CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000041395 -------------------------------------------------- ENSMUST00000051803 -------------------------------------------------- ENST00000255084 -------------------------------------------------- SINFRUP00000129119 -------------------------------------------------- Q90ZZ7_Brachydanio_rerio -------------------------------------------------- CG11140-RH -------------------------------------------------- Q90ZZ8_Brachydanio_rerio -------------------------------------------------- SINFRUP00000134540 -------------------------------------------------- SINFRUP00000148431 -------------------------------------------------- SINFRUP00000134534 -------------------------------------------------- ENSMUST00000062929 -------------------------------------------------- ENST00000325150 WQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRL ENST00000225740 -------------------------------------------------- ENSMUST00000019246 -------------------------------------------------- ci0100153506 -------------------------------------------------- ci0100135996 -------------------------------------------------- ENSMUST00000041395 ----------------FEEKLQRLKEAFNTGKTKTAKFRAEQLQSLGRFL ENSMUST00000051803 -------------MDSFEDKLQQLREAFKEGRTRSAEFRAAQLQGLSHFL ENST00000255084 -------------------------------------------------- SINFRUP00000129119 -------------MDAQSQVVGRLRSVFLTGVTLPEQFRQAQLNKLMALI Q90ZZ7_Brachydanio_rerio -------------MEGQKQVLERLRGAFRSGVTLPVHFRLTQLEAMMSLF CG11140-RH -------------MANFDDTLQRARLAFSSGKTRNVSFRRKQLENLLRCY Q90ZZ8_Brachydanio_rerio -------------MSREQLAVQQARKAFLTGRSKSLDYRIKQLKNLSRFI SINFRUP00000134540 -------------------------------------------------- SINFRUP00000148431 -------------MSREQKAVARARKAFETGRSKPLEHRIHQLKNLQRLL SINFRUP00000134534 -------------------ALQRAREAFLSGRTRAVEFRLQQLHALQKMI ENSMUST00000062929 ----------------MERQVLRLRQAFRSGRSRPLRFRLQQLEALRRMV ENST00000325150 PLPSAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMV ENST00000225740 -------------MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLI ENSMUST00000019246 -------------MSNISSIVNRARDAFNSGKTRPLQFRVEQLEALQRMI ci0100153506 --------------------IVAAKEAFSSGKTKDVKFRKQQLQKLFKCV ci0100135996 ------------------------RHAFQTGITQPIEWRIAQLNRLIDLL : : : : ENSMUST00000041395 QDNSKQLHDALDGDLGKSG-----FESDMSEIILCENEVDLALKNLQTWM ENSMUST00000051803 RDNKQQLQEALAQDLHKVAWNRDTFEAEVSEIAISQAEVDLALRNLRSWM ENST00000255084 -------------------------------------------------M SINFRUP00000129119 KENEQRILDALHKDLAKPK-----FEAVLSEIDIAINELHFAISNLSSWM Q90ZZ7_Brachydanio_rerio EDNETQILEALHEDLAKPK-----FETVLSEIDIVVNDICYNISNLQTWM CG11140-RH EEHENEIISALEADLRRPK-----QESLIVETEFMKNDIRHILFQLDEWV Q90ZZ8_Brachydanio_rerio KERAADITNALRKDLYKSA-----NSTQLFEILGLEGEINLAVSKLAEWA SINFRUP00000134540 ---------------FQSE-----HGTELFETMGLEAEINLAVGKLAEWA SINFRUP00000148431 TERKKEIVDAIKKDLGKSE-----EGTQLYETLGLEGEINMAVKKLKEWA SINFRUP00000134534 TEKETDISSALKEDLNRSQ-----YDTPLLELISIENEIKLAIEKLSEWA ENSMUST00000062929 QEREKEILAAIAADLSKSE-----LNAYSHEVITILGEIDFMLGNLPELA ENST00000325150 QEREKDILTAIAADLCKSE-----FNVYSQEVITVLGEIDFMLENLPEWV ENST00000225740 QEQEQELVGALAADLHKNE-----WNAYYEEVVYVLEEIEYMIQKLPEWA ENSMUST00000019246 NENLKGISKALASNLRKNE-----WTSYYEEVAHVLDEIDFTIKGLSDWA ci0100153506 RDNEVRWCEALKKDLNKSK-----TEAVSAEIILVNNEIVTAIKNLDQWV ci0100135996 NEQEDAIVDALQQDLRKPK-----FETLMTEVIVAKNEATYAINNVHAWS : : : : ENSMUST00000041395 KDEPVSTNLLTKLSTAFIRKEPFGLVLIIAPWNYPVNLMIIPLVGAIAAG ENSMUST00000051803 KDEKVSKNLVNWRRGPFIRKEPFGLVLIIVPWNYPINLTLVPLVGAIAAG ENST00000255084 KDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAG SINFRUP00000129119 KPEYVEKNLATKLDECFVRREPLGVVLIIGAWNYPLQLTLNPLIGAIAAG Q90ZZ7_Brachydanio_rerio QPSYVGTNLATKLDDCFVRREPLGVVLIIGAWNYPIQLILSPLIGAIAAG CG11140-RH QSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIAAG Q90ZZ8_Brachydanio_rerio APRPVNKNLLTISDDVFLQPEPLGVVLIIGAWNYPIAVTLQPLVGAIAAG SINFRUP00000134540 APRPVEKNLLTMSDEVYIQPEPLGVVLIIGAWNYPWAVTLQPLVGAIAAG SINFRUP00000148431 APRPVEKNLMTLSDTVYIRPEPLGVVLIIGAWNYPWAITIQPLIGAIAA- SINFRUP00000134534 APRPVEKNLLTISDEAYIQLEPLGVVLIIGAWNYPWAVTLLPLVGAIAAE ENSMUST00000062929 SARPAKKNLLTMMDEAYVQPEPLGVVLIIGAWNYPFVLTMQPLVGAIAAG ENST00000325150 TAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAG ENST00000225740 ADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAG ENSMUST00000019246 EDEPVAKTRQTQEDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAIAAG ci0100153506 KNEPKKKELATITADIYTRKEPFGTCLIMSAWNYPFLLMLAPMIGAIAAG ci0100135996 KPTYPSKTFPQLMDTVYIQKQPLGVVLLIGAWNYPIQLLFNQLVAVIVSG . :*:* *:: .**** : : : ..:.: ENSMUST00000041395 N---------------------CVVLKPSEISKNTEKVLAELLPQYLDQS ENSMUST00000051803 N---------------------CVVLKPSEISKATEKILAEVLPRYLDQS ENST00000255084 S---------------------CVVLKPSEISQGTEKVLAEVLPQYLDQS SINFRUP00000129119 N---------------------CAVIKPSEVSPATESLLVELIPKYLSQD Q90ZZ7_Brachydanio_rerio N---------------------CAILKPSEISKATEKLLAELIPKYLSQE CG11140-RH N---------------------CVVIKPSEIAANCAKFIADVIPKYLDND Q90ZZ8_Brachydanio_rerio N---------------------AVVVKPSEVSSHTASVM-ELMSLYLDSE SINFRUP00000134540 N---------------------AAVIKPSEVSLHSSKVMEELLPLYLDKD SINFRUP00000148431 ----------------------VLVVESSTRKNHTCLLLIRMFVS--RTE SINFRUP00000134534 VNRPSTTMGRRLYDLCCGSAGNAAVVKPSELSESSSVLLRSLLPHYLDKD ENSMUST00000062929 N---------------------AAIVKPSELSENTAKILAELLPQYLDQD ENST00000325150 N---------------------AVIIKPSELSENTAKILAKLLPQYLDQD ENST00000225740 N---------------------SVVLKPSELSENMASLLATIIPQYLDKD ENSMUST00000019246 N---------------------AVVLKPSEVSDHMADLLSTLIPQYMDKD ci0100153506 N---------------------CVVIKPSECAAHTAKLLQELLPQYIDPT ci0100135996 N---------------------CGIIKPSELSPVTADLIAKLIPQYLDKE :::.* .: :: ENSMUST00000041395 CFAVMLGGPEETGQLLE-HKFDYIFFTGSPRVGKIVMTAAAKHLTPITLE ENSMUST00000051803 CFTVVLGGRQETGQLLE-HKFDYIFFTGNAYVGKIVMAAAAKHLTPITLE ENST00000255084 CFAVVLGGPQETGQLLE-HKLDYIFFTGSPRVGKIVMTAATKHLTPVTLE SINFRUP00000129119 CYAVVQGGPEETQALLK-NRFDHIFYTGSQKVARVIMQAASVHLTPVTLE Q90ZZ7_Brachydanio_rerio CYAVVCGGAEETKTLLE-NRFDHIFYTGSQSVARCVLQAAAVHLTPVTLE CG11140-RH CYPVVCGGPSETAELLN-QRFDYIFYTGSTRVGKIIHAAANKYLTPTTLE Q90ZZ8_Brachydanio_rerio MYQVVTGGVPETQELLK-QRFDHIFYTGNSTVGKLVMEAASHHLTPVTLE SINFRUP00000134540 LYPVVTGGVSETQELLK-QRFDHIFYTGSSTVGKLVMEAAALHLTPVTLE SINFRUP00000148431 LYPVVTGGVTETQELLR-QRFDHIFYTGNGMVGKLIMEAAAKHLTPVTLE SINFRUP00000134534 LYPVVTGGASETQELLR-LRFDHIFYTGSGAVGRLVMEAAARHLTPVTLE ENSMUST00000062929 LYAIVNGGIPETTELLK-QRFDHILYTGNTAVGKIVMEAAAKHLTPVTLE ENST00000325150 LYIVINGGVEETTELLK-QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLE ENST00000225740 LYPVINGGVPETTELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLE ENSMUST00000019246 LYPVIKGGVPETTELLK-EKFDHIMYTGSTAVGKIVMAAAAKHLTPVTLE ci0100153506 CYPVIVLDAKDSADLVTNNRFDFIFFTGGTAIGRIVMKAAAEYLTPVVLE ci0100135996 CFKVYLGGIPETTLLLQ-QKFDKIIYTGSSMVGKIIMKAAAEHLTPVLLE : : . :: *: ::* *::**. :.: : ** :*** ** ENSMUST00000041395 LGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYILCSQEMQERL ENSMUST00000051803 LGGKNPCYVDDNCDPQIVANRVAWFRYFNAGQTCVAPDYILCSQEMQERL ENST00000255084 LGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERL SINFRUP00000129119 LGGKSPCMIFGGVNIRAAVHRLAWAKFFNAGQSCVAPDYVLCSPATRDAM Q90ZZ7_Brachydanio_rerio LGGKCPCLIYGRLDMKAAAKRLVWAKFFNSGQSCVAPDYVLCTDEVKEML CG11140-RH LGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKE----- Q90ZZ8_Brachydanio_rerio LGGKSPCYIDKNCDIRIACRRITWGKYLNCGQTCIAPDYILCESSIQDRV SINFRUP00000134540 LGGKSPCYIDKDCDIAVACRRITWGKFVNCGQTCIAPDYVLCEPSIQSRV SINFRUP00000148431 LGGKSPCYIDKNCDLTIACRRIAWGKYTNCGQTCIAPDYILCEPSIQNQV SINFRUP00000134534 LGGKSPCYIDKDCNIRVACRRITWGKFANCGQTCIAPDYILCEPCIQGRV ENSMUST00000062929 LGGKSPCYIDRDCDLDVACRRIAWGKYMNCGQTCIAPDYILCEASLQNQI ENST00000325150 LGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQI ENST00000225740 LGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQI ENSMUST00000019246 LGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNEI ci0100153506 LGGKNPCFVDDSCDIRNTARRICWGRFLNTGQLCLCPDYVLCSQGVRDKF ci0100135996 LGGKSPVYVHKDSNLDLVAKRVAWGKYMNLGQTCTAPDYVLCHGHVLEEF **** * : : . .*: * * ** * .***:** . ENSMUST00000041395 VPALQNSITRFYGDNPQTSPNLGRIINQKHFKRLQGLLG---CGRVAIGG ENSMUST00000051803 VPALQNAITRFYGDNPQTSPNLGRIINQKHFKRLQGLLG---CGRVAIGG ENST00000255084 LPALQSTITRFYGDDPQSSPNLGHIINQKQFQRLRALLG---CSRVAIGG SINFRUP00000129119 LPELKVTLEEFYTKNPQASPDFCRIVSPRHWSRLMELLKR-SNGKVIVGG Q90ZZ7_Brachydanio_rerio LPFMKEALESFYGSEPQESPDYGRIVTDRHWNRLIELMKK-SEGKIVIGG CG11140-RH ------------------------------------------------GG Q90ZZ8_Brachydanio_rerio IDEIQKCIKEFYTIDPKTFEDYGRIINRRHFKRIMALLEG---STVAIGG SINFRUP00000134540 IEEITKNIKEFYTDNPKTFDDYGRIINQQHFKRLVALMGG---GKVAVGG SINFRUP00000148431 IEEVQKAVKEFYTDDPKSCPDYCRIINQRHFKRIMAMLED---STIAVGG SINFRUP00000134534 VECIRQTLLEFYGPDPKSSPDYGRIISRRHFNRIMGLMEG---YTAVVGG ENSMUST00000062929 VQKIKETVKDFYGENIKASPDYERIINLRHFKRLQSLLKG---QKIAFGG ENST00000325150 VWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEG---QKIAFGG ENST00000225740 VEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG---QKVAYGG ENSMUST00000019246 VEKLKKSLKDFYGEDAKQSHDYGRIINDRHFQRVINLIDS---KKVAHGG ci0100153506 VEEIKLALKEFYGSDPKHSPDYGRIINERQTLRLKKVIESGA-GKIVVGG ci0100135996 LNKLKSTIKEMYGEDPQKSPDLARIVNARNFQRIEKLILGMSKEKLVVGG : : : : :: : :: ** ENSMUST00000041395 QSDEGERYIAPTVLVDVQETEPVMQEEIFGPILPLVTVRSLDEAIEFINR ENSMUST00000051803 QSDEGERYI---VLVDVQETEPVMQEEIFGPILPLVTVRSLDEAIEFMNR ENST00000255084 QSNESDRYIAPTVLVDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINR SINFRUP00000129119 ESDEEDKYIAPTVVVDVDEDDALMQEEIFGPILPIVTVDSVEKGIEFLNG Q90ZZ7_Brachydanio_rerio ESVKETRYIAPTVIVDVKGTDALMQEEIFGPILPILTIKSLDEGINFINE CG11140-RH NYDASERFIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINA Q90ZZ8_Brachydanio_rerio DCDESECYIAPTVLRDVKPASKVMQEEIFGPILPIVTVNGLKEAIEFIND SINFRUP00000134540 DSDESECYIAPTVLKDVTAESKVMKEEIFGPLLPIVNVSGVDEAIRFIND SINFRUP00000148431 DNDESDCYIAPTILKDVKPEAKVMQEEIFGPLLPILSVSGLDEAIKFINR SINFRUP00000134534 QSDASQRYIAPTVLKDVPPHSRLMQEEIFGPLLPIVTVSDMDEAIRFINE ENSMUST00000062929 EMDEATRYLAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVDEAINFIND ENST00000325150 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINE ENST00000225740 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQ ENSMUST00000019246 TWDQPSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLDEAIKFINQ ci0100153506 EVDVKERYVAPTVVTDIPADSAYMQQEMFGPILLVVTVKDMDEAIAVVNS ci0100135996 DMNEKTRYIAPTVYKDVHIGDPIMDSEIFGPILPVLAVNGEDEAIEIING :: : *: *..*:***:: :. : . ..* .:* ENSMUST00000041395 REKPLALYAFSNNN------------------------------------ ENSMUST00000051803 REKPLALYAFSKRSQVGSSTRGTHTGGSIENMPQGGVCVCPIRAPLALTE ENST00000255084 QEKPLALYAFSNSS------------------------------------ SINFRUP00000129119 REKPLALYVFSDDS------------------------------------ Q90ZZ7_Brachydanio_rerio KEKALALYAFSDES------------------------------------ CG11140-RH REKPLVIYVFSNSN------------------------------------ Q90ZZ8_Brachydanio_rerio REKPLALYVFSSS------------------------------------- SINFRUP00000134540 REKPLVVYVFSNQ------------------------------------- SINFRUP00000148431 GEKPLALYVFSHD------------------------------------- SINFRUP00000134534 REKPLALYLFCSD------------------------------------- ENSMUST00000062929 REKPLALYVFSRN------------------------------------- ENST00000325150 REKPLALYVFSHN------------------------------------- ENST00000225740 REKPLALYMFSSN------------------------------------- ENSMUST00000019246 REKPLALYVFSNN------------------------------------- ci0100153506 REKPLAMYIFAKN------------------------------------- ci0100135996 SDKPLAFYIFAKSDKVIYNEFLLCVSQDRNIYSISTNYFLINPLGIFCVR :*.*..* *. ENSMUST00000041395 -------------QVVNQMLERTSSGGFGGNDGFLYLTLPALPLGGVGNS ENSMUST00000051803 TRSVQECFASFLSQVIKQVLARTSSGGFCGNDGFMHMTLSSLPFGGVGTS ENST00000255084 -------------QVVNQMLERTSSGSFGGNEGFTYISLLSVPFGGVGHS SINFRUP00000129119 -------------SLVNKVLESTSSGGFCSNDGIINSGLPSFPFGGVGAS Q90ZZ7_Brachydanio_rerio -------------QVVTTVLERTSSGGFCSNDGIVHMTLPGLPFGGVGAS CG11140-RH -------------KLVKEFRRSTTSGGFSSNETIMHCGVDVLPFGGVGMS Q90ZZ8_Brachydanio_rerio ------------KKVIKQMISETSSGALLANDCMVHFTLSDLPFGGVGYS SINFRUP00000134540 ------------NKLIKRLIAETSSGAFLANDCLVHFTVNALPFGGVGNS SINFRUP00000148431 ------------SKVS-RVRDETSSGGLLANDCLVHYSVSSLPFGGVGNS SINFRUP00000134534 ------------KKAVKRMIEETSSGGVTVNDVLMHYTLCSLPFGGV--- ENSMUST00000062929 ------------NKLIKRVIDETSSGGVTGNDVIMHFTVNSLPFGGVGAS ENST00000325150 ------------HKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS ENST00000225740 ------------DKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS ENSMUST00000019246 ------------DKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS ci0100153506 ------------KKLVNKILSNTSSGGVTVNDVVMHYVPHSLPFGGVGES ci0100135996 TLIADKLKFSSGNTVVQKLLSNTSSGGATVNDVLMHAAAYNLPFGGVGNS . *:**. *: . .*:*** ENSMUST00000041395 GMGRYHGKFSFDTFSHHRACLLRSPG--MEKLNDLRYPPYGPWNQQLISW ENSMUST00000051803 GMGRYHGKFSFDTFSNQRACLLRSPG--MEKINDLRYPPYSSRNLRVLLV ENST00000255084 GMGRYHGKFTFDTFSHHRTCLLAPSG--LEKLKEIHYPPYTDWNQQLLRW SINFRUP00000129119 GLGSYHGRWGFETFSHRKACMLRGWA--LERLNGLRYPPYQENKLNWLRW Q90ZZ7_Brachydanio_rerio GMGNYHGRWGFETFSHKRGCMLRGWG--LERVNVLRYPPYTESNLSWLRW CG11140-RH GMGRYHGKYGFETFTHKKSCLGKDLSPLGEKLSSARYPPYSDRKGSLLSF Q90ZZ8_Brachydanio_rerio GTGRYHGKYSFDQVSHLRSCLIKKLNM--EAVNQMRYPPHTTEKLRWARV SINFRUP00000134540 GMGSYHGRHTFDQLSHLRSCLIKQLKM--ERVNSMRYPPHTAKKLGWARF SINFRUP00000148431 GMGCYHGKFSFDQLSHQRGCLIKQLKM--EGMNSMRYPPHTAKKLGWARF SINFRUP00000134534 -------------------------------------------------- ENSMUST00000062929 GMGAYHGKYSFDTFSHQRPCLLKGLKG--ESVNKLRYPPNSESKVSWAKF ENST00000325150 GMGAYHGKHSFDTFSHQRPCLLKSLKR--EGANKLRYPPNSQSKVDWGKF ENST00000225740 GMGSYHGKKSFETFSHRRSCLVRPLMN--DEGLKVRYPP-SPAKMTQH-- ENSMUST00000019246 GMGAYHGKKSFETFSHRRSCLVRSLRN--EEANKARYPP-SPAKMPRH-- ci0100153506 GMGAYHGKHTFDTFSHRRSCLVDGNP---EFFNSLRYPPHSQKKLSIIRL ci0100135996 GMGAYHGKYSFDALTHERSISYRGQNL--ESLVAARYPPYTEKNLSMVSH : . ENSMUST00000041395 AIGSR---------------------------------- ENSMUST00000051803 AMEER---------------------------------- ENST00000255084 GMGSQSCTLL----------------------------- SINFRUP00000129119 TTSPK---------------------------------- Q90ZZ7_Brachydanio_rerio ATTAKKKGWGGCSLM------------------------ CG11140-RH LLRKRRPLPNLHLSHVLAIGLGVGLTVLTNYYLQKSSTD Q90ZZ8_Brachydanio_rerio LLLKQINVTRWRQMAQVAVLAALAAFVVKRFLR------ SINFRUP00000134540 FLLQQVNVCRLQRVALMATFIGLAAFVVQ---------- SINFRUP00000148431 FILKTVDLGWVGRMVLFAVMVVGAA-------------- SINFRUP00000134534 --------------------------------------- ENSMUST00000062929 FLLKQFNKGRLGMLLFVCLVAVAAVIVK----------- ENST00000325150 FLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY------- ENST00000225740 --------------------------------------- ENSMUST00000019246 --------------------------------------- ci0100153506 VLMKNMQK------------------------------- ci0100135996 I--------------------------------------