CLUSTAL W (1.82) multiple sequence alignment ENST00000248545 RRQRRKRRGRRASGSEVVEAAEAAAARDWARLEAARVRAPQQAPISRLDHPPAARTPGPR ENSMUST00000038109 ------------------------------------------------------------ SINFRUP00000163586 ------------------------------------------------------------ SINFRUP00000139679 ------------------------------------------------------------ SINFRUP00000152874 ------------------------------------------------------------ ENST00000262435 -----------------------------------------EGGARRPAPSAAHGDDSRH ci0100146085 ------------------------------------------------------------ CG4943-RA ------------------------------------------------------------ ENST00000248545 SLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIR ENSMUST00000038109 ------------------------------------------------------------ SINFRUP00000163586 ------------------------------------------------------------ SINFRUP00000139679 ------------------------------------------------------------ SINFRUP00000152874 ------------------------------------------------------------ ENST00000262435 IRDPPAVAAEAPAARAPAPAAVVTPPRLAVAPVPPAAPAAPAAGDMSNPGGRRNGPVKLR ci0100146085 -------------------------------------------MSSASGSTRRNGTMKLR CG4943-RA --------------------------------------------MNKLDYPRRNGTHKVR ENST00000248545 LTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSI ENSMUST00000038109 ------------------------------------------------------------ SINFRUP00000163586 ----------------LPDPFAKVVVDGSGQCHSTDTVKSTLDPKWNQHYDLYIGKTDSI SINFRUP00000139679 -------NILLSNCTGLPDPFAKVVVDGSGQCHSTDTVRNTLDPKWNQHYDLYIGKADSI SINFRUP00000152874 ----------------------------------------------------YIGKSDSI ENST00000262435 LTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSV ci0100146085 LTVFCAKNICKRDFFRLPDPFAKILVDGSGQCHATGTCKATLDPKWNQHYDLYVGKSDSI CG4943-RA ITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGDAI : : : : : : : : ENST00000248545 TISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTD--AVRGQIV ENSMUST00000038109 -------------------------------------QRLDLCKLNPSDTD--AVRGQIV SINFRUP00000163586 TISIWNHKKIHKRQGAGFLGCIRLLSNAISRLKDTGYQRLDLCKLNPSDSD--AVRGQIV SINFRUP00000139679 TISVWNHKKIHKKQGAGFLGCVRLLSNAINRLIDTGYFNYTSSIFERELSNSSIGFIYCE SINFRUP00000152874 TISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGFQMYEPALFTEKK------LLHVK ENST00000262435 TISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDND--TVRGQIV ci0100146085 TISVWNHRKVHKKHGAGFLGCIRIMSNAINRLKDTGYQRLDLCKQTKYDQE--PVRGQIV CG4943-RA TITVWNQRKIHK--GSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDE--LVRGQII : : : :: : : : : ENST00000248545 VSLQTR--DRIGTG------GSVVDCRGLL-----ENEGT-VYEDSGPGR---------P ENSMUST00000038109 VSLQTR--DRIGGG------GSVVDCRGLL-----ENEGT-VYEDSGPGR---------P SINFRUP00000163586 VSLQTR--DRIGSG------GPVVDCRGLL-----ENDGP-VFEG--------------- SINFRUP00000139679 VSLQSR--DRIGSG------GPVVDCSRLF-----DNDLPDGWEERRTASGRIQYLNHIT SINFRUP00000152874 VSLQSR--DRIGTG------GPVVDCSRLF-----DNDLPDGWEERRTASGRIQYLNHIT ENST00000262435 VSLQSR--DRIGTG------GQVVDCSRLF-----DNDLPDGWEERRTASGRIQYLNHIT ci0100146085 VSIESRDLDDRSPS------NPVIDARSLIP--AQENDLPEGWEARMTNG-RLQYIDHYT CG4943-RA ISLLSK--DGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHAT :*: :: * . . . * ::. . :* ENST00000248545 LSCFMEEPAPY------------------------------------------------- ENSMUST00000038109 LSCLMEEPAPY------------------------------------------------- SINFRUP00000163586 --CFSEEPLPY------------------------------------------------- SINFRUP00000139679 RTTQWERPTRP------------------------------------------------- SINFRUP00000152874 RTTQWDRPTRP------------------------------------------------- ENST00000262435 RTTQWERPTRP------------------------------------------------- ci0100146085 RTTQWERPTQP------------------------------------------------- CG4943-RA KSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRD :.* ENST00000248545 ----------------------------------------TDSTGAAAGGGNCRFVESPS ENSMUST00000038109 ----------------------------------------TDGTGAAAGGGNCRFVESPS SINFRUP00000163586 ----------------------------------------SDPTG-AAGGGNCR-LDSPN SINFRUP00000139679 ----------------------------------------ASEYSSPSGRPLSCVVDENT SINFRUP00000152874 ----------------------------------------ASEYSSP-GRPLSCIVDENT ENST00000262435 ----------------------------------------ASEYSSP-GRPLSCFVDENT ci0100146085 ----------------------------------------STRPRRPLSALIISEPDQHQ CG4943-RA LSVTASDERRHSTEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNE : . . ENST00000248545 -----------------QDQRLQAQRLRNPDVRGSLQTPQNRP----------------- ENSMUST00000038109 -----------------QDQRLLVQRLRNPEVRGPLQTPQNRP----------------- SINFRUP00000163586 -----------------QESR--IQRTRGQDSRGLGHTPQNRP----------------- SINFRUP00000139679 PVMT--PVNGAEASVPPGEQRVQERRVRSQRHR----NYMSRT----------------- SINFRUP00000152874 PITTNGATPTTALPVTANDQRAQERRARSQRHR----NYMSRT----------------- ENST00000262435 PISG---TNGATCGQSS-DPRLAERRVRSQRHR----NYMSRT----------------- ci0100146085 RPRIS--SSSGSSGPRNSSSPSVPGESDSTRFRR-HKNYMTRN----------------- CG4943-RA PATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSG . . . . ENST00000248545 -----------------------------------HGHQSPE------------------ ENSMUST00000038109 -----------------------------------HGHQSPE------------------ SINFRUP00000163586 -----------------------------------HGHQPPD------------------ SINFRUP00000139679 -----------------------------------HLHTPPD------------------ SINFRUP00000152874 -----------------------------------HLHTPPD------------------ ENST00000262435 -----------------------------------HLHTPPD------------------ ci0100146085 -----------------------------------QLHGPSAP----------------- CG4943-RA NGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVH : : .. ENST00000248545 ------------------------------------------------------------ ENSMUST00000038109 ------------------------------------------------------------ SINFRUP00000163586 ------------------------------------------------------------ SINFRUP00000139679 ------------------------------------------------------------ SINFRUP00000152874 ------------------------------------------------------------ ENST00000262435 ------------------------------------------------------------ ci0100146085 ------------------------------------------------------------ CG4943-RA SPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGG ENST00000248545 ------------------------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPS ENSMUST00000038109 ------------------------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP--- SINFRUP00000163586 ------------------------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRYV SINFRUP00000139679 ------------------------LPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP--- SINFRUP00000152874 ------------------------LPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP--- ENST00000262435 ------------------------LPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP--- ci0100146085 ------------------------LPEGYEQRTTQQGQVYFLHTQTGVSSWHDPRIP--- CG4943-RA GGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPR-- ** *** *** ****** * ****:*****:* ENST00000248545 GTIPGGDAAFL----------YEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGR ENSMUST00000038109 ---------------------------------RDLNSVNCDELGPLPPGWEVRSTVSGR SINFRUP00000163586 HALLLSGPDVPGHEREPSHCRCRWFDRVLCCCCRDLASVSCEELGPLPAGWEVRSTVSGR SINFRUP00000139679 ---------------------------------RDLSNVNCEELGPLPPGWEIRNTATGR SINFRUP00000152874 ---------------------------------RDLSNINCEELGPLPPGWEIRNTATGR ENST00000262435 ---------------------------------RDLSNINCEELGPLPPGWEIRNTATGR ci0100146085 ---------------------------------RNLSHINPEDLGPLPSGWELRSTATGR CG4943-RA --------------------------------DFDTQHLTLDAIGPLPSGWEQRKTASGR : . : : :. : :****.*** *.*.:** ENST00000248545 IYFVDHNNRTTQFTDPR----LHHIMNHQ---------CQLKEPS---QPLPLPS----- ENSMUST00000038109 IYFVDHNNRTTQFTDPR----LHHIMNHQ---------CQLKEPS---QPLQLPS----- SINFRUP00000163586 IYFVDHNNRTTQFTDPR----LHTIISQQ---------SQVKESS---QAPPMDVGGDDV SINFRUP00000139679 IYFVDHNNRTTQFTDPRLSANLHRVLNLHNHP------TQVKDQSVPVAPLQALSPA--- SINFRUP00000152874 VYFVDHNNRTTQFTDPRLSANLHLVLNRQ---------SQSKDQ----AQQALVSPS--- ENST00000262435 VYFVDHNNRTTQFTDPRLSANLHLVLNRQ---------NQLKDQ----QQQQVVS----- ci0100146085 LYYVDHSSRTTQFTDPRIGRYIGQMHNRG------------RDGP--------------- CG4943-RA VYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPP :*:***..********* : : ENST00000248545 -EGSLEDEELP--------------------------AQRYERDLVQKLKVLRHELSLQQ ENSMUST00000038109 -EGSVEDEELP--------------------------AQRYERDLVQKLKVLRHELSLQQ SINFRUP00000163586 GSGGGGGEGDL--------------------------AARYERDLVHKLKLLRHELSLQQ SINFRUP00000139679 -QLPEEAECLT--------------------------VPKYKRDLVQKLKTLRQELSQQQ SINFRUP00000152874 -QLPEEGECLT--------------------------VPKYKRDLVQKLKILRQELSQHQ ENST00000262435 -LCPDDTECLT--------------------------VPRYKRDLVQKLKILRQELSQQQ ci0100146085 --NEECDQDPQ--------------------------LPRYKRDLVHKLKVLRTELQSQQ CG4943-RA QATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQ :*.**** **: ** **. * ENST00000248545 PQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCH ENSMUST00000038109 PQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCH SINFRUP00000163586 PQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCH SINFRUP00000139679 PPAGHCRIEVCREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSH SINFRUP00000152874 PQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSH ENST00000262435 PQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSH ci0100146085 PQTGHCRLEIKRSEAFEQSYSLIMKMKPKDLKKRLMVKFTGEDGLDYGGLAREWLYILSH CG4943-RA PQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSR * :****:*: *.* **:** :***:.**: ****:** **:******:*****::*.: ENST00000248545 EMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVP ENSMUST00000038109 EMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVP SINFRUP00000163586 EMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRVMGLAVFHSHYINGSFTQP SINFRUP00000139679 EMLNPYYGLFQYTRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLP SINFRUP00000152874 EMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLP ENST00000262435 EMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLP ci0100146085 EMLNPYYGLFQYSREDIYTLQINADSHINPDHLSYFHFVGRILGMAVYHGHYIDGGFTML CG4943-RA EMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTP ***** ******: :: * ****.** :**:********** :*:**:*.* ::*.** ENST00000248545 FYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPN ENSMUST00000038109 FYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPN SINFRUP00000163586 FYKQLLGKPIQLSDLETTDPELHKSLVWILENDITSVLDHTFCVEHNAFGKLSQHELKPN SINFRUP00000139679 FYKQLLGKSITLDDMESVDPDLYNSLVWILDNDITGVLDHTFCVEHNAYGEIIQHELKPN SINFRUP00000152874 FYKQLLGKSITLDDMESVDPDLHNSLVWILDNDITGVLDHTFCVEHNAYGEIVQHELKPN ENST00000262435 FYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPN ci0100146085 FYKQLLGKPISLEDMEEVDPALYKSMKWILQNDINGVLDHTFCVDQDSFGERVTHELKPN CG4943-RA FYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPG ******.*.* * *:* .** *:.*: *:*:.:*. ::: **.*:::::* *****. ENST00000248545 GRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIG ENSMUST00000038109 GRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIG SINFRUP00000163586 GRNIAVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFTELIPQHLLKPFDHKELELIIG SINFRUP00000139679 GKTISVSEDTKKEYVRLYVNWRFLHGIEAQFLALQKGFNEVIPQHLLKSFDEKELELIVC SINFRUP00000152874 GKSIPVTQDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVC ENST00000262435 GKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIIC ci0100146085 GVNIPVTEQNKREYVKLYVNWRFLRGIEAQFLSLSKGFYELIPQHLLRPFDERELELIIG CG4943-RA GASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIG * .:.*.::.*:***:****:**::*** ***:*.*** *:**.***:.**.:****:: ENST00000248545 GLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFK ENSMUST00000038109 GLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFK SINFRUP00000163586 GLGKIDIADWKTNTRLKHCTSESNVVRWFWQAVEAFNEERRGRLLQFVTGSTRVPLQGFK SINFRUP00000139679 GLGKIDISDWKANTRLKHCTPDSNIVKWFWKAVESFDEERRARLLQFVTGSSRVPLQGFK SINFRUP00000152874 GLGKIDINDWKTNTRLKHCTPDSNIVKWFWKAVESFDEERRARLLQFVTGSSRVPLQGFK ENST00000262435 GLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFK ci0100146085 GLGKIDLIDWKKHTKLKHCSQDSNIVKWFWQAVESFDEEKRARVLQFVTGSSRVPLQGFK CG4943-RA GISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFR *:..**: **: :*:**** ::. * ***:.** :..* *.*:*******:*******: ENST00000248545 ALQGSTGAAGPRLFTIHL-IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETC ENSMUST00000038109 ALQG---AAGPRLFTIHL-IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETC SINFRUP00000163586 ALQGSTGSAGPRLFTIHL-IDANTDNLPKAHT---------------------------- SINFRUP00000139679 ALQG---AAGPRLFTIHQ-IDANTNNLPKAHTCFNRIDIPPYEGYDKLYDKLLTAIEETC SINFRUP00000152874 ALQG---AAGPRLFTIHQ-IDASTNNLPKAHTCFNRIDIPPYEHYDKLYDKLLTAIEETC ENST00000262435 ALQG---AAGPRLFTIHQ-IDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETC ci0100146085 ALQGSTGTQGPRLFTIQF-VDNKTDCLPKAHTCFNRIDLPPYESYKKLLEKLTCAVENTC CG4943-RA ALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETC **** : *******: * *: ****** ENST00000248545 GFAVE ENSMUST00000038109 GFAVE SINFRUP00000163586 ----- SINFRUP00000139679 GFAVE SINFRUP00000152874 GFAVE ENST00000262435 GFAVE ci0100146085 GFYTE CG4943-RA GFAVE