CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000127104 ------------------------------------------------------------ SINFRUP00000142180 ----------------------------------------QVVDTMSDSTASSTTANDLD ENST00000269095 ---------------------------MPVAATNSETAMQQVLDNLG-SLPSATGAAELD ENSMUST00000036236 --------------------------------------MQQVLENLT-ELPSSTGAEEID ENST00000222644 --------------------------------------MQQVLENLT-ELPSSTGAEEID SINFRUP00000145264 -------------------------------------AMQQVLDNLK-ELPSGTEAKDID SINFRUP00000153448 ------------------------------------SAMQQVLDNAG-EAPASSGAKDID ENST00000318588 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLK ENSMUST00000033321 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLK CG6703-RB MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLK :: : SINFRUP00000127104 ------------------------------------------------------------ SINFRUP00000142180 --------------------------LIYLKGIMESP-----AVFKRNTHVNMLLICDIQ ENST00000269095 --------------------------LIFLRGIMESP-----IVRS-------------- ENSMUST00000036236 --------------------------LIFLKGIMENP-----IVKSLAKA---------- ENST00000222644 --------------------------LIFLKGIMENP-----IVKSLAKA---------- SINFRUP00000145264 --------------------------LIFLRGIIESP-----VVRSLAKARSCSQYSTTV SINFRUP00000153448 --------------------------LLFLRGIMESP-----TVR-FPRQICPPGISAAQ ENST00000318588 REASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASH ENSMUST00000033321 REASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASH CG6703-RB REATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACH : : :: : SINFRUP00000127104 -------------AHEQ-----FEEPKLEAVREN-------------------------- SINFRUP00000142180 YMFGFVSSLMSCMCQEQE--ASLKEVHLSPVREN-------------------------- ENST00000269095 ----------LAKAHER-----LEETKLEAVRDN-------------------------- ENSMUST00000036236 -------------------HERLEDSKLEAVSDN-------------------------- ENST00000222644 -------------------HERLEDSKLEAVSDN-------------------------- SINFRUP00000145264 QSSYLVTELWLNHRDGTNAHERLEEVKLQAVRNN-------------------------- SINFRUP00000153448 IREQTRPSSCPPPPPPPQAHEHTEEVKLEAVQDN-------------------------- ENST00000318588 YMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLG--ESGLVAGG ENSMUST00000033321 YMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLG--ESGLVAGG CG6703-RB YMRQILEALRYCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHG * . :* SINFRUP00000127104 ------------------------------------------------------------ SINFRUP00000142180 ------------------------------------------------------------ ENST00000269095 ------------------------------------------------------------ ENSMUST00000036236 ------------------------------------------------------------ ENST00000222644 ------------------------------------------------------------ SINFRUP00000145264 ------------------------------------------------------------ SINFRUP00000153448 ------------------------------------------------------------ ENST00000318588 RVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMN ENSMUST00000033321 RVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMN CG6703-RB RVGCPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFE SINFRUP00000127104 ------------------------------------------------------------ SINFRUP00000142180 ------------------------------------------------------------ ENST00000269095 ------------------------------------------------------------ ENSMUST00000036236 ------------------------------------------------------------ ENST00000222644 ------------------------------------------------------------ SINFRUP00000145264 ------------------------------------------------------------ SINFRUP00000153448 ------------------------------------------------------------ ENST00000318588 PRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKF ENSMUST00000033321 PRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKF CG6703-RB APEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDK-LQRTHLADTVEELKRY SINFRUP00000127104 ------------------------------------------------------------ SINFRUP00000142180 ------------------------------------------------------------ ENST00000269095 ------------------------------------------------------------ ENSMUST00000036236 ------------------------------------------------------------ ENST00000222644 ------------------------------------------------------------ SINFRUP00000145264 ------------------------------------------------------------ SINFRUP00000153448 ------------------------------------------------------------ ENST00000318588 NARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTS--------SGAVSQVLDSLEE ENSMUST00000033321 NARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSVSFPFVPPGAVSQVLDSLEE CG6703-RB NARRKLKGAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAG---IEAVQRILDCLDD SINFRUP00000127104 -------------------------------------------------NVELVQDILKE SINFRUP00000142180 -------------------------------------------------NVELLQEILRD ENST00000269095 -------------------------------------------------NLELVQEILRD ENSMUST00000036236 -------------------------------------------------NLELVNEILED ENST00000222644 -------------------------------------------------NLELVNEILED SINFRUP00000145264 -------------------------------------------------NVQLVTEVLDS SINFRUP00000153448 -------------------------------------------------NVELVTEILGD ENST00000318588 IHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKIN-TKSSPQIRNPPSDAVQRAKEVLEE ENSMUST00000033321 IHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKIN-TKSSPQIRNPPSDAVQRAKEVLEE CG6703-RB IYSLQDAH-VDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQ : ::* . SINFRUP00000127104 LSPIAHSSQ-----AADELVRILKEPHFQSLLETHDSVASKNY-------ETPPPSPCSF SINFRUP00000142180 LDPFKHRSN-----TAAELTSILTQPHFQSLLETHDSVASQVC-------DSPPSSPGDF ENST00000269095 LAHVAEQSS-----TAAELAHILQEPHFQSLLETHDSVASKTY-------ETPPPSPG-- ENSMUST00000036236 ITPLISVDE-----NVAELVGILKEPHFQSLLEAHDIVASKCY-------DSPPSSPE-- ENST00000222644 ITPLINVDE-----NVAELVGILKEPHFQSLLEAHDIVASKCY-------DSPPSSPE-- SINFRUP00000145264 LNNLSGKDT-----AAAELAGILQEPHFKALIEAHDLVAAKCY-------ESPLPAVN-- SINFRUP00000153448 ISSLKVKDD-----SAAELSRILQEPHFQSLLEAHDIVASKCY-------EVPPPPEM-- ENST00000318588 ISCYPENN------DAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLN ENSMUST00000033321 ISCYPENN------DAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLN CG6703-RB LSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLN : . ** :* **: :*:.:** ** . * SINFRUP00000127104 MDAALNNQP----VPPDAVRMVGIRKVSGEHLGVTFRVEN-GELVIARILHGGMIDQQGL SINFRUP00000142180 VDHNTEDEYKHTYPPPDAIRMVGIRKVAGEHLGVTFKVEG-SDLIIARILHGGMVDQQGL ENST00000269095 LDPTFSNQP----VPPDAVRMVGIRKTAGEHLGVTFRVEG-GELVIARILHGGMVAQQGL ENSMUST00000036236 MNIPSLNNQ----LPVDAIRILGIHKKAGEPLGVTFRVEN-NDLVIARILHGGMIDRQGL ENST00000222644 MNNSSINNQL---LPVDAIRILGIHKRAGEPLGVTFRVEN-NDLVIARILHGGMIDRQGL SINFRUP00000145264 SDAP-ATTAL---MPADAIRMIGIQKRAGEPLGVTFRTER-GEMVITRILHGSSIDRQGM SINFRUP00000153448 SNDAAVNSAL---MQADAVRMIGIRKKAGEPLGVTFRVEK-DDLVIARILHGGMIDRQGL ENST00000318588 GDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGT ENSMUST00000033321 GDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGT CG6703-RB GDELDNVEG-GELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQAT : :*:: ::* :.* :*:*:: . :::**:**. : :*. SINFRUP00000127104 LHVGDIIKEVNGKEVGND-PKVLQEMLKEASGSVVLKILPSYQEPHTARQ---------- SINFRUP00000142180 LHAGDIIKEVNGREVGRD-PRVLQEELQAASGNIVLKILPSYHEAILPRQ---------- ENST00000269095 LHVGDIIKEVNGQPVGSD-PRALQELLRNASGSVILKILPSYQEPHLPRQ---------- ENSMUST00000036236 LHVGDIIKEVNGHEVGNN-PKELQELLKNISGSVTLKILPSYRDTITPQQ---------- ENST00000222644 LHVGDIIKEVNGHEVGNN-PKELQELLKNISGSVTLKILPSYRDTITPQQ---------- SINFRUP00000145264 LHVGDIIREVNGREVGSD-PHHLQELLRDCSGSITLKVLPSYRDAPAPPQ---------- SINFRUP00000153448 LHVGDIIKEVNGKDVGNN-PTELQDMLKDCSGGITLKILPSYRDAPAPPQ---------- ENST00000318588 LHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCE---------- ENSMUST00000033321 LHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQS CG6703-RB LHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE---------- **.** *:*:** * : ** *: *.: :*::***: . : SINFRUP00000127104 -------------------------AFVKCHFDYDPSHDNLIPCKEAGLSFNSGDILQIF SINFRUP00000142180 -------------------------VFFKCHYDYDPANDNLIPCKEAGLRFETGDILQIV ENST00000269095 -------------------------VFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIV ENSMUST00000036236 -------------------------VFVKCHFDYNPFNDNLIPCKEAGLKFSKGEILQIV ENST00000222644 -------------------------VFVKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIV SINFRUP00000145264 -------------------------AYLKSHFNYNPNTDNLIPCKEAGLAFSKGDILQVV SINFRUP00000153448 -------------------------VYVRPYFDYNPANDSLIPCREAGMAFTKGDILQIV ENST00000318588 -------------DLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQII ENSMUST00000033321 PANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQII CG6703-RB -------------------------IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQII :.: ::*:* *.**** :**: * *:::*:. SINFRUP00000127104 NQEDLNWWQAC-HIE-GGSAGLIPSQLLEEKRKAFVKRDLELAT-AGPLCAGMGGKKKKR SINFRUP00000142180 NQDDVNWWQAR-HVE-GGSTGLIPSQTLEEKRKAFVKRDVELAP-AGNLCTGVGGKKKKK ENST00000269095 NQDDANWWQAC-HVE-GGSAGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKR ENSMUST00000036236 NREDPNWWQAS-HVKEGGSAGLIPSQFLEEKRKAFVRRDWDNSG-P--FCGTISNKKKKK ENST00000222644 NREDPNWWQAS-HVKEGGSAGLIPSQFLEEKRKAFVRRDWDNSG-P--FCGTISSKKKKK SINFRUP00000145264 NKEDSNWWQAR-KVI-GGTTGLIPSQFLEEKRKAFVRRDWDNSG-AGILCGTKTMKKRKK SINFRUP00000153448 NREDPNWWQAC-HVV-GGATGLIPSQFLEEKRKAFVPRDFEGAG-I--LCGTLAGKKKKK ENST00000318588 SKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYK ENSMUST00000033321 SKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYK CG6703-RB SKDDHHWWQARLDTVG-GSAGLIPSPELQEWRIACQTVDKTKQEQ-VNCSIFGRKKKQCR .::* :***. . *::***** *:* * * : **: : SINFRUP00000127104 MMYLTTKNAEFDRHELKIYEEVAKVPP----FRRKTLVLIGAQGVGRRSLKNKLMVSDSQ SINFRUP00000142180 IMYVTTKNAEFDRHEILLYEEVAKVPP----FKRKTLIVIGAQGVGRRRLKNKLLLRDPL ENST00000269095 MMYLTTKNAEFDRHELLIYEEVARMPP----FRRKTLVLIGAQGVGRRSLKNKLIMWDPD ENSMUST00000036236 MMYLTTRNAEFDRHEIQIYEEVAKMPP----FQRKTLVLIGAQGVGRRSLKNRFIVLNPA ENST00000222644 MMYLTTRNAEFDRHEIQIYEEVAKMPP----FQRKTLVLIGAQGVGRRSLKNRFIVLNPT SINFRUP00000145264 MMYLTSKNAEFDRYELQIYEEVAKMPP----FQRKTLVLIGAQGVGRRSLKNRLIFMNPL SINFRUP00000153448 MMYLTAKNAEFDRHELQIYEEVAKVPA----FQRKTLVLIGAQGVGRRSLKNRLMVLHPT ENST00000318588 DKYLAKHNAVFDQLDLVTYEEVVKLPA----FKRKTLVLLGAHGVGRRHIKNTLITKHPD ENSMUST00000033321 DKYLAKHNAVFDQLDLVTYEEVVKLPA----FKRKTLVLLGAHGVGRRHIKNTLITKHPD CG6703-RB DKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPD *:: :** ** :: ****.::* *:****:::**:***** :** :: . SINFRUP00000127104 RYGTTIPFTSRKPKVDERDGQMYSFMTRSEMECDIKNGRFLEHGEYDGNFYGTKISSIHE SINFRUP00000142180 LFGTTIPYTSRKPKKGERESRMFAFTSRSKMETDIKNGRYLEHGEYEGNLYGIKTDSIQE ENST00000269095 RYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRG ENSMUST00000036236 RFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILE ENST00000222644 RFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILE SINFRUP00000145264 RYGTTVPFTSRRPREEERDGQNYCFVTREEMEKDIKEGRYLEHGEYDGNLYGTKMDSIHE SINFRUP00000153448 RFGTTIPYTSRRPRDNELNGNTYHFTTRSEMEVDVKAGRFLEHGEYDGNLYGTKIESIHE ENST00000318588 RFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRK ENSMUST00000033321 RFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRK CG6703-RB KYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRR :. .:*.*:* .: * :.. : * :: :* *: ..:**:* ::. :** : .:* SINFRUP00000127104 VMDTGKICILDVNPQALKVLRTSEFLPYVVFIEAPDYEVLKAMNRSAIELGVVTKQMTDS SINFRUP00000142180 VIEAGRICILDPNPQTLKVLRTSEFLPYVVFLQSPEFEVLKAINHSAVEAGVVTKTLTDE ENST00000269095 VVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEA ENSMUST00000036236 VVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKLLTDS ENST00000222644 VVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKLLTDS SINFRUP00000145264 VVDAGRTCILDVNPQALKVLKTAEFMPFVVFIAAPELDTLRAMHKAVVDAGLTTKLLTEN SINFRUP00000153448 VVAAGRTCILDVNPQALKVLKTAEFMPYVVFVAAPDFDTLKAMHKAVVDAGITTKQLTDV ENST00000318588 IHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAP---------------TITPGLNEDE ENSMUST00000033321 IHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAP---------------TITPGLNEDE CG6703-RB IHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAP---------------SLQNIADYDG : * .:** :**::*:*:*:** *:***: :* : : : : : SINFRUP00000127104 ELKRTVDESERIKRAYGHYFDLCIINDGHEAAFRTLRSALEKLTTEQQWVPVNWVF SINFRUP00000142180 EMHRTCNESAKIQAAYGHYFDLTIVNDNLDETYRTVKAALETVSKNPQWVPVTWVF ENST00000269095 DLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY ENSMUST00000036236 DLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFEKLQTAIEKLRMEPQWVPISWVY ENST00000222644 DLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVPISWVY SINFRUP00000145264 DLKKTVDESARIRRAYSHYFDLTIVNDNLDKAFDKLQEAVEQLLTEPQWVPVSWVY SINFRUP00000153448 DLRKTVDESARIQRAYGHYFDLTIVNDNLDKAFETLQVAVDGLCSDPQWVPVNWVY ENST00000318588 SLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY ENSMUST00000033321 SLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY CG6703-RB SLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY .:.: .** :: * *:*** ::*. . : :. *:: : ****:.*::