CLUSTAL W (1.82) multiple sequence alignment ENST00000241903 ------------------------------------------------MRLRLRLLALLL ENSMUST00000024696 ------------------------------------------------LRLPAFGLPLLA ENSMUST00000031390 -----------------------------MGRRPRGPGSPRGPGPPRPGPGLPPLLLVLA ENST00000321387 ------------------------------------------------------------ ENST00000320661 LQADSGLGIQVQCLPKTKAPRGSGGATPGRGPGRGAHTARLTRWSRTMSPAPRPPRCLLL ENSMUST00000000983 -----------------------------------------------MSPAPRPSRSLLL SINFRUP00000162871 ------------------------------------------------------------ SINFRUP00000158279 ------------------------------------------------------------ ENST00000219271 ----------------------------MGSDPSAPGRPGWTGSLLGDREEAARPRLLPL ENSMUST00000034243 ----------------------------MGSDRSALGRPGCTGSCLS-----SRASLLPL CG4859-RA --------------------MTNRRASGATHCKTTNNCNISNNSNNSNKMTNCQSSVFIV ENST00000241903 LLLAP--PARAPKPSAQDVSLGVDWLTRYGYLPPPH--PAQAQLQSPEKLRDAIKVMQRF ENSMUST00000024696 LLLVPLLPVRAQNPDAKVVSMGVEWLTRYGYLPPAD--PVHAQMQSLEKLQDAIKVMQRF ENSMUST00000031390 LAAHGGCAAPA--PRAEDLSLGVEWLSRFGYLPPAD--PASGQLQTQEELSKAITAMQQF ENST00000321387 LGTSGGCAAPAPVPRAEDLSLGVEWLSRFGYLPPAD--PTTGQLQTQEELSKAITAMQQF ENST00000320661 PLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGD--LRTHTQRSPQSLSAAIAAMQKF ENSMUST00000000983 PLLTLGTALASLGWAQGSNFSPEAWLQQYGYLPPGD--LRTHTQRSPQSLSAAIAAMQKF SINFRUP00000162871 ------------------------------------------------------------ SINFRUP00000158279 ------------------------------------------------------------ ENST00000219271 LLVLLGCLGLGVAAEDAEVH-AENWLRLYGYLPQPS--RHMSTMRSAQILASALAEMQRF ENSMUST00000034243 LLVLLDCLGHGTASKDAEVYAAENWLRLYGYLPQPS--RHMSTMRSAQILASALAEMQSF CG4859-RA VGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSF ENST00000241903 AGLPETGRMDPGTVATMRKPRCSLPDVLGV---AGLVRRRRRYALSGSVWKKRTLTWRVR ENSMUST00000024696 AGLPETGQMDPMTIKTMRKPRCSLPDVLGA---AGLVRRRRRYSLSGSVWKKRTLTWSIR ENSMUST00000031390 GGLETTGILDEATLALMKTPRCSLPDLP-----PGAQSRRKRQTPPPTKWSKRNLSWRVR ENST00000321387 GGLEATGILDEATLALMKTPRCSLPDLP-----VLTQARRRRQAPAPTKWNKRNLSWRVR ENST00000320661 YGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVR--RKRYAIQGLKWQHNEITFCIQ ENSMUST00000000983 YGLQVTGKADLATMMAMRRPRCGVPDKFGTEIKANVR--RKRYAIQGLKWQHNEITFCIQ SINFRUP00000162871 ------------------------------------------------------------ SINFRUP00000158279 ------------------------------------------------------------ ENST00000219271 YGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQ ENSMUST00000034243 YGIPVTGVLDEETKTWMKRPRCGVPDQFGVHVKANLRRRRKRYTLTGKAWNNYHLTFSIQ CG4859-RA AGLNITGELDAETMKLMSLPRCGVRDRVGTG-----DSRSKRYALQGSRWRVKNLTYKIS ENST00000241903 SFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSP-----QGQEPDILIDFARAFHQ ENSMUST00000024696 SFSQKSQLSPQIVRTLLSYALAVWATESGLTFQEVNS------QYQEPDIIIHFARAYHQ ENSMUST00000031390 TFPRDSPLGRDTVRALMYYALKVWSDITPLNFHEVAG--------NAADIQIDFSKADHN ENST00000321387 TFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG--------SAADIQIDFSKADHN ENST00000320661 NYT--PKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHG ENSMUST00000000983 NYT--PKVGEYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMILFAEGFHG SINFRUP00000162871 ------------------------------------------------------------ SINFRUP00000158279 ------------------------------------------------------------ ENST00000219271 NYT--EKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHG ENSMUST00000034243 NYT--EKLGWYNSMEAVRRAFQVWEQVTPLVFQEVSYDDIRLRRRAEADIMVLFASGFHG CG4859-RA KYP--KRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSG--------PVHIEIKFVESEHG ENST00000241903 DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG ENSMUST00000024696 DSYPFDGSGGTLAHAFFPGEHPISGDTHFDDEETWTFGSTDDNGIDLFAVAVHEFGHALG ENSMUST00000031390 DGYPFDGPGGTVAHAFFPGDHHTAGDTHFDDDEPWTFRSSDAHGMDLFAVAVHEFGHAIG ENST00000321387 DGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIG ENST00000320661 DSTPFDGEGGFLAHAYFPGPNIGG-DTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALG ENSMUST00000000983 DSTPFDGEGGFLAHAYFPGPNIGG-DTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALG SINFRUP00000162871 --------------------------TSPSHPQPEAPLPTDRG----------------- SINFRUP00000158279 ------------------------------------------G----------------- ENST00000219271 DSSPFDGTGGFLAHAYFPGPGLGG-DTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALG ENSMUST00000034243 DSSPFDGVGGFLAHAYFPGPGLGG-DTHFDADEPWTFSSTDLHGISLFLVAVHELGHALG CG4859-RA DGDAFDGQGGTLAHAFFP---VFGGDAHFDDAELWTIGS--PRGTNLFQVAAHEFGHSLG ENST00000241903 LGHSSAPNSIMRPFYQGPVGDPDKYR---------------------LSQDDRDGLQQLY ENSMUST00000024696 LGHSSAPNSIMRPFYQGPVGDPATYR---------------------LPQDDRDGLQQLY ENSMUST00000031390 LSHVAAPSSIMQPYYQGPVGDPLRYG---------------------LPYEDRVRVWQLY ENST00000321387 LSHVAAAHSIMRPYYQGPVGDPLRYG---------------------LPYEDKVRVWQLY ENST00000320661 LEHSSDPSAIMAPFYQWMDTENFVLP--------------------DDDRRGIQQLYGGE ENSMUST00000000983 LEHSNDPSAIMAPFYQWMDTENFVLP--------------------DDDRRGIQQLYG-E SINFRUP00000162871 -QPPPEPDPRTTSPPIVPTTL-------------------------PDARPTTPPVRK-- SINFRUP00000158279 -QPDSGP---------------------------------------TQALPTVTARRP-- ENST00000219271 LEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGR ENSMUST00000034243 LEHSSNPSAIMAPFYQWMDTDNFQLPEDDLRGIQQLY---DGKPQPTRPLPTVRPRRPGR CG4859-RA LSHSDQSSALMAPFYRGFEPVFKLDE------------------------DDKAAIQSLY . ENST00000241903 G-KAPQTPYDK-----PTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFF ENSMUST00000024696 G-RVSQNPNAR-----PTRKPLVPPPQPPAMPPDSPATPVPDRCEGNFDAVANIRGEIFL ENSMUST00000031390 GVRESVSPTAQLDTPEPEEPPLLPEP-PNNRSSTPPQKDVPHRCTAHFDAVAQIRGEAFF ENST00000321387 GVRESVSPTAQ-----PEEPPLLPEP-PDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFF ENST00000320661 SGFPTKMPPQPR-----------TTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFV ENSMUST00000000983 LPIPIPAPPSLY-----------LSSLGLLS--AFSLHHVPNICDGNFDTVAMLRGEMFV SINFRUP00000162871 ----VPPPPPPP-----------PRPPPPPRPPRLPDDQPPDICDGDFDTVTLLRGEMFV SINFRUP00000158279 ----EPRPPQSP-----------PRHPDRPRATERPDHYGPNICEGNFDTVAMLRGEMFV ENST00000219271 PDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFV ENSMUST00000034243 PDHQPPRPPQPPHPGGKPERPPKPGPPPQPRATERPDQYGPNICDGNFDTVAVLRGEMFV CG4859-RA GRKTNQLRPTNVYP---------ATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYA . :** : ENST00000241903 FKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVF ENSMUST00000024696 FKGPWFWRLQPSGQLVSPRPAGLHRFWEGLPTHVKVIQAAYARPLDGRIILFSGPQFWVF ENSMUST00000031390 FKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVF ENST00000321387 FKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVF ENST00000320661 FKERWFWRVRNN-QVMDGYPMPIGQFWRGLPA---SINTAYERK-DGKFVFFKGDKHWVF ENSMUST00000000983 FKERWFWRVRNN-QVMDGYPMPIGQFWRGLPA---SINTAYERK-DGKFVFFKGDKHWVF SINFRUP00000162871 FKGRWFWRVRRN-RVLDNYPMPISVFWVGLPS---NIDAAYERH-DGKFVFFKDDKFWVF SINFRUP00000158279 FKGRWFWRVRRN-RVLDNYPMPINHFWRGLPG---DIDAAYERH-DGRFVFFKGNRYWLF ENST00000219271 FKGRWFWRVRHN-RVLDNYPMPIGHFWRGLPG---DISAAYERQ-DGRFVFFKGDRYWLF ENSMUST00000034243 FKGRWFWRVRHN-RVLDNYPMPIGHFWRGLPG---NISAAYERQ-DGHFVFFKGNRYWLF CG4859-RA FKGDKYYKLTTD-SVEEGYPQLISKGWPGLPG---NIDAAFTYK-NGKTYFFKGTQYWRY ** :::: . : . * : * *** :.:.: : : :*.. :.* : ENST00000241903 QDRQLEGG-ARPLTELG-LPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAAR-PDPGY ENSMUST00000024696 QERQLEGA-ARPLVEFG-LPPGEDVDAVFSWPHNGKTYLIRGQKYWRYDEVAAR-PDPGY ENSMUST00000031390 KDNNVEEGYPRPVSDFS-LPPG-GIDAVFSWAHNDRTYFFKDQLYWRYDDHTRR-MDPGY ENST00000321387 KDNNVEEGYPRPVSDFS-LPPG-GIDAAFSWAHNDRTYFFKDQLYWRYDDHTRH-MDPGY ENST00000320661 DEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRA-VDSEY ENSMUST00000000983 DEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEEFRA-VDSEY SINFRUP00000162871 READVLPGYPQPLREYGKGVPVHKIDTAIWWEPNGYTYFFSGDRYWRFNEQTRS-TDSDF SINFRUP00000158279 REANLEMGYPLELVDFGRDIPYDRVDTAIWWEPSGYTYLFQGDWYWRFDEKSRL-ADRGY ENST00000219271 REANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQR-GDPGY ENSMUST00000034243 REANLEPGYPQPLSSYGTDIPYDRIDTAIWWEPTGHTFFFQADRYWRFNEETQH-GDPGY CG4859-RA QGRQMDGVYPKEISEGFTGIPD-HLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASY .: . : . * :*:.: * .. ::. ::*:: . : ENST00000241903 PRDLSLWE-GAPPSPDDVTVSN-AGDTYFFKGAHYWRFPKNSIKTE---PDAPQPMGPNW ENSMUST00000024696 PRALSLWD-GAPFAPDDVTISN-TGDTYFFKGTHFWRFAEGSVKAE---SDSPQPIGPKW ENSMUST00000031390 PAQGPLWR-GVPSMLDDAMRWS-DGASYFFRGQEYWKVLDGELEAA---PGYPQSTARDW ENST00000321387 PAQSPLWR-GVPSTLDDAMRWS-DGASYFFRGQEYWKVLDGELEVA---PGYPQSTARDW ENST00000320661 PKNIKVWE-GIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVE---PGYPKSALRDW ENSMUST00000000983 PKNIKVWE-GIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVE---PGYPKSALRDW SINFRUP00000162871 PKPNSRWG-RIPDSPRGAFLSDDSAYTYIYQGSNYWRFDNRRTEAD---AGYPRSILKDF SINFRUP00000158279 PKPISVWGSSVPSAPKGAFLSDDGAYTFFYKGSKYWKFDNLRMKSE---PGYPKSILKDF ENST00000219271 PKPISVWQ-GIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRME---PGYPKSILRDF ENSMUST00000034243 PKPISVWQ-GIPTSPKGAFLSNDAAYTYFYKGTKYWKFNNERLRME---PGHPKSILRDF CG4859-RA PKPISNWE-GVPNNLDAALKYT-NGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWW * * * :::::* .:::. . . *:. : ENST00000241903 LDCPAPSSGPRAPR---------------------------------------------- ENSMUST00000024696 LDCPAPNSDPRVTS---------------------------------------------- ENSMUST00000031390 LVCGEPLADAEDVG---------------------------------------------- ENST00000321387 LVCGDSQADGSVAAGVDAA----------------------------------------- ENST00000320661 MGCPSGGRPDEGTE---EETEV-------------------------------------- ENSMUST00000000983 MGCPSGGRPDEGTE---EETEV-------------------------------------- SINFRUP00000162871 MGCRGAPDPKPDTD---AEAEP---KHTPVNPADRGRDEPRKPDRDGDSEEGRTSEPDAA SINFRUP00000158279 MGCSVDLDPDRDTD---TGRKYPDVNRPPFNP-DAGRTDDKSKDRDENHHNRTTKDPGRR ENST00000219271 MGCQEHVEPGPRWP---DVARP------PFNP--HGGAEPGADSAEGDVGDGDGDFGAGV ENSMUST00000034243 MGCQEHVEPRSRWP---DVARP------PFNP--NGGAEPEADGDSKEENAGD------- CG4859-RA FGCKNTPSSTGNIVEGSDNEFEQHSMIPHADD---------------------------- : * ENST00000241903 ----------------------------PPKATPVSETCD----CQCELNQAAG------ ENSMUST00000024696 ----------------------------PPKTTSKTRSCD----CHCELNQAS------- ENSMUST00000031390 -----------------------------PGPQGRSGAQDGLAVCSCTSDAHR------- ENST00000321387 -----------------------EGPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGP ENST00000320661 --------------------IIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFF-FR ENSMUST00000000983 --------------------IIIEVDEEGSGAVSAAAVVLPVLLLLLVLAVGLAVFF-FR SINFRUP00000162871 EDDEDE-----------QVNVEVSVDDET-KVMTLIMVIVPLVLILCILVLIYAILRTLQ SINFRUP00000158279 PDNDDDDRREGREEDTNEVDVVLKVDDNKERTMTILMVIIPLVLVLCILGLIYAIINTLQ ENST00000219271 NKDGGS-------------RVVVQMEEVA-RTVNVVMVLVPLLLLLCVLGLTYALVQ-MQ ENSMUST00000034243 -KDEGS-------------RVVVQMEEVV-RTVNVVMVLVPLLLLLCILGLAFALVQ-MQ CG4859-RA -------------------GNGDDFDAAVGDHQSNDEPIVPEVAERTGNGAMSQSKLTSS : ENST00000241903 RWPAPIPLLLLPLLVGGVASR------ ENSMUST00000024696 EQLSPLLLPLLPLVAGEVFS------- ENSMUST00000031390 -LALPSLLLLTPLLWGL---------- ENST00000321387 LVAATMLLLLPPLSPGALWTAAQALTL ENST00000320661 RHGTPRRLLYCQRSLLDKV-------- ENSMUST00000000983 RHGTPKRLLYCQRSLLDKV-------- SINFRUP00000162871 NKESPRALVHCKRSLQEWV-------- SINFRUP00000158279 SKGAPRLLVHCKRSLQDWV-------- ENST00000219271 RKGAPRVLLYCKRSLQEWV-------- ENSMUST00000034243 RKGAPRMLLYCKRSLQEWV-------- CG4859-RA SAVSTVITTILMCLVSKLIVS------ .