CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000029244 ------------------------------------------------------------ ENST00000264608 ------------------------------------------------------------ SINFRUP00000131848 ------------------------------------------------------------ ENSMUST00000018429 ------------------------------------------------------------ ENST00000263088 ------------------------------------------------------------ SINFRUP00000141941 ------------------------------------------------------------ CG12110-RA MADAGTVGGALPPYALTNSDEEHGSGEEDASEENSNNEEGEGVFRDCTDEAVVEHHNRCL ci0100142835 ------------------------------------------------------------ ENSMUST00000029244 ----MSLKSETRVNTSTLQKIAADMSNLIENLDTRELHFE-GEEVEYDASPGDPKAQEGC ENST00000264608 ----MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFE-GEEVDYDVSPSDPKIQEVY SINFRUP00000131848 ------------------------MADLVESLDTRELDIGDGEDLDYDAN----SLGDCR ENSMUST00000018429 -----------------MTVTQKNLFPYGDYLNSSQLHME---PDEVDTLREGEDPADRM ENST00000263088 -----------------MTATPESLFPTGDELDSSQLQME---SDEVDTLKEGEDPADRM SINFRUP00000141941 ------------------------------------------------------------ CG12110-RA PEFQFSLVDSEYDETLAFPDSVTILSNVGDKPVLVERKETDDDEEEFDDEENNSVVLRHE ci0100142835 ------YIVQITCRWFVVKDTFIAYLDPSQDKIKGVLLFDAVLNVLHQAPSSRLVISNIS ENSMUST00000029244 IPFSSIY-NTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTSRVPSINLYTIELTHG--EF ENST00000264608 IPFSAIY-NTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHG--EF SINFRUP00000131848 IQFSAVY-ATVGFKEASAKVYLPTVPITARILEMERFTTAQ-----DLFKIELKHG--EF ENSMUST00000018429 HPYLAIY-DLQPLK-AHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHG--DF ENST00000263088 HPFLAIY-ELQSLK-VHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHG--DF SINFRUP00000141941 ----------------------------------------------TLYTVRLTHG--PF CG12110-RA IPFTSIYGPSVKFNSFQRKVFIPGREIHVRIVDTERSVTTHLLNP-NLYTIELTHG--PF ci0100142835 RSLNVDCWTDRQALDWKRAIEHSFNNLSYGLTAPDIRHQSFAPPREDSYAYWFVDGRSYF : : : : .* * ENSMUST00000029244 TWQVKRKFKHFQEFHRELLKYKAFIRIPIPTKRHT------------------------- ENST00000264608 KWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHT------------------------- SINFRUP00000131848 TWLIKRKEKHFMELHRELRTYKTFIRIPLPSRRLASV----------------------- ENSMUST00000018429 TWTTKKKFRHFQELHRDLQRHKVLMSL-LPLARFAV------------------------ ENST00000263088 SWTTKKKYRHFQELHRDLLRHKVLMSL-LPLARFAV------------------------ SINFRUP00000141941 HWTVKRKYKHFQELHRDLYKHKMMIHL-LPLSRFTK------------------------ CG12110-RA KWTIKRRYKHFNSLHQQLSFFRTSLNIPFPSRSHKEKRTTLKATAREMADESTLKDLPSH ci0100142835 DAVADAIEEAREEIYITDWWLSPEIYMKRPIVHGDHWR---------------------- . . .:: : : * ENSMUST00000029244 ----------------------------------------------FRRQNVKEEPREMP ENST00000264608 ----------------------------------------------FRRQNVREEPREMP SINFRUP00000131848 ----------------------------------------------SRLCHMTGTSVSLT ENSMUST00000018429 ----------------------------------------------THSPAREAAAEDIP ENST00000263088 ----------------------------------------------AYSPARDAGNREMP SINFRUP00000141941 ----------------------------------------------DRQQLR-AMSEEMP CG12110-RA TKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPNHSSILAGLTPRRIQKKRKKKKKRKLP ci0100142835 --------------------------------------------LDKLLKRKAVEGVKIY .: ENSMUST00000029244 SLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLSFIHDLGPKG ENST00000264608 SLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKG SINFRUP00000131848 SVAHQTQHAKSLCVFM-----LTWFWTADSNIPCLH-FLSAMEFIDVSQLSFIHDLGPKG ENSMUST00000018429 SLPRGGSEGSARHTAS-KQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKG ENST00000263088 SLPRAGPEGSTRHAAS-KQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKG SINFRUP00000141941 SLQG---TERTRRTSS-KMKYLEEYLNGLLENVFCRNDHSMLEFLSVGALSFVTDLGPKG CG12110-RA RFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRSHHETLNFVEVSNVSFVPGMGIKG ci0100142835 VQLYKEVEMAVGLDSAYTKRTLNEMHPTNIRVMRHPDLTPGETLLWAHHEKIVVIDQSIA * :: .:: . ENSMUST00000029244 LEGMIMKRSGGHR--IPGVNCCGHGR--------------ACYRWSKRWLIVKDSFLLYM ENST00000264608 IEGMIMKRSGGHR--IPGLNCCGQGR--------------ACYRWSKRWLIVKDSFLLYM SINFRUP00000131848 LEGLIYKRSGGHR--IPGMNCCGQNQ--------------VCYRWSKRWLVVKDSCLIYM ENSMUST00000018429 LEGVIRKRSGGHR--VPGFTFCGRDQ--------------VCYRWSKRWLVVKDSFLLYM ENST00000263088 LEGMIRKRSGGHR--VPGLTCCGRDQ--------------VCYRWSKRWLVVKDSFLLYM SINFRUP00000141941 LEGPIFKRSGGHR--IQGLNCFGHHQ--------------FCFRWSRRWLVVKDSFLMYM CG12110-RA KEGVILKRTGSTRPGQAGCNFFGCFQKNCCVRCNYFCSDVVCGTWRNRWFFVKETCFGYI ci0100142835 FVGGIDLCYGRWDDQDHKLTDTGG----------------VCSTDVRKYFVFLNLHFNTL * * * . * * .:::.. : : : ENSMUST00000029244 KP-----DSGAIAFVLLVDKEFRVKVGRKE-TETKYGLRIDNLSRTLILKCNSYRHARWW ENST00000264608 KP-----DSGAIAFVLLVDKEFKIKVGKKE-TETKYGIRIDNLSRTLILKCNSYRHARWW SINFRUP00000131848 KP-----DSGAISFVLLLDKEFTIKMDSKD-TETKHGVRIDSLSRTLVFKCSSYRHARWW ENSMUST00000018429 RP-----ETGAISFVQLFDPGFEVQVGKRS-TETRYGVRIDTSHRSLILKCSSYRQARWW ENST00000263088 CL-----ETGAISFVQLFDPGFEVQVGKRS-TEARHGVRIDTSHRSLILKCSSYRQARWW SINFRUP00000141941 NR-----DYGRINFVLLFDKEFKVKVGRAY-TDTKYGVCFENFTRSLVIKCSSYRQAHWW CG12110-RA RP-----TDGSIRAVILFDQGFDVSTGIYQ-TGMRKGLQVLTNNRHIVLKCWTRRKCKEW ci0100142835 QVPPVPRAPSPVEPEEPAATGCEFTIQFIQSMEFPYHVSTNTIYTTVIICHLLYGISTIL . : . : . ::: . ENSMUST00000029244 GGAIEEFIRKHGADFLKDHRFG--SYAALHENTLAKWYVNAKGYFEDIANAMEEASEEIF ENST00000264608 GGAIEEFIQKHGTNFLKDHRFG--SYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIF SINFRUP00000131848 GQSIESFVRSHGKAFLRDHRFG--SFAQEQENIPAKWYVNGKTYMEDVANALEEAKEEIF ENSMUST00000018429 GQEITELAQGSGRDFLQLHQHD--SYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIF ENST00000263088 AQEITELAQGPGRDFLQLHRHD--SYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIF SINFRUP00000141941 SHEINQLAET--CDFLKEHRFD--GFAPPRENMLTKWYVNGRDYFADLADALDQAKEEIY CG12110-RA MQYLKNTANSYARDFTLPNPHM--SFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIY ci0100142835 FSPNLHVSVATMSRMIDRLRFNERSRAPFTADTHSPINDKKFHYYSESYSFYTYFIIHYK : . . * . : . * . . ENSMUST00000029244 ITD--WWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYSK ENST00000264608 ITD--WWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTK SINFRUP00000131848 ITD--WWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFVMLYKEVELALGINSGYSK ENSMUST00000018429 ITD--WWLSPEIYLKRPAHS-DDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSK ENST00000263088 ITD--WWLSPEVYLKRPAHS-DDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSK SINFRUP00000141941 ITD--WWLSPEVFLKRPATD-NYWRLDTILKRKAEQGIKVCILLYKEVELALGINSEHSK CG12110-RA IAD--WWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSK ci0100142835 CVTNVKLLISNLFSKSTSLTEXRTVSNTLISVKRFVKCLYYVLMLTYLHVIV-INSGFKQ . * .::: * . : :: * ::: . :.: : *** ..: ENSMUST00000029244 RTLMRLHPNIKVMRHPDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLT ENST00000264608 RTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLT SINFRUP00000131848 RTLLHLHPNIKVMRHPDHVSSSVYLWAHHEKIVVVDQSVAFVGGIDLAYGRWDDREHRLT ENSMUST00000018429 RTLMLLHPNIKVMRHPDLVT----LWAHHEKLLVVDQVVAFLGGLDLAFGRWDDVQYRLT ENST00000263088 RALMLLHPNIKVMRHPDQVT----LWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLT SINFRUP00000141941 RTLMNMHPNIKVMRHPDHVSSVVFLWAHHEKMVAIDQTVAFVGGIDLAFGRWDDFEYRLT CG12110-RA STLAK-HENIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLT ci0100142835 ----PGDITINGVNEPENLYTSCSRTSCNMSYTPDPHTSAHCQSITWVSFYTPDTWXTLF : . .*: :..*: : : . : *. .: * * ENSMUST00000029244 DVG---------SVKRVTSGLSLGSLTAASVESMESLSLKDKHEFHKKEPISKIVDETDM ENST00000264608 DVG---------SVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDS SINFRUP00000131848 DVG---------SAGRANALPGKGAPPSGGVS--ESNGRGTPPSDLAELP---------- ENSMUST00000018429 DLG---------DPSEPVHL---------------------------------------- ENST00000263088 DLG---------DSSESAAS---------------------------------------- SINFRUP00000141941 DLG---------LPPEGVTK---------------------------------------- CG12110-RA DLGSISTSSFSGSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNT ci0100142835 SYR----------KLQIYELFP-------------------------------------- . . . ENSMUST00000029244 KLKGIGKSRKFSKFSLYRQLHRHHLHNADSISSIDSTSSYFSHCRSHQNLIHGLKPHLKL ENST00000264608 KLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKL SINFRUP00000131848 KLKGIGRNRR-TRFSLYRHLQKHAMQHSDSVDSVDSTGS--------------------- ENSMUST00000018429 --------------------QTPTL-GSDPAATPD------------------------- ENST00000263088 --------------------QPPTP-RPDSPATPD------------------------- SINFRUP00000141941 --------------------EEPEGDTVDKEDPLD------------------------- CG12110-RA SIELKTLKPGDRLLIPSTLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKG ci0100142835 --------------------DAAPLQASSVLTQYKDMVN--------------------- : : : . . ENSMUST00000029244 FHPSSESEQGLTRHSTDTGSIRSVQTGVGELHGETR--------FWHGKDYCNFVFKDWV ENST00000264608 FHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETR--------FWHGKDYCNFVFKDWV SINFRUP00000131848 ------------------GSVRSLKTDVGELQGNTR--------FWHGKDYCNFVYKDWI ENSMUST00000018429 ------------------------------LSHNQF--------FWLGKDYSNLITKDWV ENST00000263088 ------------------------------LSHNQF--------FWLGKDYSNLITKDWV SINFRUP00000141941 ------------------------------LIGNSK--------LWLGKDYSNFIRKDWV CG12110-RA ARMGKDFMHRLTATETEEKSAEVYTIESEEATDHEVNLNMASGGQEVAITTSSTQILNWM ci0100142835 ---------------------------QVEYAAQSK--------LWIGKDYNNFILKDLT . . . : ENSMUST00000029244 QLDKPFADFIDRYSTPRMPWHDIGSVVHGKAARDVARHFIQRWNFTKIMKPKYRSLSYPF ENST00000264608 QLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPF SINFRUP00000131848 QLEKPFDDFIDRYTTPRMPWHDIASAVHGRAARDVARHFIQRWNFTKIMKPKYRSLSYPF ENSMUST00000018429 QLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTTKARYKTPLYPY ENST00000263088 QLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPY SINFRUP00000141941 QLDRPFEDNIDRAEVPRMPWRDLSAAVHGKAARDVARHFIQRWNFTKVRR-RFKKQIFLH CG12110-RA NLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLRDNTR-FPY ci0100142835 QLDDPFGDVMDRLKTPRMPWHDIACVTYGKAARDAARHFIQRWNYTKIQKAKKGEH-ISF :*: ** * :** .*****:*:. . * .*** ********* * : : . ENSMUST00000029244 LLPKSQA--TAHELRYQVPGAV-PAKVQLLRSAADWSAGIKH---HEESIHAAYIHVIEN ENST00000264608 LLPKSQT--TAHELRYQVPGSV-HANVQLLRSAADWSAGIKY---HEESIHAAYVHVIEN SINFRUP00000131848 LLPKSHS--TANELRYQIPDCV-TAKVQVLRSAADWSAGIKY---HEESIHNAYVQVIAK ENSMUST00000018429 LLPKSTS--TANNLPFMIPGGQ-CATVQVLRSVDRWSAGT-----LENSILNAYLHTIRE ENST00000263088 LLPKSTS--TANQLPFTLPGGQ-CTTVQVLRSVDRWSAGT-----LENSILNAYLHTIRE SINFRUP00000141941 LFSS-------------YFECQ-CRVCPVLRSADHWSTGT-----CENSILKAYIHTIEN CG12110-RA LMPKSYH--QVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIHDAYIQTITK ci0100142835 LLPKSYSDDAFNLPKELMRPEAVQAKVQILRSSCEWSAGLSE---VDRSIQNAYIAAIDN *:.. :*** ** * :.** **: .* : ENSMUST00000029244 SKHYIYIENQFFISCADDK-------VVFNKVGDAIAQRILKAHREGQRYRVYIVIPLLP ENST00000264608 SRHYIYIENQFFISCADDK-------VVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLP SINFRUP00000131848 SKHYIYIENQFFISCAESR-------LVYNKIGDAIIERIIRAHKEGRKYRVYVVTPLLP ENSMUST00000018429 SQHFLYIENQFFISCSDGR-------TVLNKVGDEIVDRILKAHEQGQCFRVYLLLPLLP ENST00000263088 SQHFLYIENQFFISCSDGR-------TVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLP SINFRUP00000141941 SEHFIYIENQFFISCADEK-------TVYNEIGDAIVNRILRAHREQKKYRVFVVIPLLP CG12110-RA AQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLP ci0100142835 SQHFIYIENQFFISCLRNA-------QVGNQICTTLVRRIIRAHKNKKAFRVYVVMPLLP :.*::********: * *:: : **::**.: :**::: **** ENSMUST00000029244 GFEGDISTGG-GNALQAIMHFNYRTMCRGESSILEQLKPELG-NKWINYISFCGLRTHAE ENST00000264608 GFEGDISTGG-GNALQAIMHFNYRTMCRGENSILGQLKAELG-NQWINYISFCGLRTHAE SINFRUP00000131848 GFEGDITTGG-GNAIQAVMHFNYRTMIRGEHSIISQLKKEMD-DQWMNYISFAGLRTHTE ENSMUST00000018429 GFEGDISTGG-GNSIQAILHFTYRTLCRGEHSILHRLKAAMG-TAWRDYMSICGLRTHGE ENST00000263088 GFEGDISTGG-GNSIQAILHFTYRTLCRGEYSILHRLKAAMG-TAWRDYISICGLRTHGE SINFRUP00000141941 GFEGDISEGG-GNAIKAILHFTYR------------------------------------ CG12110-RA GFEGDVGGST-GIAVRAITHWNYASISRGRTSILTRLQEAGI-ANPENYISFHSLRNHSF ci0100142835 GFEGDISKSGKSQAIRTVLHWQYKSINRGSASMFEELDKEIGPGNAWRYISFCGLRTHSK *****: . . ::::: *: * : :: : : : : ENSMUST00000029244 LEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDG ENST00000264608 LEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDG SINFRUP00000131848 LEGRLVTELIYVHSKMLIADDNTVIIGSANINDRSMLGKRDSEVAVIVEDSEKVAAVMDG ENSMUST00000018429 LGGHPISELIYIHSKMLIADDRTVIIGSANINDRSLLGKRDSELAILIKDTEMEPSLMDG ENST00000263088 LGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNG SINFRUP00000141941 ------------------------------------------------------------ CG12110-RA LNNTPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNG ci0100142835 LMGKPITEIIYVHSKMMIVDDRLVIIGSANINDRSMSGTRDSEVAMLVEDSQLVDSTMDG : : :: : ::: :: : : : :: : ENSMUST00000029244 KEYQAGRFARDLRLECFRLVLGYL-----SDPSEDLQDPVSDKFFKEIWVSTAARNATIY ENST00000264608 KEYQAGRFARGLRLQCFRVVLGYL-----DDPSEDIQDPVSDKFFKEVWVSTAARNATIY SINFRUP00000131848 REYEAGPYALQLRLECFRTILGGH-----SDTSIDLSDPVSDRFYKEVWMTTAGRNATIY ENSMUST00000018429 VEYQAGRFALSLRKHCFSVILGAN-----TWPDLDLRDPVCDDFF-QLWQETAENNATIY ENST00000263088 AEYQAGRFALSLRKHCFGVILGAN-----TRPDLDLRDPICDDFF-QLWQDMAESNANIY SINFRUP00000141941 ------------------------------------------------------------ CG12110-RA KKYPSGVFAGRLRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEIY ci0100142835 KPCKVGVYASSLRRRCFAEHLGLLP--------DDYDDVASEAFFKDVWMKTAAVNTTSY : : : : ENSMUST00000029244 DKVFRCLPNDEVHNLIQLRDFINKPILAKEDRLRAEEELRKIRGFLVQFPLYFLSEENLL ENST00000264608 DKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLL SINFRUP00000131848 EKVFRCLPSSLVRNMSELEQYQSILGLAQTDQARAQEELRKIHGFLVQFPLDFLSEQNLM ENSMUST00000018429 EQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIQGHLVHFPLKFLEDESLL ENST00000263088 EQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLL SINFRUP00000141941 ------------------------------------------------------------ CG12110-RA DEVFKCIPTDFVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLT ci0100142835 EKVFCCVPSDYVRKLTDIESFQKTP-LVESDPEAAETTLQKIKGYLVLLPLLFLIDEDLT :: : : : : : :: : : :: : ENSMUST00000029244 PSVGTKEAIVPMEVWT ENST00000264608 PSVGTKEAIVPMEVWT SINFRUP00000131848 PSVGTKEAMVPTEIWT ENSMUST00000018429 PPLGSKEGMIPLEVWT ENST00000263088 PPLGSKEGMIPLEVWT SINFRUP00000141941 ---------------- CG12110-RA PPGTSKEGLIPTSVWT ci0100142835 PDVMTKEAMAPTDLWT : :