CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000128597 ---------MSARFRLPAGRSYNVRATELERDRQHTQVVCNVLLLDNTVQ Q8JFS7_Brachydanio_rerio ---------MTARFRLPAGRSYNVRTTELARDRQRTEVVCNILLLDNTVQ ENST00000263708 ---------MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQ ENSMUST00000027633 ---------MTARFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQ ENST00000262539 ---------MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQ SINFRUP00000161080 -------------------------------------------------- ci0100144175 MSAVKEVSPAVSRNLLTGSGTYNVR--EPAKEKKQSNVNISVVLLDHTEV CG1228-RB -------------------------------------------------- : : : :: SINFRUP00000128597 AFKVNKADHGQVLLDAVFKHLELTERDYFGLHLTDDSSDTP--------- Q8JFS7_Brachydanio_rerio PFKVNKHDQGQILLDAVFKHLELTERDYFGLHLADEPSDSPRWLDPNKPI ENST00000263708 AFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPI ENSMUST00000027633 AFRVNKHDQGQVLLDIVFKHLDLTERDYFGLQLADDSTDNPRWLDPNKPI ENST00000262539 TFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAI SINFRUP00000161080 -------------------------------------------------- ci0100144175 VFKVNKRDRGQVLLDLVFQHLRVTEIKFFGLQFPNDVPDTMRWLDPTKSI CG1228-RB -------------------------------------------------- : : ::: : : : : : SINFRUP00000128597 -------VSIILKIYLDGIVMHPN-FVRDYLAYLYFLQIKQDILTGRLLC Q8JFS7_Brachydanio_rerio RKQLKRGSPHHLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILSGRLPC ENST00000263708 RKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPC ENSMUST00000027633 RKQLKRGSPYNLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLSC ENST00000262539 RKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTC SINFRUP00000161080 -------------------------------RHLYFLQIRSDIREGRLQC ci0100144175 RKQFKRGYPYILFFRVKFYATDLSTMKDEFTRYQLFMQIKLDLLERRLKC CG1228-RB -------------------------------------------------- : : : : :: : : : SINFRUP00000128597 PHNTAALLASYAVQSELGDYSETEHTAGYLSEYCFIPNPPQDFHKEVSKH Q8JFS7_Brachydanio_rerio PHNTAALLASYAVQSELGDYSEAENLPGYLSEFFFIPNQPQGFEKDVAKH ENST00000263708 PSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKL ENSMUST00000027633 PCNTAALLASFAVQSELGDYNQSENLAGYLSDYSFIPNQPQDFEKEIAKL ENST00000262539 PLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL SINFRUP00000161080 PLSAAVVLASYAVQSEMGDR-CPSQQPGYTSKCHFIPEQDEDFLSSVEDL ci0100144175 SLSEAASIAALAVQSELGDFNSAEHKKNYVAEFRFIPNQTEEFEAQVIHL CG1228-RB --------------------------------MQLLCDQTTEAERKVGEL : : : :: : .: SINFRUP00000128597 HQQHSGLSPAQAEFNYLNTARTLELYGVELHYARDQSNTEILLGVMSAGI Q8JFS7_Brachydanio_rerio HQQHNGLNPAQSEFNYLNTARTLDLYGVELHYARDQSNTEIYVGVLSAGI ENST00000263708 HQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGI ENSMUST00000027633 HQQHVGLSPAEAEFNYLNAARTLELYGVEFHYARDQSNNEILIGVMSGGI ENST00000262539 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGV SINFRUP00000161080 HPQHNGLKQSDAELCFLNTARTLELYGVELHSAMDTNNAPLMVGLASSGV ci0100144175 HKMHRGLSPSQAEYYFIKKSQKLEMYGIEMHRAKDNDEEDLDVGVTSTGM CG1228-RB HKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGL * * * :::* ::: :: *::**:::* . * : :*: : *: SINFRUP00000128597 LVYKNRVRINYFP------CDSKCRCLCDQT--------ESRETLLGFNM Q8JFS7_Brachydanio_rerio GIYKNRVRINYFPWLKIVKISFKCKQFFIQLR---KEAHDTRDTLLGFNM ENST00000263708 LIYKNRVRMNTFPWLKIVKISFKCKQFFIQLR---KELHESRETLLGFNM ENSMUST00000027633 LIYKNRVRMNTFLWLKIVKISFKCKQFFIQLR---KELHESRETLLGFNM ENST00000262539 AVYRKYICTSFYPWVNILKISFKRKKFFIHQR---QKQAESREHIVAFNM SINFRUP00000161080 AIFHNMICSSFFPWGNIIKISFKRKRFLIHLK---RKHGETQDCEVSLAL ci0100144175 LLYQNGFKKNEFRWSSIVKISFKRKQFYVQLRSAAKKEVNAIEPIHSFHM CG1228-RB LVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLR---REPSENYDTLLGFGM :::: . . : . * : : : : : .: : SINFRUP00000128597 VNYRACKNLWKACVEHHTFFRLERPIPPQKN---FFAHYFTLGSKFRYCG Q8JFS7_Brachydanio_rerio VNYRACKNLWKTCVEHHTFFRLDRPVPPQKN---FFAHYFSLGSRFRYCG ENST00000263708 VNYRACKNLWKACVEHHTFFRLDRPLPPQKN---FFAHYFTLGSKFRYCG ENSMUST00000027633 VNYRACKTLWKACVEHHTFFRLDRPLPPQKN---FFAHYFTLGSKFRYCG ENST00000262539 LNYRSCKNLWKSCVEHHTFFQAKKLLPQEKN---VLSQYWTMGS------ SINFRUP00000161080 PSPKNCKNLWRSCVDHHSFFSSNRTGRSPKHNNSAVQTYKKLIT------ ci0100144175 ENYRACKRLWKSCVDFHSFYRLDRCMSRSCG----HQHVANDGLP----- CG1228-RB SSHKHAKALWKSCVEHHSFFRLKRPHRLSRF------LNISLGSKFYYSG . : .* **::**:.*:*: .: . : SINFRUP00000128597 RTEVQSVQYGKEKGIKNRVFARSPSKPLARKLLGGTDWESVSRNSLSDER Q8JFS7_Brachydanio_rerio RTEAQSVQYGKEKGIKDRVFA---SKPLARKLMGVTDWEAVSRNSLSEER ENST00000263708 RTEVQSVQYGKEKANKDRVFARSPSKPLARKLM---DWEVVSRNSISDDR ENSMUST00000027633 RTEVQSVQYGKEKANKDRVFARSPSKPLARKLM---DWEVVSRNSLSDDR ENST00000262539 ----RNT----KKSVNN---------QYCKKVIGGMVWNPAMRRSLSVEH SINFRUP00000161080 ----QHLGLGNSKAESG---------PVCQRVVGGMVWNPVLRKSLSSEH ci0100144175 --EQEDEMARQEKHLFS-------YLTLGGRGKGRENDESTDDLTQRQRY CG1228-RB RTELQAVQESKQRG----------------RIHKVFVRSPSKRLLGAAGG . .: :: : . SINFRUP00000128597 LETQSLPTRSPPGTPNQ-NSLFVQEGTRLRPSSVGHLVDHVIHAS----- Q8JFS7_Brachydanio_rerio LETRSLPTRSPPGTPNH-NSLFVQEGPRLRPSSMGHLVDHVIHAS----- ENST00000263708 LETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTS----- ENSMUST00000027633 LETQSLPSRSPPGTPNHRNSSFTQEATRVRPSSVGHLVDHVVHMS----- ENST00000262539 LETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYIT----- SINFRUP00000161080 LETKSLPSRSPPSTPNWRSPRVRHGIRKPRPSSVE-LSSDLKDMS----- ci0100144175 LRTRAASTKSKDNMSLACNGESRNEDKAPRRLSAPPSVYYGVGESGMTDE CG1228-RB VGTSGSSGGTP--MQQHSGSESANSHNNGKPAGAGTILTITKTSR----- : * . . : . : : . SINFRUP00000128597 PSLPVFSSNHKSASSTQANS-ISLDSTP-SPEG-LDSQPPALPPKQLSRK Q8JFS7_Brachydanio_rerio PSLPVFS-NHKSASSTQANS-ISLESTP-SPEG-VEGPPPALPPKQ-SRK ENST00000263708 PSEVFVN--QRSPSSTQANS-IVLESSP-SQETPGDGKPPALPPKQSKKN ENSMUST00000027633 PSEDFVS--QRSPSSTQANS-IVLESSP-SQETPEDGQPPALPPKQSKKN ENST00000262539 ETEDVFYTYKGSLAPQDSDSEVSQNRSP-HQESLSENNPAQSYLTQKSSS SINFRUP00000161080 EGEDVFYTYRASVSSSKDGEDASLHTTH-TSQTQEQPAAAGIGLQVLSSE ci0100144175 QMMVMLHQQQASMQSAHSQPKLFVNANYESNNNSEIPPPVKIPIQYHTGD CG1228-RB -------PHDNKVTSKEADS---MPRKAWEQQSDEYDIQLDVGFIEQCTR .. . . . . : SINFRUP00000128597 TLSQIIQA-------HSQQSLLDNHVNEMYDVPINADKTTLNGVVPHDN- Q8JFS7_Brachydanio_rerio NLSQLILS-------HSQQ-DLDNHINEMYDVPTATDKVMPNGVVPHDN- ENST00000263708 SWNQIHYS-------HSQQ-DLESHINETFDIPSSPEKPTPNGGIPHDN- ENSMUST00000027633 SWNQIHFS-------NSQQ-DLVTHTNESFDVPSSPEKSTPNGGIPHDN- ENST00000262539 SVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDS SINFRUP00000161080 PALPIS---------LLNLPHLSFIRQRLFISQRSHASLFSMCVVAPGDG ci0100144175 PALTASYRTIHIRPETAGEADETAASELSVLTTGSETSSVLTSLTEKSYM CG1228-RB RFESASPS--------PMPPAYSSGQHSPILLPTTIADAVGHQQPESGSD . . . SINFRUP00000128597 ---------------------LVLIKMRPDEHGRFGFNVKGGADQKMPII Q8JFS7_Brachydanio_rerio ---------------------LVLIKMKPDENGRFGFNVKGGSDQKMPII ENST00000263708 ---------------------LVLIRMKPDENGRFGFNVKGGYDQKMPVI ENSMUST00000027633 ---------------------LVLIKMKPDENGRFGFNVKGGYDQKMPVI ENST00000262539 Y--------------------LVLIRITPDEDGKFGFNLKGGVDQKMPLV SINFRUP00000161080 D--------------------LMLICIAPDKDGKFGFNVKGGVDQKMPLS ci0100144175 LPNPVPFPHQSSGQMNGVPDDLVIIRIKPDLEGRYGFNVKGGADQNMPIL CG1228-RB ---------------------LITIRLQADEQGRYGFNVKGGVDLSLPVQ *: * : .* .*::***:*** * .:*: SINFRUP00000128597 VSRVAPGTSADLCVPRLNEGDQVVQINGRDISDHTHDQVVMFIKASCESH Q8JFS7_Brachydanio_rerio VSRVAPGTSADLCVPRLNEGDQVVLINGREIAEHSHDQVVMFIKASCESH ENST00000263708 VSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERH ENSMUST00000027633 VSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCEKH ENST00000262539 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESH SINFRUP00000161080 ISHIKPDSPAGRCEPRLMEGDLVVLINGRDISEHTHDQVVMFIRASRESH ci0100144175 VSKVAAGSPAAMCTPALNEGDEVLQINGRDISSHSHEQVVRFIRSTREHH CG1228-RB VSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQA :*:: . :.* * * : *** :: ****:: *:*** :*: . SINFRUP00000128597 SGELILLVRPNAIYDVVEEKADSEPE---FQYIPEKCPQDPTQIDQHALR Q8JFS7_Brachydanio_rerio SGELILLVRPNAIYDVVEEKLETEPD---FQYIPEKSPTDPSHLDQDAWR ENST00000263708 SGELMLLVRPNAVYDVVEEKLENEPD---FQYIPEKAPLDSVHQDDHSLR ENSMUST00000027633 SGELVLLVRPNAVYDVVEEKLESEPD---FQYIPEKAPLDSVHQDDHSLR ENST00000262539 SRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGG-----DTLE SINFRUP00000161080 SRELALLIRRRGSGRVAPLLQLPSALTLPDQSVTERPRSSGSLEKVVTLE ci0100144175 TGHLVLIVRPQNQADEDEVEVSTDDVG----EVVGADDDEG-----ALLE CG1228-RB SGELLLTVRPQRS---APLLLEEEPLYQYVPESDEIGSHSNLLDGDALFT : .* * :* . . SINFRUP00000128597 DSMVTLKEGLSSGAILAQFDQLYRKRPGMTMLCAKLPQNVSKNRYRDISP Q8JFS7_Brachydanio_rerio DSMLYLKEGLNSGTILAQFDQLYRKRPGMTMSCAKLPQNISKNRYRDISP ENST00000263708 ESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISP ENSMUST00000027633 ESMIQLAEGLITGTVLAQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISP ENST00000262539 GSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLP SINFRUP00000161080 ESMRQLERGVQSGTLSFHFENLYRRKPGLFLTCARLPENMDKNRYRDVLP ci0100144175 RSMQWLEDMLDSGQILDMFDALYRKKPGATMNDARLPQNVTKNRYRDISP CG1228-RB QSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISP *: * : :* : :: :**:.*. : *: * * ****:*: * SINFRUP00000128597 YDATRVILKS--TDDYINANYINMEIPASSLINRYIACQGPLPNTCSDFW Q8JFS7_Brachydanio_rerio YDATRVILKG--TEDYINANYINMEIPACSLINRYIACQGPLPNTCSDFW ENST00000263708 YDATRVILKG--NEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFW ENSMUST00000027633 YDATRVLLKG--NEDYINANYINMEIPSSSIINQYIACQGPLPHTCKDFW ENST00000262539 YDTTRVLLQG--NEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFW SINFRUP00000161080 YDSTRVVLQG--QENYINASHITMAPKVSGACLRYVAAQGPLPQTCTHFW ci0100144175 YDSTRVILNGIVDTDYINANYVNMFIPGNNWTNRYIACQGPLPNTSFDFW CG1228-RB YDCTRVSLVNSLTGDYINANYVNMEIPG-GAVNRYIATQGPLASTTTDFW ** *** * . :****.::.* . :*:* ****. * .** SINFRUP00000128597 QMTWEQGSSMVVMLTTQVERGRVKCHQYWPNPDSVTNYGD-FTVTCHNE- Q8JFS7_Brachydanio_rerio QMTWEQGSSMVVMLTTQV-----KCHQYWPNPSGSATYGG-FQISCQTE- ENST00000263708 QMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGC-YQVTCHSE- ENSMUST00000027633 QMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPSESSSYGC-YQVTCHSE- ENST00000262539 QVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGG-FHIQCQSE- SINFRUP00000161080 QTVWEQQIHTIIMLTTLTERGRTKCHQYWPHPPEEKDYGH-LRVKCHSE- ci0100144175 EMVWEQKSTLIVMLTTVVERGRPKCHQYWPDGGTSVQFGP-FIIESVTE- CG1228-RB RMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEK . . :: ::**** ******* . : . .* SINFRUP00000128597 -EGNSAFLVREMTLMNTQTE---------QQRELTQIQYLAWPDHGVPDD Q8JFS7_Brachydanio_rerio -EGNSAFLVREITLTHIESG---------ESRELTQIQYLAWPDHGVPDD ENST00000263708 -EGNTAYIFRKMTLFNQEKN---------ESRPLTQIQYIAWPDHGVPDD ENSMUST00000027633 -EGNPAYIFRKMTLFNQEKN---------ESRQLTQIQYTAWPDHGVPDD ENST00000262539 -DCTIAYVSREMLVTNTQTG---------EEHTVTHLQYVAWPDHGVPDD SINFRUP00000161080 -ECNLVYVTRRFTLTHTQRG---------EERAVTHLQYVAWPDHGVPDD ci0100144175 -EVTPSFAFRDFKLYKCNEDGEVNGNDLTKGRDIRQMQYIAWPDHGVPDD CG1228-RB PDETGSFVFREFVLKDKHEQ-----------RHIHHMQYLAWPDHCVPSD : . : * : : . . : : ::** ***** **.* SINFRUP00000128597 STDFLDFVALVRSKR----------------------------------- Q8JFS7_Brachydanio_rerio STDFLDFVALVRNKR----------------------------------- ENST00000263708 SSDFLDFVCHVRNKR----------------------------------- ENSMUST00000027633 SSDFLDFVCHVRDQR----------------------------------- ENST00000262539 SSDFLEFVNYVRSLR----------------------------------- SINFRUP00000161080 PSDFLLFATSIRERR----------------------------------- ci0100144175 SSDFLDFVLRVRQNR----------------------------------- CG1228-RB PNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERK .. ** *. :* * SINFRUP00000128597 -----------------------AGQDQPMVVHCSAGIGRTGVLITMETA Q8JFS7_Brachydanio_rerio -----------------------AGKDEPVVVHCSAGIGRTGVLITMETA ENST00000263708 -----------------------AGKEEPVVVHCSAGIGRTGVLITMETA ENSMUST00000027633 -----------------------AGKEEPIIVHCSAGIGRTGVLITMETA ENST00000262539 -----------------------VD-SEPVLVHCSAGIGRTGVLVTMETA SINFRUP00000161080 -----------------------RG-EEPLMVHCSAGIGRTGVLITMETA ci0100144175 -----------------------VGMAIPSTVHCSAGIGRTGVLITMETA CG1228-RB CAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTA * *************: *:** SINFRUP00000128597 LCLMECGQPVYPLEIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGLVK Q8JFS7_Brachydanio_rerio MCLMECSQPVFPLEIVRTMRDQRAMMIQTPSQFKFVCEAILKVYEEGLVK ENST00000263708 MCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVK ENSMUST00000027633 MCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVK ENST00000262539 MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQ SINFRUP00000161080 LSLLDKGLPVFPLDIVKTLRDQRAMMVQTT-------------------- ci0100144175 MCLIEANQPVYPIEIARAMRDQRAMMIQTPSQFKFVCDAILRVYKEGLAR CG1228-RB LALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKISRS :.* : *::*::*.: :***** *:*. :: : SINFRUP00000128597 PLKTA---------------------- Q8JFS7_Brachydanio_rerio PLKSILYESN----------------- ENST00000263708 PLTTSTNK------------------- ENSMUST00000027633 PLTTSSNK------------------- ENST00000262539 MLDPS---------------------- SINFRUP00000161080 --------------------------- ci0100144175 PIYYDDYDEADSSADETNIIIKKSLQT CG1228-RB SAAINDDED------------------