CLUSTAL W (1.82) multiple sequence alignment ENST00000270530 ------------------------------------------------------------ ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 ------------------------------------------------------------ ENSMUST00000011975 ------------------------------------------------------------ ENST00000263785 ------------------------------------------------------------ SINFRUP00000128859 ------------------------------------------------------------ ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 ------------------------------------------------------------ ENST00000265957 MDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEA CG7112-RA MRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKGDTTDEEV ENST00000270530 ------------------------------------------------------------ ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 ------------------------------------------------------------ ENSMUST00000011975 ------------------------------------------------------------ ENST00000263785 ------------------------------------------------------------ SINFRUP00000128859 ------------------------------------------------------------ ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 ------------------------------------------------------------ ENST00000265957 SSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQ-ISLDVTLSVPNV CG7112-RA S-----EIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNC ENST00000270530 ------------------------------------------------------------ ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 ------------------------------------------------------------ ENSMUST00000011975 ------------------------------------------------------------ ENST00000263785 ------------------------------------------------------------ SINFRUP00000128859 ------------------------------------------------------------ ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 ------------------------------------------------------------ ENST00000265957 SEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCE CG7112-RA SEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHG-DALFQCHVFRCH ENST00000270530 ------------------------------------------------------------ ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 ------------------------------------------------------------ ENSMUST00000011975 ------------------------------------------------------------ ENST00000263785 ------------------------------------------------------------ SINFRUP00000128859 ------------------------------------------------------------ ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 ------------------------------------------------------------ ENST00000265957 IQEAVSRILYSFATAFRRSAKQTPLSATAAPQTP------------DSDIFTFSVSLEIK CG7112-RA IPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIR ENST00000270530 ------------------------------------------------------------ ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 ------------------------------------------------------------ ENSMUST00000011975 ------------------------------------------------------------ ENST00000263785 ------------------------------------------------------------ SINFRUP00000128859 ------------------------------------------------------------ ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 ------------------------------------------------------------ ENST00000265957 EDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTN---KELAIERCFGLLLSPGKD CG7112-RA ERVAKNSYAAVPRD--RGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKL ENST00000270530 ------------------------------------------------------------ ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 ------------------------------------------------------------ ENSMUST00000011975 -----------------------------------------------------MVTTKMT ENST00000263785 ------------------------------------------------------------ SINFRUP00000128859 ------------------------------------------------------------ ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 ----------------------------------------------------MAQLDQFR ENST00000265957 VRNSDMHLLDLESMGKSSDGKS-----------------YVITGSWNPKSPHFQVVNEET CG7112-RA VVQKDMHLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLES ENST00000270530 -------------------------------------MASPTLSP------DSSSQEALS ENSMUST00000043710 -------------------------------------MASPTLSP------DSSSQEALS SINFRUP00000164538 ---------------------------------------------------------ALS ENSMUST00000011975 AAFRNPNRRQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASP-SASLHTTSSSTTLS ENST00000263785 ----------VATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASP-STSLHTTSSSTTLS SINFRUP00000128859 ----------VATDKVSGRLSATLSWVKNSVSHTVSQMANQVAAPTSLQTTATSSSTSLS ENSMUST00000055429 -----------------------------------------VASP-SASLHTTSSSTTLS ci0100141957 QRMRDLVRAPVTALSSNPTSNRMDGIVPNNDVMSISVVSKPAMLHNKTNNKGPQQNVITN ENST00000265957 PKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNER--LFWPFSKRSTTENFFLKLK CG7112-RA SKTN---LTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLK : . ENST00000270530 APTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSAS- ENSMUST00000043710 APTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSAS- SINFRUP00000164538 APALSP-ADSENLSPDELELLAKLEEQNRLLEADSKSMRSMSGSRRNSGSSLVSSSSAS- ENSMUST00000011975 TPTQSPSSPSK-LSPDDLELLAKLEEQNRLIETDSKSLRSVNGSRRNSGSSLVSSSSAS- ENST00000263785 TPALSPSSPSQ-LSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSAS- SINFRUP00000128859 SPALSPSTPAQ-LSPDDVELLAKLEEQNRLLEIDSKSLRSMNGSRRNSGSSLVSSSSAS- ENSMUST00000055429 TPTQSPSSPSK-LSPDDLELLAKLEEQNRLIETDSKSLRSVNGSRRNSGSSLVSSSSAS- ci0100141957 DSLALSESAMQQLNAEEIEILQKIEQQNRLLEADKKSLKSVSSEGGHSESRRSSNGSASP ENST00000265957 QIKQRERKNNTDTLYEVVCLESESERER--RKTTASPSVRLPQSGSQSSVIPSPPEDDEE CG7112-RA RTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSS : : :.. : : . : . : . . ENST00000270530 -----------SNLS-HLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIV ENSMUST00000043710 -----------SNLS-HLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIV SINFRUP00000164538 -----------SNLS-HLEEDTWILWGRIVNEWEEWRRKKDKLLKELIRKGIPHHFRAIV ENSMUST00000011975 -----------SNLS-HLEEDSWILWGRIVNEWDDVRKKKEKQVKELVRKGIPHHFRAIV ENST00000263785 -----------SNLS-HLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIV SINFRUP00000128859 -----------SNLS-HLEEDSWILWGRIVNEWEEVRKKKEKQLKELVRMGVPHHFRAIV ENSMUST00000055429 -----------SNLS-HLEEDSWILWGRIVNEWDDVRKKKEKQVKELVRKGIPHHFRAIV ci0100141957 TSMHSAGNDTNSNQSNDTDNKTWNLWGKIVNNWNDYQKKNGKQLKEMIRMGIPHHFRGLA ENST00000265957 EDNDEPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEV CG7112-RA -DGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDS--EKRPKNLAPLVRLGVPEALREKI .: * . :. *. : :*. . . * : ::: *:*. :* ENST00000270530 WQLLCSATD-MPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVM ENSMUST00000043710 WQLLCSATD-MPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVM SINFRUP00000164538 WQLLGNATD-MPVKN-HSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVM ENSMUST00000011975 WQLLCNAQS-MTIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVM ENST00000263785 WQLLCSAQS-MPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVM SINFRUP00000128859 WQLLCNAQN-MPIKDQYSELLKMTSPCEKLIRRDIARTYPEHEFFKEKDSLGQEVLFNVM ENSMUST00000055429 WQLLCNAQS-MTIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVM ci0100141957 WQHLCNAHC-STFKEKYSELLRQNSPSEKLIRRDIARTYPEQEFFKDKDGIGQEVLFNVI ENST00000265957 WQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKIC CG7112-RA WQKLANVEGRMEMNDKYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVS ** * . . : : *: : :. * *** **:* :. ** .. **: *::: ENST00000270530 KA---YSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG ENSMUST00000043710 KA---YSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG SINFRUP00000164538 KARIAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG ENSMUST00000011975 KA---YSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELG ENST00000263785 KA---YSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELG SINFRUP00000128859 KQ---VHVKRRKN-----RLRFDLMCFTQMPEEEAFCVFVKLMQDYRLRELFKPTMAELG ENSMUST00000055429 KA---YSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELG ci0100141957 KA---YSLVDREVGYCQGSAFIVGLLLMQMPEEEAFAVFVCLMKEYRLRELFKPSMAELG ENST00000265957 KA---YSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLH CG7112-RA KA---YAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLY * : : : : :****:**.*:* :* :* **:*:* : * ENST00000270530 LCIYQFEYMLQEQLPDLNTHFRSQ---SFHTSMYASSWFLTLFLTTFPLPVATRVFDIFM ENSMUST00000043710 LCIYQFEYMLQEQLPDLNTHFRSQ---SFHTSMYASSWFLTLFLTTFPLPVATRVFDIFM SINFRUP00000164538 LCIYQFEYLLQEQLPELNLHFRSQ---SFHTSMYASSWFLTLFLTFLPLPVATRIFDIFM ENSMUST00000011975 LCMYQFECMIQEYLPELFVHFQSQ---SFHTSMYASSWFLTIFLTTFPLPIATRIFDIFM ENST00000263785 LCMYQFECMIQEHLPELFVHFQSQ---SFHTSMYASSWFLTIFLTTFPLPIATRIFDIFM SINFRUP00000128859 LCMYQFEFMIQEQLPELHMHFQAQ---SFHTSMYASSWFLTIFLTSFPLPIATRIFDIFM ENSMUST00000055429 LCMYQFECMIQEYLPELFVHFQSQ---SFHTSMYASSWFLTIFLTTFPLPIATRIFDIFM ci0100141957 LCMYQLENMLQVTSPGSLHSLPSTRFPQLHVCITVVSYFW--FATTFDLNLASRVLDVFI ENST00000265957 CKFYQLERLMQEYIPDLYNHFLDIS---LEAHMYASQWFLTLFTAKFPLYMVFHIIDLLL CG7112-RA LRLYQLERLIKDQLPKLHEHFTACG---IETHMYASQWFLTLYTARFPLCFVFHVLDVFL :**:* ::: * : :.. : . .:* :: : : * .. :::*::: ENST00000270530 YEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCP-DKLVLKAY-QVKY ENSMUST00000043710 YEGLEIVFRVGLALLQVNQTELMQLDMEGMSQYFQRVIPHQFDSCP-DKLVLKAY-QVKY SINFRUP00000164538 YEGLEIIFRVGLAILQYNQTDLVQLDMEGMSQHFQKVIPHQFDSCP-DKLILRAY-QIKY ENSMUST00000011975 SEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGGP-EKLIQSAY-QVKY ENST00000263785 SEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVP-DKLIQAAY-QVKY SINFRUP00000128859 CEGLEIVFRVGLAILQMNQTELIQLDMEGMLQHFQKVIPHQFDSGP-DKVIQAAY-QVKY ENSMUST00000055429 SEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGGP-EKLIQSAY-QVKY ci0100141957 SEGMEIIFRLSLALLLSSEKELLAMDMEGMLKLITKDLPNFYNKDP-NLLFQRAFALVKY ENST00000265957 CEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKI CG7112-RA LDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERKI :*: ::*.:.: :* : :* *:** : : :*: . * ENST00000270530 NPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKG-----------QVT ENSMUST00000043710 NPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKG-----------QVT SINFRUP00000164538 NPKRMKKLK----VMIS--VQQTLVIP----YNNNIKADFDISFQG-----------QVT ENSMUST00000011975 NSKKMKKLEKEYTTIKTKEMEEQGEIKRLRTENRLLKQRIETLEKH-----------KCS ENST00000263785 NSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEKH-----------KCS SINFRUP00000128859 NGKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIDTLEK------------KGP ENSMUST00000055429 NSKKMKKLEKEYTTIKTKEMEEQGEIKRLRTENRLLKQRIETLEK--------------- ci0100141957 NPKKVKRLEKEYMTMRNKEQEEQVEMRRLRTENRLLRQRLDELEAENGQLADKLIQDRVN ENST00000265957 SQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQE-------------- CG7112-RA --KKLKQYEEEFLLKKQHKERLEKEAQIYEN---RFGEERRKMQAE-------------- *::*: : . : ENST00000270530 RAQEAEENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETEL ENSMUST00000043710 RAQEAEENYVIKRELAVVRQQCSSTAEDLQKAQSTIRQLQEQQVPGG------------- SINFRUP00000164538 RAQEAEENYVIKRELAVVRQQCTTASESLEKAQDTIRELQQQKYS----EPFVTSLQTQL ENSMUST00000011975 STYNEDFVLQLEKELVQAR----------------------------------------- ENST00000263785 SNYNEDFVLQLEKELVQAR----------------------------------------- SINFRUP00000128859 PRYSEESVLQLEKELVQAR----------------------------------------- ENSMUST00000055429 --------------GQVTR----------------------------------------- ci0100141957 RALEAEEKIIMGKELSIAKRQARLG--KKINSPASQDEETNPPSSPQHSETFIMHLQQQL ENST00000265957 -------NDDLAHELVTSKIA--------------------------------------- CG7112-RA -------IDALNKQLTSAK----------------------------------------- : : ENST00000270530 EQSRLRETETLGALREMQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRE ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 EQSRLRETELLGALKEMQDKVLDLEKRSSSLPDENNVAALQEEVKQMKLRELEMLRSFRE ENSMUST00000011975 ----LSEAESQCALKEMQDKVLDIEKKNNSFPDENNIARLQEELIAVKLREAEAIMGLKE ENST00000263785 ----LSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKE SINFRUP00000128859 ----LKEAESQCALKEMQDKILDIEKRNSSLPDDTNVARLQEELIAVKLREAEALTGLKE ENSMUST00000055429 ----AQEAEENYLIKR--------------------------ELATIKQQTDAARAKLEQ ci0100141957 VQAKLQEAEAASTIVELQDKLCDLREKNRELVDQSKVTSLQEELIAVKMREAESNLSMKE ENST00000265957 ----LRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAES CG7112-RA ---------ERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQQ : : ENST00000270530 LKLQLQELSDTWQAHLARG-------GRWKESPRKLVVGELQDELMSVRLREAQALAEGR ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 MQDTVSELNQRWQLHMSRGSSTGGGGGHWKESPKKNAMNELQDKLMTVRLREAEAQAELR ENSMUST00000011975 LRQQVRTLEEHWQRHLARTS------GRWKDPPKKNAVNELQDELMSIRLREAETQAEIR ENST00000263785 LRQQVKDLEEHWQRHLARTT------GRWKDPPKKNAMNELQDELMTIRLREAETQAEIR SINFRUP00000128859 LRQQVRDLEDHWQRHLARTA------GRWKDNQRKNTLSELQDELMSVRLREAEAQAELR ENSMUST00000055429 AESTIRELRHHR------------------------------------------------ ci0100141957 LAHKLHQLEDNWQKHMSRMANSRR-TTLTSSKQHKVALQELQEEVLSARFRETKLSAELA ENST00000265957 EIKKNSSIIGDYKQICSQLSE-----RLEKQQTANKVEIEKIRQKVDDCERCREFFNKEG CG7112-RA IDAGNDNAKSDDGKNRGQT---------DAMRNANEHPLGPLDPLNAASQRIRELELELA ENST00000270530 ELRQRVVELETQDHIHRNLLNRVEAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAEC ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 EVKLKALQLESQNQIHSKLIGRNEQERSSLQDRLQMLANQNKALQTQLSEMKRKQAD--- ENSMUST00000011975 EMKQRMMEMETQNQINSNQLRRAEQEVNSLQEKVCSLSVKNKGLLAQLSEAKRRQAEIEC ENST00000263785 EIKQRMMEMETQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIEC SINFRUP00000128859 ENRQRLLETETQNHIHNNQLRRAEQDNHCLQKCVQTLTTQNKDLHVQLQEIKRRQAEFEC ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 EGRHRIMELETANQVCNSQLRRSDEDRCLHKERSRVAVDNERVLRQELNEVSARLAHTES ENST00000265957 RVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLG---- CG7112-RA QAKLAQVEAECKNQDLN---HQLSNTLSELQTNRNSWQPWLSKTFNSLQEKVTTRGGHRD : ENST00000270530 KSKEEVMAVRLREADSMAAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIE ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 --KEEVMAVRLREADSMATMAELRQKVAELEIQKEEGLVKGQLNHSDLRQYINQMKNQIT ENSMUST00000011975 KNKEEVMAVRLREADSIAAVAELQQHIAELEIQKEEGKLQGQLNRSDSNQYIRELKDQIA ENST00000263785 K--EEVMAVRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIA SINFRUP00000128859 KSKEDVMAVRLREADNIAAMAELQQQISELEIQ--------------------------- ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 KNQEALMSLRLREADSSMEMAELKQEISSLKVKVIFLNCFAVLIMIWKLLYGNN------ ENST00000265957 LALNEVQAAKKTWFNRTLSSIKTATGVQGKETC--------------------------- CG7112-RA NGSGGPMPSFQSYMGQAPTTLSEASSPSGNQVT--------------------------- ENST00000270530 ELKAEVRLLKGPPPFEDPLAFDGLSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSP ENSMUST00000043710 ------------------------------------------------------------ SINFRUP00000164538 ELKNEV------------------------------------------------------ ENSMUST00000011975 ELTHELRCLKGQRDFSSRPPFDGIHIVSHLIGDDELFHSSDEDFIDSSLQESAIGFPLHR ENST00000263785 ELNHELRCLKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHG SINFRUP00000128859 ------------------------------------------------------------ ENSMUST00000055429 ------------------------------------------------------------ ci0100141957 ------------------------------------------------------------ ENST00000265957 ------------------------------------------------------------ CG7112-RA ------------------------------------------------------------ ENST00000270530 RDARFFRRLERPAKDSEGSSDSDADELAAPYSQGLDN------------ ENSMUST00000043710 ------------------------------------------------- SINFRUP00000164538 ------------------------------------------------- ENSMUST00000011975 KSGPMSLNPALADGSESEAEDGMLGPQESDPEAPQKQPPQR-ESYSTTV ENST00000263785 KSGSMSLDPAVADGSESETEDSVLETRESNQVVQKERPPRRRESYSTTV SINFRUP00000128859 ------------------------------------------------- ENSMUST00000055429 ------------------------------------------------- ci0100141957 ------------------------------------------------- ENST00000265957 ------------------------------------------------- CG7112-RA -------------------------------------------------