CLUSTAL W (1.82) multiple sequence alignment ci0100139760 ------------------------------------------------------------ CG2019-RA ------------------------------------------------------------ SINFRUP00000163646 ------------------------------------------------------------ ENST00000267889 -------------------------------------------------------EYQGG ENSMUST00000037547 MAPEASPERSCSLHTCPLEDPTGAPVPPPTVSTLQAIDPTSPLTAGHFAFPRAPQDYQEG SINFRUP00000151728 ------------------------------------------------------------ ci0100139760 ----------------------------------------------MFNCLLHSRYCWLL CG2019-RA --------------------------------------------MLCFDSERMNWYYHVL SINFRUP00000163646 ------------------------------------------------------SYAELI ENST00000267889 SSLPGLGDRAALCSHGSSLSPSPAPSQRDGTWKPPAVQHHVVSVRQERAFQMPKSYSQLI ENSMUST00000037547 SSLLGLGDQASLCAHVSNLSTSIDTSQHDGVWKQPSVQRHVVSVRQERTFRMPKSYSHMI SINFRUP00000151728 ------------------------------------------------------------ ci0100139760 SEYPALIIFLCVCLSSTLLVVTLVYGELPDFSDPAKGFEVRGTELSDRLVTWENMMNQTG CG2019-RA ARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETD SINFRUP00000163646 ADWPVVVLGVCTVLIVVCALVGILVPDLPDFSDPLRGFEPRGTAIGQRLVTWNNMLKNTG ENST00000267889 AEWPVAVLMLCLAVIFLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVVWRALQALTG ENSMUST00000037547 ADWPVAVIVGCLAFIFLCTLAGLLGSPPLDFSEPLLGFEPRDTEIGRRLEVWKAMQALTG SINFRUP00000151728 ------------------------------------------------------------ ci0100139760 YNSTLSNYPYVYLKRKALMG-----KARKKNKRKKKKKKNRMKRSFNEDWN--------- CG2019-RA HHGALFSNPSDLWERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDV SINFRUP00000163646 YKATLANYPFKYAD-----------EQAKNHQEPRWPEDHHDRDKRQAEWD--------- ENST00000267889 PRKLLFLSPDLELNSSSSHNTLRPAPRGSAQESAVRPRRMVEPLEDRRQEN--------- ENSMUST00000037547 PKNLLSLSPDPEMNSSSLLSTLSPAAWGRAEESVVRTKRMVGPVEVKEEEN--------- SINFRUP00000151728 ------------------------------------------------------------ ci0100139760 ------------------------------------------------------------ CG2019-RA AQKMMQFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGH SINFRUP00000163646 ------------------------------------------------------------ ENST00000267889 ------------------------------------------------------------ ENSMUST00000037547 ------------------------------------------------------------ SINFRUP00000151728 ------------------------------------------------------------ ci0100139760 -----------------------------FITDGYTCPNSREPIV--------KLGYSRW CG2019-RA NTTSVDEEEHQQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHF SINFRUP00000163646 -----------------------------FSKEFFCDVPGQ--------------RYSRL ENST00000267889 -----------------------------------------------FFCGPPEKSYAKL ENSMUST00000037547 -----------------------------------------------FFCGRPEKSHAKL SINFRUP00000151728 ------------------------------------------------------------ ci0100139760 IYEATDG---VTLWSLQSLLQMCKTAHQILDHQEYPEVCLRKTLS-SCCPTISLANHVAY CG2019-RA VVQRIGPNATDSLFDLNGLLAMCQLQDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAM SINFRUP00000163646 VFTSAEG---KNLWSIQAIKSMCNLDNSRVRSHRDYWSLCQRTSDASCCPSWTIGNYVAV ENST00000267889 VFMSTSS---GSLWNLHAIHSMCRMEQDQIRSHTSFGALCQRTAANQCCPSWSLGNYLAV ENSMUST00000037547 VFVSTSG---GSLWNLQAIHSMCRIEQEQIRSHISFGALCQRSAANECCPSWSLGNYLAV SINFRUP00000151728 -----------------QIRSQAQF-QDLCQQHVKVEADG--AAGTGCCPSWSLGNYLAV : .. .. ** . :: *: * ci0100139760 ISGVKSCFNLTQDDVLKAEQVLMLCAPYYCSGDLQLGCNSSDL---NTLNRYMSGSRCGN CG2019-RA LANKSSCFDLTTEDVTSLHTLLLGCYEYFHDLKMDNHCN--------EIPHCRAPEECKR SINFRUP00000163646 LTNRSSCQKITERDVSHILKILRSCAKYYHNGTLGPDCWDMTLRRKDQLKCANVPRKCTK ENST00000267889 LSNRSSCLDTTQADAARTLALLRTCALYYHSGALVPSCLGPG--QNKSPRCAQVPTKCSQ ENSMUST00000037547 LSNRSSCQDTTQADTDRTLALLRFCATFYHRGVLVPACVGSS--QDKPPFCAQVPAKCTG SINFRUP00000151728 LTNASRCLSLTSQQVSESLNILRKCAPYYHEGHLVEACVD----RPKLGGCSSVPSHCKQ ::. . * . * :. :* * :: : * .* ci0100139760 VPGVCTDAVYNIFHYLIQGSLCTNHSMR---FNFTLSSVFLPAYTGKGMLDLYYDKFHN- CG2019-RA LN-----IVFNVLNFLTDFSFIKSNDSN---VYLKYAMIFIPVAQSNRLLPLFHEWEDV- SINFRUP00000163646 YN-----AVYQILHFLVDKDFLSPKSLESPPPVLKHSMLFSPTEKGKSMMNIYLDNFEN- ENST00000267889 SS-----AIYQLLHFLLDRDFLSPQTTDYQVPSLKYSLLFLPTPKGASLMDIYLDRLATP ENSMUST00000037547 SN-----VVYEFLHYLLDRDFLSPQTADYQVPSLKFALLFLPIIKTSSLLDIYLDGLGDP SINFRUP00000151728 SR-----VVFQILHFLVDKDFLSPQTVRYQIPTLKYSLLFLPISKGEHMMKMYVNGLES- :::.:::* : .: . : :. : :* * :: :: : ci0100139760 QPQQN-SIRVSSIDFGVDGLVFEDLLLADSIYPGVAMLLLLVIVWIYTSSLFITTMHLVA CG2019-RA ELINE-LVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVA SINFRUP00000163646 WNSSDGVTTVTGIEFGIKHDLFQDYLLTDTVYPAIAIMIVLLVMCVYTRSVFITLMTIIA ENST00000267889 WGLADNYTSVTGMDLGLKQELLRHFLVQDTVYPLLALVAIFFGMALYLRSLFLTLMVLLG ENSMUST00000037547 IKVSDNYTSISGMDLGLKPRLLKYYLAEDTMYPLIALVVIFFGMSLYLRSLFITFMSLLG SINFRUP00000151728 KDLTYNSTTITGIDFGIKQMLFKYYLARDSIYPILAVVALLFTMVLYLHSAFIVVLSAVA : .:::*:. ::. * * :. :: : :* * *:. : :. ci0100139760 TTAAMVTSYFIYQFIFDVTFFPFLNLTSTLVMLGLSTDHILVLYSTWKRCCSEDKVYERV CG2019-RA ICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWH-CVLTERFSNRC SINFRUP00000163646 IISSLIVSYFLYRMVFNFEFFPFMNLTALIIVVGIGADDAFVLCDVWNYTKFDKPHAELS ENST00000267889 VLGSLLVAFFLYQVAFRMAYFPFVNLAALLLLSSVCANHTLIFFDLWRLSKSQLPSGGLA ENSMUST00000037547 VLGSLMVAYFLYHVAFRMAYFPFVNLAALLLLSGVCVNYTLIFLDMWRLSRGQVPSGGMP SINFRUP00000151728 VAGSLLTSYFFYKVVFHLNFFPLVNLLAAVVLLGICSNQVFIFTDFWNQQLSQNPPASLE :: ::*:* . : . :** :** : ::: .: : ::: . *. ci0100139760 TTKHPVGRRIGVVAKS------------TMRHVGWSLFVTSFTTSSAFFSNAWSSVSAIK CG2019-RA TLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIK SINFRUP00000163646 ETVG-----------------------VSLQHAALSMFVTSFTTAAAFYANYVSNITAIR ENST00000267889 QRVG-----------------------RTMHHFGYLLLVSGLTTSAAFYASYLSRLPAVR ENSMUST00000037547 HRVG-----------------------RTMHHFGYLLLVSGLTTSAAFYGSYLSRLPAVR SINFRUP00000151728 KRVN-----------------------RTLQEVGYLILASGLTSSATFFSGYLSSITAIR :::. . ::.:.:*::.:*:.. * :.*:: ci0100139760 CFGIYTGLAVLCNLIFALTWLPASIIFHHKYLQFTCNTK--------------------- CG2019-RA CFGIFAGTVVVTNYLLMITWLPASVSIMER--LFATRMS--------------------- SINFRUP00000163646 CFGVYAGTAILVNYILMVTWLPAVVVLHERYLPNLLPCSK-----------PPHQERGYC ENST00000267889 CLALFMGTAVLVHLALTLVWLPASAVLHERYLARG------------CARRARGRWEGSA ENSMUST00000037547 CFALFMGTAVLVHMGLTLLWLPATVVLHERYLAHG------------CVAQAHGQRGGSD SINFRUP00000151728 CFSIYLGTASIISSISALVWLPCSFIARERHTEASSASAAVQGWNPCCSKTTGGFWDTSS *:.:: * . : : ***. .: : ci0100139760 --SVFCCIIRLFTRIRNQASEVSRVFFHQIQVLLVVRFRILWVTFFTLLAITSMYIVVFN CG2019-RA --CHHPMSIKLIHACKKSINRFCQMFEECITKSIMN-YAYLWLLIFGALGASSAVIVFWY SINFRUP00000163646 ACTFLAGLCQKVSKCLFALSETSRIFFEKVLPCIVIKLRYLWLLWFLAITVGGAYVVCIN ENST00000267889 PRRLLLALHRRLRGLRRAAAGTSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIAGVS ENSMUST00000037547 PLRLLLALHRRIRIFRKIISILSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIGGVS SINFRUP00000151728 RKKCLFVVQQKLREIKRGLADTSNLLFMKILPCGVVKFRYIWVCCFAVLAAGGTYMSCVD : . ..:: : : :*: * : . : ci0100139760 PGFQLPR-SASYLQFFEQKHLFEQYPLQQRYFDFDKDYKG----FLSVRFIFGIEPIDDG CG2019-RA PGLQLP--EKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDG SINFRUP00000163646 PKMKLPSLELAEFQVFRSSHPFERYDAEFKKLFMFERFHHGEELHMPITIIWGVMPVDNG ENST00000267889 PRLRLPTLPPPGGQVFRPSHPFERFDAEYRQLFLFEQLPQGEGGHMPVVLVWGVLPVDTG ENSMUST00000037547 PRLQLPILLPLGGQFFRSSHPFERFDAEYRQQFLFEDLPPNEGGNLPVVLVWGILPVDTS SINFRUP00000151728 PGMKLPTLDGRAPQLFRSSHPFERYDAEYRHMFMFERQRNGEDKPFTLMLVWGVQPIDNG * ::** : *.* .* ** : : : : : : :::*: .:* . ci0100139760 NPRNPDDKGNIHFTR-FNVSDPQSQRWLLNFCTILRSHKFYRE---PENSQFSSMCFIET CG2019-RA DYTNPNSYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKE---TLG-MLLPNCFIEN SINFRUP00000163646 DPLNPKNKGKLMLDSSFNIASPAAQLWILNFCQKLRNQSFVFQ---SEE-QDFTSCFIET ENST00000267889 DPLDPRSNSSLVRDPAFSASGPEAQRWLLALCHRARNQSFFD----TLQEGWPTLCFVET ENSMUST00000037547 DPLDPRTNSSVVSDPDFSPSSPEAQEWLLALCHGAQNQSFFG----DQPEGWPTLCLVEA SINFRUP00000151728 DQFDPKSNGSLVFDADFNMNRPEAQVWLKDLCGRVQNLSFYAPPSPEDKDLTDNICLVEQ : :* . : *. :* *: :* :. * *::* ci0100139760 LKKWIES------RPCKTGAPCCKMTKFPYKPNVFELCLKEAISRLNVVPQLQLFPSSP- CG2019-RA LIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPK SINFRUP00000163646 FKQWMENQ----DCEEASVYPCCSQSTFPYKQDVFELCIKRAIMELDRSTTYHLVSRTP- ENST00000267889 LQRWMESP--SCAR--LGPDLCCGHSDFPWAPQFFLHCLKMMALEQGPDGTQDLG----- ENSMUST00000037547 LQQWMESP--SCGR--LGPDLCCGQSEFPWAPQLYLHCLKMMALEQSPDGTRDLG----- SINFRUP00000151728 LINWLSLR--QCSETDYASNYCCNDILFPYPPAVFENCLSMMLAERYAEGHLDHRG---- : ::. * **: .: *: . ci0100139760 ---GPRFDSKD---------------------SIRSVIIEFPTNQKTSSTQSEIAEFVKE CG2019-RA FAEAPRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYES SINFRUP00000163646 ---GPRFDIND---------------------TIRAIVLEFQSTYLFTLAYEKMFQFYSE ENST00000267889 ----LRFDAHG---------------------SLAALVLQFQTNFRNSPDYNQTQLFYNE ENSMUST00000037547 ----LRFDTHG---------------------NLAALVLKFQTNLPYSTEYGPVHHFYTE SINFRUP00000151728 ----LYFQPDG---------------------RVAALVLSFRTTYHYSFNYSRTSLSYRE :: .. : ::::.* :. : . ci0100139760 IEETLQVHVDSAPRTLAGGWFVSSLNLYALQTSLYTGTLTSVGISLLVAQIVILITSRNL CG2019-RA VEHWFQMQLKTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNI SINFRUP00000163646 VDAWITEELRHAPAGLSHGWFISSLEFYDLQDSLSGGTLVAMALSVAVAFSVMLLTTWNV ENST00000267889 VSHWLAAELGMAPPGLRRGWFTSRLELYSLQHSLSTEPAVVLGLALALAFATLLLGTWNV ENSMUST00000037547 ISRWLSTEMSKAPPGLNQGWFTSNLELYSLQHSLSTEPAVVLGLALALAFATLLLSTWNV SINFRUP00000151728 FTTWFKREISDAPLGLRNGWFISNLTLFDLQQSLSSEILLVAGFSVALTLALLLLTTWNI . : .: ** * *** * * :: :* :* ::: : :* : *: ci0100139760 VVSIFVNLSIGGVIFVTVATLALAGWELNVLESVTVSISVGLSVDFTAHYAIAYLLAPEK CG2019-RA LISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVK SINFRUP00000163646 IISLYAILSIAGTIFVTVGSLVLLGWEMNVLESVTISVAVGLSVDFAVHYGVAYRLAPEP ENST00000267889 PLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDFTVNYCISYHLCPHP ENSMUST00000037547 PLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDLTINYCISYHLCPHP SINFRUP00000151728 PLSIYGTVAVGGSVFVTVSLFVLLEWQLSGTEALFVSSAAGLSVDFIANYCVSYSMAPHS :*:: ::. :: **. : * *::. *:: :* : **:**: :* : * :.* ci0100139760 SDRQRRVEHALARIGSAIATAAFTTFLAGLGMLPASVLAYKRFGIFLMVIMTSSWVYSNY CG2019-RA -ERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATF SINFRUP00000163646 -DREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATF ENST00000267889 -DRLSRVAFSLRQTSCATAVGAAALFAAGVLMLPATVLLYRKLGIILMMVKCVSCGFASF ENSMUST00000037547 -DRLSRVAFSLRQISRATAMTTGVLFASGVIMLPSTILLYRKLGIIVMMVKFLGCGFASF SINFRUP00000151728 -DKIGKVAHSTKRMGCPVAIVSGAFFSMGILMLPATALLFRKLGIFLFLVKCVACGFSTF :: . . : . . : . * *:.:. * : ::* ::.:: . ::.: ci0100139760 FFLGLLSLLGPQG--------------------------------------------NCG CG2019-RA FLMSLLRVAGPQHGFLELKWP--------------------------------LWSKRSS SINFRUP00000163646 FFQCMCRCLGPQG------------------------------------------NCGQI ENST00000267889 FFQSLCCFFGPEKNCGQILWP-CAHLPWDAGTGDPGG---------EKAGRPRPGSVGGM ENSMUST00000037547 FFQSLCCFFGPEKNCGQILWP-CAHLPWDAGTEDP-----------DEKGRAGP------ SINFRUP00000151728 FFQSLCCFCGPQTKCGKLSLPRCSDHPEATLASCSAAEGGGFLYPNHQLQRQKQTSLGGG *: : **: : :: ci0100139760 SLSCLSQKRNENEEHTTTLITESTSVRPALIEGRTISTEPSSIN------------HNGG CG2019-RA GSSKFYERKPSQVIASEQLLTPTSSAIVELANSETHELESLNSNSLIKTISGIESAHALS SINFRUP00000163646 PLPKQLQCQVFSEVTPAGPSSQGKGSYGGGGEAEHYELEPLAS----------------- ENST00000267889 PGSCSEQYELQPLARRRSPSFDTSTATSKLSHRPSVLSEDLQLHDGPCCSRPPPAPASPR ENSMUST00000037547 PG-FSEHYELQPLARRRSPSFDTSTATSKLSHRPSILSEDLQIHDGSCCLQHAQAPVSPR SINFRUP00000151728 GGRRPEQYELQPLAYRRSDSFENSTCTSKLSNRPSILSDEIVYCGKDAG-RGSMNGDSEE . . . . : ci0100139760 NVPE-------------------------------------------------------- CG2019-RA SLPRDFEHSFQTMHECKYQTYPSTSN---------------------------------- SINFRUP00000163646 ------------------------------------------------------------ ENST00000267889 ELLLDHQAVFSQCPALQTSSPYKQAGPSPKTRARQDSQGEEAEPLPASPEAPAHSPKAKA ENSMUST00000037547 DLLLDHQTVFSQCPALQTSSPYKQAGPTPQTWIRQDSQGQKTEPLQALPEGPAHCPKSKV SINFRUP00000151728 MCGLEHN-ICQAPPALQTSSPYREKTAG----LEQDDASNDKLLCNACRGQPREQPCANN ci0100139760 ------------------------------------------------------------ CG2019-RA ------------------------------------------------------------ SINFRUP00000163646 ------------------------------------------------------------ ENST00000267889 ADPPDGFCSSASTLEGLSVSDETCLSTSEPSARVPDSVGVSPDDLDDTGQPVLERGQLNG ENSMUST00000037547 EELPDGLCSSASTLEGLSVSDDTCAS--EHSVRVPDSVGTSPEVMNGTGHPILERGQLNG SINFRUP00000151728 QE----ISFQSQSSDGLEDSKETCLT--------DTEPGPSTMPQKDREEAHLKPGHLNG : : : : ci0100139760 ------------------------------------------------------------ CG2019-RA ------------------------------------------------------------ SINFRUP00000163646 ------------------------------------------------------------ ENST00000267889 KRDTLWLALRETVYDPSLPASHHSSLSWKGRGGPGDGSPVVLPNSQPDLPDVWLRRPSTH ENSMUST00000037547 KRDTLWLALKETIYDPNMPNSHHSSLSWKGRGGPGDISPVMLPNSQPDLPDVWLRRPSTY SINFRUP00000151728 RREMLRLSLKETVYEMG------------GKGRP-VQEVVILPNSKPDLPDVWIKR---- : : : : ::: : : : ci0100139760 ------ CG2019-RA ------ SINFRUP00000163646 ------ ENST00000267889 TSGYSS ENSMUST00000037547 TSGYSS SINFRUP00000151728 ------