CLUSTAL W (1.82) multiple sequence alignment ci0100136603 MNVFQQKVNSCTLKIALSSSLSWRAIQTHRANRLFVQCSSRPILPSQPDV ENSMUST00000037615 ----------------MATCFLLRSF-----------WAARPALPPP--- CG4685-RA ----------------MWRQLS---------------------------- Q8QGQ1_Brachydanio_rerio ----------------------------------------MTSSEVELP- Q90Y03_Brachydanio_rerio ----------------------------------------MTSSEVELP- Q90XS8_Brachydanio_rerio ----------------------------------------MTSSEVELP- ENSMUST00000034723 -------------------------------------------------- ENST00000297785 -------------------------------------------------- ENSMUST00000044384 ----------------------------------------MLTARLLLPR ENST00000271359 -------------------------------------------------- ENST00000265605 -------------------------------------------------- SINFRUP00000144622 -------------------------------------------------- SINFRUP00000152737 -------------------------------------------------- ENSMUST00000054045 -------------------------------------------------- ENST00000238696 --------------------------------------MAALLAAAAVRA ci0100142299 -------------------------------------------------- ci0100136603 KTFLKQPAFT-FLSYRSKSE--MESFITDKAYINGKWES---VADSFEVL ENSMUST00000037615 GRFRPEPAGTPRRSYASGPGGLHADLLRGDSFVGGRWLP---APATFPVY CG4685-RA GVARTGSSLSLCRMRG------FSALVQDKALVDGAWVDSSNAKATFEVR Q8QGQ1_Brachydanio_rerio GEVKNDPAALMASLHLMPSPVPNPEIKYTKIFINNEWHD-SVSGKVFHTY Q90Y03_Brachydanio_rerio GEVKNDPAALMASLHLMPSPVPNPEIKYTKIFINNEWHD-SVSGKVFHTY Q90XS8_Brachydanio_rerio GEVKNDPAALMASLHLMPSPVPNPEIKYTKIFINNEWHD-SVSGKVFPTY ENSMUST00000034723 ----------MASLQLLPSPTPNLEIKYTKIFINNEWQN-SESGRVFPVC ENST00000297785 --------MSSSGTPDLPVLLTDLKIQYTKIFINNEWHD-SVSGKKFPVF ENSMUST00000044384 LLCLQGRTTSYSTAAALPNPIPNPEICYNKLFINNEWHD-AVSKKTFPTV ENST00000271359 ----------MSTGTFVVSQPLN----YRGGARVEPADA-SGTEKAF--- ENST00000265605 ----------MAGTNALL---------MLENFIDGKFLP-CSS--YIDSY SINFRUP00000144622 -------------------------------------------------- SINFRUP00000152737 ---------------------SFSSQPTTKLFIDGKFIE-SKTSEWLDIH ENSMUST00000054045 ----VSSKVN--ATWYPASSFSSSSVPTVKLFIDGKFVE-SKSDKWIDIH ENST00000238696 RILQVSSKVKSSPTWYSASSFSSS-VPTVKLFIGGKFVE-SKSDKWIDIH ci0100142299 --MLRYKSISSLSKNFFSTSTRCASVPNTKLFIDGKFID-STTDKWIDLH ci0100136603 NPYNGEVVGRAADCDKALAEATVKHAHVAFQS---WKNTCAKARSSILKK ENSMUST00000037615 DPASGAKLGTVADCGVPEARAAVRAAYDAFNS---WKGVSVKERSLLLRK CG4685-RA NPANGAVIGKVPNMTVADAQKAIDAAKQAYESKE-WRSLTAKDRSNLLKK Q8QGQ1_Brachydanio_rerio NPATGEKICDVQEADKADVDKAVQAARSAFSLGSVWRKMDASERGKLLFK Q90Y03_Brachydanio_rerio NPATGEKICDVQESDKADVDKAVQAARSAFSLGSVWRKMDASERGKLLFK Q90XS8_Brachydanio_rerio NPATGEKICDVQEADKADVDKAVQAARSAFSLGSVWRKMDASERGKLLFK ENSMUST00000034723 NPATGEQVCEVQEADKVDIDKAVQAARLAFSLGSVWRRMDASERGRLLDK ENST00000297785 NPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYK ENSMUST00000044384 NPTTGEVIGHVAEGDRADVDLAVKAAREAFRLGSPWRRMDASERGRLLNR ENST00000271359 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLE ENST00000265605 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQ SINFRUP00000144622 --ATNEVVGRVPKATQEEMLAAVDSCSRAFHS---WSETSILSRQQIFLR SINFRUP00000152737 NPSTNEVIYRVPKATQEEMLAAVDSCSRAYRS---WSETSILARQQLFLR ENSMUST00000054045 NPATNEVVGRVPQSTKAEMDAAVESCKRAFPA---WADTSILSRQQVLLR ENST00000238696 NPATNEVIGRVPQATKAEMDAAIASCKRAFPA---WADTSVLSRQQVLLR ci0100142299 NPATNEVITRVPEATQDEMFAAVAAAKRAFRG---WADSSVLHRQQIMFK . :: . *: * * :: . ci0100136603 WFELILKNQKSLAELITKENGKPIKESI-GEVAYAASFVEWLAEEAKRNY ENSMUST00000037615 WYDLMIQNKDDLAKIITAESGKPLKEAQ-GEILYSALFLEWFSEEARRIY CG4685-RA WHKLIEQHSQEIAEIMTAESGKPINESK-GEVAYGNAFVEWFAEEARRIY Q8QGQ1_Brachydanio_rerio LADLVERDSAYLATLESLDSGKPFLPCFFVDLQGIIKTFRYYAGWADKIH Q90Y03_Brachydanio_rerio LADLVERDSAYLATLESLDSGKPFLPCFFVDLQGIIKTFRYYAGWADKIH Q90XS8_Brachydanio_rerio LADLVERDSAYLATLESLDSGKPFLPCFFVDLQGIIKTFRYYAGWADKIH ENSMUST00000034723 LADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIH ENST00000297785 LADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ ENSMUST00000044384 LADLVERDRVYLASLETLDNGKPFQESYVLDLDEVIKVYRYFAGWADKWH ENST00000271359 AARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMA ENST00000265605 VADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT SINFRUP00000144622 YQQLIKDNIKELAKMITLEQGKTLADAE-GDVFRGLQVVEHACSITSLML SINFRUP00000152737 YQQLIKDNIKELAKSITYEQGKTLADAE-GDVFRGLQVVEHACSITSLML ENSMUST00000054045 YQQLIKENLKEIARLITLEQGKTLADAE-GDVFRGLQVVEHACSVTSLML ENST00000238696 YQQLIKENLKEIAKLITLEQGKTLADAE-GDVFRGLQVVEHACSVTSLMM ci0100142299 YQQLIKDNMKELAESITKEQGKTLADAE-GDVMRGLQVVEHCCSITNLNL :: :* : ** . :: . . : ci0100136603 GTTIPTPHPNKRLMSIKQPIGVAGMITPWNFPAGMITRKACAAIAAGCTV ENSMUST00000037615 GDIIYTSAKDKRGLVLKQPVGVAAIITPWNFPSAMITRKVGAALAAGCTV CG4685-RA GEIVPSASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTV Q8QGQ1_Brachydanio_rerio GSTIPIDGE-FFTLTRHEPIGVCGQIIPWNFPLVMTAWKLGPALSCGNTV Q90Y03_Brachydanio_rerio GSTIPIDGE-FFTLTRHEPIGVCGQIIPWNFPLVMTAWKLGPALSCGNTV Q90XS8_Brachydanio_rerio GSTIPIDGE-FFTLTRHEPIGVCGQIIPWNFPLVMTAWKLGPALSCGNTV ENSMUST00000034723 GMTIPVDGD-YFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTV ENST00000297785 GRTIPIDGN-FFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTV ENSMUST00000044384 GKTIPMDGE-HFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTV ENST00000271359 GEHIQLPGG-SFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAM ENST00000265605 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTV SINFRUP00000144622 GETLPSITKDMDTYTYRLPIGVCAGIAPFNFPAMIPLWMFPIGMVCGNTY SINFRUP00000152737 GETLPSITKDMDTYTYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTY ENSMUST00000054045 GETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTF ENST00000238696 GETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTF ci0100142299 GETMTSVAKDMDTLTYRYPLGVCAGITPFNFPAMIPLWMFPMAMVCGNTY . : *:**. * .:* * : .: * : ci0100136603 VLKPAEDTPFSALAIAKLGEEAGLPAGVLNIIPSSREHAPEIGNVICTHP ENSMUST00000037615 VVKPAEDTPYSALALAQLANQAGIPAGVYNVIPCSRNKAKEVGEVLCTDP CG4685-RA VVKPSEDTPLTALAVAKLAVDAGIPKGVINVVTTN--KAAPIGDLFCKSP Q8QGQ1_Brachydanio_rerio VLKPAEQTPLTCLYLGALIKEAGFPPGVVNILPGY---GPTAGAAISSHM Q90Y03_Brachydanio_rerio VLKPAEQTPLTCLYLGALIKEAGFPPGVVNILPGY---GPTAGAAISSHM Q90XS8_Brachydanio_rerio VLKPAEQTPLTCLYLGALIKEAGFPPGVVNILPGY---GPTAGAAISSHM ENSMUST00000034723 VIKPAEQTPLSALYMGALIKEAGFPPGVVNILPGY---GPTAGAAIASHI ENST00000297785 VVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGY---GPTAGAAISSHM ENSMUST00000044384 VMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGY---GPTAGAAIAQHM ENST00000271359 VFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG----GAATGQFLCQHP ENST00000265605 IAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGT---GPRVGEALVSHP SINFRUP00000144622 LMKPSERVPGCTMLLGKMLQDAGAPDGTLNIIHGQ----HAAVNFICDHP SINFRUP00000152737 LLKPSERVPTCAMLLAKMLQDAGAPDGTLNIIHGQ----HAAVNFICDHP ENSMUST00000054045 LMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQ----HDAVNFICDHP ENST00000238696 LMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQ----HEAVNFICDHP ci0100142299 VLKPSERDPGCTMLLAQLAQDAGVPDGALNVIHGA----HDAVNFVCDNP : * : . : : .:* * * *:: . ci0100136603 DVAAVSFTGSTATGKILLGLAAST-VKKVSMELGGLAPFIVFDSADMNKV ENSMUST00000037615 LVSKISFTGSTATGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQA CG4685-RA DVRGISFTGSTEVGKLLFRNSADG-IKRICLELGGNAPFIVFDSADIEKA Q8QGQ1_Brachydanio_rerio GIDKVAFTGSTEVGKLIQEAAGKSNLKRVTLELGGKSPNIIFADADFELA Q90Y03_Brachydanio_rerio GIDKVAFTGSTEVGKLIQEAAGKSNLKRVTLELGGKSPNIIFADADFELA Q90XS8_Brachydanio_rerio GIDKVAFTGSTEVGKLIQEAAGKSNLKRVTLELGGKSPNIIFADADFELA ENSMUST00000034723 GIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA ENST00000297785 DIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNA ENSMUST00000044384 DVDKVAFTGSTEVGHLIQKAAGESNLKRVTLELGGKSPSIVLADADMEHA ENST00000271359 DVAKVSFTGSVPTGMKIMEMSAKG-IKPVTLELGGKSPLIIFSDCDMNNA ENST00000265605 EVPLISFTGSQPTAERITQLSAPH-CKKLSLELGGKNPAIIFEDANLDEC SINFRUP00000144622 AIKAISFVGSNSAGEYIYERGSKN-GKRVQSNMGAKNHGVVMPDANKENT SINFRUP00000152737 AIKAISFVGSNQAGEYIYERGSRN-GKRVQSNMGAKNHGVVMPDANKENT ENSMUST00000054045 DIKAISFVGSNQAGEYIFERGSRN-GKRVQANMGAKNHGVVMPDANKENT ENST00000238696 DIKAISFVGSNKAGEYIFERGSRH-GKRVQANMGAKNHGVVMPDANKENT ci0100142299 DIRAVSFVGSNQAGEYIYDRATKT-GKRVQSNMGAKNHGIIMPDAAKENT : ::*.** .. : . * : ::*. ::: .. : ci0100136603 IPNAIACKFRYMGQTCVCANRIFVQESVHDEFVSKLVAAMKKELILGDTL ENSMUST00000037615 VAGAMASKFRNAGQTCVCSNRFLVQRGIHDSFVTKFAEAMKKSLRVGNGF CG4685-RA VDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRV-EALKIGDGQ Q8QGQ1_Brachydanio_rerio LEQAHQGVFFNNGQCCTAGSRIFVEEPIYDEFVRRSVERA-QRRKVGNPF Q90Y03_Brachydanio_rerio LEQAHQGVFFNNGQCCTAGSRIFVEEPIYDEFVRRSVERA-QRRKVGNPF Q90XS8_Brachydanio_rerio LEQAHQGVFFNNGQCCTAGSRIFVEEPIYDEFVRRSVERA-QRRKVGNPF ENSMUST00000034723 VEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERA-KRRIVGSPF ENST00000297785 VEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERA-KKYILGNPL ENSMUST00000044384 VDQCHEALFFNMGQCCCAGSRTFVEESIYREFLERTVEKA-KQRKVGNPF ENST00000271359 VKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQT-QRIKIGDPL ENST00000265605 IPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEAT-RKWKVGIPS SINFRUP00000144622 INQLVGAAFGAAGQRCMALS-TAIFVGESRNWLPELVERS-RSLRVNAGD SINFRUP00000152737 LNQLVGAAFGAAGQRCMALS-TAILVGEARSWLPELVERA-KALRVNAGD ENSMUST00000054045 LNQLVGAAFGAAGQRCMALS-TAILVGEAKKWLPELVDRA-KNLRVNAGD ENST00000238696 LNQLVGAAFGAAGQRCMALS-TAVLVGEAKKWLPELVEHA-KNLRVNAGD ci0100142299 LNQLTGAAFGAAGQRCMALS-TVVFVGESKEWITDIKERA-EKLTVNAGD : * *: * . : .: . :. ci0100136603 DPANSFGPLINEKALEKVESQVEDAIKNGATVVCGGK-RGSLG------G ENSMUST00000037615 EEGTTQGPLINEKAVEKVEKQVNDAVAKGATVVTGGK-RHQSG------G CG4685-RA GCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKG------S Q8QGQ1_Brachydanio_rerio DPTTEHGPQVSEEQQRRVLELIQSGITEGAKLECGGKAPA-------TKG Q90Y03_Brachydanio_rerio DPTTEHGPQVSEEQQRRVLELIQSGITEGAKLECGGKAPP-------TKG Q90XS8_Brachydanio_rerio DPTTEHGPQVSEEQQRRVLELIQSGITEGAKLECGGKAPA-------TKG ENSMUST00000034723 DPTTEQGPQIDKKQYNKVLELIQSGVAEGAKLECGGKGLG-------RKG ENST00000297785 TPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG-------NKG ENSMUST00000044384 ELDTQQGPQVDKEQFERILGYIRLGQKEGAKLLCGGERLG-------ERG ENST00000271359 LEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL-KDG ENST00000265605 DPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAG SINFRUP00000144622 QPGADVGPLISPQAKERVECLIQSGVEEGAKVLLDGRNVKVKG---YENG SINFRUP00000152737 QPGADVGPLISPQAKERVCSLIQSGVDQGAKLLLDGRNVKVKG---YESG ENSMUST00000054045 QPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRRIKVKG---YENG ENST00000238696 QPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKG---YENG ci0100142299 QAGADLGPLISPEAKDRVCRLIQSGVDEGANILLDGRNVNVKG---YENG *. : :: : . : * : . . ci0100136603 TFYEPTLITGVTPAMKCCNEETFGPIAAIIKFKTEDEVIALANDSRVGLA ENSMUST00000037615 NFFEPTLLSNVTRDMLCITEETFGPLAPVIKFDKEEEAVAIANAAEVGLA CG4685-RA LFYAPTIVTDVPPSAQLYSEEVFGPVVSIIRFRDEEEAVKKANDTRRGLA Q8QGQ1_Brachydanio_rerio FFVEPTVFSNVKDHMRIAKEEIFGPVQQIMKFKTIEEVIERANNTEYGLA Q90Y03_Brachydanio_rerio FFVEPTVFSNVKDHMRIAKEEIFGPVQQIMKFKTIEEVIERANNTEYGLA Q90XS8_Brachydanio_rerio FFVEPTVFSNVKDHMRIAKEEIFGPVQQIMKFKTIEEVIERANNTEYGLA ENSMUST00000034723 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLV ENST00000297785 YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS ENSMUST00000044384 FFIKPTVFGDVQDGMRIAKEEIFGPVQPLFKFKKIEEVIQRANNTRYGLA ENST00000271359 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA ENST00000265605 YFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA SINFRUP00000144622 NFVGPTILSKVMPNMTCYKEEIFGPVLVVLEADSLDEAISIINQNPYGNG SINFRUP00000152737 YFVGPTILGNVTPDMKCYTEEIFGPVLVVLEADTLDDAICMVNRNPYGNG ENSMUST00000054045 NFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNG ENST00000238696 NFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNG ci0100142299 NFVGPTIITNVTTDMTCYREEIFGPVLVVLEADTLDDAINITNANPYGNG : * :. ** ***: :. :.: * * ci0100136603 GYFFSNDVAQCWRVAEKLEVGMVGINEGL-MSTAEAPFGGVKESGLGRE- ENSMUST00000037615 GYFYSQDPAQIWRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQSGLGRE- CG4685-RA GYFYSENLQQVFRVAKRLEVGMVGVNEGI-ISAAEAPFGGVKESGVGRE- Q8QGQ1_Brachydanio_rerio AAVFTRDISKAMTISAAVQAGTVWINCYN-ALSCQCPFGGFKMSGNGRE- Q90Y03_Brachydanio_rerio AAVFTRDISKAMTISAAVQAGTVWINCYN-ALSCQCPFGGFKMSGNGRE- Q90XS8_Brachydanio_rerio AAVFTRDISKAMTISAAVQAGTVWINCYN-AMSCQCPFGGFKMSGNGRE- ENSMUST00000034723 AAVFTNDINKALMVSSAMQAGTVWINCYN-ALNAQSPFGGFKMSGNGRE- ENST00000297785 AGVFTKDIDKAITISSALQAGTVWVNCYG-VVSAQCPFGGFKMSGNGRE- ENSMUST00000044384 AAVFTRDLDKAIYFTQALQAGTVWVNTYN-IVTCHTPFGGFKESGNGRE- ENST00000271359 AGVFTRDIQRAHRVVAELQAGTCFINNYN-VSPVELPFGGYKKSGFGRE- ENST00000265605 ATVWSSNVGRVHRVAKKLQSGLVWTNCWL-IRELNLPFGGMKSSGIGRE- SINFRUP00000144622 TAIFTTNGATARKYTHEVDVGQIGVNVPIPVPLPMFSFTGSRGSFRGDTN SINFRUP00000152737 TAIFTTNGATARKYTHEVDVGQVGVNVPIPVPLPMFSFTGSRGSFRGDTN ENSMUST00000054045 TAIFTTNGATARKYAHMVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTN ENST00000238696 TAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTN ci0100142299 TAIFTRSGATARKFINDIDVGQVGVNVPIPVPLPMFSFTGSRASFRGDTH .:: . :: * * .* * : * * ci0100136603 -GSQFALDEFTEMKYMCWGV------------------- ENSMUST00000037615 -GSKYGIDEYLEVKYVCYGGL------------------ CG4685-RA -GSKHGIDDYVDIKYICMGNLKYD--------------- Q8QGQ1_Brachydanio_rerio -LGEIGLKEYTELKTITMKMSGKTS-------------- Q90Y03_Brachydanio_rerio -LGEIGLKEYTELKTITMKMSGKTS-------------- Q90XS8_Brachydanio_rerio -LGEIGLKEYTELKTITMKMSGKTS-------------- ENSMUST00000034723 -MGEFGLREYSEVKTVTVKIPQKNS-------------- ENST00000297785 -LGEYGFHEYTEVKTVTVKISQKNS-------------- ENSMUST00000044384 -LGEDGLRAYTEVKTVTIKVPEKNS-------------- ENST00000271359 -NGRVTIEYYSQLKTVCVEMGDVESAF------------ ENST00000265605 -GAKDSYDFFTEIKTITVKH------------------- SINFRUP00000144622 FYGKQGIQFYTQIKTVTSQWKAEDATVTSPAVTMPTMGR SINFRUP00000152737 FYGKQGIQFYTQIKTVTSQWKAEDATLKSPAVTMPTMGR ENSMUST00000054045 FYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR ENST00000238696 FYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR ci0100142299 FYGKEGIQFYTQLKTITQLWREEDVEHSKPAVAMPVMR- : .. : ::* : : : :