CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000031795 MALGARGWRRRSLLLLLLWVTGQAAPVLGLAVSSELQIQQSFVPDECPRTVHSGDFVRYH ENST00000242209 -----------------------------------------------------GDFVRYH ENST00000275598 ------------------------------------------------------------ SINFRUP00000163781 -------------------------------PLDDISIEKTFVPEQCVRAVKVGDYVRYH ENSMUST00000001595 ------------------------------------------------------------ ENST00000269598 ------------------------------------------------------------ SINFRUP00000135539 ------------------------------------------------------------ SINFRUP00000141233 ------------------------------GLLVDVVVDRYDIPKYCPREVETEDFIRYH ci0100152107 ------MFVMFYKIFIVCFFLILKVFCKELENNDKVDIKVIWKPQVCKRFVEKGDFVRYH CG9847-RB ------------------------------------------------------------ : : : : ENSMUST00000031795 YVG-TFLDGQKFDSSYDRDSTFNVFVGKGQLIAGMDQALVGMCVNERRLVTIPPNLAYGS ENST00000242209 YVG-TFPDGQKFDSSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYGN ENST00000275598 ----------------------------------MDQALVGMCVNERHFVKIPPKLAYGS SINFRUP00000163781 YIG-TFPDGKKFDSSYDRGSTYNVYVGKKQLIEGMDKALVGMCVNERSLVKIPPQLAYGK ENSMUST00000001595 ----------------------------------------MFLVGSSSHTLHRLRILP-- ENST00000269598 ----GKRTGRGGASSGRRGEGGWWRLPRSPSLPAVPTPGTMFPAGPPSHSLLRLPLLQL- SINFRUP00000135539 ------------------------------------------VVPPDSTLVFDIHLLD-- SINFRUP00000141233 FNGSFYTDGKKFDSSHDRGKAFISQVGLGRLITGMDRGLQGMCVGERRRITIPPHLAYGS ci0100152107 YYG-MHTDGKVFDTSYQRAKTYDTYVGSGWLIPGMDDGLLGTCVNEHRLISIPPSLAYGE CG9847-RB ------------------------------------------------------------ : : : : ENSMUST00000031795 EGVSGVIPPNSVLHFDVLLVDIWNSEDQVHIQTYFKPPSCPRTIQVSDFVRYHYNGTFLD ENST00000242209 EGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLD ENST00000275598 EGVSGVIPPNSVLHFDVLLMDIWNSEDRVQIHTYFKPLSCPQTIQVSDFVRYHYNGTFLD SINFRUP00000163781 KGYGDLIPPDSILHFDVLLLDVWNPEDGVQIKTYHTPSVCTRKVEVSDYVRYHYNGTLLD ENSMUST00000001595 ----LLLLLQTLERGLGRASPAGAPLEDVVIERYHIPRACPREVQMGDFVRYHYNGTFED ENST00000269598 ----LLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQMGDFVRYHYNGTFED SINFRUP00000135539 ---------------------VWNKADLVVTRTVTTPKDCKRSVIRTDFVRYHFNGTLLD SINFRUP00000141233 IGTGGVIPPDAVLVYDVLLLDVWNAEDKVDIRTISKPSSCNRTTASSDFIRYHYNGTLLS ci0100152107 DG-TDDIPGNSTLLFNFVLVDIWNSKDDVKITTTYMPETCERKLEDSDYVRYHYNGTLLN CG9847-RB ---------------------------------------------MNNFLEYIS------ : : :::.* : ENSMUST00000031795 GTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITVPPFLAYGEEGDGKDIP ENST00000242209 GTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIP ENST00000275598 GTLFDSRYSKYSHWQEHP---------------------REAVLP---------RRKDIP SINFRUP00000163781 GTLFDSSHTRMRTYDTYVGIGWLIAGMDQGLLGMCVGERRFITMPPSLGYGENGDGSDIP ENSMUST00000001595 GKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGLIP ENST00000269598 GKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGLAGLIP SINFRUP00000135539 GTAFDSSYTRKQTHNSLVGEGWLIKGMDEGLLGMCVGEIRNIIIPPFKAYGEKGSGTEIP SINFRUP00000141233 GEAFDSSHSRNATYDTYLGQGDIIKGMDEGLLGMCVGERRIVIVPPFLAYGETGSGTLVP ci0100152107 GKVFHTSYEEDSTYNTYVGQGWLIKGMDVGLVGACFGERRTIEIPPHLGYGEKGDGKNIP CG9847-RB -VLHCSSMSKSN------------------------------------------------ . : . :: : :: . : : ENSMUST00000031795 GQASLVFDVALLDLHNPKDTISIENKVVPENCERRSQS---------------------- ENST00000242209 GQASLVFDVALLDLHNPKDSISIENKVVPENCERISQS---------------------- ENST00000275598 GQASLVFDVALLDLHNPKDSISIENKAVPENCERLSQS---------------------- SINFRUP00000163781 GQASLVFDVVLLDLHNPRDGITVTNQIVPDSCTRKSVS---------------------- ENSMUST00000001595 PDATLYFDVVLLDVWNKADTVQSTILLRPPYCPRMVQNSDFVRYHYNGTLLDGTAFDNSY ENST00000269598 PDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQD---------------------- SINFRUP00000135539 PHATLVFDVLLVDLHNPKDNITIEEQVVPETCTRRTVA---------------------- SINFRUP00000141233 PQATLVFDVLLVDVFNPKDDLIVEVKEVPDGCTRRSAV---------------------- ci0100152107 ASATIVFDIEIIDFHNPKDEPQIKIVVEVEGCERKLES---------------------- CG9847-RB LVISCLLLVAISNSLVRAQDLKVEVISTPEVCEQKSKN---------------------- : : : : : : * : ENSMUST00000031795 ------------------------------------------------------------ ENST00000242209 ------------------------------------------------------------ ENST00000275598 ------------------------------------------------------------ SINFRUP00000163781 ------------------------------------------------------------ ENSMUST00000001595 SRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTVIPPQASLVFY ENST00000269598 ------------------------------------------------------------ SINFRUP00000135539 ------------------------------------------------------------ SINFRUP00000141233 ------------------------------------------------------------ ci0100152107 ------------------------------------------------------------ CG9847-RB ------------------------------------------------------------ ENSMUST00000031795 ------------------------------GDFLRYHYNGTLLD-GTLFDSSYSRNHTFD ENST00000242209 ------------------------------GDFLRYHYNGTLLD-GTLFDSSYSRNRTFD ENST00000275598 ------------------------------GDFLRYHYNGTLLD-GTLFDSSYSQNRTFD SINFRUP00000163781 ------------------------------GDFIRYHYNGSLLD-GTFFDSSYSRNHTYD ENSMUST00000001595 VLLLDVHNPKDTVQLETLELPQGCVRRAVAGDFMRYHYNGSLMD-GTLFDSSYSRNHTYN ENST00000269598 ------------------------------GDFMRYHYNGSLMD-GTLFDSSYSRNHTYN SINFRUP00000135539 ------------------------------GDYIRYHYNGTLLN-GVTFDTSYQRNSTYN SINFRUP00000141233 ------------------------------GDYIRYHYNGSFQD-GTAFDSSYQRNSTYN ci0100152107 ------------------------------SDFVRYHYNGSFAD-GSLFDSSYQRNKTYD CG9847-RB ------------------------------GDSLTMHYTGTLQADGKKFDSSFDRDQPFT .* : **.*:: * **:*:.:: .: ENSMUST00000031795 TYIGQGYVIPGMDEGLLGVCIGERRRIVVPPHLGYGEKGRG-SIPGSAVLVFDIHVIDFH ENST00000242209 TYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRG-NIPGSAVLVFDIHVIDFH ENST00000275598 TYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGR-------------------- SINFRUP00000163781 TYVGLGYVIAGMDQGLIGICVGEKRTITIPPHLAYGEEGTGSKIPGSAVLVFDVHIIDFH ENSMUST00000001595 TYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSAVLIFDVHVIDFH ENST00000269598 TYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPGSAVLIFNVHVIDFH SINFRUP00000135539 TYIGMGYVIPGMDQALLGLCAGQRRRVTLPPHLAYGENGAGEVIPPSAVLVFDIHVIDFH SINFRUP00000141233 TYIGLGYVIQGMDKALQGLCVGEKRRITIPPHLAYGETGVGELIPSSAVLVFDIHVIDFH ci0100152107 TYVGFKRVIPGMELGLVGSCMGERRVIKLPPHLGYGEPGIEGRIPGSAVLIFSVHIVDFH CG9847-RB FQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGYGDQGAGNVIPPKATLLFDVELINIG :* :* * : .* . * *::* : :**:*.**: * : ::: : :: : ENSMUST00000031795 NPSDSISITSHYKP----PDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLG ENST00000242209 NPSDSISITSHYKP----PDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLG ENST00000275598 ------------------------------------------------------------ SINFRUP00000163781 NPSDITEITVTKKA----EDCEKKTKKGDFVKYHYNASLMDGTAIDSTYNYGKTYNIVLG ENSMUST00000001595 NPSDPVEIKTLSRPP---ENCNETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLG ENST00000269598 NPADVVEIRTLSRPS---ETCNETTKLGDFVRYHYNCSLLDGTQLFTSHDYGAPQEATLG SINFRUP00000135539 NPNDTVGIQTTYRP----DPCNETTEVNDLIRYHYNCTLVDGTLLFSSHDHENLQDVVLG SINFRUP00000141233 NPKDPVQIKVIHKP----EDCSLTSEADDLIQYRYNCSLMDGTLLYSSDHFDSPSFTTLG ci0100152107 NPKDDVEIKVESMPPSCLEDGVVVARKGNYLTYDYKLLLMDGTFIESSTDSTGDWGNYLG CG9847-RB N----------------------------------------------------------- : : :: : : ENSMUST00000031795 SGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGE-VPGSAVLVFDIELLELVSGL ENST00000242209 SGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGE-VPGSAVLVFDIELLELVAGL ENST00000275598 ------------------------------------------------------------ SINFRUP00000163781 ANQVVPGMETGLMDMCVGEKRHLIIPPHLAYGERGVTGE-VPGSAVLVFDVELISVEEGL ENSMUST00000001595 ANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARG--VPGSAVLLFEVELVSREDGL ENST00000269598 ANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARG--VPGSAVLLFEVELVSREDGL SINFRUP00000135539 TDKVIDGLDLALRGMCVGEKRLVTVPPHLGHGENGATG--VPGSAVLVFDIEMVTFEKGV SINFRUP00000141233 ADKVIPGLEKGLSGMCVGERREVVVPPHWGHGENGAGG--VPRSAVLFFQLKLVELQKGV ci0100152107 RGELIPGVERGLTGMCVGEIRRVVVPPHIGYGEQGRDSLNIPGSAVLVYTFHLHKIQESL CG9847-RB ------------------------APPTT------------------------------- :: : : : : : : ::. . : : ENSMUST00000031795 PEGYMFIWNGEVSP----NLFEEIDRDGNGEVLLEE-----FSEYIHAQVATGKGKLAPG ENST00000242209 PEGYMFIWNGEVSP----NLFEEIDKDGNGEVLLEE-----FSEYIHAQVASGKGKLAPG ENST00000275598 ------------------------------------------------------------ SINFRUP00000163781 PEGYMFIWNEDVSP----DLFSEMDKDNNKLVEPSE-----FTDYIMRQVNEGKGRLAPG ENSMUST00000001595 PTGYLFVWYQDPST----SLFEDMDLNKDGEVPPEE-----FSSFIKAQVNEGKGRLMPG ENST00000269598 PTGYLFVWHKDPPA----NLFEDMDLNKDGEVPPEE-----FSTFIKAQVSEGKGRLMPG SINFRUP00000135539 PPGYLFVWLQENPP----NLFETLDLNSNKEVPQEE-----FGEYIKLQVAEGRGRIKPG SINFRUP00000141233 PEGFMLVWLEDGPN----ALFPAMDLNGDKEVPLEELRLKTFSAFIRLQVEEGKGRLRPG ci0100152107 PEGFTFVWSKEYSPQSKEEVFAAMDEDKDEQVSLPE-----MTSFILDQVERGHAHLLPG CG9847-RB ------------------NVFKEIDDNADKQLSREE-----VSEYLKKQMTAVEGQDSEE :: :: : : : : . : : ENSMUST00000031795 FN-----AEMIVKNMFTNQDRNGDGKVTAEEFKLKDQE-AKHDEL----- ENST00000242209 FD-----AELIVKNMFTNQDRNGDGKVTAEEFKLKDQE-AKHDEL----- ENST00000275598 -------------------------------------------------- SINFRUP00000163781 FD-----PYRIIDNMFFNQDRNGDGKITEAEFKLKADESASHDEL----- ENSMUST00000001595 QD-----PDKTISDMFQNQDRNQDGKITAEELKLKSDEDQER---VHEEL ENST00000269598 QD-----PEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEER---VHEEL SINFRUP00000135539 MT-----MEQVVADMFKNQDRNEDGVITADELKLKVDEDLEKEAMRHEEL SINFRUP00000141233 VD-----PDRIIRDMFNNQDQNKDGKVTEDELSPREDDKAEK-------- ci0100152107 HA-----PEKVITDLFKTQDIDHDEALTIEEFRLKMPDALGEKVGDEL-- CG9847-RB LKNMLAENDKLVEEIFQHEDKDKNGFISHDEFSGPKHDEL---------- : :: : :