CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000040654 RPPRRGSECQGQKPPPHPLLPSSGLIRRRRCPDEESAAVVPREDPRAMSASSLLEQRPKG ENST00000294415 -----------------------------------------------MSASSLLEQRPKG SINFRUP00000158963 ------------------------------------------------------------ ENSMUST00000050490 ------------------------------------------MFYLDLTLLHRATEETGE ENST00000321203 ------------------------------------------------------------ SINFRUP00000158366 ------------------------------------------------------------ ENSMUST00000037299 -------------------------------------------------------QRTKG ENST00000279070 ------------------------------------------------------------ SINFRUP00000130274 ------------------------------------------------------------ ci0100151465 --------------------------------------------MSNATLDPDQHHKTQT CG6422-RA ------------------------------------------------------------ ENSMUST00000040654 QGNKVQNGSVHQKDGLNDDDFEPYLSPQARPNNAY--TAMSDSYLPSYYSPSIGFSYSLG ENST00000294415 QGNKVQNGSVHQKDGLNDDDFEPYLSPQARPNNAY--TAMSDSYLPSYYSPSIGFSYSLG SINFRUP00000158963 -------------------------------SNAY--TAMSDSYMPSYYSPSVGFSYSLN ENSMUST00000050490 ESFSVQNGSIHQKDAVNDDDFEPYLSSQTNQNNSY--PPMSDPYMPSYYAPSIGFPYSLG ENST00000321203 --------------------------------------------MPSYYAPSIGFPYSLG SINFRUP00000158366 -------------------------------NNSY--PPMSDPYMPSYYAPSIGFPYSLG ENSMUST00000037299 QDNKVQNGSLHQKDAVHDNDFEPYLSGQSNPSNSY--PSMSDPYLSSYYPPSIGFPYSLS ENST00000279070 --VLVQNGSLHQKDTVHDNDFEPYLTGQSNQSNSY--PSMSDPYLSSYYPPSIGFPYSLN SINFRUP00000130274 ----VQNGSLHQKDTVHDTDFEPYLTNQSNQNNSY--QSMTDPYLSSYYAPSIGFPYPLS ci0100151465 GRSRMQNGLESKGQTGRNDEFDSSYMHQANVNPAYGMAPTSDSYMPSYYG-QMPFPY-MG CG6422-RA --MSGVDQMKIPGNTAKSVEERNIPWSQQVDEASYENLSSPTHDEVSGNDNSMQFQYPPF * .: * * ENSMUST00000040654 EAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQP-GALGSTP-FLGQHGFNFFPSGI ENST00000294415 EAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQP-GALGSTP-FLGQHGFNFFPSGI SINFRUP00000158963 EAAWSTGGDPPMPYLASYGQLSNGEPHYLPDAMFGQP-GPLGSNP-FLNQHGFNFFPGGI ENSMUST00000050490 EAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQP-GALGNTPPFLGQHGFNFFPGNA ENST00000321203 EAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQP-GALGNTPPFLGQHGFNFFPGNA SINFRUP00000158366 EAAWSTAGDPPMPYLTTYGQMSNGEPHFIPDGLFSQP-GALGNTPPFLGQHGFNFFPGNA ENSMUST00000037299 EAPWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQP-GGLGNNI---YQHRFNFFPENP ENST00000279070 EAPWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQP-GGLGNNI---YQHRFNFFPENP SINFRUP00000130274 EAPWSTGGDPPIPYLTPYAPLSNGDHHFMHDTVFGQP-GGLSSSI---YPHRFNFFPENP ci0100151465 SSEWSTGSTDNMPYLSGFGGEAQ-QHSFLPDAMFSHPPAALGNTP-AYYNQPYNFFQHGT CG6422-RA NFKENCN--------TPWNNMNKGRKANANHDSYRRHGHSIPNNTRRDEHQVNPWNSRKP . . : :: : : . : : : .. : : ENSMUST00000040654 DFSAWGNNSSQ----------GQS--TQSSGYSSNYAYAPSSL----------GGAMI-- ENST00000294415 DFSAWGNNSSQ----------GQS--TQSSGYSSNYAYAPSSL----------GGAMI-- SINFRUP00000158963 DFSAWGNSSSQ----------GQSGTPQSSGYSSSYAYAPSSL----------GGAMI-- ENSMUST00000050490 DFSTWGTSGSQ----------GQS--TQNSAYSSSYGYPPSSL----------GRAIT-- ENST00000321203 DFSTWGTSGSQ----------GQS--TQSSAYSSSYGYPPSSL----------GRAIT-- SINFRUP00000158366 DFSTWGTSVSQ----------GQS--TQSSVYSNSYGYAPSSL----------GRAIA-- ENSMUST00000037299 AFSAWGTSGSQ----------GQQ--TQSSAYGSSYTYPPSSL----------GGTVV-- ENST00000279070 AFSAWGTSGSQ----------GQQ--TQSSAYGSSYTYPPSSL----------GGTVV-- SINFRUP00000130274 AFSAWGTSGSQ----------GQQ--TQSSAYGGSYSYPPSSL----------GGTLVP- ci0100151465 DFSPWASHSSAHGTGMPETPGGTGFGQQTAAPTYNGDYYPSIMPATPHDYLGTGEAIVSN CG6422-RA AAQSFRNENDQP---------STKLDNRTSDEAQNQEVVAAPK----------------- ..: . . . :.: . .: : ENSMUST00000040654 -----DGQSAFA------------NETLNKAPG------MNTIDQGMAALKLGSTEVASS ENST00000294415 -----DGQSAFA------------NETLNKAPG------MNTIDQGMAALKLGSTEVASN SINFRUP00000158963 -----DGQSPFAPG---------ANEPLNKAPG------MNSLDQGMAGLKLGGAAPGGN ENSMUST00000050490 -----DGQAGFG-----------NDT-LSKVPG------ISSIEQGMTGLKIGGDLTAAV ENST00000321203 -----DGQAGFG-----------NDT-LSKVPG------ISSIEQGMTGLKIGGDLTAAV SINFRUP00000158366 -----DGQAGFG-----------SDTQLSKVPV------LNSIEQGMTGLKLGTEMVSAV ENSMUST00000037299 -----DGQTGFH------------SDSLNKAPG------MNSLEQGMVGLKIG-DVTTS- ENST00000279070 -----DGQPGFH------------SDTLSKAPG------MNSLEQGMVGLKIG-DVSSS- SINFRUP00000130274 -----DGQTGFH------------SDTLSKAPG------MNSIEQGMLGLKIGGDVTGSG ci0100151465 GSVLGHGAPGAAIPGVGGSTVMSSGDPIGKLPVGSSSNSMKMVEQGIQNMGLGMSSMSGD CG6422-RA -------KTTWAS---IASQPAKLTS--------------RAASTTSNSKKKGPGMPPPP . : : . * ENSMUST00000040654 -----------------VPKVVGS-AVGSGSIT---SNIVASSSLPP-ATIAPPKPASWA ENST00000294415 -----------------VPKVVGS-AVGSGSIT---SNIVASNSLPP-ATIAPPKPASWA SINFRUP00000158963 GD--------------MAPKVVGSGLPGAGPLGP--VSSVGTPSMPP-VSIATAKPASWA ENSMUST00000050490 ------------------TKTVGTALS-SSGMT-----SIATNNVPP-VSSAAPKPTSWA ENST00000321203 ------------------TKTVGTALS-SSGMT-----SIATNSVPP-VSSAAPKPTSWA SINFRUP00000158366 ------------------TKTVGSPIGGTAGMS-----SLATNSLPPSVSSSTPKPASWA ENSMUST00000037299 -----------------AVKTVGSVVNSVALTG-----VLSGNGGTN-VNMPVSKPTSWA ENST00000279070 -----------------AVKTVGSVVSSVALTG-----VLSGNGGTN-VNMPVSKPTSWA SINFRUP00000130274 S----------------AVKSPGSVIGG---SG-----SVAAAVATP-IGMPPPKPTSWA ci0100151465 PMKQMQVTPVIPMPGGGSIVSAGAPQNATNISGQSSQSASSSNNSTPVPGSNAPKPVSWA CG6422-RA -------------------MVPGKHNLDVNVWD------LPNNKPPPVPSPPSPIDLGYS * . . .:: ENSMUST00000040654 DIASKPAKQQP-KLKTKNGIA---GSSLPPPPIKHNMDIGTWDNKG-PVAKAPSQALVQN ENST00000294415 DIASKPAKQQP-KLKTKNGIA---GSSLPPPPIKHNMDIGTWDNKG-PVAKAPSQALVQN SINFRUP00000158963 DIASKPAKPQP-KLKTKGGMA---GANLPPPPIKHNMDIGTWDNKG-TMPKA-------- ENSMUST00000050490 AIARKPAKPQP-KLKPKGNVG-IGGSAVPPPPIKHNMNIGTWDEKG-SVVKAP------- ENST00000321203 AIARKPAKPQP-KLKPKGNVG-IGGSAVPPPPIKHNMNIGTWDEKG-SVVKAP------- SINFRUP00000158366 AIAKKPAKLQP-KVKPKANMGMVGGATIPPPPIKHNFNIGTWDDKG-SLNKPP------- ENSMUST00000037299 AIASKPAKPQP-KMKTKSG-P-IVGGALPPPPIKHNMDIGTWDNKG-PAPKAS------- ENST00000279070 AIASKPAKPQP-KMKTKSG-P-VMGGGLPPPPIKHNMDIGTWDNKG-PVPKAP------- SINFRUP00000130274 AIASKPAKLQQQKSKNKPGTP-IAGGALPPPPIKHNMDIDTWDNKGTPQLHSH------- ci0100151465 AIASKPAKPQP-KPKAKSMVG----PGLPPP-IKHNMDIGTWDSQT--PAKGP------- CG6422-RA DLSSDFSISSN---TAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVS------- :: . : . . . : : . . :.: : ENSMUST00000040654 IGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQP------- ENST00000294415 IGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQP------- SINFRUP00000158963 ------AAPQQVPLNPSNGQPPIQIPQVPLSQGPPPPS--------QQQAPQP------- ENSMUST00000050490 -PTQPVLPPQTIIQQPQPLIQP-PPLVQSQLPQQQPQPPQPQ----QQQGPQPQAQPHQV ENST00000321203 -PTQPVLPPQTIIQQPQPLIQP-PPLVQSQLPQQQPQPPQPQ----QQQGPQPQAQPHQV SINFRUP00000158366 -LAQTMLPPQPLSSQHHHPLPPGPPHLQLSSQPGPPLHHQHP----QQPGPPP------- ENSMUST00000037299 -------APQQTPSPQAAPQ-PQQVAQPLPVQPPPLVQPQYQ---SPQQPLQP------- ENST00000279070 -------VPQQAPSPQAAPQ-PQQVAQPLPAQPPALAQPQYQ---SPQQPPQT------- SINFRUP00000130274 -------APSLLPPLQQSLQSAQSLMQQMTMQGPPPPPPSYQN-HNSALTPQT------- ci0100151465 -------AKGQMPGQPGAPQRWSAPRQGPADGSVSSNHHSAN------------------ CG6422-RA -------PTGPVRRNLGPQQPVHHAAPRPATNAGPFGPPNARRHDGGPHPSRNS------ ENSMUST00000040654 --------TRWVAPRNRGSGFGHNGV---DGNGVGQSQAGSG------STPSEPHPVLEK ENST00000294415 --------TRWVAPRNRGSGFGHNGV---DGNGVGQSQAGSG------STPSEPHPVLEK SINFRUP00000158963 --------SRWVAPRNRANGFGDP-----SGNGAGQSPPTSSGVAVLPGVPSEPHPVLEK ENSMUST00000050490 QSQQPQLQNRWVAPRNRGTGFNQNNGTGSENFGLGVVPVSAS------PSSVEVHPVLEK ENST00000321203 QPQQQQLQNRWVAPRNRGAGFNQNNGAGSENFGLGVVPVSAS------PSSVEVHPVLEK SINFRUP00000158366 --------NRWVAPRNRGEGFCLGGG----------VPLSAS------LCSGELHPMLEK ENSMUST00000037299 ---------RWVAPRNRNAAFGQSGGANSDSNSVGNAQP-------TSAPSVESHPVLEK ENST00000279070 ---------RWVAPRNRNAAFGQSGGAGSDSNSPGNVQP-------NSAPSVESHPVLEK SINFRUP00000130274 ---------RWVAPRNRTFCYGSGSLDSSGSSSGGGVGNGGGG--ITPEPGAESHPVLEK ci0100151465 -----------AGNTNTNFHYNNAQ-----------------------TKEESGNEVLEK CG6422-RA -------ERSGNYSSFRGSEFESASKFEYRDENQSRPVEATS---ATEELPVDSQLVLDE : : . : :*:: ENSMUST00000040654 LRSINNYNPKDFDWNLK-HGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN ENST00000294415 LRSINNYNPKDFDWNLK-HGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN SINFRUP00000158963 LRMVNNYNPKDFDWNPK-QGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSLG ENSMUST00000050490 LKAINNYNPKDFDWNLK-NGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLN ENST00000321203 LKAINNYNPKDFDWNLK-NGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLN SINFRUP00000158366 LQALNNYNPKDFDWSLK-NGRIFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDGAYRSLG ENSMUST00000037299 LKAAHSYNPKEFDWNLK-SGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDGAFRSMS ENST00000279070 LKAAHSYNPKEFEWNLK-SGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRCMS SINFRUP00000130274 LRAAHSYNPKDFDWNLK-NGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRAMN ci0100151465 LKAENDYNPKRLTIDVR-NARFFVIKSYSEDDIHRSIKYNIWCSTDHGNKRLDAAFREQQ CG6422-RA LKDKNNYNPKVLDLKKAGSARFFVIKSYSEDDIHRSIKYEIWCSTDHGNKRLDDAFKERH *: :.**** : . .*.*:***************.*****:******* *:: ENSMUST00000040654 GKG-PVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQ ENST00000294415 GKG-PVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQ SINFRUP00000158963 AKG-PLYLLFSVNGSGHFCGVAEMRSPVDYNTSAGVWSQDKWKGRFDVRWIFVKDVPNSQ ENSMUST00000050490 GKG-PLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQ ENST00000321203 GKG-PLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQ SINFRUP00000158366 NKG-PLYLLFSVNGSGHFCGVAEMRSPVDYNAYAGVWSQDKWKGKFEVKWIFIKDVPNNQ ENSMUST00000037299 SKG-PVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVPNNQ ENST00000279070 SKG-PVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQ SINFRUP00000130274 SKG-PVYLLFSVNGSGHFCGVAEMRSPVDYGTSAGVWAQDKWKGKFDVNWLFVKDVPNSQ ci0100151465 GHG-PVILLYSVNGSGHFCGVAEMLTQIDYSKRAGVWAQDKWKGKFQVKWIYAKDVPNSQ CG6422-RA EEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVKWIYVKDVPNGT .* : *::**********:*:* : :**. :.**:****:*:*.*.*:: *****. ENSMUST00000040654 LRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEES ENST00000294415 LRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEES SINFRUP00000158963 LRHIRLENNENKPVTNSRDTQEVPLDKARQVLKIIAGYKHTTSIFDDFSHYEKRQEEEEC ENSMUST00000050490 LRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEA ENST00000321203 LRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEA SINFRUP00000158366 LRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATYKHTTSIFDDFAHYEKRQEEEEI ENSMUST00000037299 LRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEEV ENST00000279070 LRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIISSYKHTTSIFDDFAHYEKRQEEEEV SINFRUP00000130274 LRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIAQYKHTTSIFDDFSHYEKKQEEEEV ci0100151465 LRHIRLENNENKPVTNSRDTQEVPAEKGRQVLKIISSYKHQTSIFDDFSHYERRQVEEEG CG6422-RA LRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKKQEEEVS *********:**.*********** :*. :**:*: ::* ******* ***::* ** ENSMUST00000040654 VKKERQGRGK-------------------------------------------------- ENST00000294415 VKKERQGRGK-------------------------------------------------- SINFRUP00000158963 VKK--------------------------------------------------------- ENSMUST00000050490 MRRERNRNKQ-------------------------------------------------- ENST00000321203 MRRERNRNKQ-------------------------------------------------- SINFRUP00000158366 LRKV-------------------------------------------------------- ENSMUST00000037299 VRKERQNRNKQ------------------------------------------------- ENST00000279070 VRKERQSRNKQ------------------------------------------------- SINFRUP00000130274 VKKVT------------------------------------------------------- ci0100151465 LRQKRNELRSRDNHKEKQSAHPDQASPKN------------------------------- CG6422-RA SKRPPMHGPDGNNHAPAPLARSFNRQADDKDRDRDGRGGMSQKHFNSGGGAGFRNPGHRG :: ENSMUST00000040654 ------------------------------------------------------------ ENST00000294415 ------------------------------------------------------------ SINFRUP00000158963 ------------------------------------------------------------ ENSMUST00000050490 ------------------------------------------------------------ ENST00000321203 ------------------------------------------------------------ SINFRUP00000158366 ------------------------------------------------------------ ENSMUST00000037299 ------------------------------------------------------------ ENST00000279070 ------------------------------------------------------------ SINFRUP00000130274 ------------------------------------------------------------ ci0100151465 ------------------------------------------------------------ CG6422-RA GAGSGGSHNNYSEYRRGFDIHKSSSDYQFKDRDGPDFDRENDFGSHYGSNNRKNEYKHNN ENSMUST00000040654 -------------------------------------- ENST00000294415 -------------------------------------- SINFRUP00000158963 -------------------------------------- ENSMUST00000050490 -------------------------------------- ENST00000321203 -------------------------------------- SINFRUP00000158366 -------------------------------------- ENSMUST00000037299 -------------------------------------- ENST00000279070 -------------------------------------- SINFRUP00000130274 -------------------------------------- ci0100151465 -------------------------------------- CG6422-RA TNKARLKTRDRDFSTEQIKIGVRFKDTDKDKMRSNEYS