ SINFRUP00000165508 MTEL-------------------YVNREREVQMFQVLHSYRCGPQIYCTFQNGICYEFVP ci0100139234 GTEI-------------------FLDRKAEVENFEILHEHNCAPILYCIFNNGLAYQFIK ENSMUST00000025760 ILKM------------------GAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIP ENST00000265689 ILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIP SINFRUP00000135201 ILQG-------------------TEAMVLESVMFAILAERELGPKLYGIFPQGRLEQYIP ENSMUST00000023289 ILQG-------------------VDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYLP ENST00000216113 LFQG-------------------VDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYIP ci0100150144 ILQD-------------------FKAQIQESVVFSILAERKVGPKLYAVFPGGRLEEFLP CG2201-RA THGD-----------------HALESMITESVVFALLSERNYGPKLHGIFPGGRIEQYIP * * :* .* :. * * ::: ENSMUST00000032413 GEALDPQHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADENI ENST00000266517 GEALDPKHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDI SINFRUP00000160317 GMALEPEDIRSQHVFRLIARQLAKYHAIHAHNGWVPQSDLWLKMGKYFALIPKYFKNPEK SINFRUP00000156844 GEALGTEDVRDPTILRLIAKEMARIHAIHAHNGCIPKPDLWIKMRKYFSLVATEFTDQAS ENST00000306755 GVALEPEHIREPRLFRLIALEMAKIHTIHAN-GSLPKPILWHKMHNYFTLVKN-----EI ENSMUST00000000167 GVALGPEHIREPQLFRLIALEMAKIHTIHAN-GSLPKPTLWHKMHRYFTLVKD-----EI SINFRUP00000165508 GTVLDDTLVRQPPIYRLVL-DYGTILRMFSS--FLSPS--WVAFP--------------- ci0100139234 GVTLTTESVRQETVFRLVGKEMAKMHKIPLSAADRASEPQTFKLCRKFLKIVFG--ETEN ENSMUST00000025760 SRRLDTEELRLPDISAEIAEKMATFHGMKMP-FNKEPKWLFGTMEKYLNQVLRLKFSREA ENST00000265689 SRRLDTEELSLPDISAEIAEKMATFHGMKMP-FNKEPKWLFGTMEKYLKEVLRIKFTEES SINFRUP00000135201 SRRLDTWELSDPSISAEVAEKMAKFHGMRMP-FNKEPKWLFGTMEKVINHTP-------- ENSMUST00000023289 SRPLKTQELRDPVLSGAIATRMARFHGMEMP-FTKEPRWLFGTMERYLKQIQDLPSTS-- ENST00000216113 SRPLKTQELREPVLSAAIATKMAQFHGMEMP-FTKEPHWLFGTMERYLKQIQDLPPTG-- ci0100150144 SRTLKTSDLFDPSTSRHIAQRMVEYHSLQMP-VKKEPTFIISKLYTYFENAKSAEFSDEY CG2201-RA ARALTTAELGEQRILKRVAEKMGEIHSLNIP-MSKEPDWIWNCMQRWVSGLESIVNGSVQ . * : : : : . ENSMUST00000032413 N------KRFLSEIPSPQLLQEEMTWMKELLSSLGSPVVLCHNDLLCKNIIYNEKQG--- ENST00000266517 N------KRFLSDIPSSQILQEEMTWMKEILSNLGSPVVLCHNDLLCKNIIYNEKQG--- SINFRUP00000160317 N------TRLRTEVPSPRCLREELLWLQQDLSVLGSPVVLCHNDLLCKNIIYNKGAG--- SINFRUP00000156844 N------TRIQQEVPSKVVLEQEMAWMKEHLSSLGSPVVLCHNDLLCKNIIHNSKEG--- ENST00000306755 N------PSLSADVPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKG--- ENSMUST00000000167 S------PSLSADVPKVEVLEQELAWLKEHLSQLDSPVVFCHNDLLCKNIIYDSDKG--- SINFRUP00000165508 ------------GVPSFGILSGEMETLKRHLSQIDSPVVLCHNDLLIKNIIYNHTDG--- ci0100139234 R------LSLTSDLKLKTMMYSEVEQLEELLNALHSPLVFTHNDLLLHNIIYNKDQE--- ENSMUST00000025760 R-------VQQLHKILSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQE--- ENST00000265689 R-------IKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRE--- SINFRUP00000135201 --------VSADHPLMCA---IYFHLFRILLDSTNSPVVFCHNDCQEGNILLLKGCQ--- ENSMUST00000023289 --------LPQMNLVEMYSLKDEMNSLRKLLDDTPSPVVFCHNDIQEGNILLLSEPD--- ENST00000216113 --------LPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPE--- ci0100150144 K-------QSLYLKLMACNIEAEVQFVTRIISKQ-DVVVFCHNDIQEGNLLQSIRDD--- CG2201-RA TNQKSSVLKKQMELMRTFDYVQEMAWIRSIIDEGDYPVVFCHNDLQEGNILMRQPSAGQN . . :. :*: *** *:: ENSMUST00000032413 ------------------------------------------------------------ ENST00000266517 ------------------------------------------------------------ SINFRUP00000160317 ------------------------------------------------------------ SINFRUP00000156844 ------------------------------------------------------------ ENST00000306755 ------------------------------------------------------------ ENSMUST00000000167 ------------------------------------------------------------ SINFRUP00000165508 ------------------------------------------------------------ ci0100139234 ------------------------------------------------------------ ENSMUST00000025760 ------------------------------------------------------------ ENST00000265689 ------------------------------------------------------------ SINFRUP00000135201 ------------------------------------------------------------ ENSMUST00000023289 ------------------------------------------------------------ ENST00000216113 ------------------------------------------------------------ ci0100150144 ------------------------------------------------------------ CG2201-RA ERTPRESISSLRSNFDETLGDSLDGNSNISDTETHKSRSVSPSPCPELDTTNDSALDSSF ENSMUST00000032413 ------DVQFIDYEYSGYNYLAYDIGNHFNEFAG--------VSDVDYSLYPDRELQGQW ENST00000266517 ------DVQFIDYEYSGYNYLAYDIGNHFNEFAG--------VSDVDYSLYPDRELQSQW SINFRUP00000160317 ------SVKFIDYEYSGYNYQAYDIGNHFNEFAG--------LNEVDYSHYPDRAFQLQW SINFRUP00000156844 ------HVRFIDYEYSSYNYQAFDIGNHFNEFAG--------MTEPDYLLYPDREMQMDW ENST00000306755 ------HVRFIDYEYAGYNYQAFDIGNHFNEFAG--------VNEVDYCLYPARETQLQW ENSMUST00000000167 ------RVCFIDYEYAGYNYQAFDIGNHFNEFAG--------VNVVDYSRYPARETQVQW SINFRUP00000165508 ------MVKFIDYEYADYNYQAFDIGNHFNEFAG-------------------------- ci0100139234 ------KVSFIDYEYAGVNYQAADIGNHFCEFAG--------VEEVDYSLYPDRDFQLKW ENSMUST00000025760 -NSERRKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPSRKQQLHF ENST00000265689 -NSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHF SINFRUP00000135201 -SSDKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSCEEFPFFKVNPQSYPSKALQLHF ENSMUST00000023289 -SDD--NLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTYEEWPFYKARPTDYPTREQQLHF ENST00000216113 -NAD--SLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARPTDYPTQEQQLHF ci0100150144 -QNN--PVQMIDFEYSSYNYRGFDIANHFCEWMYDYSYSSWPFFSYKFEHYANQQQQANL CG2201-RA MADNEPDLIIIDFEYCAYNYRGYDLANHFIEWTFDYTNPQFPYFYHNSSNCATVQQRRDF : ::*:**. ** . *:.*** *: ENSMUST00000032413 LRSYLEA-YKEYKGFGSDVTEKEVETLFIQVNQFALASHFFWGLWALIQAKYSTIEFDFL ENST00000266517 LRAYLEA-YKEFKGFGTEVTEKEVEILFIQVNQFALASHFFWGLWALIQAKYSTIEFDFL SINFRUP00000160317 LRSYLEA-YKEHKGQAGEVTDREVEIIYVQVNRFALASHFFWGLWSLIQAKLSSIDFDFV SINFRUP00000156844 LRVYLQA-YKKFTKKTEEVSQIELETLYVQVNKFALASHFFWGFWALIQAKYSTIDFDFL ENST00000306755 LHYYLQA-QKG-----MAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFDFL ENSMUST00000000167 LRYYLEA-QKG-----TAASPREVERLYAQVNKFALASHFFWALWALIQNQYSTISFDFL SINFRUP00000165508 ------------------------------------------------------------ ci0100139234 LRNYLAC-FRD--VALTDVPDNDVERLYKQANKFALASHLFWSIWALVQAKYSKIDFDYK ENSMUST00000025760 ISSYLTTFQNDFESLSSEEQFATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYM ENST00000265689 ISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYM SINFRUP00000135201 IDNYLRASDPGFVNLYAADQLKMKE-LYVEVNRFSLASHFFWGLWSIIQARLSTIEFGYL ENSMUST00000023289 IRHYLAEVQKG-EILSEEEQKKREEELLLEISRYSLASHFFWGLWSTLQASMSTIEFGYL ENST00000216113 IRHYLAEAKKG-ETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQASMSTIEFGYL ci0100150144 VEVYLEESYRVRPSRRS-DPKWQKAYIMDEIKRFSLLSHIFWALWSVVQAQISDIGFGYM CG2201-RA IVNYLKKFHDDENYNITGQELMKVD---AEIQFFTMLSHLFWSLWSVIN-VTSAIEFGYW : : : : :: : : : : ENSMUST00000032413 GYAVVRFNQYFKMKPEVTALKMPE ENST00000266517 GYAIVRFNQYFKMKPEVTALKVPE SINFRUP00000160317 GYAVLRFNQYFKMK---------- SINFRUP00000156844 ------------------------ ENST00000306755 RYAVIRFNQYFKVKPQASALEMPK ENSMUST00000000167 RYAVIRFNQYFKVKPQVSALEMPK SINFRUP00000165508 ------------------------ ci0100139234 GYSKLRMDEYKRRKQEFLSL---- ENSMUST00000025760 EYAQARFEAYFDQKRKLGV----- ENST00000265689 DYAQARFDAYFHQKRKLGV----- SINFRUP00000135201 ------------------------ ENSMUST00000023289 EYAQSRFQFYFQQKGQLTSSPSS- ENST00000216113 ------------------------ ci0100150144 EYALARMDAFFKHKELVTQK---- CG2201-RA EYGIARILEYQKLKAAYQAN---- :